Digital Pharmacy - Dashboard Peneliti

1D-myo-inositol 1,4,5-trisphosphate DB03401

small molecule | CAS: 85166-31-0

Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium i…

Kategori:

AlcoholsCarbohydratesInositol 1,4,5-Trisphosphate +3

Target Protein:

Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 +6

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine DB08398

small molecule | CAS: 105650-23-5

PhIP (2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine) has been used in trials studying the basic science of Pancreas Cancer.

Kategori:

CarcinogensMutagensNoxae +1

Target Protein:

Estrogen receptorNuclear receptor coactivator 2

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

4,5-bis(4-methoxyphenyl)-2-thiophen-2-yl-1H-imidazole DB08383

small molecule

Deskripsi belum tersedia.

Target Protein:

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

4-(2-amino-1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)phenol DB06898

small molecule

Deskripsi belum tersedia.

Target Protein:

Estrogen receptorNuclear receptor coactivator 2

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

Cis-[4,5-Bis-(4-Bromophenyl)-2-(2-Ethoxy-4-Methoxyphenyl)-4,5-Dihydroimidazol-1-Yl]-[4-(2-Hydroxyethyl)Piperazin-1-Yl]Methanone DB02872

small molecule

Deskripsi belum tersedia.

Target Protein:

E3 ubiquitin-protein ligase Mdm2

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

Cis-[4,5-Bis-(4-Chlorophenyl)-2-(2-Isopropoxy-4-Methoxyphenyl)-4,5-Dihyd Roimidazol-1-Yl]-Piperazin-1-Yl-Methanone DB04144

small molecule

Deskripsi belum tersedia.

Target Protein:

E3 ubiquitin-protein ligase Mdm2

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

Dimethylaminomicheliolide DB17111

small molecule | CAS: 1403357-81-2

Deskripsi belum tersedia.

Kategori:

CycloheptanesCycloparaffinsPolycyclic Sesquiterpenes +4

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

Emavusertib DB18060

small molecule | CAS: 1801344-14-8

Deskripsi belum tersedia.

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

EP-0042 DB18120

small molecule | CAS: 1402709-93-6

Deskripsi belum tersedia.

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

Idelalisib Approved DB09054

small molecule | CAS: 870281-82-6

Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is…

Kategori:

Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsBCRP/ABCG2 Substrates +47

Target Protein:

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Waktu ParuhThe terminal elimin…

Vol. Distribusi23 L

Klirens14.9 L/hr

Genetik -

Miransertib DB14982

small molecule | CAS: 1313881-70-7

Miransertib is under investigation in clinical trial NCT01473095 (Phase 1 Dose Escalation Study of ARQ 092 in Adult Subjects With Advanced Solid Tumors and Recurrent Malignant Lymphoma).

Kategori:

AminesPyridines

Target Protein:

RAC-gamma serine/threonine-protein kinaseRAC-alpha serine/threonine-protein kinase

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

Nutlin-3 DB17039

small molecule | CAS: 548472-68-0

Nutlin-3 is a small molecule inhibitor that targets p53-Mdm2 interaction.[A253057]

Kategori:

Stereoisomerism

Target Protein:

Cellular tumor antigen p53

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

PIK3CA DB14954

biotech

PIK3CA is under investigation in clinical trial NCT02957266 (Cervical Cancer Radiotherapy by Use of VMAT, Individualized Polyradiosensitization and Interstitial Brachytherapy).

Waktu Paruh-

Vol. Distribusi-

Klirens-

Genetik -

Pyridoxine Approved DB00165

small molecule | CAS: 65-23-6

Pyridoxine is the 4-methanol form of vitamin B6, an important water-soluble vitamin that is naturally present in many foods. As its classification as a vitamin implies, Vitamin B6 (and pyridoxine) are essential nutrients required for normal functioning of man…

Kategori:

Alimentary Tract and MetabolismAnalogs/DerivativesAntiinfectives for Systemic Use +10

Target Protein:

Aromatic-L-amino-acid decarboxylasePyridoxal kinase

Waktu ParuhThe total adult bod…

Vol. DistribusiPyridoxine main act…

Klirens-

Genetik -

Topiramate Approved DB00273

small molecule | CAS: 97240-79-4

Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines.[A175249] It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults.[A188309,L10544,L43478] Since 2012, the extende…

Kategori:

Alimentary Tract and MetabolismAnti-Obesity AgentsAnticonvulsants +23

Target Protein:

Glutamate receptor ionotropic, kainate 1Gamma-aminobutyric acid receptor subunit alpha-1Voltage-gated sodium channel alpha subunit +7

Waktu ParuhThe elimination hal…

Vol. DistribusiThe mean apparent v…

KlirensThe mean oral plasm…

Genetik -

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