Hasil Pencarian (2)
small molecule | CAS: 1256580-46-7
Alectinib is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase. It is specifically used in the treatment of non-small cell lung cancer (NSCLC) expressing the ALK-EML4 (echinoderm microtubu…
Kategori:
Anaplastic lymphoma kinase (ALK) inhibitorsAntineoplastic AgentsAntineoplastic and Immunomodulating Agents
+14
Target Protein:
ALK tyrosine kinase receptor
Waktu ParuhThe mean eliminatio…
Vol. Distribusi4016 L
KlirensThe apparent cleara…
Genetik
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small molecule | CAS: 1108743-60-7
Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor.[L8081] It was approved by the FDA in August 2019 for use in the treatment of ROS1-positi…
Kategori:
AmidesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents
+17
Target Protein:
ALK tyrosine kinase receptorHigh affinity nerve growth factor receptorNT-3 growth factor receptor
+4
Waktu ParuhEntrectinib has a h…
Vol. DistribusiEntrectinib has an …
KlirensThe apparent cleara…
Genetik
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