Hasil Pencarian (2)
small molecule | CAS: 606143-89-9
Binimetinib, also known as _Mektovi_, is a potent and selective oral mitogen-activated protein kinase 1/2 (MEK 1/2) inhibitor which is combined with [Encorafenib].[A34275,L3335] On June 27, 2018, the Food and Drug Administration approved the combination of…
Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsBCRP/ABCG2 Substrates
+16
Target Protein:
Dual specificity mitogen-activated protein kinase kinase 2Dual specificity mitogen-activated protein kinase kinase 1
Waktu ParuhThe mean (CV%) term…
Vol. DistribusiThe geometric mean …
KlirensThe apparent cleara…
Genetik
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small molecule | CAS: 1269440-17-6
Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations.[L12216] This protein plays a role in regulating the MAP kinase/E…
Kategori:
AmidesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents
+47
Target Protein:
Serine/threonine-protein kinase B-rafG1/S-specific cyclin-D1RAF proto-oncogene serine/threonine-protein kinase
+7
Waktu ParuhThe mean (CV%) term…
Vol. DistribusiThe blood-to-plasma…
KlirensThe apparent cleara…
Genetik
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