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12

Total database: 17430
Struktur (SMILES)
12 (100.0%)
Target
11 (91.7%)
Genomik
5 (41.7%)
Referensi
12 (100.0%)

Tipe Molekul

Distribusi Wujud Zat

Status Regulasi

Hasil Pencarian (12)

small molecule

Deskripsi belum tersedia.

Target Protein:
Dihydrofolate reductase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Amoxapine Approved DB00543
small molecule | CAS: 14028-44-5

Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine subs…

Kategori:
Adrenergic AgentsAdrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-Antagonists +49
Target Protein:
Sodium-dependent serotonin transporterSodium-dependent noradrenaline transporterD(2) dopamine receptor +22
Waktu Paruh8 hours
Vol. DistribusiWidely distributed …
Klirens-
Genetik -
Carbamazepine Approved DB00564
small molecule | CAS: 298-46-4

Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965.[A180301] Aside from the above uses, this drug is …

Kategori:
AnalgesicsAnalgesics, Non-NarcoticAnticonvulsants +65
Target Protein:
Voltage-gated sodium channel alpha subunitNeuronal acetylcholine receptor subunit alpha-4Nuclear receptor subfamily 1 group I member 2
Gen Terkait:
SCN1A HSPA1L HSPA1A +7
Waktu ParuhThe mean eliminatio…
Vol. DistribusiThe volume of distr…
KlirensIn a pharmacokineti…
Genetik 10 Varian
Clomipramine Approved DB01242
small molecule | CAS: 303-49-1

Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-de…

Kategori:
Agents that produce hypertensionAgents that reduce seizure thresholdAntidepressive Agents +45
Target Protein:
Sodium-dependent serotonin transporter5-hydroxytryptamine receptor 2A5-hydroxytryptamine receptor 2B +3
Gen Terkait:
CYP2D6 CYP2D6 CYP2D6 +6
Waktu ParuhFollowing oral admi…
Vol. Distribusi~ 17 L/kg (range: 9…
Klirens-
Genetik 9 Varian
Eslicarbazepine acetate Approved DB09119
small molecule | CAS: 236395-14-5

Eslicarbazepine acetate (ESL) is an anticonvulsant medication approved for use in Europe, the United States and Canada as an adjunctive therapy for partial-onset seizures that are not adequately controlled with conventional therapy. Eslicarbazepine acetate is…

Kategori:
AnticonvulsantsCarboxamide DerivativesCardiovascular Agents +16
Target Protein:
P2X purinoceptor 4
Waktu ParuhThe apparent plasma…
Vol. DistribusiThe apparent volume…
KlirensRenal clearance of …
Genetik -
Imipramine Approved DB00458
small molecule | CAS: 50-49-7

Imipramine, the prototypical tricyclic antidepressant (TCA), is a dibenzazepine-derivative TCA. TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individ…

Kategori:
Adrenergic AgentsAdrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-Antagonists +70
Target Protein:
Sodium-dependent noradrenaline transporterSodium-dependent serotonin transporter5-hydroxytryptamine receptor 2A +21
Gen Terkait:
CYP2D6 CYP2D6 CYP2D6 +6
Waktu ParuhImipramine has a me…
Vol. DistribusiImipramine has a hi…
KlirensImipramine has a me…
Genetik 9 Varian
Loxapine Approved DB00408
small molecule | CAS: 1977-10-2

An antipsychotic agent used in schizophrenia. [PubChem]

Kategori:
Antidepressive AgentsAntipsychotic AgentsAntipsychotic Agents (First Generation [Typical]) +24
Target Protein:
5-hydroxytryptamine receptor 2AD(2) dopamine receptor5-hydroxytryptamine receptor 2C +30
Waktu ParuhOral-4 hours
Vol. Distribusi-
Klirens-
Genetik -
Oxcarbazepine Approved DB00776
small molecule | CAS: 28721-07-5

Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of [carbamazepine][A186101] and exerts a majority of i…

Kategori:
Anti-epileptic AgentAnticonvulsantsCarboxamide Derivatives +29
Target Protein:
Sodium channel protein type 11 subunit alphaSodium channel protein
Gen Terkait:
HLA-B
Waktu ParuhThe plasma half-lif…
Vol. DistribusiThe apparent volume…
KlirensPlasma clearance of…
Genetik 1 Varian
Quetiapine Approved DB01224
small molecule | CAS: 111974-69-7

Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder.[L8546] Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects …

Kategori:
Adrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-AntagonistsAdrenergic Antagonists +44
Target Protein:
5-hydroxytryptamine receptor 2AD(2) dopamine receptor5-hydroxytryptamine receptor 1A +21
Waktu ParuhThe average termina…
Vol. DistribusiQuetiapine distribu…
KlirensThe clearance of qu…
Genetik -
Trimipramine Approved DB00726
small molecule | CAS: 739-71-9

Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties.

Kategori:
Adrenergic AgentsAdrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-Antagonists +44
Target Protein:
Sodium-dependent serotonin transporterSodium-dependent noradrenaline transporterSodium-dependent dopamine transporter +15
Gen Terkait:
CYP2D6 CYP2D6 CYP2D6 +5
Waktu Paruh11-18 hrs
Vol. Distribusi-
Klirens-
Genetik 8 Varian
Vebicorvir DB18784
small molecule | CAS: 2090064-66-5

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Dihydrofolate reductase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -