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16004

Total database: 17430
Struktur (SMILES)
12010 (75.0%)
Target
9041 (56.5%)
Genomik
112 (0.7%)
Referensi
16004 (100.0%)

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Hasil Pencarian (16004)

Halaman 90 / 321
small molecule | CAS: 2356354-82-8

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
Bococizumab DB12456
biotech | CAS: 1407495-02-6

Bococizumab has been used in trials studying the treatment and prevention of Dyslipidemia, Hyperlipidemia, Hypercholesterolemia, Cardiovascular Disease, and Heterozygous Familial Hypercholesterolemia.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +11
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bolandiol DB01554
small molecule | CAS: 19793-20-5

Deskripsi belum tersedia.

Kategori:
EstranesEstrenesFused-Ring Compounds +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bolasterone DB01471
small molecule | CAS: 1605-89-6

Deskripsi belum tersedia.

Kategori:
Anabolic AgentsAndrostanesAndrostenes +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Boldenone DB01541
small molecule | CAS: 846-48-0

Boldenone is an anabolic steroid developed for veterinary use, mostly for treatment of horses. It is not indicated for use in humans in the US and is only available through veterinary clinics.

Kategori:
Anabolic AgentsAndrostanesAndrostenes +9
Target Protein:
Androgen receptor
Waktu Paruh14 days
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 13103-34-9

Deskripsi belum tersedia.

Kategori:
AndrostanesAndrostenesAndrostenols +6
Target Protein:
Androgen receptor
Waktu Paruh14 days
Vol. Distribusi-
Klirens-
Genetik -
Boldione DB07373
small molecule | CAS: 897-06-3

Deskripsi belum tersedia.

Kategori:
AndrostanesAndrostenesFused-Ring Compounds +1
Target Protein:
AromatasePentaerythritol tetranitrate reductase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bombesin DB11724
small molecule | CAS: 31362-50-2

Bombesin is under investigation in clinical trial NCT01205321 (PET/CT Imaging for Radiation Dosimetry, Plasma Pharmacokinetics, Biodistribution, Safety and Tolerability and Diagnostic Performance of BAY86-7548 in Patients With Prostate Cancer and Healthy Volu…

Kategori:
Amino Acids, Peptides, and ProteinsAmphibian VenomsBiological Factors +12
Target Protein:
Gastrin-releasing peptide receptorBombesin receptor subtype-3Neuromedin-B receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bomedemstat DB17234
small molecule | CAS: 1990504-34-1

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicAmidesBenzene Derivatives +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 2364477-20-1

Deskripsi belum tersedia.

Kategori:
Adeno-associated Viral Vector Therapies
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bopindolol DB08807
small molecule | CAS: 62658-63-3

Bopindolol (INN) is an ester prodrug for the beta blocker [pindolol].

Kategori:
Adrenergic AgentsAdrenergic AntagonistsAdrenergic beta-Antagonists +12
Target Protein:
Beta-1 adrenergic receptorBeta-2 adrenergic receptorBeta-3 adrenergic receptor +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Borage oil Approved DB11238
biotech

Borage oil, or borage seed oil, is a rich source of gamma-linolenic acid (GLA) that is obtained from the seeds of the Borago officinalis (borage). Borage oil is used as an herbal treatment of skin disorders including eczema, seborrheic dermatitis, and neurode…

Kategori:
Agents that reduce seizure thresholdAntirheumatic AgentsBiological Products +11
Waktu Paruh-
Vol. Distribusi-
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Borate ion DB14553
small molecule | CAS: 12258-53-6

Deskripsi belum tersedia.

Kategori:
AnionsBoric AcidsBoron Compounds +2
Waktu Paruh-
Vol. Distribusi-
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Genetik -
biotech

Bordetella pertussis fimbriae 2/3 antigen is a vaccine for the prophylaxis of the disease caused by Bordetella pertussis which is a a Gram-negative coccobacillus that expresses two serologically distinct fimbriae (Fim2 and Fim3).

Kategori:
Actively Acquired ImmunityInactivated Bordetella Pertussis Vaccine
Waktu Paruh-
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biotech

Bordetella pertussis pertactin antigen is a vaccine for the prophylaxis of whooping cough that contains pertactin, a membrane-associated antigen of Bordetella pertussis [A31248].

Kategori:
Amino Acids, Peptides, and ProteinsBacterial ProteinsBacterial Toxins +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Bordetella pertussis toxoid antigen (formaldehyde, glutaraldehyde inactivated) is a vaccine that is used in the prophylaxis of Pertussis (whooping cough), which is caused by a small Gram-negative coccobacillus that infects the mucosal layers of the human resp…

Kategori:
Actively Acquired ImmunityBiological ProductsComplex Mixtures +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Boric acid Approved DB11326
small molecule | CAS: 10043-35-3

Boric acid, also known as hydrogen borate, is a weak monobasic Lewis acid of boron with the chemical formula H3BO3. Boric acid is typically utilized in industrial processing and manufacturing, but is also used as an additive in pharmaceutical products, cosmet…

Kategori:
AcidsAcids, NoncarboxylicAgrochemicals +12
Waktu ParuhAccording to human …
Vol. DistribusiVolume of distribut…
KlirensA case report of ac…
Genetik -
Bornaprine DB13619
small molecule | CAS: 20448-86-6

Deskripsi belum tersedia.

Kategori:
Agents producing tachycardiaAnti-Parkinson DrugsAnticholinergic Agents +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Borneol DB11288
small molecule | CAS: 507-70-0

Deskripsi belum tersedia.

Kategori:
Bicyclic MonoterpenesBridged-Ring CompoundsMonoterpenes +3
Target Protein:
Transient receptor potential cation channel subfamily V member 3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bornyl acetate DB14665
small molecule | CAS: 76-49-3

Deskripsi belum tersedia.

Kategori:
Bicyclic MonoterpenesBridged-Ring CompoundsMonoterpenes +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Boron DB11203
small molecule | CAS: 7440-42-8

Boron (B) is a chemical element with an atomic number 5 that belongs in the Period 2 and Group 13 in the periodic table. It is a low-abundant metalloid that is a poor electrical conductor at room temperature. Natural boron exists in 2 stable isotopes however …

Kategori:
Diet, Food, and NutritionElementsFood +4
Waktu Paruh-
Vol. Distribusi-
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Bortezomib Approved DB00188
small molecule | CAS: 179324-69-7

Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma.[A204083] The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reve…

Kategori:
AcidsAcids, NoncarboxylicAntineoplastic Agents +36
Target Protein:
Proteasome subunit beta type-5Serine protease 1Proteasome subunit beta type-1
Waktu ParuhThe mean eliminatio…
Vol. DistribusiThe mean distributi…
KlirensFollowing the admin…
Genetik -
Bortezomib D-mannitol Approved DB16741
small molecule | CAS: 444576-08-3

Deskripsi belum tersedia.

Kategori:
Antineoplastic AgentsProteasome Inhibitors
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Bos taurus gallstone is an animal extract used in some OTC (over-the-counter) products. It is not an approved drug.

Kategori:
Complex MixturesGallstones
Waktu Paruh-
Vol. Distribusi-
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BOS172722 DB15498
small molecule | CAS: 1578245-44-9

BOS172722 is a novel and selective Monopolar spindle 1 (Mps1) kinase inhibitor identified as a potential anticancer agent.[A187123] Normally, Mps1 supports the proper division of cancer cells, ensuring survival and replication. The key role of Mps1 in the gro…

Target Protein:
Dual specificity protein kinase TTK
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Bosakitug DB19101
biotech | CAS: 2762183-23-1

Bosakitug (BSI-045B) is under investigation in clinical trial NCT05932654 (POC Study to Evaluate BSI-045B Monotherapy and BSI-045B Add-on Therapy With Dupilumab in Atopic Dermatitis).

Waktu Paruh-
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Boscalid Approved DB12792
small molecule | CAS: 188425-85-6

Boscalid has been investigated for the treatment of OSDI, Glaucoma, Staining, Schirmers, and Disease Severity, among others.

Kategori:
Benzene DerivativesNicotinic AcidsPyridines
Waktu Paruh-
Vol. Distribusi-
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Bosentan Approved DB00559
small molecule | CAS: 147536-97-8

Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the…

Kategori:
AmidesAntihypertensive AgentsAntihypertensives for Pulmonary Arterial Hypertension +24
Target Protein:
Endothelin receptor type BEndothelin-1 receptor
Waktu ParuhTerminal eliminatio…
Vol. Distribusi* 18 L
Klirens* 4 L/h [patients w…
Genetik -
Boserolimab DB17452
biotech | CAS: 2444297-08-7

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
Bosutinib Approved DB06616
small molecule | CAS: 380843-75-4

Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hall…

Kategori:
AminesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +22
Target Protein:
Tyrosine-protein kinase ABL1Tyrosine-protein kinase LynProto-oncogene tyrosine-protein kinase Src +8
Waktu ParuhThe mean (SD) bosut…
Vol. DistribusiThe mean (SD) appar…
KlirensThe mean (SD) appar…
Genetik -
biotech | CAS: 2417551-39-2

Deskripsi belum tersedia.

Kategori:
Adeno-associated Viral Vector Therapies
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Botensilimab DB16651
biotech | CAS: 2408310-37-0

Botensilimab is under investigation in clinical trial NCT03860272 (Fc-engineered Anti-ctla-4 Monoclonal Antibody in Advanced Cancer).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Botulinum toxin type A Approved DB00083
biotech | CAS: 93384-43-1

In 2002, botulinum toxin A, also known as onabotulinumtoxinA or Botox, was the first type A botulism toxin to be introduced into the market for cosmetic use.[A231824] With a wide variety of applications and favourable safety profile, Botulinum toxin A injecti…

Kategori:
Acetylcholine Release InhibitorsAgents that produce neuromuscular block (indirect)Amino Acids, Peptides, and Proteins +29
Target Protein:
Synaptosomal-associated protein 25Rho-related GTP-binding protein RhoB
Waktu ParuhThere is no readily…
Vol. DistribusiThere are extremely…
KlirensClearance informati…
Genetik -
Botulinum toxin type B Approved DB00042
biotech | CAS: 93384-44-2

Neurotoxin produced by fermentation of clostridium botulinum type B. The protein exists in noncovalent association with hemagglutinin and nonhemagglutinin proteins as a neurotoxin complex. The neurotoxin complex is recovered from the fermentation process and …

Kategori:
Acetylcholine Release InhibitorsAgents that produce neuromuscular block (indirect)Amino Acids, Peptides, and Proteins +28
Target Protein:
Vesicle-associated membrane protein 2Vesicle-associated membrane protein 1Synaptotagmin-2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Botulinum toxin type e is under investigation in clinical trial NCT03193593 (Study to Evaluate EB-001 in Reducing Musculoskeletal Pain).

Kategori:
Amino Acids, Peptides, and ProteinsBacterial ProteinsBacterial Toxins +13
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 1383710-57-3

Bovhyaluronidase azoximer is under investigation in clinical trial NCT06458543 (Optimization of Bacterial Vaginosis Treatment in Women of Reproductive Age).

Waktu Paruh-
Vol. Distribusi-
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Genetik -
Bovine type I collagen Approved DB10771
biotech | CAS: 9050-08-2

Bovine collagen alpha-1 is a naturally occurring extracellular matrix protein which is found in tendons and other connective tissues. It plays a vital role in cell growth, differentiation, attachment, and migration [L2481]. Often combined with other ingredie…

Kategori:
Allogeneic Cultured Cell Scaffold
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BP-14979 DB16302
small molecule | CAS: 1000036-77-0

BP-14979 is under investigation in clinical trial NCT01785147 (Efficacy and Safety of BP1.4979 in Smoking Cessation).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BPC-157 DB11882
small molecule | CAS: 137525-51-0

Bepecin is under investigation in clinical trial NCT02637284 (PCO-02 - Safety and Pharmacokinetics Trial).

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Ulcer AgentsGastrointestinal Agents +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BPH-608 DB07404
small molecule

Deskripsi belum tersedia.

Target Protein:
Farnesyl pyrophosphate synthaseDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BPI-3016 DB15158
biotech

BPI-3016 is under investigation in clinical trial NCT03188848 (Dose Escalating Study of BPI-3016 in Healthy Subjects).

Kategori:
Amino Acids, Peptides, and ProteinsGastrointestinal HormonesGlucagon-Like Peptides +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BPR-0L075 DB17155
small molecule | CAS: 613679-11-1

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BQ-123 DB12054
small molecule | CAS: 136553-81-6

BQ-123 has been investigated for the basic science and treatment of Coronary Artery Disease, Aorto-coronary Bypass Grafting, and ST-Elevation Myocardial Infarction.

Kategori:
Amino Acids, Peptides, and ProteinsAntihypertensive AgentsCardiovascular Agents +2
Target Protein:
Endothelin-1 receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BQ-788 DB17984
small molecule | CAS: 156161-89-6

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAntihypertensive AgentsCardiovascular Agents +3
Target Protein:
Endothelin receptor type B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BR-007 DB18408
small molecule | CAS: 2409546-40-1

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BR101801 DB17387
small molecule

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
Bradanicline DB06090
small molecule | CAS: 639489-84-2

Bradanicline, a novel small molecule that modulates the activity of the neuronal nicotinic receptor (NNR) subtype known as alpha7(?7). Bradanicline belongs to a new class of drugs for the treatment of central nervous system diseases and disorders.

Kategori:
Heterocyclic Compounds, Fused-RingReceptors, Nicotinic
Target Protein:
Neuronal acetylcholine receptor subunit alpha-7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bradykinin DB12126
small molecule | CAS: 58-82-2

Bradykinin has been investigated for the basic science and treatment of Hypertension and Diabetes Type 2.

Kategori:
Amino Acids, Peptides, and ProteinsAutacoidsBiological Factors +11
Target Protein:
B2 bradykinin receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Branaplam DB14918
small molecule | CAS: 1562338-42-4

Branaplam is under investigation in clinical trial NCT02268552 (An Open Label Study of LMI070 (Branaplam) in Type 1 Spinal Muscular Atrophy (SMA)).

Target Protein:
Survival motor neuron protein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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