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Total database: 17430
Struktur (SMILES)
20 (100.0%)
Target
13 (65.0%)
Genomik
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Referensi
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Hasil Pencarian (20)

small molecule

Deskripsi belum tersedia.

Target Protein:
MAP kinase-activated protein kinase 2
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule

Deskripsi belum tersedia.

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Genetik -
small molecule

9-amino-n-[3-(dimethylamino)propyl]acridine-4-carboxamide is an inactive derivative of the antitumour agents N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) and 9-amino-DACA.

Target Protein:
DNA
Waktu Paruh-
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Genetik -
small molecule | CAS: 89459-25-6

Acridine Carboxamide has been used in trials studying the treatment of Lung Cancer and Brain and Central Nervous System Tumors.

Kategori:
Antineoplastic AgentsEnzyme InhibitorsHeterocyclic Compounds, Fused-Ring +2
Waktu Paruh-
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Almotriptan Approved DB00918
small molecule | CAS: 154323-57-6

Almotriptan is a triptan drug for the treatment of migraine headaches. Almotriptan is in a class of medications called selective serotonin receptor agonists. It works by narrowing blood vessels in the brain, stopping pain signals from being sent to the brain,…

Kategori:
Agents that produce hypertensionAminesAnalgesics +30
Target Protein:
5-hydroxytryptamine receptor 1D5-hydroxytryptamine receptor 1B
Gen Terkait:
GNB3
Waktu Paruh3-4 hours
Vol. Distribusi* 180 to 200 L
Klirens* 57 L/h [healthy] …
Genetik 1 Varian
Befotertinib DB18844
small molecule | CAS: 1835667-63-4

Befotertinib is under investigation in clinical trial NCT05007938 (Befotertinib and Icotinib in Treatment-naive Patients With Advanced Egfr-mutant Lung Cancer).

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Bufotenine DB01445
small molecule | CAS: 487-93-4

A hallucinogenic serotonin analog found in frog or toad skins, mushrooms, higher plants, and mammals, especially in the brains, plasma, and urine of schizophrenics. Bufotenin has been used as a tool in CNS studies and misused as a psychedelic.

Kategori:
Amphibian VenomsAntidepressive AgentsBiological Factors +19
Target Protein:
5-hydroxytryptamine receptor 1D5-hydroxytryptamine receptor 2A5-hydroxytryptamine receptor 6 +2
Waktu Paruh-
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Chlorpheniramine Approved DB01114
small molecule | CAS: 132-22-9

A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation …

Kategori:
Anti-Allergic AgentsAntidepressive AgentsAntihistamines for Systemic Use +27
Target Protein:
Histamine H1 receptorSodium-dependent serotonin transporterSodium-dependent noradrenaline transporter +1
Waktu Paruh21-27 hours
Vol. Distribusi-
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Genetik -
Cyclopentolate Approved DB00979
small molecule | CAS: 512-15-2

A parasympatholytic anticholinergic used solely to obtain mydriasis or cycloplegia.

Kategori:
Acids, CarbocyclicAnticholinergic AgentsAutonomic Agents +11
Target Protein:
Muscarinic acetylcholine receptor M1Muscarinic acetylcholine receptor M5
Waktu Paruh-
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Diltiazem Approved DB00343
small molecule | CAS: 42399-41-7

Diltiazem is a benzothiazepine derivative with antihypertensive and vasodilating properties. Approved in 1982 by the FDA, it is a member of the non-dihydropyridine calcium channel blockers drug class. It works through various mechanisms of action, but it prim…

Kategori:
Agents causing hyperkalemiaAgents for Treatment of Hemorrhoids and Anal Fissures for Topical UseAntiarrhythmic agents +44
Target Protein:
Voltage-dependent L-type calcium channel subunit alpha-1CVoltage-dependent calcium channel subunit alpha-2/delta-1Voltage-dependent calcium channel gamma-1 subunit
Gen Terkait:
ADRB1
Waktu ParuhThe plasma eliminat…
Vol. DistribusiThe apparent volume…
KlirensFollowing a single …
Genetik 1 Varian
small molecule | CAS: 61-50-7

An N-methylated indoleamine derivative, a serotonergic hallucinogen found in several plants, especially Prestonia amazonica (Apocynaceae) and in mammalian brain, blood, and urine. It apparently acts as an agonist at some types of serotonin receptors and an an…

Kategori:
AminesAntidepressive AgentsBiogenic Amines +13
Target Protein:
5-hydroxytryptamine receptor 6Sigma non-opioid intracellular receptor 15-hydroxytryptamine receptor 2A
Waktu Paruh-
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Methapyrilene DB04819
small molecule | CAS: 91-80-5

Methapyrilene, formerly marketed in many drug products, was shown to be a potent carcinogen. Manufacturers voluntarily withdrew methapyriline drug products from the market in May and June 1979.

Kategori:
AminesAminopyridinesAnti-Allergic Agents +13
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Moxisylyte Approved DB09205
small molecule | CAS: 54-32-0

Moxisylyte, denominated as thymoxamine in the UK, is a specific and orally active ?1-adrenergic antagonist.[T45] According to the WHO, moxisylyte is approved since 1987[T91] and in the same year, it acquired the denomination of orphan product by the FDA.[L117…

Kategori:
Adrenergic AgentsAdrenergic alpha-AntagonistsAdrenergic Antagonists +17
Target Protein:
Alpha-1D adrenergic receptorAlpha adrenergic receptor
Waktu ParuhThe half-life of mo…
Vol. DistribusiIn preclinical tria…
KlirensIn preclinical tria…
Genetik -
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Osimertinib Approved DB09330
small molecule | CAS: 1421373-65-0

Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCL…

Kategori:
Acids, AcyclicAcrylatesAmides +29
Target Protein:
Epidermal growth factor receptor
Waktu ParuhThe population esti…
Vol. DistribusiThe mean volume of …
KlirensOral clearance is 1…
Genetik -
Sudapyridine DB18984
small molecule | CAS: 1859978-72-5

Sudapyridine is under investigation in clinical trial NCT05824871 (Sudapyridine (WX-081) in Rr/mdr/xdr-tuberculosis Patients).

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Sumatriptan Approved DB00669
small molecule | CAS: 103628-46-2

Sumatriptan is a serotonin receptor agonist commonly used to treat migraines and sometimes cluster headaches.[L6793,L6796,L6799,L6805,L6808,L6811] Sumatriptan is the first of the triptans and was made available in Europe in 1991 to treat migraines.[A179761] S…

Kategori:
Agents that produce hypertensionAmidesAmines +33
Target Protein:
5-hydroxytryptamine receptor 1A5-hydroxytryptamine receptor 1D5-hydroxytryptamine receptor 1B +1
Gen Terkait:
GNB3
Waktu ParuhSubcutaneous sumatr…
Vol. DistribusiSumatriptan has a v…
KlirensSubcutaneous sumatr…
Genetik 1 Varian
TBAJ-876 DB18807
small molecule

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-RingQuinolines
Waktu Paruh-
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Tetracaine Approved DB09085
small molecule | CAS: 94-24-6

Tetracaine is an ester local anaesthetic currently available in combination with lidocaine as a cream and patch.

Kategori:
Acids, CarbocyclicAgents for Treatment of Hemorrhoids and Anal Fissures for Topical UseAminobenzoates +23
Target Protein:
Ryanodine receptor 1Sodium channel protein type 10 subunit alphaRyanodine receptor 2 +1
Waktu ParuhTetracaine is hydro…
Vol. DistribusiTetracaine is rapid…
KlirensTetracaine is hydro…
Genetik -
Zolmitriptan Approved DB00315
small molecule | CAS: 139264-17-8

Zolmitriptan is a member of the triptan class of 5-hydroxytryptamine(5-HT)<sub>1B/1D/(1F)</sub> receptor agonists used to treat acute migraine.[A462, L12978] [Sumatriptan] was the first triptan to be developed, but had poor oral bioavailability and lipophilic…

Kategori:
Agents that produce hypertensionAminesAnalgesics +24
Target Protein:
5-hydroxytryptamine receptor 1B5-hydroxytryptamine receptor 1D5-hydroxytryptamine receptor 1F +5
Gen Terkait:
GNB3
Waktu ParuhZolmitriptan has a …
Vol. DistribusiZolmitriptan has a …
KlirensZolmitriptan has a …
Genetik 1 Varian