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11793

Total database: 17430
Struktur (SMILES)
8607 (73.0%)
Target
6418 (54.4%)
Genomik
102 (0.9%)
Referensi
11793 (100.0%)

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Hasil Pencarian (11793)

Halaman 87 / 236
small molecule | CAS: 524-84-5

Dimethylthiambutene (N,N-Dimethyl-1-methyl-3,3-di-2-thienylallylamine, Dimethibutin, Ohton) is an opioid analgesic drug. It is now under international control under Schedule I of the UN Single Convention On Narcotic Drugs 1961, presumably due to high abuse po…

Target Protein:
Mu-type opioid receptorDelta-type opioid receptor
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small molecule | CAS: 61-50-7

An N-methylated indoleamine derivative, a serotonergic hallucinogen found in several plants, especially Prestonia amazonica (Apocynaceae) and in mammalian brain, blood, and urine. It apparently acts as an agonist at some types of serotonin receptors and an an…

Kategori:
AminesAntidepressive AgentsBiogenic Amines +13
Target Protein:
5-hydroxytryptamine receptor 6Sigma non-opioid intracellular receptor 15-hydroxytryptamine receptor 2A
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Dimetindene Approved DB08801
small molecule | CAS: 5636-83-9

Dimetindene (Fenistil) is an antihistamine/anticholinergic used orally and locally as an antipruritic.

Kategori:
Agents producing tachycardiaAnti-Allergic AgentsAnticholinergic Agents +13
Target Protein:
Histamine H1 receptorMuscarinic acetylcholine receptor M2
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Dimetotiazine Approved DB08967
small molecule | CAS: 7456-24-8

Dimetotiazine has considerable antiemetic & serotonin antagonistic action used mainly in allergic skin conditions.

Kategori:
AnalgesicsAntimigraine PreparationsHeterocyclic Compounds, Fused-Ring +6
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Diminazene DB03608
small molecule | CAS: 536-71-0

Diminazene, also known as Diminazine, 4,4'-(Diazoamino)benzamidine, 4,4'-(1-triazene-1,3-diyl)bis-benzenecarboximidamide, diminazine aceturate, or Diminazene aceturate, is a trypanocidal agent. Major brands of Diminazene are Berenil, Pirocide, Ganasag, and Az…

Kategori:
AmidinesAnti-Infective AgentsAntiparasitic Agents +4
Target Protein:
HTH-type transcriptional regulator QacRSerine protease 1Diamine oxidase [copper-containing] +1
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Dimiracetam DB13018
small molecule | CAS: 126100-97-8

Dimiracetam has been used in trials studying the treatment of AIDS, Neuropathy, and Acquired Immunodeficiency Syndrome.

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small molecule | CAS: 311768-81-7

Dinalbuphine sebacate is under investigation in clinical trial NCT02468128 (A Study of Intramuscular Sebacoyl Dinalbuphine Ester for Post-Hemorrhoidectomy Pain Management).

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Dinoprost tromethamine Approved DB01160
small molecule | CAS: 38562-01-5

The tromethamine (THAM) salt of the naturally occurring prostaglandin F2 alpha, dinoprost tromethamine occurs as a white to off-white, very hygroscopic, crystalline powder. Dinoprost tromethamine may also be known as dinoprost trometamol, PGF2 alpha THAM, or …

Kategori:
Abortifacient AgentsAbortifacient Agents, NonsteroidalAngiography +11
Target Protein:
Prostaglandin F2-alpha receptorProstacyclin receptor
Waktu ParuhThe half-life of di…
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Dinoprostone Approved DB00917
small molecule | CAS: 363-24-6

Dinoprostone is a naturally occurring prostaglandin E2 (PGE2). It has important effects in labour. It also stimulates osteoblasts to release factors which stimualtes bone resorption by osteoclasts. As a prescription drug it is used as a vaginal suppository, t…

Kategori:
AutacoidsBiological FactorsDinoprostone, antagonists & inhibitors +19
Target Protein:
Prostaglandin F2-alpha receptorProstaglandin E2 receptor EP2 subtypeProstaglandin E2 receptor EP1 subtype +3
Waktu ParuhLess than 5 minutes.
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Dinutuximab Approved DB09077
biotech | CAS: 1363687-32-4

Dinutuximab is an IgG1 monoclonal human/mouse chimeric antibody against GD2, a disialoganglioside expressed on tumors of neuroectodermal origin, including human neuroblastoma and melanoma, with highly restricted expression on normal tissues. It is composed of…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +17
Target Protein:
GD2 disialoganglioside
Waktu ParuhThe terminal half-l…
Vol. DistribusiThe mean volume of …
KlirensThe clearance is 0.…
Genetik -
Dioctyldimonium Approved DB13970
small molecule | CAS: 20256-55-7

Deskripsi belum tersedia.

Kategori:
AminesAmmonium CompoundsNitrogen Compounds +1
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Diodone DB13568
small molecule | CAS: 300-37-8

Deskripsi belum tersedia.

Kategori:
Compounds used in a research, industrial, or household settingContrast MediaDiagnostic Uses of Chemicals +5
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small molecule | CAS: 467-86-7

Deskripsi belum tersedia.

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Diperodon DB11513
small molecule | CAS: 101-08-6

Deskripsi belum tersedia.

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Diphemanil Approved DB13720
small molecule | CAS: 15394-62-4

Deskripsi belum tersedia.

Kategori:
Agents producing tachycardiaAlimentary Tract and MetabolismAnti-Asthmatic Agents +9
Target Protein:
Muscarinic acetylcholine receptor M3Muscarinic acetylcholine receptor M1
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Diphenadione DB13347
small molecule | CAS: 82-66-6

Deskripsi belum tersedia.

Kategori:
AnticoagulantsBlood and Blood Forming OrgansCytochrome P-450 CYP3A Substrates +5
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Diphencyprone DB12173
small molecule | CAS: 886-38-4

Diphencyprone has been used in trials studying the treatment and basic science of Melanoma, Ultraviolet Rays, Immunosuppression, Neoplasm Metastasis, and Hypersensitivity, Delayed, among others.

Kategori:
Cycloparaffins
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Diphenhydramine Approved DB01075
small molecule | CAS: 58-73-1

Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, …

Kategori:
Agents producing tachycardiaAminesAminoalkyl Ethers +41
Target Protein:
Histamine N-methyltransferaseHistamine H1 receptorMuscarinic acetylcholine receptor M2
Waktu ParuhThe elimination hal…
Vol. DistribusiDiphenhydramine is …
KlirensValues for plasma c…
Genetik -
Diphenylguanidine Approved DB14191
small molecule | CAS: 102-06-7

Diphenylguanidine is a complexing agent used in the detection of metals and organic bases and used as an accelerator in the vulcanization of rubber. It is found in some rubber products. It is also a dermatological sensitizer and allergen. Sensitivity to di…

Kategori:
AmidinesCell-mediated ImmunityIncreased Histamine Release +1
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Diphenylpyraline Approved DB01146
small molecule | CAS: 147-20-6

Diphenylpyraline is an antihistamine. Antihistamines used in the treatment of allergy act by competing with histamine for H 1-receptor sites on effector cells. Antihistamines prevent, but do not reverse, responses mediated by histamine alone. Antihistamines a…

Kategori:
Aminoalkyl EthersAntihistamines for Systemic UseHistamine Antagonists +1
Target Protein:
Histamine H1 receptorSodium-dependent dopamine transporter
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Diphthamide DB03223
small molecule | CAS: 75645-22-6

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, CyclicAmino Acids, Peptides, and Proteins
Target Protein:
Elongation factor 2
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small molecule | CAS: 499-83-2

Deskripsi belum tersedia.

Kategori:
Chelating AgentsCompounds used in a research, industrial, or household settingEnzyme Inhibitors +3
Target Protein:
4-hydroxy-tetrahydrodipicolinate reductase4-hydroxy-tetrahydrodipicolinate reductase
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Dipipanone DB01491
small molecule | CAS: 467-83-4

Deskripsi belum tersedia.

Kategori:
Ketones
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Dipivefrin Approved DB00449
small molecule | CAS: 52365-63-6

Dipivefrin is a prodrug of adrenaline, which is used to treat glaucoma. It is available as ophthalmic solution (eye drops).

Kategori:
Adrenergic AgentsAdrenergic AgonistsAdrenergic alpha-1 Receptor Agonists +24
Target Protein:
Beta-1 adrenergic receptorAlpha-1A adrenergic receptorAlpha-2A adrenergic receptor +3
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Dipraglurant DB12733
small molecule | CAS: 872363-17-2

Dipraglurant has been used in trials studying the treatment of Parkinson's Disease. It is a metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator (NAM).

Target Protein:
Metabotropic glutamate receptor 5
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small molecule | CAS: 63065-88-3

Dipropyl-4-hydroxytryptamine is the 4-hydroxyl analog of dipropyltryptamine (DPT). Dipropyl-4-hydroxytryptamine was first synthesized by Alexander Shulgin. This agent and its properties haven't been fully elucidated.

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small molecule | CAS: 25265-71-8

Deskripsi belum tersedia.

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Dipyrithione Approved DB11327
small molecule | CAS: 3696-28-4

Dipyrithione, a bactericidal and fungicidal pyrithione derivate, was formulated as Crimanex anti-dandruff shampoo, but is no longer available.[L2611] It is currently used as a pesticide, and not used in any FDA approved drug products.[A32829] Interestingl…

Target Protein:
Nitric oxide synthase, inducibleProstaglandin G/H synthase 2
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Dipyrocetyl DB13839
small molecule | CAS: 486-79-3

Deskripsi belum tersedia.

Kategori:
AnalgesicsAntiinflammatory and Antirheumatic ProductsMusculo-Skeletal System +2
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Diquafosol DB15919
small molecule | CAS: 59985-21-6

Deskripsi belum tersedia.

Kategori:
AcidsAcids, NoncarboxylicAnions +12
Target Protein:
P2Y purinoceptor 2
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Diridavumab DB12607
biotech | CAS: 1393659-46-5

Cr6261 is under investigation in clinical trial NCT02016066 (A Study to Assess the Safety, Pharmacokinetics and Immunogenicity of Diridavumab in Japanese Healthy Participants).

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Dirithromycin DB00954
small molecule | CAS: 62013-04-1

Dirithromycin is a macrolide glycopeptide antibiotic used to treat many different types of bacterial infections, such as bronchitis, pneumonia, tonsillitis, and even skin infections.

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsAntibacterials for Systemic Use +9
Target Protein:
23S ribosomal RNA
Waktu ParuhThe mean plasma hal…
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biotech | CAS: 2163074-23-3

Deskripsi belum tersedia.

Kategori:
Adeno-associated Viral Vector Therapies
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Dirlotapide DB11399
small molecule | CAS: 481658-94-0

Dirlotapide is a drug employed in the treatment of obesity in dogs. It is marketed by Pfizer and Zoetis under the brand name, _Slentrol_, and is not intended for human use.

Kategori:
Acids, AcyclicHeterocyclic Compounds, Fused-Ring
Target Protein:
Microsomal triglyceride transfer protein large subunit
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Dirocaftor DB16143
small molecule | CAS: 2137932-23-9

Dirocaftor is under investigation in clinical trial NCT03251092 (Study Designed to Assess the Safety, Tolerability and PK of PTI-808 in Healthy Volunteers and in Adults With Cystic Fibrosis).

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Diroximel fumarate Approved DB14783
small molecule | CAS: 1577222-14-0

Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life.[A176474] It is the main cause of neurological disability not caused by trauma in the young a…

Kategori:
Acids, AcyclicAntineoplastic and Immunomodulating AgentsDicarboxylic Acids +3
Target Protein:
Neuronal acetylcholine receptor subunit alpha-10
Waktu ParuhThe terminal half-l…
Vol. DistribusiThe apparent volume…
KlirensNo clearance inform…
Genetik -
small molecule | CAS: 130114-83-9

Disaccharide tripeptide glycerol dipalmitoyl is under investigation in clinical trial NCT00003667 (Combination Chemotherapy and Biological Therapy in Treating Patients With High-Risk Ewing's Sarcoma).

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biotech | CAS: 2136633-23-1

Disitamab vedotin is an antibody-drug conjugate drug targeting human epidermal growth factor receptor 2 (HER2). It is currently being investigated for cancers.[A254721]

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibody-drug Conjugates +9
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Disomotide DB17469
biotech | CAS: 181477-43-0

Disomotide is a synthetic peptide cancer vaccine.

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Disperse Blue 106 Approved DB14203
small molecule | CAS: 68516-81-4

Disperse Blue 106 is used in allergenic testing.

Kategori:
AllergensAntigensBiological Factors +3
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Distigmine DB13694
small molecule | CAS: 17299-00-2

Distigmine is a parasympathomimetic agent with a longer duration of action and enhanced drug accumulation compared to [DB00545] and [DB01400]. It is an anticholinergic drug and long-acting reversible carbamate cholinesterase inhibitor that binds directly and …

Kategori:
Cholinergic AgentsCholinesterase InhibitorsEnzyme Inhibitors +4
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Disufenton DB17298
small molecule | CAS: 168021-77-0

Deskripsi belum tersedia.

Kategori:
AntioxidantsArylsulfonatesArylsulfonic Acids +9
Target Protein:
Extracellular sulfatase Sulf-2
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Dithiazanine DB11516
small molecule | CAS: 7187-55-5

Dithiazanine is a highly potent anthelmintic, introduced in 1959 for the treatment of strongyloid worms and whipworms. However, its use is severely limited due to its toxicity. Dithiazanine iodide was associated with eight fatal cases of severe acidosis and s…

Kategori:
AnthelminticsAnti-Infective AgentsAntinematodal Agents +11
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small molecule | CAS: 6892-68-8

A compound that, along with its isomer, Cleland's reagent (dithiothreitol), is used for the protection of sulfhydryl groups against oxidation to disulfides and for the reduction of disulfides to sulfhydryl groups. [PubChem]

Kategori:
AlcoholsCarbohydratesCompounds used in a research, industrial, or household setting +6
Target Protein:
Listeriolysin regulatory protein6,7-dimethyl-8-ribityllumazine synthaseThymidine kinase, cytosolic
Waktu Paruh-
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Dithiopyr DB15230
small molecule | CAS: 97886-45-8

Dithiopyr is under investigation in clinical trial NCT01236781 (Comparison of Full-Field Digital Mammography With Digital Breast Tomography for Screening Call-Back Rates).

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Divarasib DB17488
small molecule | CAS: 2417987-45-0

Deskripsi belum tersedia.

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Divozilimab DB18878
biotech | CAS: 2254061-60-2

Divozilimab is under investigation in clinical trial NCT05730699 (Efficacy and Safety of Divozilimab in Patients With Neuromyelitis Optica Spectrum Disorders (AQUARELLE)).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodies, MonoclonalAntineoplastic and Immunomodulating Agents +5
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Dixanthogen DB13712
small molecule | CAS: 502-55-6

Deskripsi belum tersedia.

Kategori:
AnionsAntiparasitic Products, Insecticides and RepellentsEctoparasiticides, Incl. Scabicides +7
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DL-alpha-Tocopherol Approved DB14476
small molecule | CAS: 10191-41-0

Deskripsi belum tersedia.

Kategori:
Vitamin EVitaminsVitamins (Fat Soluble)
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small molecule | CAS: 18656-38-7

A synthetic phospholipid used in liposomes and lipid bilayers for the study of biological membranes. It is used in commercial drug preparations to solubilize drugs for injection [A32711]

Kategori:
Compounds used in a research, industrial, or household settingGlycerophosphatesGlycerophospholipids +7
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