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Total database: 17430
Struktur (SMILES)
4 (100.0%)
Target
4 (100.0%)
Genomik
0 (0%)
Referensi
4 (100.0%)

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Distribusi Wujud Zat

Status Regulasi

Hasil Pencarian (4)

Brinzolamide Approved DB01194
small molecule | CAS: 138890-62-7

Brinzolamide is a highly specific, non-competitive, reversible carbonic anhydrase II (CA-II) inhibitor indicated to reduce ocular pressure in patients with ocular hypertension or open-angle glaucoma.[L35310] Although the exact pathophysiology of glaucoma is s…

Kategori:
AmidesAntiglaucoma Preparations and MioticsCarbonic Anhydrase Inhibitors +17
Target Protein:
Carbonic anhydrase 2Carbonic anhydrase 1Carbonic anhydrase 4 +2
Waktu ParuhDue to its affinity…
Vol. Distribusi-
Klirens-
Genetik -
Dorzolamide Approved DB00869
small molecule | CAS: 120279-96-1

Dorzolamide is a non-bacteriostatic sulfonamide derivative [A1304] and topical carbonic anhydrase (CA) inhibitor that treats elevated intraocular pressure (IOP) associated with open-angle glaucoma and ocular hypertension.[L11377] It works by blocking an enzym…

Kategori:
AmidesAntiglaucoma Preparations and MioticsAntihypertensive Agents +16
Target Protein:
Carbonic anhydrase 2Carbonic anhydrase 4Carbonic anhydrase 1 +1
Waktu ParuhAs the drug adminis…
Vol. DistribusiThere is limited in…
KlirensThere is limited in…
Genetik -
Latanoprost Approved DB00654
small molecule | CAS: 130209-82-4

Latanoprost is a prodrug analog of prostaglandin F2 alpha that is used to treat elevated intraocular pressure (IOP). It was initially approved by the FDA in 1998. Latanoprost is the first topical prostaglandin F2 alpha analog used for glaucoma treatment.[A184…

Kategori:
Antiglaucoma Preparations and MioticsAntihypertensive AgentsAutacoids +18
Target Protein:
Prostaglandin F2-alpha receptor
Waktu ParuhThe elimination hal…
Vol. DistribusiThe volume of distr…
KlirensThe systemic cleara…
Genetik -
Timolol Approved DB00373
small molecule | CAS: 26839-75-8

Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes.[L6724] It is also used in tablet form as a drug to treat hypertension.[L6727] Timolol was first approved by the FDA in …

Kategori:
Adrenergic AntagonistsAdrenergic beta-AntagonistsAgents causing hyperkalemia +28
Target Protein:
Beta-1 adrenergic receptorBeta-2 adrenergic receptorEndolysin
Waktu ParuhTimolol half-life w…
Vol. Distribusi1.3 - 1.7 L/kg [L6]…
KlirensOne pharmacokinetic…
Genetik -