Hasil Filter

3

Total database: 17430
Struktur (SMILES)
2 (66.7%)
Target
3 (100.0%)
Genomik
0 (0%)
Referensi
3 (100.0%)

Tipe Molekul

Distribusi Wujud Zat

Status Regulasi

Hasil Pencarian (3)

Alendronic acid Approved DB00630
small molecule | CAS: 66376-36-1

Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label][A959].

Kategori:
Agents Causing Muscle ToxicityBisphosphonatesBone Density Conservation Agents +5
Target Protein:
Farnesyl pyrophosphate synthaseHydroxylapatiteTyrosine-protein phosphatase non-receptor type 4 +3
Waktu ParuhDue to alendronic a…
Vol. Distribusi28L[FDA Label].
Klirens71mL/min[FDA Label].
Genetik -
Pamidronic acid Approved DB00282
small molecule | CAS: 40391-99-9

Pamidronic acid is a second generation, nitrogen containing bisphosphonate similar to [neridronic acid] and [alendronic acid].[A203111] Pamidronic acid was first described in the literature in 1977.[A203267] The second generation bisphosphonates are less comm…

Kategori:
Agents Causing Muscle ToxicityAntineoplastic AgentsBisphosphonates +7
Target Protein:
Farnesyl pyrophosphate synthaseHydroxylapatiteGeranylgeranyl pyrophosphate synthase +2
Waktu ParuhThe mean eliminatio…
Vol. Distribusi-
KlirensThe mean total clea…
Genetik -
Romosozumab Approved DB11866
biotech | CAS: 909395-70-6

Romosozumab is a humanized monoclonal antibody indicated for the treatment of osteoperosis in postmenopausal women at high risk of fracture and patients who have failed in other treatments or are intolerant to other osteoperosis therapies[L9554]. Romosozumab …

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +12
Target Protein:
Sclerostin
Waktu Paruh12.8 days[L9554].
Vol. Distribusi3.92L[L9554].
Klirens0.38mL/hr/kg[L9554].
Genetik -