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12560

Total database: 17430
Struktur (SMILES)
9109 (72.5%)
Target
6912 (55.0%)
Genomik
109 (0.9%)
Referensi
12560 (100.0%)

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Hasil Pencarian (12560)

Halaman 87 / 252
Cytisine DB09028
small molecule | CAS: 485-35-8

Cytisine is an alkaloid naturally derived from the Fabaceae family of plants including the genera Laburnum and Cytisus. Recent studies have shown it to be a more effective and significantly more affordable smoking cessation treatment than nicotine replacement…

Kategori:
AlkaloidsDrugs Used in Addictive DisordersDrugs Used in Nicotine Dependence +5
Target Protein:
Neuronal acetylcholine receptor subunit alpha-2Neuronal acetylcholine receptor subunit beta-4Neuronal acetylcholine receptor subunit alpha-4 +4
Waktu Paruh4.8 hours.
Vol. DistribusiOral: 6.2 l/kg Oral…
KlirensRenal: 43 mL/min.
Genetik -
Cytochlor DB12383
small molecule | CAS: 32387-56-7

Cytochlor has been used in trials studying the treatment of Head and Neck Cancer and Brain and Central Nervous System Tumors.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cytochrome C DB18543
biotech | CAS: 9007-43-6

Cytochrome C is a hemeprotein that plays a role in the mitochondrial electron-transport chain.

Kategori:
Amino Acids, Peptides, and ProteinsCytochrome c GroupCytochromes +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CZEN 002 DB05479
small molecule

CZEN-002 is a novel, non-azole anti-fungal synthetic octapeptide, derived from alpha-Melanocyte-Stimulating Hormone (a-MSH). CZEN-002 modulates inflammatory and immune responses. It has also been shown to kill Candida albicans (C. albicans), a single-celled f…

Target Protein:
Melanocyte-stimulating hormone receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Chymotrypsinogen B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-157495 DB16938
small molecule | CAS: 1005504-62-0

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
m7GpppX diphosphatase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-3082-L DB17440
biotech | CAS: 2170657-73-3

D-3082-L is one of the components of the human papilloma virus (HPV) type 16 E6/E7 synthetic long peptide (SLP) vaccine ISA101b.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-Allopyranose DB03989
small molecule | CAS: 2595-97-3

Deskripsi belum tersedia.

Target Protein:
D-allose-binding periplasmic protein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-alpha-Tocopherol acetate Approved DB14002
small molecule | CAS: 58-95-7

Alpha-tocopherol is the primary form of vitamin E that is preferentially used by the human body to meet appropriate dietary requirements. In particular, the RRR-alpha-tocopherol (or sometimes called the d-alpha-tocopherol stereoisomer) stereoisomer is conside…

Kategori:
AntioxidantsBenzopyransBiological Factors +12
Target Protein:
SEC14-like protein 3SEC14-like protein 2Nuclear receptor subfamily 1 group I member 2 +3
Waktu Paruh_In addition to any…
Vol. Distribusi_In addition to any…
Klirens_In addition to any…
Genetik -
D-arginine DB04027
small molecule | CAS: 157-06-2

A D-?-amino acid that is the D-isomer of arginine (only the L-form is physiologically active).

Target Protein:
Creatine kinase M-type
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-Asparagine DB03943
small molecule | CAS: 2058-58-4

A non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. It is biosynthesized from ASPARTIC ACID and AMMONIA by asparagine synthetase. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd …

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-Aspartic Acid DB02655
small molecule | CAS: 1783-96-6

The D-isomer of aspartic acid. [PubChem]

Kategori:
Amino AcidsAmino Acids, AcidicAmino Acids, Dicarboxylic +1
Target Protein:
Glutamate receptor ionotropic, NMDA 2BGlutamate receptor ionotropic, NMDA 2AGlutamate receptor ionotropic, NMDA 1 +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 643-12-9

D-chiro-Inositol is under investigation in clinical trial NCT03201601 (Evaluation of the Mixture Myoinositol:D-chiro-inositol 3.6:1 in Women With Polycystic Ovary Syndrome).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 25023-78-3

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 585-18-2

Deskripsi belum tersedia.

Target Protein:
2-dehydro-3-deoxyphosphooctonate aldolaseGlucose-6-phosphate isomerasePhospho-2-dehydro-3-deoxyheptonate aldolase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 870452-26-9

D-fluoromethyltyrosine F-18 is under investigation in clinical trial NCT01089998 (PET/CT Imaging for Radiation Dosimetry, Plasma Pharmacokinetics, Safety and Tolerability in Healthy Volunteers and Safety, Tolerability and Diagnostic Performance of BAY86-9596 …

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 15892-28-1

Deskripsi belum tersedia.

Target Protein:
Beta-galactosidase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 20479-58-7

Deskripsi belum tersedia.

Kategori:
CarbohydratesSugar Phosphates
Target Protein:
Glucose-6-phosphate isomerase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Lactase/phlorizin hydrolase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-glucose Approved DB01914
small molecule | CAS: 50-99-7

Glucose is a simple sugar (monosaccharide) generated during phosynthesis involving water, carbon and sunlight in plants. It is produced in humans via hepatic gluconeogenesis and breakdown of polymeric glucose forms (glycogenolysis). It circulates in human cir…

Kategori:
CarbohydratesCompounds used in a research, industrial, or household settingDiet, Food, and Nutrition +11
Waktu ParuhThe approximate hal…
Vol. DistribusiThe mean volume of …
KlirensThe mean metabolic …
Genetik -
D-Glutamic Acid DB02517
small molecule | CAS: 6893-26-1

Glutamic acid is the most common excitatory neurotransmitter in the central nervous system.

Target Protein:
Thermolysin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-Glutamine DB02174
small molecule | CAS: 5959-95-5

A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from glutamic acid and ammonia. It is the principal carrier of nitrogen in the body and is an important energy source for many cel…

Kategori:
Amino AcidsAmino Acids, BasicAmino Acids, Diamino +3
Target Protein:
Glutamate racemase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 453-17-8

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 591-57-1

An aldotriose which is an important intermediate in glycolysis and in tryptophan biosynthesis.

Target Protein:
Glyceraldehyde-3-phosphate dehydrogenase AGlyceraldehyde-3-phosphate dehydrogenaseNADP-dependent glyceraldehyde-3-phosphate dehydrogenase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-JNKI-1 DB05660
small molecule | CAS: 1198367-70-2

A synthetic, cell permeable peptide that blocks the MAPK-JNK signal pathway; has potential therapeutic value for long-term protection of both the morphological integrity and physiological function of the organ of Corti during times of oxidative stress.

Kategori:
Amino Acids, Peptides, and ProteinsNeuroprotective Agents
Target Protein:
Mitogen-activated protein kinase 8Mitogen-activated protein kinase 9Mitogen-activated protein kinase 10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-Levofloxacin DB03034
small molecule | CAS: 100986-86-5

A synthetic fluoroquinolone (FLUOROQUINOLONES) antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.

Target Protein:
Autolysin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-Lysine DB03252
small molecule | CAS: 923-27-3

An essential amino acid. It is often added to animal feed. [PubChem]

Target Protein:
Alanine racemase, catabolicDiaminopimelate decarboxylase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 27251-84-9

Deskripsi belum tersedia.

Kategori:
CarbohydratesHexosephosphatesSugar Phosphates
Target Protein:
Phosphomannomutase/phosphoglucomutase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 47055-78-7

Deskripsi belum tersedia.

Target Protein:
Type II inositol 1,4,5-trisphosphate 5-phosphatase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-norleucine DB04419
small molecule | CAS: 327-56-0

An unnatural amino acid that is used experimentally to study protein structure and function. It is structurally similar to METHIONINE, however it does not contain SULFUR.

Target Protein:
Phenylalanine-4-hydroxylaseParathyroid hormoneHepatocyte nuclear factor 1-alpha
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-Phenylalanine DB02556
small molecule | CAS: 673-06-3

An essential aromatic amino acid that is a precursor of melanin; dopamine; noradrenalin (norepinephrine), and thyroxine. [PubChem]

Target Protein:
Kynurenine--oxoglutarate transaminase 1Corticoliberin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Prothrombin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-Proline DB02853
small molecule | CAS: 344-25-2

D-proline is an isomer of the naturally occurring amino acid, L-Proline. D-amino acids have been found in relatively high abundance in human plasma and saliva [A19262]. These amino acids may be of bacterial origin, but there is also evidence that they are end…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-Serine Approved DB03929
small molecule | CAS: 312-84-5

A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids. [PubChem]

Target Protein:
Glutamate receptor ionotropic, NMDA 1Glycine receptor subunit alpha-1Serpin B3 +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 10162-32-0

A pteridine derivative present in body fluids; elevated levels result from immune system activation, malignant disease, allograft rejection, and viral infections. (From Stedman, 26th ed) Neopterin also serves as a precursor in the biosynthesis of biopterin.

Kategori:
CoenzymesEnzymes and CoenzymesHeterocyclic Compounds, Fused-Ring +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-Tryptophan DB03225
small molecule | CAS: 153-94-6

Tryptophan is one of the 20 standard amino acids, as well as an essential amino acid in the human diet. It is encoded in the standard genetic code as the codon UGG. The D-stereoisomer is occasionally found in naturally produced peptides (for example, the mari…

Target Protein:
Hydroxycarboxylic acid receptor 3D-amino-acid oxidase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-Tyrosine DB03839
small molecule | CAS: 556-02-5

A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-Xylulose DB03947
small molecule | CAS: 551-84-8

Deskripsi belum tersedia.

Target Protein:
Xylose isomerase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
2,2-dialkylglycine decarboxylaseAlanine racemaseUDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

D2C7 immunotoxin (D2C7-IT) is an investigational dual-specific monoclonal antibody targeting EGFRwt and EGFRvIII with a genetically engineered form of the _Pseudomonas exotoxin_, PE38-KDEL. D2C7-IT is under investigation in clinical trial NCT04160494 (D2C7-IT…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D3S-001 DB19008
small molecule | CAS: 2706637-43-4

D3S-001 is under investigation in clinical trial NCT05410145 (A Study of D3S 001 Monotherapy or Combination Therapy in Subjects With Advanced Solid Tumors With a KRAS p.g12c Mutation).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
DA-6886 DB12853
small molecule | CAS: 1342815-16-0

DA-6886 has been used in trials studying the treatment of Irritable Bowel Syndrome.

Kategori:
Acids, CarbocyclicAmidesBenzene Derivatives +1
Target Protein:
5-hydroxytryptamine receptor 4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
DA-8031 DB19024
small molecule | CAS: 1148027-74-0

DA-8031 is under investigation in clinical trial NCT01798667 (Clinical Trial to Evaluate the Efficacy and Safety of DA-8031 in Male Patients With Premature Ejaculation).

Kategori:
Antidepressive AgentsCentral Nervous System DepressantsHeterocyclic Compounds, Fused-Ring +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dabigatran Approved DB14726
small molecule | CAS: 211914-51-1

Dabigatran is the active form of the orally bioavailable prodrug [dabigatran etexilate].

Kategori:
AnticoagulantsAntithrombinsBenzimidazoles +9
Target Protein:
Prothrombin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dabigatran etexilate Approved DB06695
small molecule | CAS: 211915-06-9

Dabigatran etexilate is an oral prodrug that is hydrolyzed to the competitive and reversible direct thrombin inhibitor [dabigatran].[A177463, A6970, L34675, L34680] Dabigatran etexilate may be used to decrease the risk of venous thromboembolic events in patie…

Kategori:
AnticoagulantsAntithrombinsBenzimidazoles +11
Target Protein:
Prothrombin
Waktu ParuhDabigatran has a ha…
Vol. DistribusiDabigatran has a vo…
KlirensFollowing intraveno…
Genetik -
biotech | CAS: 2365353-63-3

Dabocemagene autoficel is an _ex vivo_, autologous cell-based gene therapy. It comprises autologous dermal fibroblasts genetically modified to express functional type VII collagen. Developed by Castle Creek Biosciences Inc., dabocemagene autoficel is being in…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dabrafenib Approved DB08912
small molecule | CAS: 1195765-45-7

Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation.[L41955] It was also used for metastatic non-small cell …

Kategori:
AminesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +64
Target Protein:
Serine/threonine-protein kinase B-rafRAF proto-oncogene serine/threonine-protein kinaseSerine/threonine-protein kinase SIK1 +2
Waktu ParuhThe mean terminal h…
Vol. DistribusiThe apparent volume…
KlirensThe clearance of da…
Genetik -
Dacarbazine Approved DB00851
small molecule | CAS: 4342-03-4

An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma.

Kategori:
Alkylating ActivityAlkylating DrugsAntineoplastic Agents +15
Target Protein:
DNADNA polymerase alpha subunit B6-phosphogluconate dehydrogenase, decarboxylating
Waktu Paruh5 hours
Vol. Distribusi-
Klirens-
Genetik -
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