Hasil Filter

5

Total database: 17430
Struktur (SMILES)
5 (100.0%)
Target
5 (100.0%)
Genomik
3 (60.0%)
Referensi
5 (100.0%)

Tipe Molekul

Distribusi Wujud Zat

Status Regulasi

Hasil Pencarian (5)

Atorvastatin Approved DB01076
small molecule | CAS: 134523-00-5

Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiova…

Kategori:
Agents Causing Muscle ToxicityAnticholesteremic AgentsBSEP/ABCB11 Substrates +37
Target Protein:
3-hydroxy-3-methylglutaryl-coenzyme A reductaseDipeptidyl peptidase 4Aryl hydrocarbon receptor +2
Gen Terkait:
KIF6 HMGCR CYP3A4
Waktu ParuhThe half-life of at…
Vol. DistribusiThe reported volume…
KlirensThe registered tota…
Genetik 3 Varian
Lovastatin Approved DB00227
small molecule | CAS: 75330-75-5

Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of _Aspergillus terreus_.[A174550] Originally named Mevinolin, lovastatin belongs to the statin class of…

Kategori:
Agents Causing Muscle ToxicityAnticholesteremic AgentsBSEP/ABCB11 Substrates +21
Target Protein:
3-hydroxy-3-methylglutaryl-coenzyme A reductaseIntegrin alpha-LHistone deacetylase 2
Waktu ParuhLovastatin half-lif…
Vol. DistribusiLovastatin is able …
Klirens-
Genetik -
Pitavastatin Approved DB08860
small molecule | CAS: 147511-69-1

Pitavastatin, also known as the brand name product Livalo, is a lipid-lowering drug belonging to the statin class of medications. By inhibiting the endogenous production of cholesterol within the liver, statins lower abnormal cholesterol and lipid levels and …

Kategori:
Agents Causing Muscle ToxicityAnticholesteremic AgentsBCRP/ABCG2 Substrates +20
Target Protein:
3-hydroxy-3-methylglutaryl-coenzyme A reductaseIntegrin alpha-L
Waktu ParuhThe mean plasma eli…
Vol. DistribusiThe mean volume of …
KlirensFollowing a single …
Genetik -
Rosuvastatin Approved DB01098
small molecule | CAS: 287714-41-4

Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous prod…

Kategori:
Agents Causing Muscle ToxicityAlimentary Tract and MetabolismAmides +32
Target Protein:
3-hydroxy-3-methylglutaryl-coenzyme A reductaseIntegrin alpha-L
Gen Terkait:
KIF6 HMGCR ABCG2
Waktu ParuhThe elimination hal…
Vol. DistribusiRosuvastatin underg…
Klirens-
Genetik 3 Varian
Simvastatin Approved DB00641
small molecule | CAS: 79902-63-9

Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular dis…

Kategori:
Agents Causing Muscle ToxicityAnticholesteremic AgentsBSEP/ABCB11 Substrates +37
Target Protein:
3-hydroxy-3-methylglutaryl-coenzyme A reductaseIntegrin alpha-LHistone deacetylase 2
Gen Terkait:
KIF6 HMGCR SLCO1B1
Waktu Paruh4.85 hours[A181571]
Vol. DistribusiRat studies indicat…
Klirens-
Genetik 3 Varian