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15718

Total database: 17430
Struktur (SMILES)
10762 (68.5%)
Target
7957 (50.6%)
Genomik
112 (0.7%)
Referensi
15718 (100.0%)

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Hasil Pencarian (15718)

Halaman 88 / 315
Carisoprodol Approved DB00395
small molecule | CAS: 78-44-4

Originally approved by the FDA in 1959 [FDA label], carisoprodol is a centrally acting muscle relaxant used in painful musculoskeletal conditions in conjunction with physical therapy and other medications [A176047]. This drug is available by itself in an ora…

Kategori:
CarbamatesCarbamic Acid EstersCentral Nervous System Agents +7
Target Protein:
Gamma-aminobutyric acid receptor subunit alpha-1Gamma-aminobutyric acid receptor subunit beta-2Gamma-aminobutyric acid receptor subunit gamma-2 +2
Waktu ParuhThe terminal half-l…
Vol. Distribusi0.93 to 1.3 L/kg, a…
KlirensFollowing an oral d…
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carlumab DB12718
biotech | CAS: 915404-94-3

Carlumab has been used in trials studying the treatment of Cancer and Prostate Cancer.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carmegliptin DB12268
small molecule | CAS: 813452-18-5

Carmegliptin has been used in trials studying the treatment of Diabetes Mellitus Type 2.

Kategori:
Agents causing angioedemaBlood Glucose Lowering AgentsDipeptidyl Peptidase 4 +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carmofur DB09010
small molecule | CAS: 61422-45-5

Carmofur is a derivative of fluorouracil, and is an antineoplastic agent that has been used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopathy.

Kategori:
AntimetabolitesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carmoterol DB15784
small molecule | CAS: 147568-66-9

Deskripsi belum tersedia.

Kategori:
AminesEthylaminesHeterocyclic Compounds, Fused-Ring +2
Target Protein:
Beta-2 adrenergic receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carmustine Approved DB00262
small molecule | CAS: 154-93-8

A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a c…

Kategori:
Alkylating ActivityAlkylating DrugsAmides +15
Target Protein:
RNAGlutathione reductase, mitochondrialDNA
Waktu Paruh15-30 minutes
Vol. Distribusi-
Klirens-
Genetik -
Carnosine DB11695
small molecule | CAS: 305-84-0

Carnosine has been investigated for the treatment of Gulf War Illness.

Kategori:
Amino Acids, Peptides, and ProteinsDipeptidesNerve Tissue Proteins +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carob Approved DB10852
biotech

Carob allergenic extract is used in allergenic testing.

Kategori:
AntidiarrhealsBiological ProductsBiopolymers +12
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 401905-67-7

Carotegrast methyl is under investigation in clinical trial NCT03531892 (A Study to Evaluate the Safety and Efficacy of AJM300 in Participants With Active Ulcerative Colitis).

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carotuximab DB06322
biotech | CAS: 1268714-50-6

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +5
Target Protein:
Endoglin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Caroverine DB13835
small molecule | CAS: 23465-76-1

Deskripsi belum tersedia.

Kategori:
Agents causing hyperkalemiaAlimentary Tract and MetabolismAntiarrhythmic agents +14
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Caroxazone DB09254
small molecule | CAS: 18464-39-6

Caroxazone is an antidepressant that has been withdrawn from the market. It is a reversible monoamine oxidase inhibitor (MAOI) of both A and B monoamine oxidase subtypes. However, it presents a five-fold preference for the MAO-B subtype.

Kategori:
AcetamidesAgents that produce hypertensionAgents that reduce seizure threshold +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carphenazine DB01038
small molecule | CAS: 2622-30-2

Carphenazine is an antipsychotic drug, used in hospitalized patients in the management of chronic schizophrenic psychoses.

Kategori:
Dopamine AntagonistsDopamine D2 Receptor Antagonists
Target Protein:
D(2) dopamine receptorD(1A) dopamine receptorD(1B) dopamine receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carpinus caroliniana pollen Approved DB10911
biotech

Carpinus caroliniana pollen is the pollen of the Carpinus caroliniana plant. Carpinus caroliniana pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carprofen Approved DB00821
small molecule | CAS: 53716-49-7

Carprofen is a non-steroidal anti-inflammatory drug (NSAID) that is used by veterinarians as a supportive treatment for the relief of arthritic symptoms in geriatric dogs. Carprofen was previously used in human medicine for over 10 years (1985-1995). It was g…

Kategori:
Agents causing hyperkalemiaAgents that produce hypertensionAnalgesics +15
Target Protein:
Prostaglandin G/H synthase 2Prostaglandin G/H synthase 1
Waktu ParuhApproximately 8 hou…
Vol. Distribusi-
Klirens-
Genetik -
Carpropamide DB02946
small molecule | CAS: 127640-90-8

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carrimycin DB16476
small molecule

Deskripsi belum tersedia.

Kategori:
Anti-Bacterial AgentsExperimental Unapproved Treatments for COVID-19Lactones +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carrot Approved DB10515
biotech

Carrot allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carteolol Approved DB00521
small molecule | CAS: 51781-06-7

A beta-adrenergic antagonist used as an anti-arrhythmia agent, an anti-angina agent, an antihypertensive agent, and an antiglaucoma agent.

Kategori:
Adrenergic AgentsAdrenergic AntagonistsAdrenergic beta-Antagonists +28
Target Protein:
Beta-2 adrenergic receptorBeta-1 adrenergic receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Carthamus tinctorius flower bud is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carumonam DB13553
small molecule | CAS: 87638-04-8

Deskripsi belum tersedia.

Kategori:
AmidesAntibacterials for Systemic UseAntiinfectives for Systemic Use +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carvacrol DB16404
small molecule | CAS: 499-75-2

Deskripsi belum tersedia.

Kategori:
Benzene DerivativesMonoterpenesTerpenes
Target Protein:
Transient receptor potential cation channel subfamily V member 3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carvasept DB15886
small molecule | CAS: 5665-94-1

Deskripsi belum tersedia.

Kategori:
Benzene DerivativesMonoterpenesTerpenes
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carvedilol Approved DB01136
small molecule | CAS: 72956-09-3

Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and …

Kategori:
Adrenergic AgentsAdrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-Antagonists +40
Target Protein:
Beta-1 adrenergic receptorAlpha-1A adrenergic receptorAlpha-1 adrenergic receptors +16
Gen Terkait:
ADRB1
Waktu ParuhThe half life of ca…
Vol. DistribusiCarvedilol has a vo…
KlirensThe plasma clearanc…
Genetik 1 Varian
Carya cordiformis pollen Approved DB10882
biotech

Carya cordiformis pollen is the pollen of the Carya cordiformis plant. Carya cordiformis pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carya glabra pollen Approved DB10883
biotech

Carya glabra pollen is the pollen of the Carya glabra plant. Carya glabra pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carya illinoinensis pollen Approved DB10380
biotech

Carya illinoinensis pollen allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carya laciniosa pollen Approved DB10987
biotech

Carya laciniosa pollen allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carya ovata pollen Approved DB10364
biotech

Carya ovata pollen is the pollen of the Carya ovata plant. Carya ovata pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carya tomentosa pollen Approved DB10926
biotech

Carya tomentosa pollen is the pollen of the Carya tomentosa plant. Carya tomentosa pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Caryophyllene DB16854
small molecule | CAS: 87-44-5

Deskripsi belum tersedia.

Kategori:
AnalgesicsAnalgesics, Non-NarcoticAnti-Inflammatory Agents +6
Target Protein:
Cannabinoid receptor 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Casdozokitug DB17513
biotech | CAS: 2643331-37-5

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Casein Approved DB10516
biotech | CAS: 9000-71-9

Casein allergenic extract is used in allergenic testing.

Kategori:
Amino Acids, Peptides, and ProteinsAnimal Proteins, DietaryBeverages +17
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cashew Approved DB10653
biotech

Cashew allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cashew fruit Approved DB15602
biotech

Cashew fruit extract is used in allergenic testing.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Casimersen Approved DB14984
biotech | CAS: 1422958-19-7

Duchenne muscular dystrophy (DMD) is an X-linked recessive allelic disorder characterized by a lack of functional dystrophin protein, which leads to progressive impairment of ambulatory, pulmonary, and cardiac function and is invariably fatal. A related, albe…

Kategori:
Antisense OligonucleotidesCytochrome P-450 CYP2C19 InhibitorsCytochrome P-450 CYP2C19 inhibitors (strength unknown) +16
Target Protein:
DMD gene (exon 45 casimersen target site)
Waktu ParuhCasimersen has an e…
Vol. DistribusiCasimersen administ…
KlirensCasimersen administ…
Genetik -
Casimiroin DB08744
small molecule | CAS: 477-89-4

Casimiroin is a quinone reductase 2 inhibitor isolated from _Casimiroa edulis_.

Kategori:
AromataseDioxolesHeterocyclic Compounds, Fused-Ring +2
Target Protein:
Ribosyldihydronicotinamide dehydrogenase [quinone]
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Casirivimab Approved DB15941
biotech | CAS: 2415933-42-3

Casirivimab is a monoclonal antibody combined with [Imdevimab] in Regeneron's antibody cocktail known as REGN-COV2 for the treatment of COVID-19.[L23539] This drug is a combination of antibodies derived from humanized VelocImmune® mice in addition to blood s…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +10
Target Protein:
Spike glycoprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Casopitant DB06634
small molecule | CAS: 414910-27-3

Deskripsi belum tersedia.

Kategori:
Alimentary Tract and MetabolismAmidesAntiemetics +7
Target Protein:
Substance-P receptorCytochrome P450 3A4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Caspofungin Approved DB00520
small molecule | CAS: 162808-62-0

Caspofungin (brand name Cancidas worldwide) is an antifungal drug and the first member of a new drug class called the echinocandins, as coined by Merck & Co., Inc. It is typically administered intravenously. It shows activity against infections with Aspergill…

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Infective AgentsAntifungal Agents +18
Target Protein:
1,3-beta-glucan synthase component FKS11,3-beta-glucan synthase component GSC2
Waktu Paruh9-11 hours
Vol. Distribusi-
Klirens* 12 mL/min [After …
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Castanospermine DB01816
small molecule | CAS: 79831-76-8

Deskripsi belum tersedia.

Kategori:
AnalgesicsAnalgesics, Non-NarcoticAnti-Inflammatory Agents +10
Target Protein:
Glucan 1,3-beta-glucosidase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Castor oil Approved DB11113
biotech | CAS: 8001-79-4

Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (_Ricinus communis_ L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of [DB02955], which represents up to 90% of the total castor…

Kategori:
Alimentary Tract and MetabolismBiological ProductsComplex Mixtures +10
Target Protein:
Prostaglandin E2 receptor EP3 subtypeProstaglandin E2 receptor EP4 subtype
Waktu ParuhNo pharmacokinetic …
Vol. DistribusiNo pharmacokinetic …
KlirensNo pharmacokinetic …
Genetik -
biotech

Casuarina equisetifolia pollen is the pollen of the Casuarina equisetifolia plant. Casuarina equisetifolia pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cat dander extract Approved DB13904
biotech

Cat dander extract is either subcutaneously or intracutaneously administered and contains dry cat dander or dry defatted cat pelt. It is used in the diagnosis and treatment (immunotherapy) of patients with a history of allergy to cats. An allergic reaction to…

Kategori:
Allergenic Extracts
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Catfish Approved DB14758
biotech

Catfish (unspecified) allergenic extract is used in allergenic testing.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cathine DB01486
small molecule | CAS: 492-39-7

Cathine, also known as d-norpseudoephedrine and (+)-norpseudoephedrine, is a psychoactive drug with stimulant properties. It belongs to the phenethylamine and amphetamine chemical classes. In the United States, it is classified as a Schedule IV controlled sub…

Kategori:
AlcoholsAlimentary Tract and MetabolismAmines +7
Waktu Paruh5.2 +/- 3.4 hours
Vol. Distribusi-
Klirens-
Genetik -
Cathinone DB01560
small molecule | CAS: 71031-15-7

Cathinone is a monoamine alkaloid found in the shrub Catha edulis (Khat). Closely related to ephedrine, cathine and other amphetamines, it is probably the main contributor to the stimulant effect of Catha edulis. Cathinone differs from many other amphetamines…

Kategori:
Central Nervous System AgentsCentral Nervous System DepressantsCentral Nervous System Stimulants +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Catridecacog Approved DB09310
biotech | CAS: 606138-08-3

Coagulation Factor XIII A-Subunit (Recombinant), also known as catridecacog, is a recombinant form of the Factor XIII-A2 homodimer composed of two factor XIII (FXIII) A-subunits [FDA Label]. For people with congenital deficiency or mutation of Factor XIII, a …

Kategori:
Blood and Blood Forming OrgansBlood Coagulation FactorsHemostatics
Target Protein:
Coagulation factor XIII B chain
Waktu Paruh7.1 days
Vol. Distribusi-
Klirens0.41 mL/h/kg
Genetik -
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