Hasil Filter

3

Total database: 17430
Struktur (SMILES)
3 (100.0%)
Target
2 (66.7%)
Genomik
0 (0%)
Referensi
3 (100.0%)

Tipe Molekul

Distribusi Wujud Zat

Status Regulasi

Hasil Pencarian (3)

Apremilast Approved DB05676
small molecule | CAS: 608141-41-9

Apremilast, also known as Otezla, is a phosphodiesterase 4 (PDE4) inhibitor used to treat various types of symptoms resulting from certain inflammatory autoimmune diseases. It belongs to the same drug class as [Roflumilast] and [Crisaborole].[A181244,L7495] I…

Kategori:
Agents reducing cytokine levelsAnti-Inflammatory AgentsAntineoplastic and Immunomodulating Agents +17
Target Protein:
Phosphodiesterase isozyme 4Cyclin-dependent kinase 4Cyclin-dependent kinase 6
Waktu ParuhThe average elimina…
Vol. DistribusiThe average apparen…
KlirensIn healthy patients…
Genetik -
Crisaborole Approved DB05219
small molecule | CAS: 906673-24-3

Crisaborole is a novel oxaborole approved by FDA on December 14, 2016 as Eucrisa, a topical treatment of for mild to moderate atopic dermatitis. This non-steroidal agent is efficacious in improving disease severity, reducing the risk of infection and reduci…

Kategori:
Agents for Dermatitis, Excluding CorticosteroidsAnti-Inflammatory AgentsCytochrome P-450 CYP2B6 Inhibitors +9
Target Protein:
3',5'-cyclic-AMP phosphodiesterase 4A3',5'-cyclic-AMP phosphodiesterase 4B3',5'-cyclic-AMP phosphodiesterase 4C +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
PF-07038124 DB19143
small molecule | CAS: 2415085-44-6

PF-07038124 is under investigation in clinical trial NCT05298033 (Study of Efficacy, Safety and Tolerability of Crisaborole and PF-07038124 With and Without NBUVB in Vitiligo).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -