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14063

Total database: 17430
Struktur (SMILES)
10481 (74.5%)
Target
8038 (57.2%)
Genomik
107 (0.8%)
Referensi
14063 (100.0%)

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Hasil Pencarian (14063)

Halaman 90 / 282
small molecule | CAS: 9012-76-4

Deskripsi belum tersedia.

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Chloral betaine DB01494
small molecule | CAS: 2218-68-0

Deskripsi belum tersedia.

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Chloral hydrate Approved DB01563
small molecule | CAS: 302-17-0

A hypnotic and sedative used in the treatment of insomnia. The safety margin is too narrow for chloral hydrate to be used as a general anesthetic in humans, but it is commonly used for that purpose in animal experiments. It is no longer considered useful as a…

Kategori:
AlcoholsCentral Nervous System AgentsCentral Nervous System Depressants +7
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Chlorambucil Approved DB00291
small molecule | CAS: 305-03-3

A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Repor…

Kategori:
Agents that reduce seizure thresholdAlkylating ActivityAlkylating Drugs +12
Target Protein:
DNA
Waktu Paruh1.5 hours
Vol. Distribusi-
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Chloramphenicol Approved DB00446
small molecule | CAS: 56-75-7

An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein sy…

Kategori:
AlcoholsAmphenicolsAnti-Acne Preparations +34
Target Protein:
50S ribosomal protein L16Dr hemagglutinin structural subunitComplement decay-accelerating factor
Waktu ParuhHalf-life in adults…
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Chloramphenicol succinate Approved DB07565
small molecule | CAS: 3544-94-3

Chloramphenicol succinate is an ester prodrug of [chloramphenicol].[A192987] Chloramphenicol is a bacteriostatic antibiotic.[A204065] Use of chloramphenicol succinate and chloramphenicol has decreased due to the risk of potentially fatal blood dyscrasias.[L14…

Kategori:
AlcoholsAnti-Bacterial AgentsAnti-Infective Agents +8
Target Protein:
Dr hemagglutinin structural subunit
Waktu ParuhThe half life of ch…
Vol. DistribusiChloramphenicol suc…
KlirensChloramphenicol suc…
Genetik -
small molecule | CAS: 522-18-9

Deskripsi belum tersedia.

Kategori:
Alimentary Tract and MetabolismDrugs for Functional Gastrointestinal Disorders
Waktu Paruh-
Vol. Distribusi-
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Chlorcyclizine Approved DB08936
small molecule | CAS: 82-93-9

Chlorcyclizine is a first generation phenylpiperazine class antihistamine used to treat urticaria, rhinitis, pruritus, and other allergy symptoms. Chlorcyclizine also has some local anesthetic, anticholinergic, and antiserotonergic properties, and can be used…

Kategori:
Antihistamines for Systemic UseHistamine AntagonistsHistamine H1 Antagonists +3
Target Protein:
Histamine H1 receptor
Waktu Paruhabout 12 h.
Vol. DistribusiAfter a single oral…
Klirens-
Genetik -
Chlordiazepoxide Approved DB00475
small molecule | CAS: 58-25-3

An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal.

Kategori:
Adjuvants, AnesthesiaAnti-Anxiety AgentsBenzazepines +22
Target Protein:
Translocator proteinGABA(A) ReceptorGABA(A) Receptor Benzodiazepine Binding Site
Waktu Paruh24-48 hours
Vol. Distribusi-
Klirens-
Genetik -
Chlorhexidine Approved DB00878
small molecule | CAS: 55-56-1

Chlorhexidine is a broad-spectrum antimicrobial biguanide used as a topical antiseptic and in dental practice for the treatment of inflammatory dental conditions caused by microorganisms.[L11512] It is one of the most common skin and mucous membrane antisepti…

Kategori:
Alimentary Tract and MetabolismAmidinesAnti-Infective Agents +25
Target Protein:
Bacterial outer membrane
Waktu Paruh-
Vol. Distribusi-
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Chlorindanol DB19355
small molecule | CAS: 145-94-8

Deskripsi belum tersedia.

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Chlorine DB11109
small molecule | CAS: 7782-50-5

Chlorine is a stongly oxidizing agent and the third most electronegative element which belongs to the group of halogens with the atomic number 17 and symbol Cl. Being a yellow-green gas at room temperature, chlorine is the second most abundant halogen on Eart…

Kategori:
Compounds used in a research, industrial, or household settingElementsGases +4
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small molecule | CAS: 10049-04-4

Chlorine Dioxide has been used in trials studying the treatment of Halitosis.

Kategori:
AnionsAnti-Infective AgentsCompounds used in a research, industrial, or household setting +5
Waktu Paruh-
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Chlorisondamine Approved DB19358
small molecule | CAS: 7701-62-4

Deskripsi belum tersedia.

Kategori:
AminesAnticholinergic AgentsAntihypertensive Agents +12
Waktu Paruh-
Vol. Distribusi-
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Chlormadinone DB13528
small molecule | CAS: 1961-77-9

Deskripsi belum tersedia.

Kategori:
Adrenal Cortex HormonesAntiandrogensCombination Contraceptives (with Estrogen and derivatives) +23
Waktu Paruh-
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small molecule | CAS: 302-22-7

Chlormadinone acetate is a progesterone derivative first synthesized in 1961. In the US, chlormadinone acetate was formerly marketed as a component of the combination drug products Estalor-21 and C-Quens. However, the use of these drugs was associated with th…

Kategori:
Adrenal Cortex HormonesAntiandrogensContraceptive Agents, Female +13
Waktu Paruh-
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Chlormerodrin Approved DB00534
small molecule | CAS: 62-37-3

Chlormerodrin is a mercurial compound with toxic side effects that was previously used as a diuretic. The radiolabeled form has been used as a diagnostic and research tool. It is no longer used and has been replaced with new classes of diuretic drugs.

Kategori:
Alkylmercury CompoundsOrganomercury CompoundsOrganometallic Compounds
Target Protein:
Solute carrier family 12 member 1Succinate-semialdehyde dehydrogenase, mitochondrial
Waktu Paruh-
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Chlormezanone Approved DB01178
small molecule | CAS: 80-77-3

A non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm.

Kategori:
Anti-Anxiety AgentsCentral Nervous System AgentsCentral Nervous System Depressants +10
Target Protein:
Translocator protein
Waktu Paruh-
Vol. Distribusi-
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Chlorobutanol Approved DB11386
small molecule | CAS: 57-15-8

Chlorobutanol, or chlorbutol, is an alcohol-based preservative with no surfactant activity [A32746]. It also elicits sedative-hypnotic and weak local anesthetic actions in addition to antibacterial and antifungal properties. Similar in nature to chloral hydra…

Kategori:
AlcoholsAlimentary Tract and MetabolismAntiemetics and Antinauseants +8
Target Protein:
Voltage-gated inwardly rectifying potassium channel KCNH2
Waktu ParuhFollowing oral admi…
Vol. DistribusiThe volume of distr…
KlirensIn healthy subjects…
Genetik -
Chloroform Approved DB11387
small molecule | CAS: 67-66-3

Chloroform is an organic small molecule, member of the family of the chloromethanes that presents a formula of CHCl3. It is a colorless, sweet-smelling, dense liquid that is produced on a large scale as a precursor to PTFE and refrigerants, but the latter app…

Kategori:
AnestheticsAnesthetics, GeneralCompounds used in a research, industrial, or household setting +5
Waktu Paruh-
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small molecule | CAS: 202650-88-2

Chlorogenic Acid has been used in trials studying the treatment of Advanced Cancer and Impaired Glucose Tolerance.

Kategori:
Acids, CarbocyclicCinnamatesCyclohexanecarboxylic Acids
Waktu Paruh-
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Chlorophetanol DB11368
small molecule | CAS: 1892-43-9

Chlorophetanol is an agent known to have antifungal activities.

Kategori:
Antifungals for Dermatological UseAntifungals for Topical UseDermatologicals
Waktu Paruh-
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Chlorophyll A DB02133
small molecule | CAS: 479-61-8

Deskripsi belum tersedia.

Kategori:
ChlorophyllHeterocyclic Compounds, Fused-Ring
Target Protein:
Beta-lactamase 2
Waktu Paruh-
Vol. Distribusi-
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Chlorophyll B DB04506
small molecule | CAS: 519-62-0

A light, silvery, metallic element. It has the atomic symbol Mg, atomic number 12, and atomic weight 24.31. Its salts are essential in nutrition, being required for the activity of many enzymes, especially those concerned with oxidative phosphorylation. It is…

Kategori:
Heterocyclic Compounds, Fused-Ring
Waktu Paruh-
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small molecule | CAS: 52080-57-6

Deskripsi belum tersedia.

Kategori:
OphthalmologicalsSensory Organs
Waktu Paruh-
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Chloroprocaine Approved DB01161
small molecule | CAS: 133-16-4

Chloroprocaine is an ester local anesthetic commonly available in its salt form, chloroprocaine hydrochloride. Similar to other local anesthetics, it increases the threshold for electrical excitation in nerves by slowing the propagation of the nerve impulse a…

Kategori:
Acids, CarbocyclicAminobenzoatesAnesthetics +15
Target Protein:
Sodium/potassium-transporting ATPase subunit alpha-1Voltage-gated sodium channel alpha subunitSodium-dependent dopamine transporter
Waktu ParuhIn adults, the aver…
Vol. Distribusi-
Klirens-
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Chloropyramine DB08800
small molecule | CAS: 59-32-5

Chlorpyramine is a first generation antihistamine used in Eastern European countries to treat bronchial asthma as well as allergice rhinitis, allergic conjunctivitis, and other allergic reactions. It is also indicated for Quincke's edema, allergic reactions t…

Kategori:
AminesAntihistamines for Systemic UseAntihistamines for Topical Use +9
Target Protein:
Histamine H1 receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Chloroquine Approved DB00608
small molecule | CAS: 54-05-7

Chloroquine is an aminoquinolone derivative first developed in the 1940s for the treatment of malaria.[A191655] It was the drug of choice to treat malaria until the development of newer antimalarials such as [pyrimethamine], [artemisinin], and [mefloquine].[A…

Kategori:
Agents Causing Muscle ToxicityAgents that produce neuromuscular block (indirect)Agents that reduce seizure threshold +39
Target Protein:
Atypical chemokine receptor 1Glutathione S-transferase A2Tumor necrosis factor +5
Waktu ParuhThe half life of ch…
Vol. DistribusiThe volume of distr…
KlirensChloroquine has a t…
Genetik -
Chlorothiazide Approved DB00880
small molecule | CAS: 58-94-6

A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812)

Kategori:
Antihypertensive AgentsBenzothiadiazinesCardiovascular Agents +17
Target Protein:
Solute carrier family 12 member 3Carbonic anhydrase 1Carbonic anhydrase 2
Waktu Paruh45-120 minutes
Vol. Distribusi-
Klirens-
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Chlorothymol Approved DB19375
small molecule | CAS: 89-68-9

Chlorotymol is a [Thymol] derivative.

Waktu Paruh-
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Chlorotoxin DB15210
biotech | CAS: 163515-35-3

Chlorotoxin is under investigation in clinical trial NCT00733798 (A Safety and Efficacy Study of Intravenous 131I-TM601 in Adult Patients With Malignant Melanoma).

Kategori:
Arthropod VenomsBiological FactorsComplex Mixtures +5
Waktu Paruh-
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small molecule

Chlorotoxin I-131 is investigated in clinical trials for treating brain cancer. Chlorotoxin I-131 binds to and reduces the activity of a matrix metalloproteinase (MMP) that regulates functioning of the chloride channels on cell membranes. Chlorotoxin is a sma…

Kategori:
Arthropod VenomsBiological FactorsComplex Mixtures +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 569-57-3

A powerful synthetic, non-steroidal estrogen. [PubChem]

Kategori:
Antineoplastic AgentsAntineoplastic Agents, HormonalBenzene Derivatives +9
Target Protein:
Estrogen receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Chloroxine Approved DB01243
small molecule | CAS: 773-76-2

Chloroxine is a synthetic antibacterial compound. Chloroxine is a compound used in some shampoos for the treatment of dandruff and seborrheic dermatitis of the scalp.

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsAntifungal Agents +3
Target Protein:
Kappa-type opioid receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Chloroxylenol Approved DB11121
small molecule | CAS: 88-04-0

Chloroxylenol, or para-chloro-meta-xylenol (PCMX), is an antiseptic and disinfectant agent used for skin disinfection and surgical instruments. It is found in antibacterial soaps, wound-cleansing applications, and household antiseptics. The halophenol is show…

Kategori:
Anti-Infective AgentsAnti-Infective Agents, LocalAntiparasitic Agents +10
Waktu ParuhOne study estimated…
Vol. DistribusiThe only data avail…
KlirensThe only data avail…
Genetik -
Chlorphenesin Approved DB00856
small molecule | CAS: 104-29-0

Deskripsi belum tersedia.

Kategori:
AlcoholsAntifungals for Dermatological UseAntifungals for Topical Use +12
Waktu Paruh2.3-5 hours
Vol. Distribusi-
Klirens-
Genetik -
Chlorphenesin carbamate Approved DB14656
small molecule | CAS: 886-74-8

Deskripsi belum tersedia.

Kategori:
AlcoholsGlycolsPropylene Glycols
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Chlorpheniramine Approved DB01114
small molecule | CAS: 132-22-9

A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation …

Kategori:
Anti-Allergic AgentsAntidepressive AgentsAntihistamines for Systemic Use +27
Target Protein:
Histamine H1 receptorSodium-dependent serotonin transporterSodium-dependent noradrenaline transporter +1
Waktu Paruh21-27 hours
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 461-78-9

A sympathomimetic agent that was formerly used as an anorectic. It has properties similar to those of dextroamphetamine. It has been implicated in lipid storage disorders and pulmonary hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1223)

Kategori:
Agents producing tachycardiaAgents that produce hypertensionAmines +7
Target Protein:
Sodium-dependent serotonin transporter
Waktu Paruh40 hours
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 84-01-5

Deskripsi belum tersedia.

Kategori:
Antipsychotic AgentsCentral Nervous System AgentsCentral Nervous System Depressants +11
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Chlorproguanil DB12314
small molecule | CAS: 537-21-3

Chlorproguanil has been used in trials studying the treatment of MALARIA. It is a dichloro-derivative of chloroguanide.

Kategori:
AmidinesAnti-Infective AgentsAntimalarials +4
Target Protein:
Peptide deformylase, mitochondrial
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Chlorpromazine Approved DB00477
small molecule | CAS: 50-53-3

The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions a…

Kategori:
Adrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-AntagonistsAdrenergic Antagonists +63
Target Protein:
D(2) dopamine receptorD(1A) dopamine receptor5-hydroxytryptamine receptor 1A +21
Waktu Paruh~ 30 hours
Vol. Distribusi* 20 L/kg
Klirens-
Genetik -
Chlorpropamide Approved DB00672
small molecule | CAS: 94-20-2

Chlorpropamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating ? cells of the pancreas to release insulin. Su…

Kategori:
Alimentary Tract and MetabolismAmidesBenzene Derivatives +17
Target Protein:
ATP-binding cassette sub-family C member 8ATP-sensitive inward rectifier potassium channel 10
Waktu ParuhApproximately 36 ho…
Vol. Distribusi-
Klirens-
Genetik -
Chlorprothixene Approved DB01239
small molecule | CAS: 113-59-7

Chlorprothixene is a typical antipsychotic drug of the thioxanthene (tricyclic) class. Chlorprothixene exerts strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors.

Kategori:
Agents producing tachycardiaAnticholinergic AgentsAntidepressive Agents +28
Target Protein:
D(2) dopamine receptorD(1A) dopamine receptorD(3) dopamine receptor +8
Waktu Paruh8 to 12 hours
Vol. Distribusi-
Klirens-
Genetik -
Chlorquinaldol Approved DB13306
small molecule | CAS: 72-80-0

Chlorquinaldol was used historically as a topical antiseptic under the trade name Sterosan.[F4549] It was marketed in the 1950s as an iodine-free alternative which was also unrelated to sulfa drugs or hormones. Chlorquinaldol is currently approved by the Euro…

Kategori:
Anti-Infective AgentsAnti-Infective Agents, LocalAntiparasitic Products, Insecticides and Repellents +15
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 97919-22-7

Chlorsulfaquinoxaline has been used in trials studying the treatment of Lung Cancer and Colorectal Cancer.

Kategori:
AmidesAminesAniline Compounds +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Chlortetracycline Approved DB09093
small molecule | CAS: 57-62-5

Chlortetracycline is a _tetracycline_ antibiotic, and historically the first member of this class to be identified. It was discovered in 1945 by the scientist, Benjamin Minge Duggar, working at Lederle Laboratories under the supervision of Yellapragada Subbar…

Kategori:
Agents that produce neuromuscular block (indirect)Alimentary Tract and MetabolismAnti-Bacterial Agents +15
Target Protein:
16S ribosomal RNA30S ribosomal protein S330S ribosomal protein S8 +8
Waktu ParuhThe half-life of Ch…
Vol. DistribusiChlortetracycline h…
Klirens-
Genetik -
Chlorthalidone Approved DB00310
small molecule | CAS: 77-36-1

Chlorthalidone is a thiazide-like diuretic used for the treatment of hypertension and for management of edema caused by conditions such as heart failure or renal impairment. Chlorthalidone improves blood pressure and swelling by preventing water absorption fr…

Kategori:
AmidesAntihypertensive AgentsAntihypertensive Agents Indicated for Hypertension +25
Target Protein:
Carbonic anhydrase 1Solute carrier family 12 member 1
Waktu Paruh40-50 hours[FDA Lab…
Vol. DistribusiChlorthalidone has …
Klirens-
Genetik -
Chlorzoxazone Approved DB00356
small molecule | CAS: 95-25-0

A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p…

Kategori:
Benzoxazoles and derivativesCentral Nervous System AgentsCentral Nervous System Depressants +21
Target Protein:
Calcium-activated potassium channel subunit alpha-1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

This vaccine candidate, developed in China, uses SARS-CoV-2 protein subunits that are entirely engineered, created, and secreted by Chinese Hamster Ovary (CHO) cells[A219758]. The vaccine candidate is sponsored by Anhui Zhifei Longcom Biologic Pharmacy Co., L…

Waktu Paruh-
Vol. Distribusi-
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Genetik -
Menampilkan 4451–4500 dari 14063
Sebelumnya Halaman 90 / 282 Berikutnya