Hasil Filter

4

Total database: 17430
Struktur (SMILES)
4 (100.0%)
Target
4 (100.0%)
Genomik
1 (25.0%)
Referensi
4 (100.0%)

Tipe Molekul

Distribusi Wujud Zat

Status Regulasi

Hasil Pencarian (4)

Amlodipine Approved DB00381
small molecule | CAS: 88150-42-9

Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called _dihydropyridine calcium channel blockers_. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channe…

Kategori:
ACE Inhibitors and Calcium Channel BlockersAgents causing hyperkalemiaAngiotensin II Antagonists and Calcium Channel Blockers +43
Target Protein:
Voltage-dependent L-type calcium channel subunit alpha-1CVoltage-dependent calcium channel subunit alpha-2/delta-1Voltage-dependent T-type calcium channel subunit alpha-1I +6
Gen Terkait:
NPPA
Waktu ParuhThe terminal elimin…
Vol. Distribusi21 L/kg [A175327], …
KlirensTotal body clearanc…
Genetik 1 Varian
Barnidipine DB09227
small molecule | CAS: 104713-75-9

Barnidipine is a long-acting novel calcium antagonist that belongs to the dihydropyridine (DHP) group of calcium channel blockers. Used in the treatment of hypertension, barnidipine displays high affinity for the calcium channels of the smooth muscle cells in…

Kategori:
Agents causing hyperkalemiaAntiarrhythmic agentsBradycardia-Causing Agents +17
Target Protein:
Voltage-dependent L-type calcium channel subunit alpha-1CVoltage-dependent T-type calcium channel subunit alpha-1GVoltage-dependent T-type calcium channel subunit alpha-1H
Waktu ParuhIn a two-compartmen…
Vol. DistribusiAfter administratio…
Klirens-
Genetik -
Levamlodipine Approved DB09237
small molecule | CAS: 103129-82-4

Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of [amlodipine], an antihypertensive medication.[L10833] Levamlodipine belongs to the dihydropyridine group of calcium channel blockers.[L10833] This medication was first mark…

Kategori:
Antiarrhythmic agentsAntihypertensive AgentsAntihypertensive Agents Indicated for Hypertension +11
Target Protein:
Voltage-dependent L-type calcium channel subunit alpha-1CVoltage-dependent L-type calcium channel subunit alpha-1DNitric oxide synthase 3 +1
Waktu ParuhLevamlodipine has a…
Vol. DistribusiThe volume of distr…
KlirensThe oral clearance …
Genetik -
Nifedipine Approved DB01115
small molecule | CAS: 21829-25-4

Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridin…

Kategori:
Agents causing hyperkalemiaAntiarrhythmic agentsAntihypertensive Agents +57
Target Protein:
Voltage-dependent L-type calcium channel subunit alpha-1CVoltage-dependent L-type calcium channel subunit alpha-1DVoltage-dependent L-type calcium channel subunit beta-2 +5
Waktu ParuhThe terminal elimin…
Vol. DistribusiThe steady state vo…
KlirensThe total body clea…
Genetik -