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16004

Total database: 17430
Struktur (SMILES)
12010 (75.0%)
Target
9041 (56.5%)
Genomik
112 (0.7%)
Referensi
16004 (100.0%)

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Hasil Pencarian (16004)

Halaman 92 / 321
Bromfenac Approved DB00963
small molecule | CAS: 91714-94-2

Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and establ…

Kategori:
Agents causing hyperkalemiaAnalgesicsAnalgesics, Non-Narcotic +16
Target Protein:
Prostaglandin G/H synthase 2Prostaglandin G/H synthase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bromhexine Approved DB09019
small molecule | CAS: 3572-43-8

Bromhexine is mucolytic agent used for a variety of respiratory conditions associated with increased mucus secretion. It is derived from the Adhatoda vasica plant and aids in the clearance of excess mucus, improving breathing and reducing cough. It was introd…

Kategori:
AminesAniline CompoundsCough and Cold Preparations +5
Target Protein:
Transmembrane protease serine 2Angiotensin-converting enzyme 2
Waktu ParuhFollowing single or…
Vol. DistribusiAfter intravenous a…
KlirensThe clearance of br…
Genetik -
Bromisoval DB13370
small molecule | CAS: 496-67-3

Deskripsi belum tersedia.

Kategori:
AmidesCentral Nervous System AgentsCentral Nervous System Depressants +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Glutamate receptor 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bromo-WR99210 DB04007
small molecule

Deskripsi belum tersedia.

Target Protein:
Peptide deformylase, mitochondrialDihydrofolate reductase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 3679-64-9

Deskripsi belum tersedia.

Kategori:
Antifungals for Dermatological UseAntifungals for Topical UseDermatologicals
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bromocriptine Approved DB01200
small molecule | CAS: 25614-03-3

Bromocriptine mesylate is a semisynthetic ergot alkaloid derivative with potent dopaminergic activity. It inhibits prolactin secretion and may be used to treat dysfunctions associated with hyperprolactinemia. Bromocriptine is also indicated for the management…

Kategori:
Adrenergic AgonistsAdrenergic alpha-1 Receptor AgonistsAdrenergic alpha-1 Receptor Antagonists +41
Target Protein:
D(2) dopamine receptorD(3) dopamine receptor5-hydroxytryptamine receptor 1D +15
Waktu Paruh2-8 hours
Vol. Distribusi-
Klirens-
Genetik -
Bromodiphenhydramine Approved DB01237
small molecule | CAS: 118-23-0

Bromodiphenhydramine is an ethanolamine antihistamine with antimicrobial property. Bromodiphenhydramine is used in the control of cutaneous allergies. Ethanolamine antihistamines produce marked sedation in most patients.

Kategori:
AminesAminoalkyl EthersAntihistamines for Systemic Use +5
Target Protein:
Histamine H1 receptor
Waktu Paruh1 to 4 hours
Vol. Distribusi-
Klirens-
Genetik -
Bromoform DB03054
small molecule | CAS: 75-25-2

Deskripsi belum tersedia.

Kategori:
CarcinogensHydrocarbons, HalogenatedNoxae +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bromopride DB09018
small molecule | CAS: 4093-35-0

Bromopride is a dopamine antagonist used as an antiemetic. Its prokinetic properties are similar to those of metoclopramide. It is unavailable in America or the United Kingdom.

Kategori:
Acids, CarbocyclicAlimentary Tract and MetabolismAmides +22
Target Protein:
D(2) dopamine receptor
Waktu Paruh-
Vol. Distribusi-
KlirensRenal, 10-14% as or…
Genetik -
Bromopyruvate DB17135
small molecule | CAS: 1113-59-3

Deskripsi belum tersedia.

Kategori:
Affinity LabelsCompounds used in a research, industrial, or household settingEnzyme Inhibitors +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bromothalonil Approved DB14199
small molecule | CAS: 35691-65-7

Bromothalonil, also known as Methyldibromo glutaronitrile (MDBGN), is a widely used preservative that can be found in many personal hygiene and industrial products. It is also a known allergen and dermatological irritant that has been banned in many EU countr…

Kategori:
AllergensAntigensBiological Factors +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bromotheophylline Approved DB14018
small molecule | CAS: 10381-75-6

Bromotheophylline is the active moiety of pamabrom, a mixture of 2-amino-2-methyl-propanol and bromotheophylline. From this mixture, bromotheophylline acts as a weak diuretic that has been used along with some analgesics to relieve the symptoms of premenstrua…

Kategori:
AlcoholsAlkaloidsAmines +11
Target Protein:
Adenosine receptor
Waktu ParuhThe apparent elimin…
Vol. DistribusiThis pharmacokineti…
KlirensThis pharmacokineti…
Genetik -
Bromperidol Approved DB12401
small molecule | CAS: 10457-90-6

Bromperidol has been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and Psychosomatic Disorders, among others.

Kategori:
Antipsychotic AgentsButyrophenone DerivativesButyrophenones +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Brompheniramine Approved DB00835
small molecule | CAS: 86-22-6

Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria.

Kategori:
Agents producing tachycardiaAnti-Allergic AgentsAnticholinergic Agents +14
Target Protein:
Histamine H1 receptorMuscarinic acetylcholine receptor M1Muscarinic acetylcholine receptor M2 +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bronopol Approved DB13960
small molecule | CAS: 52-51-7

Bronopol, or 2-Bromo-2-nitro-1,3-propanediol, is an organic compound with wide-spectrum antimicrobial properties. First synthesized in 1897, bronopol was primarily used as a preservative for pharmaceuticals and was registered in the United States in 1984 for …

Kategori:
AlcoholsAnti-Infective AgentsAnti-Infective Agents, Local +9
Target Protein:
Thiol groups
Waktu ParuhThe half-life of br…
Vol. DistribusiThe highest concent…
KlirensNo data available.
Genetik -
Brontictuzumab DB12737
biotech | CAS: 1447814-75-6

Brontictuzumab has been used in trials studying the treatment of Adenoid Cystic Carcinoma, Relapsed or Refractory Solid Tumors, and Relapsed or Refractory Lymphoid Malignancies.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodies, MonoclonalAntibodies, Monoclonal, Humanized +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bropirimine DB04168
small molecule | CAS: 56741-95-8

Deskripsi belum tersedia.

Kategori:
Adjuvants, ImmunologicAntineoplastic AgentsImmunologic Factors +3
Target Protein:
Dihydroneopterin aldolase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Brostallicin DB06598
small molecule | CAS: 203258-60-0

Deskripsi belum tersedia.

Kategori:
Amidines
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Brotizolam DB09017
small molecule | CAS: 57801-81-7

Brotizolam is a sedative-hypnotic thienodiazepine drug which is a benzodiazepine analog. It demonstrates anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant effects. Brotizolam has similar effects to short-acting benzodiazepines such a…

Kategori:
Benzodiazepine hypnotics and sedativesBenzodiazepines and benzodiazepine derivativesCentral Nervous System Agents +7
Target Protein:
GABA(A) ReceptorGABA(A) Receptor Benzodiazepine Binding Site
Waktu Paruh4.4 hours.
Vol. Distribusi0.63 l/kg.
KlirensTotal clearance: 10…
Genetik -
Brovanexine DB14720
small molecule | CAS: 54340-61-3

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicAmidesBenzene Derivatives +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Brown iron oxide Approved DB14567
small molecule | CAS: 52357-70-7

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Broxuridine DB12028
small molecule | CAS: 59-14-3

Broxuridine has been used in trials studying the treatment of Leukemia, Stage I Prostate Cancer, Stage IIB Prostate Cancer, and Stage IIA Prostate Cancer.

Kategori:
Anti-Infective AgentsAntimetabolitesAntineoplastic Agents +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Broxyquinoline DB13536
small molecule | CAS: 521-74-4

Deskripsi belum tersedia.

Kategori:
Alimentary Tract and MetabolismAntidiarrheals, Intestinal Antiinflammatory/antiinfective AgentsAntiparasitic Products, Insecticides and Repellents +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bryostatin 1 DB11752
small molecule | CAS: 83314-01-6

Bryostatin 1 has been investigated for the treatment of HIV Infection and Alzheimer's Disease.

Kategori:
Adjuvants, ImmunologicAnti-Bacterial AgentsAntineoplastic Agents +15
Target Protein:
Protein kinase C epsilon typeProtein kinase C alpha typeCaspase-8 +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BS-001 DB17415
biotech

BS-001 is a recombinant oncolytic herpes simplex virus type II (OH2) therapeutic injection (Vero cell) for human use (rHSV2hGM-CSF).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BSG-005 DB18014
small molecule

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BSK02 DB17434
biotech

BSK02 is a Sperm Protein-17 oral microparticle vaccine

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BT200 DB18333
biotech

BT200 (Rondoraptivon pegol) is a PEGylated anti-von Willebrand factor (VWF) aptamer targeted against the VWF A1 domain.[A261491] It is under investigation for the treatment of von Willebrand disease and hemophilia A.[L48156]

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BTRX-246040 DB16048
small molecule | CAS: 1307245-86-8

BTRX-246040 is under investigation in clinical trial NCT03193398 (BTRX-246040 Administered Once Daily to Patients With Major Depressive Disorder).

Target Protein:
Nociceptin receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BTRX-335140 DB16068
small molecule | CAS: 2244614-14-8

BTRX-335140 is under investigation in clinical trial NCT04221230 (Study in Major Depressive Disorder With BTRX-335140 vs Placebo).

Kategori:
Heterocyclic Compounds, Fused-RingOxazoles
Target Protein:
Kappa-type opioid receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BTZ-043 DB17737
small molecule | CAS: 1161233-85-7

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bucelipase alfa DB16664
biotech | CAS: 9026-00-0

Bucelipase alfa is under investigation in clinical trial NCT00743483 (Efficacy of Bucelipase Alfa (BSSL) in Patients With Cystic Fibrosis and Pancreatic Insufficiency).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bucetin Approved DB13278
small molecule | CAS: 1083-57-4

Bucetin is an analgesic and antipyretic medication which was approved for use in Germany but was withdrawn from the market in 1986 due to renal toxicity caused by the medication.[A175636]

Kategori:
AminesAminophenolsAnalgesics +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bucillamine DB12160
small molecule | CAS: 65002-17-7

Bucillamine has been used in trials studying the treatment and prevention of Gout and Rheumatoid Arthritis.

Kategori:
Amino AcidsAmino Acids, NeutralAmino Acids, Peptides, and Proteins +17
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bucindolol DB12752
small molecule | CAS: 71119-11-4

Bucindolol has been investigated in Heart Failure.

Kategori:
Adrenergic AgentsAdrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-Antagonists +17
Target Protein:
Beta-2 adrenergic receptorBeta-1 adrenergic receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bucladesine DB13242
small molecule | CAS: 362-74-3

Deskripsi belum tersedia.

Kategori:
Adenine NucleotidesCardiac Stimulants Excl. Cardiac GlycosidesCardiac Therapy +9
Target Protein:
Plasminogen activator inhibitor 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Buclizine Approved DB00354
small molecule | CAS: 82-95-1

Buclizine is an antihistamine medication with both antiemetic and anticholinergic effects [L6220], belonging to the _piperazine derivative_ family of drugs. It was manufactured by Stuart Pharms and initially approved by the FDA in 1957.[L6217] Following this,…

Kategori:
Agents producing tachycardiaAnticholinergic AgentsAntihistamines for Systemic Use +8
Target Protein:
Histamine H1 receptorMuscarinic acetylcholine receptor M1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Budesonide Approved DB01222
small molecule | CAS: 51333-22-3

Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on …

Kategori:
Adrenal Cortex HormonesAdrenalsAgents to Treat Airway Disease +48
Target Protein:
Glucocorticoid receptorAnnexin A1
Gen Terkait:
TBX21
Waktu ParuhBudesonide has a pl…
Vol. DistribusiThe volume of distr…
KlirensBudesonide has a pl…
Genetik 1 Varian
Budigalimab DB16668
biotech | CAS: 2098225-93-3

Budigalimab is under investigation in clinical trial NCT04807972 (Study to Evaluate Adverse Events and Change in Disease Activity When Intravenous (IV) Infusion of ABBV-927 Is Administered in Combination With IV Modified FOLFIRINOX (Mffx) With or Without IV B…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
Target Protein:
Programmed cell death protein 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Budiodarone DB05519
small molecule | CAS: 335148-45-3

Budiodarone (ATI-2042) is an antiarrhythmic related to amiodarone that is currently being studied in clinical trials.

Kategori:
BenzofuransHeterocyclic Compounds, Fused-Ring
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Budipine DB13502
small molecule | CAS: 57982-78-2

Deskripsi belum tersedia.

Kategori:
Anti-Dyskinesia AgentsAnti-Parkinson DrugsCentral Nervous System Agents +2
Target Protein:
Amine oxidase [flavin-containing] B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Budoprutug DB19316
biotech | CAS: 2720478-38-4

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bufexamac Approved DB13346
small molecule | CAS: 2438-72-4

Bufexamac is a non-steroidal anti-inflammatory drug (NSAID) under the market name Droxaryl, Malipuran, Paraderm and Parfenac. It is typically administered topically for the treatment of subacute and chronic eczema of the skin, including atopic eczema and othe…

Kategori:
AcetamidesAcetic Acid Derivatives and Related SubstancesAgents causing hyperkalemia +24
Target Protein:
Prostaglandin G/H synthase 1Prostaglandin G/H synthase 2Histone deacetylase 6 +1
Waktu ParuhNo data available.
Vol. DistribusiNo data available.
KlirensNo data available.
Genetik -
Buflomedil DB13510
small molecule | CAS: 55837-25-7

Deskripsi belum tersedia.

Kategori:
Adrenergic alpha-AntagonistsAdrenergic AntagonistsAgents that produce hypertension +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Buformin DB04830
small molecule | CAS: 692-13-7

Buformin is an anti-diabetic drug of the biguanide class, chemically related to metformin and phenformin. It was withdrawn from the market in most countries due to a high risk of causing lactic acidosis.

Kategori:
Alimentary Tract and MetabolismAmidinesBiguanides +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bufotenine DB01445
small molecule | CAS: 487-93-4

A hallucinogenic serotonin analog found in frog or toad skins, mushrooms, higher plants, and mammals, especially in the brains, plasma, and urine of schizophrenics. Bufotenin has been used as a tool in CNS studies and misused as a psychedelic.

Kategori:
Amphibian VenomsAntidepressive AgentsBiological Factors +19
Target Protein:
5-hydroxytryptamine receptor 1D5-hydroxytryptamine receptor 2A5-hydroxytryptamine receptor 6 +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bufuralol DB06726
small molecule | CAS: 54340-62-4

Bufuralol is a new, non-selective -adrenoceptor blocking agent.

Kategori:
Adrenergic AgentsAdrenergic AntagonistsAdrenergic beta-Antagonists +8
Target Protein:
Beta adrenergic receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bufylline DB13812
small molecule | CAS: 5634-34-4

Deskripsi belum tersedia.

Kategori:
AlkaloidsAnti-Asthmatic AgentsAutonomic Agents +12
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bulevirtide Approved DB15248
biotech | CAS: 2012558-47-1

Hepatitis D is considered the most severe type of viral hepatitis and leads to the rapid development of cirrhosis, severe decompensation of liver function, and an increased risk of mortality.[A226340,L30235] Until recently, there have been extremely limited t…

Kategori:
Amino Acids, Peptides, and ProteinsAntiinfectives for Systemic UseAntiviral Agents +4
Target Protein:
Hepatic sodium/bile acid cotransporter
Waktu ParuhThe half-life of bu…
Vol. DistribusiThe volume of distr…
KlirensThe clearance after…
Genetik -
Menampilkan 4551–4600 dari 16004
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