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4

Total database: 17430
Struktur (SMILES)
4 (100.0%)
Target
3 (75.0%)
Genomik
0 (0%)
Referensi
4 (100.0%)

Tipe Molekul

Distribusi Wujud Zat

Status Regulasi

Hasil Pencarian (4)

Fexinidazole Approved DB12265
small molecule | CAS: 59729-37-2

Human African trypanosomiasis (HAT, also colloquially referred to as sleeping sickness), caused by _T. brucei gambiense_ and _T. brucei rhodesiense_, remains a moderate risk (>1/10,000 inhabitants per year in endemic areas) despite focussed control efforts. T…

Kategori:
Agents Against Leishmaniasis and TrypanosomiasisAntiparasitic Products, Insecticides and RepellentsAntiprotozoals +43
Waktu ParuhFexinidazole, M1, a…
Vol. DistribusiFexinidazole has an…
KlirensFexinidazole has a …
Genetik -
Fezolinetant Approved DB15669
small molecule | CAS: 1629229-37-3

Vasomotor symptoms (VMS), more colloquially known as hot flashes or night sweats, are some of the most common symptoms in menopause. With a median duration of 7.4 years, vasomotor symptoms are also the most common reasons why women seek treatments for menopau…

Kategori:
Cytochrome P-450 CYP1A2 SubstratesCytochrome P-450 CYP2C19 SubstratesCytochrome P-450 CYP2C9 Substrates +6
Target Protein:
Neuromedin-K receptor
Waktu ParuhThe effective half-…
Vol. DistribusiThe mean apparent v…
KlirensThe apparent cleara…
Genetik -
Levofloxacin Approved DB01137
small molecule | CAS: 100986-85-4

Levofloxacin is a fluoroquinolone antibiotic and the optical S-(-) isomer of racemic [ofloxacin].[A190663] It reportedly carries 8 to 128-fold more activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin[A190663] and remains…

Kategori:
4-QuinolonesAlimentary Tract and MetabolismAnti-Bacterial Agents +35
Target Protein:
DNA gyrase subunit ADNA gyrase subunit BDNA gyrase subunit A +1
Waktu ParuhThe average termina…
Vol. DistribusiLevofloxacin is wid…
KlirensThe average apparen…
Genetik -
Phylloquinone Approved DB01022
small molecule | CAS: 84-80-0

Vitamin K1, also called phylloquinone or phytonadione, is a fat soluble vitamin.[L33319,L33345] Phylloquinone is a cofactor of the enzyme ?-carboxylase, which modifies and activates precursors to coagulation factors II, VII, IX, and X.[A234264,A234195,A234259…

Kategori:
Blood and Blood Forming OrgansCoagulantsDiet, Food, and Nutrition +20
Target Protein:
Vitamin K-dependent gamma-carboxylaseOsteocalcin
Waktu ParuhIntravenous phylloq…
Vol. DistribusiThe steady state vo…
KlirensIntravenous phylloq…
Genetik -