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13591

Total database: 17430
Struktur (SMILES)
10177 (74.9%)
Target
7625 (56.1%)
Genomik
104 (0.8%)
Referensi
13591 (100.0%)

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Hasil Pencarian (13591)

Halaman 90 / 272
Clobazam Approved DB00349
small molecule | CAS: 22316-47-8

Clobazam belongs to the 1,5-benzodiazepine class of drugs and is marketed under different names, Onfi, Frisium, Urbanyl, and others.[A256868]. Clobazam was first synthesized in 1966 and first published in 1969, following the incidental synthesis and discovery…

Kategori:
Anti-Anxiety AgentsAnticonvulsantsBenzazepines +35
Target Protein:
GABA(A) ReceptorGamma-aminobutyric acid receptor subunit gamma-3Gamma-aminobutyric acid receptor subunit alpha-1 +1
Gen Terkait:
CYP2C19
Waktu ParuhThe estimated mean …
Vol. DistribusiClobazam is lipophi…
KlirensAfter a 20 to 40 mg…
Genetik 1 Varian
Clobenzorex DB13561
small molecule | CAS: 13364-32-4

Deskripsi belum tersedia.

Kategori:
Alimentary Tract and MetabolismAminesAntiobesity Preparations, Excl. Diet Products +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Clobetasol propionate Approved DB01013
small molecule | CAS: 25122-46-7

Clobetasol propionate is a prednisolone derivative with higher specificity for glucocorticoid receptors than mineralocorticoid receptors.[L11815] It has demonstrated superior activity compared to [fluocinonide][A190963] and was first described in the literatu…

Kategori:
Adrenal Cortex HormonesAnti-Inflammatory AgentsCorticosteroids +21
Target Protein:
Glucocorticoid receptorAnnexin A1Mineralocorticoid receptor
Waktu ParuhData regarding the …
Vol. DistribusiData regarding the …
KlirensData regarding the …
Genetik -
Clobetasone Approved DB13158
small molecule | CAS: 54063-32-0

Clobetasone is a corticosteroid that is often employed topically as a treatment for a variety of conditions such as eczema, psoriasis, various forms of dermatitis, and also for certain ophthalmologic conditions. Topical clobetasone butyrate has shown minimal …

Kategori:
Adrenal Cortex HormonesAnti-Inflammatory AgentsCorticosteroids +19
Target Protein:
Glucocorticoid receptor
Waktu ParuhN/A
Vol. DistribusiThe use of pharmaco…
Klirens-
Genetik -
Clocapramine DB09003
small molecule | CAS: 47739-98-0

Clocapramine is an atypical antipsychotic of the imidobenzyl class which was introduced in Japan in 1974 for the treatment of schizophrenia. In addition to psychosis, clocapramine has also been used to augment antidepressants in the treatment of anxiety and p…

Kategori:
Heterocyclic Compounds, Fused-Ring
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Clocortolone Approved DB00838
small molecule | CAS: 4828-27-7

Clocortolone is a medium potency corticosteroid that is often used as a topical cream for the relief of inflammatory oand pruritic (itching) arising from steroid-responsive dermatoses of the scalp.

Kategori:
Adrenal Cortex HormonesAnti-Inflammatory AgentsCorticosteroid Hormone Receptor Agonists +13
Target Protein:
Phospholipase A2Glucocorticoid receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 4891-71-8

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Clodantoin DB13516
small molecule | CAS: 5588-20-5

Deskripsi belum tersedia.

Kategori:
Genito Urinary System and Sex HormonesGynecological Antiinfectives and AntisepticsImidazoles +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Clodronic acid Approved DB00720
small molecule | CAS: 10596-23-3

Clodronic acid is a first generation bisphosphonate similar to [etidronic acid] and [tiludronic acid].[A203111] These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification.[A1923] clodronate’s use has decr…

Kategori:
BisphosphonatesBone Density Conservation AgentsDrugs Affecting Bone Structure and Mineralization +4
Target Protein:
HydroxylapatiteADP/ATP translocase 1ADP/ATP translocase 2 +1
Waktu ParuhThe mean plasma hal…
Vol. Distribusi-
KlirensThe renal clearance…
Genetik -
Clofarabine Approved DB00631
small molecule | CAS: 123318-82-1

Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukae…

Kategori:
Adenine NucleotidesAntimetabolitesAntineoplastic Agents +23
Target Protein:
DNARibonucleoside-diphosphate reductase subunit M2 BRibonucleoside-diphosphate reductase subunit M2 +2
Waktu ParuhThe terminal half-l…
Vol. Distribusi* 172 L/m2
Klirens* 28.8 L/h/m2 [Pedi…
Genetik -
Clofazimine Approved DB00845
small molecule | CAS: 2030-63-9

Clofazimine is a highly lipophilic antimicrobial riminophenazine dye used in combination with other agents, such as [dapsone], for the treatment of leprosy. It was originally described in 1957 and was the prototypical riminophenazine dye - a bright-red dye th…

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsAnti-Inflammatory Agents +23
Target Protein:
Peroxisome proliferator-activated receptor gammaPotassium voltage-gated channel subfamily A member 3
Waktu ParuhThe mean eliminatio…
Vol. DistribusiClofazimine is high…
Klirens-
Genetik -
Clofedanol Approved DB04837
small molecule | CAS: 791-35-5

Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States.

Kategori:
AlcoholsAminesAmino Alcohols +5
Target Protein:
Histamine H1 receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Clofenamide DB13663
small molecule | CAS: 671-95-4

Deskripsi belum tersedia.

Kategori:
DiureticsLow-Ceiling Diuretics, Excl. ThiazidesSulfonamides
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Clofenotane DB13424
small molecule | CAS: 50-29-3

Deskripsi belum tersedia.

Kategori:
Antiparasitic Products, Insecticides and RepellentsChlorine Containing ProductsEctoparasiticides, Incl. Scabicides +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Clofibrate Approved DB00636
small molecule | CAS: 637-07-0

A fibric acid derivative used in the treatment of hyperlipoproteinemia type III and severe hypertriglyceridemia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p986)

Kategori:
Acids, AcyclicAgents Causing Muscle ToxicityAnticholesteremic Agents +25
Target Protein:
Peroxisome proliferator-activated receptor alphaLipoprotein lipase
Waktu ParuhHalf-life in normal…
Vol. Distribusi-
Klirens-
Genetik -
Clofibride DB13849
small molecule | CAS: 26717-47-5

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicAgents Causing Muscle ToxicityBenzene Derivatives +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Clofoctol DB13237
small molecule | CAS: 37693-01-9

Deskripsi belum tersedia.

Kategori:
Antibacterials for Systemic UseAntiinfectives for Systemic UseBenzene Derivatives +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Clomethiazole DB06470
small molecule | CAS: 533-45-9

Clomethiazole is a well-established ?-aminobutyric acid (GABAA)-mimetic drug. It is a sedative and hypnotic that is widely used in treating and preventing symptoms of acute alcohol withdrawal. It is a drug which is structurally related to thiamine (vitamin B1…

Kategori:
AnticonvulsantsCentral Nervous System AgentsCentral Nervous System Depressants +17
Target Protein:
Gamma-aminobutyric acid receptor subunit gamma-3Gamma-aminobutyric acid receptor subunit alpha-1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Clometocillin DB13686
small molecule | CAS: 1926-49-4

Deskripsi belum tersedia.

Kategori:
Anti-Bacterial AgentsAntibacterials for Systemic UseAntiinfectives for Systemic Use +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Clomifene Approved DB00882
small molecule | CAS: 911-45-5

A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue.

Kategori:
Benzene DerivativesBenzylidene CompoundsClomiphene +15
Target Protein:
Estrogen receptorSex hormone-binding globulin
Waktu Paruh5-7 days
Vol. Distribusi-
Klirens-
Genetik -
Clomipramine Approved DB01242
small molecule | CAS: 303-49-1

Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-de…

Kategori:
Agents that produce hypertensionAgents that reduce seizure thresholdAntidepressive Agents +45
Target Protein:
Sodium-dependent serotonin transporter5-hydroxytryptamine receptor 2A5-hydroxytryptamine receptor 2B +3
Gen Terkait:
CYP2D6 CYP2D6 CYP2D6 +6
Waktu ParuhFollowing oral admi…
Vol. Distribusi~ 17 L/kg (range: 9…
Klirens-
Genetik 9 Varian
Clomocycline DB00453
small molecule | CAS: 1181-54-0

Clomocycline is a tetracycline used to treat bacterial infections.

Kategori:
Agents that produce neuromuscular block (indirect)Anti-Bacterial AgentsAntibacterials for Systemic Use +3
Target Protein:
30S ribosomal protein S430S ribosomal protein S916S ribosomal RNA
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Clonazepam Approved DB01068
small molecule | CAS: 1622-61-3

A benzodiazepine used to treat various seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop.[FDA Label][L5572,F3763,F3787,F3796] The agent has also been indicated for treating panic dis…

Kategori:
AnticonvulsantsBenzazepinesBenzodiazepines and benzodiazepine derivatives +16
Target Protein:
GABA(A) ReceptorGABA(A) Receptor Benzodiazepine Binding SiteNuclear receptor subfamily 1 group I member 2
Waktu ParuhThe mean eliminatio…
Vol. DistribusiClonazepam distribu…
KlirensThe documented clea…
Genetik -
Clonazolam DB14716
small molecule | CAS: 33887-02-4

Deskripsi belum tersedia.

Kategori:
BenzazepinesHeterocyclic Compounds, Fused-RingPharmaceutical Preparations +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Clonazoline DB15881
small molecule | CAS: 17692-28-3

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Clonidine Approved DB00575
small molecule | CAS: 4205-90-7

Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors.[A180559] This activity is useful for the treatment of hypertension, severe pain, and ADHD.[L7237,L7240,L7243,L7246] Clonidine was granted FDA approval on 3 September 1974.…

Kategori:
Adrenergic AgentsAdrenergic AgonistsAdrenergic alpha-1 Receptor Agonists +42
Target Protein:
Amine oxidase [copper-containing] 3Alpha-2B adrenergic receptorAlpha-2C adrenergic receptor +4
Waktu ParuhThe elimination hal…
Vol. DistribusiThe volume of distr…
KlirensThe clearance of cl…
Genetik -
Clonitazene DB01523
small molecule | CAS: 3861-76-5

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Clonixin DB09218
small molecule | CAS: 17737-65-4

Clonixin is a non-steroidal anti-inflammatory drug.

Kategori:
Agents causing hyperkalemiaAgents that produce hypertensionAmino Acids +14
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Clopamide DB13792
small molecule | CAS: 636-54-4

Clopamide is an oral diuretic agent with antihypertensive activity. Like thiazide diuretics, it has an aromatic sulfonamide base but with no double-ring structure.

Kategori:
AmidesDiureticsLow-Ceiling Diuretics, Excl. Thiazides +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Clopenthixol DB13841
small molecule | CAS: 982-24-1

Clopenthixol is a thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors.

Kategori:
Antipsychotic AgentsCentral Nervous System AgentsCentral Nervous System Depressants +13
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cloperastine DB09002
small molecule | CAS: 3703-76-2

Cloperastine is a cough suppressant that acts on the central nervous system.

Kategori:
Antitussive AgentsCough and Cold Preparations
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Clopidogrel Approved DB00758
small molecule | CAS: 113665-84-2

Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), …

Kategori:
Antiplatelet agentsBlood and Blood Forming OrgansCytochrome P-450 CYP1A2 Substrates +31
Target Protein:
P2Y purinoceptor 12
Gen Terkait:
CYP2C9 CYP2C19 CYP2C19 +1
Waktu ParuhThat half life of c…
Vol. DistribusiThe apparent volume…
KlirensThe clearance of a …
Genetik 4 Varian
Cloprednol DB13843
small molecule | CAS: 5251-34-3

Cloprednol is a synthetic glucocorticoid that has been investigated for use in the treatment of asthma. [A31775,A31776]

Kategori:
Adrenal Cortex HormonesCorticosteroidsCorticosteroids for Systemic Use +15
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cloranolol DB13508
small molecule | CAS: 39563-28-5

Deskripsi belum tersedia.

Kategori:
Adrenergic AgentsAdrenergic AntagonistsAdrenergic beta-Antagonists +12
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Clorazepic acid Approved DB00628
small molecule | CAS: 23887-31-2

Clorazepic acid (clorazepate) is a water-soluble benzodiazepine with muscle-relaxant and anticonvulsant actions effective in the treatment of anxiety.[A957,L44788] Following administration, clorazepate is rapidly converted to nordiazepam (N-desmethyldiazepam)…

Kategori:
Anti-Anxiety AgentsAnticonvulsantsBenzazepines +15
Target Protein:
GABA(A) ReceptorTranslocator proteinGABA(A) Receptor Benzodiazepine Binding Site
Waktu ParuhThe serum half-life…
Vol. DistribusiFollowing a single …
KlirensFollowing a single …
Genetik -
Clorexolone DB13617
small molecule | CAS: 2127-01-7

Deskripsi belum tersedia.

Kategori:
AmidesDiureticsHeterocyclic Compounds, Fused-Ring +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cloricromen DB13367
small molecule | CAS: 68206-94-0

Deskripsi belum tersedia.

Kategori:
Antiplatelet agentsBenzopyransBlood and Blood Forming Organs +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cloridarol DB13291
small molecule | CAS: 3611-72-1

Cloridarol is an experimental medication in the treatment of heart disease, which acts through vasodilation. It was studied for the treatment of coronary insufficiency in Italy in the 1970s [A176222].

Kategori:
Cardiac TherapyHeterocyclic Compounds, Fused-RingVasodilators Used in Cardiac Diseases
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Clorindione DB13275
small molecule | CAS: 1146-99-2

Clorindione is a vitamin K antagonist, which may be useful to decrease prothrombin levels in humans.

Kategori:
AnticoagulantsBlood and Blood Forming OrgansIndenes +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Clorobiocin DB03966
small molecule | CAS: 39868-96-7

Clorobiocin is an aminocoumarin antibiotic, similar to [novobiocin] and coumermycin A1.

Kategori:
AminocoumarinsBenzopyransCarbohydrates +4
Target Protein:
DNA topoisomerase 2-betaDNA topoisomerase 2-alphaDNA gyrase subunit B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Clorotepine DB15971
small molecule | CAS: 13448-22-1

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-RingSulfur CompoundsThiepins
Target Protein:
5-hydroxytryptamine receptor 2CHistamine H1 receptorAlpha-1B adrenergic receptor +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Clorsulon DB11389
small molecule | CAS: 60200-06-8

Deskripsi belum tersedia.

Kategori:
AmidesAminesAniline Compounds +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Clortermine DB01527
small molecule | CAS: 10389-73-8

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Clostebol DB01521
small molecule | CAS: 1093-58-9

Deskripsi belum tersedia.

Kategori:
AndrostanesAndrostenesAndrostenols +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Clostridium tetani toxoid antigen (formaldehyde inactivated) is a vaccine for intramuscular injection. It is used for active immunization of children 7 years of age or older, and adults, for prevention of tetanus. The toxoid in the Clostridium tetani culture …

Kategori:
Actively Acquired ImmunityAntiinfectives for Systemic UseBacterial Vaccines +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Clothiapine Approved DB13256
small molecule | CAS: 2058-52-8

Clothiapine has been approved in European countries and is an atypical antipsychotic, shown to be useful in some treatment-resistant patients.

Kategori:
Antipsychotic AgentsCentral Nervous System AgentsCentral Nervous System Depressants +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Clotiazepam Approved DB01559
small molecule | CAS: 33671-46-4

Clotiazepam is a thienodiazepine, not approved for sale in the U.S. or Canada, but has been approved in the U.K. It is a schedule IV drug in Canada.

Kategori:
Anti-Anxiety AgentsBenzodiazepines and benzodiazepine derivativesCentral Nervous System Depressants +8
Target Protein:
GABA(A) ReceptorTranslocator proteinGABA(A) Receptor Benzodiazepine Binding Site
Waktu Paruh4 hours
Vol. Distribusi-
Klirens-
Genetik -
Clotrimazole Approved DB00257
small molecule | CAS: 23593-75-1

This drug is a broad spectrum antimycotic or antifungal agent. Clotrimazole's antimycotic properties were discovered in the late 1960s [A174094]. Clotrimazole falls under the _imidazole_ category of _azole_ antifungals, possessing broad-spectrum antimycotic a…

Kategori:
Anti-Infective AgentsAnti-Infective Agents, LocalAntifungal Agents +54
Target Protein:
C-X-C chemokine receptor type 2Lanosterol 14-alpha demethylaseIntermediate conductance calcium-activated potassium channel protein 4 +3
Waktu Paruh-
Vol. DistribusiThe topical form is…
Klirens-
Genetik -
Clove oil Approved DB11338
biotech | CAS: 8000-34-8

Clove oil is obtained by extraction from the dried flower buds of the clove plant. Traditionally, it has been used as a flavouring spice in foods, or as a fragrance. It is also found in topical analgesics. Clove oil has shown to exert some antimicrobial activ…

Kategori:
Biological ProductsComplex MixturesDrugs that are Mainly Renally Excreted +3
Target Protein:
Vascular cell adhesion protein 1C-X-C motif chemokine 10Collagen alpha-1(I) chain +1
Waktu ParuhIn a pharmacokineti…
Vol. Distribusi-
Klirens-
Genetik -
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