Hasil Filter

9

Total database: 17430
Struktur (SMILES)
8 (88.9%)
Target
9 (100.0%)
Genomik
0 (0%)
Referensi
9 (100.0%)

Tipe Molekul

Distribusi Wujud Zat

Status Regulasi

Hasil Pencarian (9)

AP1081 DB05233
small molecule

A transdermal gel containing ethinyl estradiol and norelgestromin being investigated by Antares Pharma for use as a female contraceptive.

Target Protein:
Estrogen receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Desogestrel Approved DB00304
small molecule | CAS: 54024-22-5

Desogestrel, a prodrug, is a third generation progestogen[A176315] and hence, a member of the gonane family which was largely used in Europe before being approved in the US and Canada.[A176339] It was firstly generated from a study that showed that 11-beta an…

Kategori:
Adrenal Cortex HormonesCombination Contraceptives (with Estrogen and derivatives)Contraceptive Agents, Female +25
Target Protein:
Progesterone receptorEstrogen receptor
Waktu ParuhThe terminal half-l…
Vol. DistribusiThe apparent volume…
KlirensThe metabolic clear…
Genetik -
Drospirenone Approved DB01395
small molecule | CAS: 67392-87-4

Drospirenone is a synthetic progestin commonly found in the popular oral contraceptive, Yaz in combination with [Ethinyl estradiol].[L7973] Most recently, it was approved by both Health Canada and the FDA in combination with [Estetrol] as an oral contraceptiv…

Kategori:
Adrenal Cortex HormonesAgents causing hyperkalemiaAndrostanes +21
Target Protein:
Mineralocorticoid receptorAndrogen receptorProgesterone receptor +1
Waktu ParuhThe serum half-life…
Vol. DistribusiThe volume of distr…
KlirensDrospirenone is rap…
Genetik -
Estradiol Approved DB00783
small molecule | CAS: 50-28-2

Estradiol is a naturally occurring hormone circulating endogenously in females. It is commercially available in several hormone therapy products for managing conditions associated with reduced estrogen, such as vulvovaginal atrophy and hot flashes. Some avail…

Kategori:
Adrenal Cortex HormonesAndrogens and EstrogensAnti-Gonadotropin-Releasing Hormones +47
Target Protein:
Estrogen receptorEstrogen receptor betaNuclear receptor subfamily 1 group I member 2 +4
Waktu ParuhThe terminal half-l…
Vol. DistribusiEstrogens administe…
KlirensIn one pharmacokine…
Genetik -
Ethinylestradiol Approved DB00977
small molecule | CAS: 57-63-6

Ethinylestradiol was first synthesized in 1938 by Hans Herloff Inhoffen and Walter Hohlweg at Schering.[A191107] It was developed in an effort to create an estrogen with greater oral bioavailability.[A191107] These properties were achieved by the substitution…

Kategori:
Adrenal Cortex HormonesAntineoplastic and Immunomodulating AgentsBSEP/ABCB11 inducers +48
Target Protein:
Estrogen receptorNuclear receptor subfamily 1 group I member 2
Waktu ParuhA 30µg oral dose ha…
Vol. DistribusiA 30µg oral dose ha…
KlirensEthinylestradiol ha…
Genetik -
Mestranol Approved DB01357
small molecule | CAS: 72-33-3

The 3-methyl ether of ethinyl estradiol. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL contraceptives.

Kategori:
Adrenal Cortex HormonesContraceptive Agents, FemaleContraceptive Agents, Hormonal +25
Target Protein:
Estrogen receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Norgestrel Approved DB09389
small molecule | CAS: 6533-00-2

Norgestrel is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. Norgestrel is composed of a racemic mixture of two stereoisomers, dextronorgestrel and levonorgestrel. However, only the levorotary enantio…

Kategori:
Adrenal Cortex HormonesCombination Contraceptives (with Estrogen and derivatives)Contraceptive Agents, Female +20
Target Protein:
Progesterone receptor3-oxo-5-alpha-steroid 4-dehydrogenase 1Androgen receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Quinestrol Approved DB04575
small molecule | CAS: 152-43-2

The 3-cyclopentyl ether of ethinyl estradiol.

Kategori:
Estradiol CongenersEstrogenic Steroids, AlkylatedEstrogens +11
Target Protein:
Estrogen receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Segesterone acetate Approved DB14583
small molecule | CAS: 7759-35-5

Segesterone acetate is a steroidal progestin or synthetic progesterone and a 19-norprogesterone derivative with no CH3 group radical in position 6 [A37048]. In animal studies, segesterone acetate was shown to be one of the most potent progestins [A37090]. It …

Kategori:
Adrenal Cortex HormonesContraceptive Agents, FemaleContraceptive Agents, Hormonal +24
Target Protein:
Progesterone receptorAndrogen receptorGlucocorticoid receptor
Waktu ParuhThe mean (SD) half …
Vol. DistribusiThe volume of distr…
KlirensNo pharmacokinetic …
Genetik -