Hasil Filter

4

Total database: 17430
Struktur (SMILES)
4 (100.0%)
Target
2 (50.0%)
Genomik
1 (25.0%)
Referensi
4 (100.0%)

Tipe Molekul

Distribusi Wujud Zat

Status Regulasi

Hasil Pencarian (4)

Amiodarone Approved DB01118
small molecule | CAS: 1951-25-3

Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings.[A36817] Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting f…

Kategori:
Agents causing hyperkalemiaAgents Causing Muscle Toxicityalpha-Galactosidase, antagonists & inhibitors +50
Target Protein:
HERG human cardiac K+ channelBeta adrenergic receptorVoltage-dependent T-type calcium channel subunit alpha-1I +5
Gen Terkait:
KCNH2
Waktu ParuhThe terminal half-l…
Vol. DistribusiIn a pharmacokineti…
KlirensThe clearance of am…
Genetik 1 Varian
Budiodarone DB05519
small molecule | CAS: 335148-45-3

Budiodarone (ATI-2042) is an antiarrhythmic related to amiodarone that is currently being studied in clinical trials.

Kategori:
BenzofuransHeterocyclic Compounds, Fused-Ring
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Celivarone DB16012
small molecule | CAS: 401925-43-7

Celivarone is under investigation in clinical trial NCT00233441 (Placebo Controlled Double-blind Dose Ranging Study of the Efficacy and Safety of SSR149744C 50, 100, 200 or 300 Mg OD With Amiodarone as Calibrator for the Maintenance of Sinus Rhythm in Patient…

Kategori:
Heterocyclic Compounds, Fused-Ring
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dronedarone Approved DB04855
small molecule | CAS: 141626-36-0

Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke pr…

Kategori:
Adrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-AntagonistsAdrenergic Antagonists +35
Target Protein:
Alpha-1A adrenergic receptorPotassium voltage-gated channel subfamily A member 5Alpha-1B adrenergic receptor +22
Waktu ParuhThe elimination hal…
Vol. DistribusiThe volume of distr…
KlirensFollowing intraveno…
Genetik -