Hasil Filter

11778

Total database: 17430
Struktur (SMILES)
8554 (72.6%)
Target
6383 (54.2%)
Genomik
96 (0.8%)
Referensi
11778 (100.0%)

Tipe Molekul

Distribusi Wujud Zat

Status Regulasi

Hasil Pencarian (11778)

Halaman 98 / 236
Erythrityl tetranitrate Approved DB01613
small molecule | CAS: 7297-25-8

A vasodilator with general properties similar to nitroglycerin. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1020)

Kategori:
AlcoholsAntianginal AgentsCarbohydrates +7
Target Protein:
Atrial natriuretic peptide receptor 1Atrial natriuretic peptide receptor 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Erythromycin Approved DB00199
small molecule | CAS: 114-07-8

Erythromycin is a bacteriostatic antibiotic drug produced by a strain of Saccharopolyspora erythraea (formerly Streptomyces erythraeus) and belongs to the macrolide group of antibiotics which consists of [Azithromycin], [Clarithromycin], [Spiramycin] and othe…

Kategori:
Anti-Acne PreparationsAnti-Acne Preparations for Topical UseAnti-Bacterial Agents +38
Target Protein:
23S ribosomal RNAMotilin receptorVoltage-gated inwardly rectifying potassium channel KCNH2
Waktu ParuhThe elimination hal…
Vol. DistribusiErythromycin is fou…
KlirensThe clearance of er…
Genetik -
Erythropoietin Approved DB00016
biotech | CAS: 11096-26-7

Erythropoietin (EPO) is a growth factor produced in the kidneys that stimulates the production of red blood cells. It works by promoting the division and differentiation of committed erythroid progenitors in the bone marrow [FDA Label]. Epoetin alfa (Epoge) w…

Kategori:
Amino Acids, Peptides, and ProteinsAntianemic PreparationsBiological Factors +15
Target Protein:
Erythropoietin receptor
Waktu Paruh**Healthy volunteer…
Vol. DistribusiIn healthy voluntee…
Klirens**Healthy volunteer…
Genetik -
biotech

"Catuaba" is a general term for a medicinal infusion created by the bark of plants belonging to the _Erythroxylum_ genus, though this name is also applied to infusions of plants belonging to other genera.[A215262] The infusion is thought to carry stimulant an…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Erzotabart DB19063
biotech | CAS: 2430792-01-9

Erzotabart is under investigation in clinical trial NCT04824794 (GEN3014 Safety Trial in Relapsed or Refractory Hematologic Malignancies).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
ES-936 DB02400
small molecule | CAS: 192820-78-3

Deskripsi belum tersedia.

Target Protein:
NAD(P)H dehydrogenase [quinone] 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Esatenolol DB13443
small molecule | CAS: 93379-54-5

Esatenolol is a beta blocker.

Kategori:
Adrenergic AntagonistsAdrenergic beta-AntagonistsAgents causing hyperkalemia +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Esaxerenone DB15207
small molecule | CAS: 1632006-28-0

Esaxerenone is under investigation in clinical trial NCT02722265 (Long-term Study of CS-3150 as Monotherapy or in Combination With Other Antihypertensive Drug in Japanese Patients With Essential Hypertension).

Kategori:
Sulfur Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

Kategori:
Fused-Ring CompoundsSteroids
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Escin DB15907
small molecule | CAS: 6805-41-0

Sodium aescinate is under investigation in clinical trials for its potential to treat cerebral conditions, including NCT04247659 (studying the relationship between asymmetric vascular sign of cortex and prognosis in massive cerebral infarction) and NCT0526316…

Kategori:
CarbohydratesCardiovascular AgentsGlycosides +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Escitalopram Approved DB01175
small molecule | CAS: 128196-01-0

Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram].[A185420] It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 15…

Kategori:
AminesAnticholinergic AgentsAntidepressive Agents +35
Target Protein:
Sodium-dependent serotonin transporterMuscarinic acetylcholine receptor M1Histamine H1 receptor +8
Gen Terkait:
CYP2C19 CYP2C19 SLC6A4
Waktu ParuhThe elimination hal…
Vol. DistribusiEscitalopram appear…
KlirensThe oral plasma cle…
Genetik 3 Varian
Esculin Approved DB13155
small molecule | CAS: 531-75-9

Esculin is found in barley. Vitamin C2 is generally considered a bioflavanoid, related to vitamin P esculin is a glucoside that naturally occurs in the horse chestnut (Aesculus hippocastanum), California Buckeye (Aesculus californica) and in daphnin (the dark…

Kategori:
BenzopyransCarbohydratesCoumarins +4
Target Protein:
Androgen receptor
Waktu ParuhAbsorption half lif…
Vol. Distribusi-
Klirens-
Genetik -
Esflurbiprofen DB16159
small molecule | CAS: 51543-39-6

Esflurbiprofen is under investigation in clinical trial NCT03434197 (Safety and Efficacy of SFPP in Knee Osteoarthritis).

Kategori:
Antiinflammatory Preparations, Non-Steroids for Topical UseMusculo-Skeletal SystemTopical Products for Joint and Muscular Pain
Target Protein:
Gamma-secretase subunit APH-1BNicastrinGamma-secretase subunit APH-1A +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Esketamine Approved DB11823
small molecule | CAS: 33643-46-8

Major depressive disorder (MDD) is a significant cause of disability worldwide and the most common illness preceding suicide.[L5596,A175462] On March 5, 2019, the nasal spray drug, _esketamine_, also known as _Spravato_ (by Janssen Pharmaceuticals), was appro…

Kategori:
Agents producing tachycardiaAnestheticsAnesthetics, General +24
Target Protein:
NMDA receptorGlutamate receptor ionotropic, NMDA 2BElongation factor 2 +2
Waktu ParuhThe mean terminal h…
Vol. DistribusiThe average steady-…
KlirensThe average clearan…
Genetik -
Eslicarbazepine Approved DB14575
small molecule | CAS: 104746-04-5

Eslicarbazepine is an anti-epileptic medication available commercially as [eslicarbazepine acetate].

Kategori:
AnticonvulsantsCarboxamide DerivativesCardiovascular Agents +15
Target Protein:
Sodium channel protein type 11 subunit alphaP2X purinoceptor 4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Esmirtazapine DB06678
small molecule | CAS: 61337-87-9

Esmirtazapine, known by the standardized identifier SCH 900265, was under development by Organon to treat insomnia and vasomotor symptoms associated with menopause. Esmirtazapine is the (S)-(+)-enantiomer of mirtazapine and possesses similar overall pharmacol…

Kategori:
Adrenergic AgentsAdrenergic alpha-2 Receptor AntagonistsAdrenergic alpha-Antagonists +21
Target Protein:
Histamine H1 receptor5-hydroxytryptamine receptor 2Alpha-2 adrenergic receptors
Waktu Paruh10 hours
Vol. Distribusi-
Klirens-
Genetik -
Esmolol Approved DB00187
small molecule | CAS: 81147-92-4

Esmolol, commonly marketed under the trade name Brevibloc, is a cardioselective beta-1 receptor blocker. It has a rapid onset but short duration of action without causing significant intrinsic sympathomimetic or membrane stabilizing activities at recommended …

Kategori:
Adrenergic AgentsAdrenergic AntagonistsAdrenergic beta-1 Receptor Antagonists +18
Target Protein:
Beta-1 adrenergic receptor
Waktu ParuhRapid distribution …
Vol. Distribusi-
Klirens* 20 L/kg/hr [Men]
Genetik -
Esomeprazole Approved DB00736
small molecule | CAS: 119141-88-7

Esomeprazole, sold under the brand name Nexium, is a proton pump inhibitor (PPI) medication used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of…

Kategori:
2-PyridinylmethylsulfinylbenzimidazolesAcid ReducersAlimentary Tract and Metabolism +29
Target Protein:
Potassium-transporting ATPase alpha chain 1Potassium-transporting ATPase subunit betaN(G),N(G)-dimethylarginine dimethylaminohydrolase 1
Gen Terkait:
CYP2C19 CYP2C19
Waktu Paruh1-1.5 hours
Vol. DistribusiThe apparent volume…
Klirens-
Genetik 2 Varian
Esreboxetine DB12395
small molecule | CAS: 98819-76-2

Esreboxetine has been used in trials studying the treatment and basic science of Fibromyalgia.

Kategori:
Adrenergic Uptake InhibitorsAntidepressive AgentsCentral Nervous System Depressants +1
Target Protein:
Sodium-dependent noradrenaline transporter
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Estazolam Approved DB01215
small molecule | CAS: 29975-16-4

A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than diazepam or nitrazepam.

Kategori:
Anti-Anxiety AgentsAnticonvulsantsBenzazepines +20
Target Protein:
GABA(A) ReceptorTranslocator proteinGABA(A) Receptor Benzodiazepine Binding Site
Waktu ParuhThe range of estima…
Vol. Distribusi-
Klirens-
Genetik -
Esterified estrogens Approved DB09381
small molecule

Esterified estrogens contain a mixture of estrogenic substances; the principle component is estrone. Preparations contain 75% to 85% sodium estrone sulfate and 6% to 15% sodium equilin sulfate such that the total is not <90%. Esterified estrogens are a man-ma…

Kategori:
Cytochrome P-450 CYP3A SubstratesCytochrome P-450 CYP3A4 SubstratesCytochrome P-450 Substrates +2
Waktu ParuhHalf-life varies, i…
Vol. DistribusiThe distribution of…
KlirensThere is variation …
Genetik -
Estetrol Approved DB12235
small molecule | CAS: 15183-37-6

Naturally or synthetically produced steroid estrogens have a wide range of pharmaceutical uses ranging from hormonal contraception to the treatment of menopausal symptoms.[L33184] Estetrol (E4) is a native estrogen occurring naturally during pregnancy, but ca…

Kategori:
Adrenal Cortex HormonesContraceptives, OralCytochrome P-450 CYP3A Substrates +19
Target Protein:
Estrogen receptorEstrogen receptor beta
Waktu ParuhThe elimination hal…
Vol. DistribusiLimited distributio…
Klirens-
Genetik -
Estradiol Approved DB00783
small molecule | CAS: 50-28-2

Estradiol is a naturally occurring hormone circulating endogenously in females. It is commercially available in several hormone therapy products for managing conditions associated with reduced estrogen, such as vulvovaginal atrophy and hot flashes. Some avail…

Kategori:
Adrenal Cortex HormonesAndrogens and EstrogensAnti-Gonadotropin-Releasing Hormones +47
Target Protein:
Estrogen receptorEstrogen receptor betaNuclear receptor subfamily 1 group I member 2 +4
Waktu ParuhThe terminal half-l…
Vol. DistribusiEstrogens administe…
KlirensIn one pharmacokine…
Genetik -
Estradiol acetate Approved DB13952
small molecule | CAS: 4245-41-4

Estradiol acetate is a pro-drug ester of [DB00783], a naturally occurring hormone that circulates endogenously within the human body. Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex hormone. As a pro-dru…

Kategori:
BCRP/ABCG2 InhibitorsCytochrome P-450 CYP1A2 InhibitorsCytochrome P-450 CYP1A2 Inhibitors (strength unknown) +24
Target Protein:
Estrogen receptorEstrogen receptor betaNuclear receptor subfamily 1 group I member 2 +7
Waktu Paruh-
Vol. DistribusiThe distribution of…
Klirens-
Genetik -
Estradiol benzoate Approved DB13953
small molecule | CAS: 50-50-0

Estradiol Benzoate is a pro-drug ester of [DB00783], a naturally occurring hormone that circulates endogenously within the human body. Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex hormone. As a pro-dr…

Kategori:
Adrenal Cortex HormonesBCRP/ABCG2 InhibitorsContraceptive Agents, Hormonal +35
Target Protein:
Estrogen receptorEstrogen receptor betaNuclear receptor subfamily 1 group I member 2 +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Estradiol cypionate Approved DB13954
small molecule | CAS: 313-06-4

Estradiol Cypionate is a pro-drug ester of [DB00783], a naturally occurring hormone that circulates endogenously within the human body. Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex hormone. As a pro-d…

Kategori:
Adrenal Cortex HormonesBCRP/ABCG2 InhibitorsContraceptive Agents, Female +38
Target Protein:
Estrogen receptorEstrogen receptor betaNuclear receptor subfamily 1 group I member 2 +7
Waktu Paruh-
Vol. DistribusiThe distribution of…
Klirens-
Genetik -
Estradiol dienanthate Approved DB13955
small molecule | CAS: 7732-97-0

Estradiol Dienanthate is a pro-drug ester of [DB00783], a naturally occurring hormone that circulates endogenously within the human body. Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex hormone. As a pro…

Kategori:
BCRP/ABCG2 InhibitorsCytochrome P-450 CYP1A2 InhibitorsCytochrome P-450 CYP1A2 Inhibitors (strength unknown) +31
Target Protein:
Estrogen receptorEstrogen receptor betaNuclear receptor subfamily 1 group I member 2 +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 7698-93-3

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 172377-52-5

Deskripsi belum tersedia.

Kategori:
AmidesEstradiol CongenersEstranes +10
Target Protein:
Steryl-sulfatase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Estradiol valerate Approved DB13956
small molecule | CAS: 979-32-8

Estradiol Valerate (also known as E2V) is a pro-drug ester of [DB00783], a naturally occurring hormone that circulates endogenously within the human body. Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex …

Kategori:
Adrenal Cortex HormonesBCRP/ABCG2 InhibitorsContraceptive Agents, Female +38
Target Protein:
Estrogen receptorEstrogen receptor betaNuclear receptor subfamily 1 group I member 2 +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Estramustine Approved DB01196
small molecule | CAS: 2998-57-4

A nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also has radiation protective properties.

Kategori:
Alkylating ActivityAlkylating DrugsAntineoplastic Agents +18
Target Protein:
Estrogen receptor betaEstrogen receptorMicrotubule-associated protein 2 +1
Waktu Paruh20 hours
Vol. Distribusi-
Klirens-
Genetik -
Estramustine phosphate Approved DB14674
small molecule | CAS: 4891-15-0

A nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also has radiation protective properties.

Kategori:
Alkylating DrugsAntineoplastic AgentsAntineoplastic Agents, Alkylating +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 5696-58-2

Estrane-3,17-dione is a potent inhibitor of isomerase.

Kategori:
Fused-Ring CompoundsSteroids
Target Protein:
Steroid Delta-isomerase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Estriol Approved DB04573
small molecule | CAS: 50-27-1

A hydroxylated metabolite of estradiol or estrone that has a hydroxyl group at C3-beta, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During pregnancy, large amount of estriol is produced by the placenta. Isomers with inversion of the h…

Kategori:
Estradiol CongenersEstranesEstrenes +13
Target Protein:
Estrogen receptorEstrogen receptor betaSex hormone-binding globulin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Estrone Approved DB00655
small molecule | CAS: 53-16-7

Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. It is produced in vivo from androstenedione or from testosterone via estradiol. It is produced primarily in the ovaries, placenta, and in peri…

Kategori:
17-KetosteroidsAdrenal Cortex HormonesBCRP/ABCG2 Inhibitors +28
Target Protein:
Estrogen receptorEstrogen receptor betaAndrogen receptor +2
Waktu Paruh19 hours
Vol. Distribusi-
Klirens-
Genetik -
Estrone sulfate Approved DB04574
small molecule | CAS: 481-97-0

Estrone sulfate (as estropipate) is a form of estrogen. It has several uses such as: alleviate symptoms of menopause as hormone replacement therapy, treatment some types of infertility, treatment of some conditions leading to underdevelopment of female sexual…

Kategori:
17-KetosteroidsAdrenal Cortex HormonesContraceptive Agents, Hormonal +31
Target Protein:
Estrogen receptorEstrogen receptor beta
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Esuberaprost DB18464
small molecule | CAS: 94132-88-4

Esuberaprost (GP-1681), a drug intended for participants with pulmonary arterial hypertension, was under investigation in clinical trial NCT03657095 to evaluate its efficacy and safety.

Target Protein:
Prostacyclin receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Eszopiclone Approved DB00402
small molecule | CAS: 138729-47-2

Eszopiclone, marketed by Sepracor under the brand-name Lunesta, is a nonbenzodiazepine hypnotic drug used to treat insomnia. It is the active stereoisomer of zopiclone, belonging to the class of drugs known as _cyclopyrrolones_.[A179638,L6850] Cyclopyrrolone …

Kategori:
Benzodiazepine hypnotics and sedativesCentral Nervous System AgentsCentral Nervous System Depressants +18
Target Protein:
Gamma-aminobutyric acid receptor subunit alpha-1Translocator proteinGABA(A) Receptor +3
Waktu ParuhThe half-life is 6.…
Vol. DistribusiThe volume of distr…
KlirensThe mean clearance …
Genetik -
ET140203 DB17196
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Etafedrine Approved DB11587
small molecule | CAS: 48141-64-6

Etafedrine (INN) or ethylephedrine is a long-acting bronchodilator and has been an ingredient combined with other drugs in the brand names Nethaprin [A32757] and Dalmacol [L2568]. It was previously available as both the free base and as the hydrochloride salt…

Kategori:
Adrenergic AgonistsAdrenergic beta-2 Receptor AgonistsAdrenergic beta-Agonists +10
Target Protein:
Beta-2 adrenergic receptor
Waktu ParuhIt has a plasma hal…
Vol. DistribusiSimilar to ephedrin…
Klirens-
Genetik -
Etalocib DB12850
small molecule | CAS: 161172-51-6

Etalocib has been used in trials studying the treatment of Pancreatic Cancer, Carcinoma, Non-Small-Cell Lung, and Unspecified Adult Solid Tumor, Protocol Specific.

Kategori:
Acids, CarbocyclicBenzene Derivatives
Target Protein:
Leukotriene B4 receptor 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Etamicastat DB15288
small molecule | CAS: 760173-05-5

Etamicastat is under investigation in clinical trial NCT02840565 (Tolerability, Pharmacokinetics and Pharmacodynamics of Six Multiple Rising Dose Regimens of BIA 5-453).

Kategori:
Heterocyclic Compounds, Fused-RingPyrans
Target Protein:
Dopamine beta-hydroxylase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Etamivan DB08989
small molecule | CAS: 304-84-7

Etamivan (INN) or ethamivan (USAN) is marketed under the name Analepticon. Etamvin is a respiratory stimulant drug similar to nikethamide. It is no longer used in the United States.

Kategori:
Acids, CarbocyclicAmidesBenzene Derivatives +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Etanautine DB13636
small molecule | CAS: 857401-00-4

Deskripsi belum tersedia.

Kategori:
Agents producing tachycardiaAnti-Parkinson DrugsAnticholinergic Agents +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Etanercept Approved DB00005
biotech | CAS: 185243-69-0

Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain…

Kategori:
Agents reducing cytokine levelsAmino Acids, Peptides, and ProteinsAnti-Inflammatory Agents +18
Target Protein:
Tumor necrosis factorLymphotoxin-alphaHigh affinity immunoglobulin gamma Fc receptor I +6
Waktu ParuhEtanercept has a me…
Vol. DistribusiPopulation pharmaco…
KlirensEtanercept has a me…
Genetik -
Etanidazole DB12736
small molecule | CAS: 22668-01-5

Etanidazole has been used in trials studying the diagnostic of Adult Ependymoma, Malignant Ascites, Adult Gliosarcoma, Adult Mixed Glioma, and Adult Glioblastoma, among others.

Kategori:
Antineoplastic AgentsImidazolesNitro Compounds +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Etarfolatide DB11810
small molecule | CAS: 479578-27-3

Etarfolatide has been used in trials studying the treatment and diagnostic of Breast Neoplasms, Non Small Cell Lung Cancer, and Adenocarcinoma of the Lung.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Etavopivat DB18176
small molecule | CAS: 2245053-57-8

Etavopivat is a small molecule activator of erythrocyte pyruvate kinase (PKR) under investigation for the treatment of sickle cell disease.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
ETBX-011 DB17464
biotech

ETBX-011 is a cancer vaccine used to treat patients with cancers that express carcinoembryonic antigen (CEA).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
ETBX-021 DB17528
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 4851–4900 dari 11778
Sebelumnya Halaman 98 / 236 Berikutnya