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8

Total database: 17430
Struktur (SMILES)
8 (100.0%)
Target
5 (62.5%)
Genomik
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Referensi
8 (100.0%)

Tipe Molekul

Distribusi Wujud Zat

Status Regulasi

Hasil Pencarian (8)

Artemether Approved DB06697
small molecule | CAS: 71963-77-4

Artemether is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with lumefantrine for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of <i>Plasmodium spp.</i> and…

Kategori:
Anti-Infective AgentsAntimalarialsAntiparasitic Agents +25
Target Protein:
Sodium/potassium-transporting ATPase subunit alpha-1
Waktu ParuhArtemether, 1.6 +/-…
Vol. Distribusi-
Klirens-
Genetik -
Artemisinin DB13132
small molecule | CAS: 63968-64-9

Artemisinin has been used in trials studying the treatment of Schizophrenia, Malaria, Falciparum, and Plasmodium Falciparum.

Kategori:
Anti-Infective AgentsAntimalarialsAntiparasitic Products, Insecticides and Repellents +13
Target Protein:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Artemotil Approved DB13851
small molecule | CAS: 75887-54-6

Artemotil, also known as ?-arteether, is a semi-synthetic derivative of artemisinin and a fast acting blood schizonticide specifically indicated for the treatment of chloroquine-resistant _Plasmodium falciparum_ malaria and cerebral malaria cases.

Kategori:
AmebicidesAnti-Infective AgentsAntimalarials +11
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Artenimol Approved DB11638
small molecule | CAS: 71939-50-9

Artenimol is an artemisinin derivative and antimalarial agent used in the treatment of uncomplicated *Plasmodium falciparum* infections [FDA Label]. It was first authorized for market by the European Medicines Agency in October 2011 in combination with [DB139…

Kategori:
Anti-Infective AgentsAntimalarialsAntiparasitic Agents +16
Target Protein:
Actin, cytoplasmic 2Alpha-aminoadipic semialdehyde dehydrogenaseAnnexin A2 +188
Waktu ParuhArtenimol was repor…
Vol. DistribusiArtenimol was obser…
KlirensArtenimol was obser…
Genetik -
Artesunate Approved DB09274
small molecule | CAS: 88495-63-0

Artesunate is indicated for the initial treatment of severe malaria.[L14099] The World Health Organization recommends artesunate as first line treatment for severe malaria.[L890] Artesunate was developed out of a need for a more hydrophilic derivative of [art…

Kategori:
Acids, AcyclicAnionsAnthelmintics +28
Target Protein:
Malaria protein EXP-1
Waktu ParuhThe elimination hal…
Vol. DistribusiThe volume of distr…
KlirensThe clearance of ar…
Genetik -
Chloroquine Approved DB00608
small molecule | CAS: 54-05-7

Chloroquine is an aminoquinolone derivative first developed in the 1940s for the treatment of malaria.[A191655] It was the drug of choice to treat malaria until the development of newer antimalarials such as [pyrimethamine], [artemisinin], and [mefloquine].[A…

Kategori:
Agents Causing Muscle ToxicityAgents that produce neuromuscular block (indirect)Agents that reduce seizure threshold +39
Target Protein:
Atypical chemokine receptor 1Glutathione S-transferase A2Tumor necrosis factor +5
Waktu ParuhThe half life of ch…
Vol. DistribusiThe volume of distr…
KlirensChloroquine has a t…
Genetik -
Lumefantrine co-artemether Approved DB13085
small molecule | CAS: 141204-94-6

Lumefantrine Co-Artemether (Riamet) has been investigated for the treatment of Malaria, Malaria, Falciparum, Malaria in Pregnancy, Uncomplicated Malaria, and Uncomplicated Knowlesi Malaria. Lumefantrine Co-Artemether is a tablet formulation of artemether and …

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Piperaquine Approved DB13941
small molecule | CAS: 4085-31-8

Piperaquine is an antimalarial agent first synthesized in the 1960's and used throughout China [A31550]. Its use declined in the 1980's as piperaquine resistant strains of *Plasmodium falciparum* appeared and artemisinin derivatives became available. It has c…

Kategori:
Anti-Infective AgentsAntimalarialsAntiparasitic Agents +19
Waktu ParuhThe terminal elimin…
Vol. DistribusiPiperaquine is thou…
KlirensThe mean apparent t…
Genetik -