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16004

Total database: 17430
Struktur (SMILES)
12010 (75.0%)
Target
9041 (56.5%)
Genomik
112 (0.7%)
Referensi
16004 (100.0%)

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Distribusi Wujud Zat

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Hasil Pencarian (16004)

Halaman 99 / 321
Casimiroin DB08744
small molecule | CAS: 477-89-4

Casimiroin is a quinone reductase 2 inhibitor isolated from _Casimiroa edulis_.

Kategori:
AromataseDioxolesHeterocyclic Compounds, Fused-Ring +2
Target Protein:
Ribosyldihydronicotinamide dehydrogenase [quinone]
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Casirivimab Approved DB15941
biotech | CAS: 2415933-42-3

Casirivimab is a monoclonal antibody combined with [Imdevimab] in Regeneron's antibody cocktail known as REGN-COV2 for the treatment of COVID-19.[L23539] This drug is a combination of antibodies derived from humanized VelocImmune® mice in addition to blood s…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +10
Target Protein:
Spike glycoprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Casopitant DB06634
small molecule | CAS: 414910-27-3

Deskripsi belum tersedia.

Kategori:
Alimentary Tract and MetabolismAmidesAntiemetics +7
Target Protein:
Substance-P receptorCytochrome P450 3A4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Caspofungin Approved DB00520
small molecule | CAS: 162808-62-0

Caspofungin (brand name Cancidas worldwide) is an antifungal drug and the first member of a new drug class called the echinocandins, as coined by Merck & Co., Inc. It is typically administered intravenously. It shows activity against infections with Aspergill…

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Infective AgentsAntifungal Agents +18
Target Protein:
1,3-beta-glucan synthase component FKS11,3-beta-glucan synthase component GSC2
Waktu Paruh9-11 hours
Vol. Distribusi-
Klirens* 12 mL/min [After …
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Castanospermine DB01816
small molecule | CAS: 79831-76-8

Deskripsi belum tersedia.

Kategori:
AnalgesicsAnalgesics, Non-NarcoticAnti-Inflammatory Agents +10
Target Protein:
Glucan 1,3-beta-glucosidase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Castor oil Approved DB11113
biotech | CAS: 8001-79-4

Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (_Ricinus communis_ L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of [DB02955], which represents up to 90% of the total castor…

Kategori:
Alimentary Tract and MetabolismBiological ProductsComplex Mixtures +10
Target Protein:
Prostaglandin E2 receptor EP3 subtypeProstaglandin E2 receptor EP4 subtype
Waktu ParuhNo pharmacokinetic …
Vol. DistribusiNo pharmacokinetic …
KlirensNo pharmacokinetic …
Genetik -
Cat dander extract Approved DB13904
biotech

Cat dander extract is either subcutaneously or intracutaneously administered and contains dry cat dander or dry defatted cat pelt. It is used in the diagnosis and treatment (immunotherapy) of patients with a history of allergy to cats. An allergic reaction to…

Kategori:
Allergenic Extracts
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cathine DB01486
small molecule | CAS: 492-39-7

Cathine, also known as d-norpseudoephedrine and (+)-norpseudoephedrine, is a psychoactive drug with stimulant properties. It belongs to the phenethylamine and amphetamine chemical classes. In the United States, it is classified as a Schedule IV controlled sub…

Kategori:
AlcoholsAlimentary Tract and MetabolismAmines +7
Waktu Paruh5.2 +/- 3.4 hours
Vol. Distribusi-
Klirens-
Genetik -
Cathinone DB01560
small molecule | CAS: 71031-15-7

Cathinone is a monoamine alkaloid found in the shrub Catha edulis (Khat). Closely related to ephedrine, cathine and other amphetamines, it is probably the main contributor to the stimulant effect of Catha edulis. Cathinone differs from many other amphetamines…

Kategori:
Central Nervous System AgentsCentral Nervous System DepressantsCentral Nervous System Stimulants +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Catridecacog Approved DB09310
biotech | CAS: 606138-08-3

Coagulation Factor XIII A-Subunit (Recombinant), also known as catridecacog, is a recombinant form of the Factor XIII-A2 homodimer composed of two factor XIII (FXIII) A-subunits [FDA Label]. For people with congenital deficiency or mutation of Factor XIII, a …

Kategori:
Blood and Blood Forming OrgansBlood Coagulation FactorsHemostatics
Target Protein:
Coagulation factor XIII B chain
Waktu Paruh7.1 days
Vol. Distribusi-
Klirens0.41 mL/h/kg
Genetik -
Catumaxomab Approved DB06607
biotech | CAS: 509077-98-9

Catumaxumab is a trifunctional monoclonal antibody developed for use in cancer treatment. It has affinity for T-cells, accessory immune cells, and cancer cells. Catumaxumab was initially authorized for market by the European Medicines Agency in April 2009 for…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +13
Target Protein:
Low affinity immunoglobulin gamma Fc region receptor II-aLow affinity immunoglobulin gamma Fc region receptor III-ALow affinity immunoglobulin gamma Fc region receptor III-B +3
Waktu ParuhCatumaxomab has an …
Vol. Distribusi-
Klirens-
Genetik -
Caviar, unspecified Approved DB14241
biotech

Caviar, unspecified is an animal extract used in some OTC (over-the-counter) products. It is not an approved drug.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cavosonstat DB14775
small molecule | CAS: 1371587-51-7

Cavosonstat is under investigation in clinical trial NCT02589236 (Study of Cavosonstat (N91115) in Patients With CF Homozygous for the F508del-CFTR Mutation).

Kategori:
Benzene Derivatives
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cavrotolimod DB18216
small molecule | CAS: 2378664-12-9

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CB-010 DB17711
biotech

CB-010 is a CRISPR-edited allogeneic CAR-T cell therapy targeting CD19. It is being investigated for the treatment of follicular lymphoma.[L46158]

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CB-103 DB15279
small molecule | CAS: 218457-67-1

CB-103 is under investigation in clinical trial NCT03422679 (Study of CB-103 in Adult Patients With Advanced or Metastatic Solid Tumours and Haematological Malignancies).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CB-1158 DB15286
small molecule | CAS: 2095732-06-0

CB-1158 is under investigation in clinical trial NCT03910530 (A Study of INCMGA00012, INCB001158, and the Combination in Japanese Participants With Advanced Solid Tumors).

Kategori:
Enzyme Inhibitors
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CB-5083 DB16874
small molecule | CAS: 1542705-92-9

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Transitional endoplasmic reticulum ATPase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CBP-501 DB17277
small molecule | CAS: 565434-85-7

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsCell Cycle ProteinsDual-Specificity Phosphatases +11
Target Protein:
MAP/microtubule affinity-regulating kinase 3MAP kinase-activated protein kinase 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CC-115 DB12740
small molecule | CAS: 1228013-15-7

CC-115 has been used in trials studying the treatment of Prostate Cancer, Neoplasm Metastasis, Ewing's Osteosarcoma, Glioblastoma Multiforme, and Chronic Lymphocytic Leukemia, among others.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CC-401 DB12432
small molecule | CAS: 395104-30-0

CC-401 has been used in trials studying the treatment of Myeloid Leukemia.

Kategori:
JNK Mitogen-Activated Protein Kinases, antagonists & inhibitorsPyrazoles
Target Protein:
Mitogen-activated protein kinase 8Mitogen-activated protein kinase 9Mitogen-activated protein kinase 10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CC-90001 DB18445
small molecule | CAS: 1403859-14-2

Deskripsi belum tersedia.

Kategori:
AminesCyclohexanesCycloparaffins
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CCR5 mAb DB05906
biotech

CCR5 mAb is a fully human monoclonal antibody that specifically recognizes and binds the chemokine receptor CCR5, which is known to be a key facilitator of infection with human immunodeficiency virus (HIV-1). It was generated by HGS using the Abgenix XenoMous…

Target Protein:
C-C chemokine receptor type 5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CCT-018159 DB07594
small molecule | CAS: 171009-07-7

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Heat shock protein HSP 90-alphaHeat shock protein HSP 90-beta
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CCX-354 DB12963
small molecule | CAS: 1010073-75-2

CCX354-C has been used in trials studying the treatment of Rheumatoid Arthritis.

Target Protein:
C-C chemokine receptor type 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CDC-801 DB15640
small molecule | CAS: 192819-27-5

CDC-801 is under investigation in clinical trial NCT00006097 (Chemotherapy in Treating Patients With Chronic Lymphocytic Leukemia).

Target Protein:
3',5'-cyclic-AMP phosphodiesterase 4B3',5'-cyclic-AMP phosphodiesterase 4D3',5'-cyclic-AMP phosphodiesterase 4A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CDD-0102 DB16945
small molecule | CAS: 146422-58-4

Deskripsi belum tersedia.

Kategori:
Muscarinic AgonistsOxazolesReceptor, Muscarinic M1, agonists
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CDP323 DB05092
small molecule

CDP323 is an antagonist of the _vascular cell adhesion molecule 1_ (VCAM-1) binding to alpha4-integrins (other adhesion molecules), a process thought to be implicated in the pathophysiology of Multiple Sclerosis (MS). It is considered a small-molecule prodrug…

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +3
Target Protein:
Integrin alpha-4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CDX-1135 DB17607
biotech

CDX-1135, formerly TP-10, is a soluble, recombinant human Complement Receptor Type 1 (sCR1) developed by Avant Immunotherapeutics (now Celldex). It was investigated in clinical trials for post-cardiopulmonary bypass syndrome and kidney damage.

Kategori:
Amino Acids, Peptides, and ProteinsMembrane ProteinsProteins +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CDX-301 DB19293
biotech

CDX-301 is under investigation in clinical trial NCT02129075 (A Vaccine (CDX-1401) With or Without a Biologic Drug (CDX-301) for the Treatment of Patients With Stage IIB-IV Melanoma).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CDX-6210 DB17610
biotech

CDX-6210 is a modified version of a leucine decarboxylase enzyme from _Planctomycetaceae bacterium_.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CDX-6512 DB17841
biotech

CDX-6512 is a modified, gastrointestinal-stable bacterial leucine decarboxylase. Developed by Codexis, it is being investigated for the treatment of homocystinuria And Maple Syrup Urine Disease.[L46651, L46656]

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CE-224535 DB12113
small molecule | CAS: 724424-43-5

CE-224535 has been used in trials studying the treatment of Osteoarthritis.

Kategori:
Acids, CarbocyclicAmidesBenzene Derivatives +4
Target Protein:
P2X purinoceptor 7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CE-326597 DB12694
small molecule | CAS: 870615-40-0

CE-326,597 has been used in trials studying the treatment of Obesity.

Kategori:
BenzazepinesHeterocyclic Compounds, Fused-Ring
Target Protein:
Cholecystokinin receptor type A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CE-VST01-JC DB17190
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CEB-01 DB18505
small molecule

CEB-01 is a biocompatible polymeric PLGA nanofiber membrane containing the active substance 7-ethyl-10-hydroxycamptothecin

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cebranopadol DB12830
small molecule | CAS: 863513-91-1

Cebranopadol has been used in trials studying the treatment of Pain, Neoplasms, and Chronic Pain.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Mu-type opioid receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ceclazepide DB17270
small molecule | CAS: 1801749-44-9

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cedar leaf oil DB15836
biotech | CAS: 8007-20-3

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cedar oil Approved DB10917
biotech | CAS: 8000-27-9

Cedar oil (Juniperus virginiana) allergenic extract is used in allergenic testing.

Kategori:
Biological ProductsLipidsOils +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cedazuridine Approved DB15694
small molecule | CAS: 1141397-80-9

Myelodysplastic syndromes (MDS) are a group of hematopoietic neoplasms that give rise to variable cytopenias progressing to secondary acute myeloid leukemia (sAML), which is invariably fatal if untreated.[A215082, A215092, A215097] Hypomethylating agents such…

Kategori:
Cytidine Deaminase, antagonists & inhibitorsNucleic Acids, Nucleotides, and NucleosidesNucleosides +3
Target Protein:
Cytidine deaminase
Waktu ParuhCedazuridine has a …
Vol. DistribusiThe apparent volume…
KlirensCedazuridine has an…
Genetik -
Cediranib DB04849
small molecule | CAS: 288383-20-0

The novel indole-ether quinazoline Cediranib is a highly potent (IC<sub>50</sub> &lt; 1 nmol/L) ATP-competitive inhibitor of recombinant KDR tyrosine kinase in vitro. It is being developed clinically as a once-daily oral therapy for the treatment of cancer.

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsEnzyme Inhibitors +4
Target Protein:
Vascular endothelial growth factor receptor 2
Waktu Paruh12 to 35 hours
Vol. Distribusi-
Klirens-
Genetik -
Cedirogant DB18951
small molecule | CAS: 2055496-11-0

Cedirogant is under investigation in clinical trial NCT05044234 (A Study to Assess Adverse Events and Disease Activity With Cedirogant (ABBV-157) in Adult Participants With Moderate to Severe Psoriasis).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cefacetrile DB01414
small molecule | CAS: 10206-21-0

A derivative of 7-aminocephalosporanic acid.

Kategori:
AmidesAnti-Bacterial AgentsAnti-Infective Agents +14
Target Protein:
Penicillin-binding protein 1APenicillin-binding protein 1B
Waktu Paruh1.2 hours
Vol. DistribusiVd of 0.2 to 0.5L/.…
Klirens-
Genetik -
Cefaclor Approved DB00833
small molecule | CAS: 53994-73-3

Semisynthetic, broad-spectrum antibiotic derivative of cephalexin.

Kategori:
AmidesAnti-Bacterial AgentsAnti-Infective Agents +14
Target Protein:
Penicillin-binding protein 3Penicillin-binding protein 1A
Waktu Paruh0.6-0.9 hour
Vol. Distribusi-
Klirens-
Genetik -
Cefadroxil Approved DB01140
small molecule | CAS: 50370-12-2

Long-acting, broad-spectrum, water-soluble, cephalexin derivative.

Kategori:
AmidesAnti-Bacterial AgentsAnti-Infective Agents +13
Target Protein:
Penicillin-binding protein 3Penicillin-binding protein 1APenicillin-binding protein 1b +1
Waktu Paruh1.5 hours
Vol. Distribusi-
Klirens-
Genetik -
Cefalonium DB11385
small molecule | CAS: 5575-21-3

Deskripsi belum tersedia.

Kategori:
Amidesbeta-LactamsHeterocyclic Compounds, Fused-Ring +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cefaloridine DB09008
small molecule | CAS: 50-59-9

Cephaloridine or cefaloridine is a first generation semisynthetic cephalosporin. It is derived from cephalosporin C and is a zwitterion at physiological pH.

Kategori:
AmidesAnti-Bacterial AgentsAnti-Infective Agents +13
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 4901–4950 dari 16004
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