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Total database: 17430
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Target
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Hasil Pencarian (6)

Aripiprazole Approved DB01238
small molecule | CAS: 129722-12-9

Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's.[L45859] It is also indicated as an injection for agitation associated wit…

Kategori:
Adrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-AntagonistsAdrenergic Antagonists +48
Target Protein:
D(2) dopamine receptor5-hydroxytryptamine receptor 2A5-hydroxytryptamine receptor 1A +35
Waktu ParuhThe mean eliminatio…
Vol. DistribusiThe steady-state vo…
KlirensThe clearance of ar…
Genetik -
Aripiprazole lauroxil Approved DB14185
small molecule | CAS: 1259305-29-7

Aripiprazole lauroxil is a long-acting injectable atypical antipsychotic drug used in the treatment of schizophrenia in adult patients. It is a prodrug of [aripiprazole], which acts as a partial agonist at the D2 and 5-HT1A receptors, and as an antagonist at …

Kategori:
Adrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-AntagonistsAdrenergic Antagonists +29
Target Protein:
D(2) dopamine receptor5-hydroxytryptamine receptor 1A5-hydroxytryptamine receptor 2A +22
Waktu ParuhThe mean aripiprazo…
Vol. DistribusiBased on population…
KlirensIn rats, the cleara…
Genetik -
Bifeprunox DB04888
small molecule | CAS: 350992-10-8

Bifeprunox is a novel atypical antipsychotic agent which, along with SLV313, [aripiprazole] and SSR-181507 combines minimal D2 receptor agonism with 5-HT receptor agonism.

Kategori:
Antipsychotic AgentsAntipsychotic Agents (Second Generation [Atypical])Central Nervous System Depressants +2
Target Protein:
5-hydroxytryptamine receptor 1AD(2) dopamine receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Brexpiprazole Approved DB09128
small molecule | CAS: 913611-97-9

Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). It has a high affinity for serotonin, dopamine and alpha (?)-adrenergic receptors.[L46417] Although it is …

Kategori:
Adrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-AntagonistsAdrenergic Antagonists +30
Target Protein:
5-hydroxytryptamine receptor 1AD(2) dopamine receptorD(3) dopamine receptor +9
Waktu ParuhAfter multiple once…
Vol. DistribusiThe volume of distr…
KlirensApparent oral clear…
Genetik -
Lumateperone Approved DB06077
small molecule | CAS: 313368-91-1

Schizophrenia is a complex mental illness and impacts approximately 1% of the population.[L10902] Although there are several antipsychotics including [aripiprazole], [paliperidone] and [clozapine] available for clinical use, they are generally accompanied by …

Kategori:
Antidepressive AgentsAntipsychotic AgentsAntipsychotic Agents (Second Generation [Atypical]) +21
Target Protein:
Sodium-dependent serotonin transporter5-hydroxytryptamine receptor 2AD(2) dopamine receptor +1
Waktu ParuhLumateperone's half…
Vol. DistribusiThe volume of distr…
KlirensLumateperone's clea…
Genetik -
Ziprasidone Approved DB00246
small molecule | CAS: 146939-27-7

Disorders such as schizophrenia and bipolar disorder can significantly impair mood, cognition, and behavior.[A190525] These mental illnesses can often be accompanied by comorbidities such as depression and substance abuse, and can significantly impact the qua…

Kategori:
Adrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-AntagonistsAdrenergic Antagonists +45
Target Protein:
D(2) dopamine receptorNeuronal acetylcholine receptor subunit alpha-75-hydroxytryptamine receptor 2A +24
Waktu ParuhThe half life of zi…
Vol. DistribusiThe mean apparent v…
KlirensThe mean apparent s…
Genetik -