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14063

Total database: 17430
Struktur (SMILES)
10481 (74.5%)
Target
8038 (57.2%)
Genomik
107 (0.8%)
Referensi
14063 (100.0%)

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Hasil Pencarian (14063)

Halaman 86 / 282
small molecule | CAS: 401905-67-7

Carotegrast methyl is under investigation in clinical trial NCT03531892 (A Study to Evaluate the Safety and Efficacy of AJM300 in Participants With Active Ulcerative Colitis).

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carotuximab DB06322
biotech | CAS: 1268714-50-6

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +5
Target Protein:
Endoglin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Caroverine DB13835
small molecule | CAS: 23465-76-1

Deskripsi belum tersedia.

Kategori:
Agents causing hyperkalemiaAlimentary Tract and MetabolismAntiarrhythmic agents +14
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Caroxazone DB09254
small molecule | CAS: 18464-39-6

Caroxazone is an antidepressant that has been withdrawn from the market. It is a reversible monoamine oxidase inhibitor (MAOI) of both A and B monoamine oxidase subtypes. However, it presents a five-fold preference for the MAO-B subtype.

Kategori:
AcetamidesAgents that produce hypertensionAgents that reduce seizure threshold +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carphenazine DB01038
small molecule | CAS: 2622-30-2

Carphenazine is an antipsychotic drug, used in hospitalized patients in the management of chronic schizophrenic psychoses.

Kategori:
Dopamine AntagonistsDopamine D2 Receptor Antagonists
Target Protein:
D(2) dopamine receptorD(1A) dopamine receptorD(1B) dopamine receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carprofen Approved DB00821
small molecule | CAS: 53716-49-7

Carprofen is a non-steroidal anti-inflammatory drug (NSAID) that is used by veterinarians as a supportive treatment for the relief of arthritic symptoms in geriatric dogs. Carprofen was previously used in human medicine for over 10 years (1985-1995). It was g…

Kategori:
Agents causing hyperkalemiaAgents that produce hypertensionAnalgesics +15
Target Protein:
Prostaglandin G/H synthase 2Prostaglandin G/H synthase 1
Waktu ParuhApproximately 8 hou…
Vol. Distribusi-
Klirens-
Genetik -
Carpropamide DB02946
small molecule | CAS: 127640-90-8

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carteolol Approved DB00521
small molecule | CAS: 51781-06-7

A beta-adrenergic antagonist used as an anti-arrhythmia agent, an anti-angina agent, an antihypertensive agent, and an antiglaucoma agent.

Kategori:
Adrenergic AgentsAdrenergic AntagonistsAdrenergic beta-Antagonists +28
Target Protein:
Beta-2 adrenergic receptorBeta-1 adrenergic receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Carthamus tinctorius flower bud is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carvacrol DB16404
small molecule | CAS: 499-75-2

Deskripsi belum tersedia.

Kategori:
Benzene DerivativesMonoterpenesTerpenes
Target Protein:
Transient receptor potential cation channel subfamily V member 3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carvedilol Approved DB01136
small molecule | CAS: 72956-09-3

Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and …

Kategori:
Adrenergic AgentsAdrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-Antagonists +40
Target Protein:
Beta-1 adrenergic receptorAlpha-1A adrenergic receptorAlpha-1 adrenergic receptors +16
Gen Terkait:
ADRB1
Waktu ParuhThe half life of ca…
Vol. DistribusiCarvedilol has a vo…
KlirensThe plasma clearanc…
Genetik 1 Varian
Carya cordiformis pollen Approved DB10882
biotech

Carya cordiformis pollen is the pollen of the Carya cordiformis plant. Carya cordiformis pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carya tomentosa pollen Approved DB10926
biotech

Carya tomentosa pollen is the pollen of the Carya tomentosa plant. Carya tomentosa pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Caryophyllene DB16854
small molecule | CAS: 87-44-5

Deskripsi belum tersedia.

Kategori:
AnalgesicsAnalgesics, Non-NarcoticAnti-Inflammatory Agents +6
Target Protein:
Cannabinoid receptor 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Casdozokitug DB17513
biotech | CAS: 2643331-37-5

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cashew fruit Approved DB15602
biotech

Cashew fruit extract is used in allergenic testing.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Casimersen Approved DB14984
biotech | CAS: 1422958-19-7

Duchenne muscular dystrophy (DMD) is an X-linked recessive allelic disorder characterized by a lack of functional dystrophin protein, which leads to progressive impairment of ambulatory, pulmonary, and cardiac function and is invariably fatal. A related, albe…

Kategori:
Antisense OligonucleotidesCytochrome P-450 CYP2C19 InhibitorsCytochrome P-450 CYP2C19 inhibitors (strength unknown) +16
Target Protein:
DMD gene (exon 45 casimersen target site)
Waktu ParuhCasimersen has an e…
Vol. DistribusiCasimersen administ…
KlirensCasimersen administ…
Genetik -
Casimiroin DB08744
small molecule | CAS: 477-89-4

Casimiroin is a quinone reductase 2 inhibitor isolated from _Casimiroa edulis_.

Kategori:
AromataseDioxolesHeterocyclic Compounds, Fused-Ring +2
Target Protein:
Ribosyldihydronicotinamide dehydrogenase [quinone]
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Casirivimab Approved DB15941
biotech | CAS: 2415933-42-3

Casirivimab is a monoclonal antibody combined with [Imdevimab] in Regeneron's antibody cocktail known as REGN-COV2 for the treatment of COVID-19.[L23539] This drug is a combination of antibodies derived from humanized VelocImmune® mice in addition to blood s…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +10
Target Protein:
Spike glycoprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Casopitant DB06634
small molecule | CAS: 414910-27-3

Deskripsi belum tersedia.

Kategori:
Alimentary Tract and MetabolismAmidesAntiemetics +7
Target Protein:
Substance-P receptorCytochrome P450 3A4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Caspofungin Approved DB00520
small molecule | CAS: 162808-62-0

Caspofungin (brand name Cancidas worldwide) is an antifungal drug and the first member of a new drug class called the echinocandins, as coined by Merck & Co., Inc. It is typically administered intravenously. It shows activity against infections with Aspergill…

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Infective AgentsAntifungal Agents +18
Target Protein:
1,3-beta-glucan synthase component FKS11,3-beta-glucan synthase component GSC2
Waktu Paruh9-11 hours
Vol. Distribusi-
Klirens* 12 mL/min [After …
Genetik -
Castanospermine DB01816
small molecule | CAS: 79831-76-8

Deskripsi belum tersedia.

Kategori:
AnalgesicsAnalgesics, Non-NarcoticAnti-Inflammatory Agents +10
Target Protein:
Glucan 1,3-beta-glucosidase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Castor oil Approved DB11113
biotech | CAS: 8001-79-4

Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (_Ricinus communis_ L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of [DB02955], which represents up to 90% of the total castor…

Kategori:
Alimentary Tract and MetabolismBiological ProductsComplex Mixtures +10
Target Protein:
Prostaglandin E2 receptor EP3 subtypeProstaglandin E2 receptor EP4 subtype
Waktu ParuhNo pharmacokinetic …
Vol. DistribusiNo pharmacokinetic …
KlirensNo pharmacokinetic …
Genetik -
Cathine DB01486
small molecule | CAS: 492-39-7

Cathine, also known as d-norpseudoephedrine and (+)-norpseudoephedrine, is a psychoactive drug with stimulant properties. It belongs to the phenethylamine and amphetamine chemical classes. In the United States, it is classified as a Schedule IV controlled sub…

Kategori:
AlcoholsAlimentary Tract and MetabolismAmines +7
Waktu Paruh5.2 +/- 3.4 hours
Vol. Distribusi-
Klirens-
Genetik -
Catridecacog Approved DB09310
biotech | CAS: 606138-08-3

Coagulation Factor XIII A-Subunit (Recombinant), also known as catridecacog, is a recombinant form of the Factor XIII-A2 homodimer composed of two factor XIII (FXIII) A-subunits [FDA Label]. For people with congenital deficiency or mutation of Factor XIII, a …

Kategori:
Blood and Blood Forming OrgansBlood Coagulation FactorsHemostatics
Target Protein:
Coagulation factor XIII B chain
Waktu Paruh7.1 days
Vol. Distribusi-
Klirens0.41 mL/h/kg
Genetik -
Catumaxomab Approved DB06607
biotech | CAS: 509077-98-9

Catumaxumab is a trifunctional monoclonal antibody developed for use in cancer treatment. It has affinity for T-cells, accessory immune cells, and cancer cells. Catumaxumab was initially authorized for market by the European Medicines Agency in April 2009 for…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +13
Target Protein:
Low affinity immunoglobulin gamma Fc region receptor II-aLow affinity immunoglobulin gamma Fc region receptor III-ALow affinity immunoglobulin gamma Fc region receptor III-B +3
Waktu ParuhCatumaxomab has an …
Vol. Distribusi-
Klirens-
Genetik -
Caviar, unspecified Approved DB14241
biotech

Caviar, unspecified is an animal extract used in some OTC (over-the-counter) products. It is not an approved drug.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cavosonstat DB14775
small molecule | CAS: 1371587-51-7

Cavosonstat is under investigation in clinical trial NCT02589236 (Study of Cavosonstat (N91115) in Patients With CF Homozygous for the F508del-CFTR Mutation).

Kategori:
Benzene Derivatives
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cavrotolimod DB18216
small molecule | CAS: 2378664-12-9

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CB-103 DB15279
small molecule | CAS: 218457-67-1

CB-103 is under investigation in clinical trial NCT03422679 (Study of CB-103 in Adult Patients With Advanced or Metastatic Solid Tumours and Haematological Malignancies).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CB-1158 DB15286
small molecule | CAS: 2095732-06-0

CB-1158 is under investigation in clinical trial NCT03910530 (A Study of INCMGA00012, INCB001158, and the Combination in Japanese Participants With Advanced Solid Tumors).

Kategori:
Enzyme Inhibitors
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CB-5083 DB16874
small molecule | CAS: 1542705-92-9

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Transitional endoplasmic reticulum ATPase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CBP-501 DB17277
small molecule | CAS: 565434-85-7

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsCell Cycle ProteinsDual-Specificity Phosphatases +11
Target Protein:
MAP/microtubule affinity-regulating kinase 3MAP kinase-activated protein kinase 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CC-115 DB12740
small molecule | CAS: 1228013-15-7

CC-115 has been used in trials studying the treatment of Prostate Cancer, Neoplasm Metastasis, Ewing's Osteosarcoma, Glioblastoma Multiforme, and Chronic Lymphocytic Leukemia, among others.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CC-401 DB12432
small molecule | CAS: 395104-30-0

CC-401 has been used in trials studying the treatment of Myeloid Leukemia.

Kategori:
JNK Mitogen-Activated Protein Kinases, antagonists & inhibitorsPyrazoles
Target Protein:
Mitogen-activated protein kinase 8Mitogen-activated protein kinase 9Mitogen-activated protein kinase 10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CC-90001 DB18445
small molecule | CAS: 1403859-14-2

Deskripsi belum tersedia.

Kategori:
AminesCyclohexanesCycloparaffins
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CCX-354 DB12963
small molecule | CAS: 1010073-75-2

CCX354-C has been used in trials studying the treatment of Rheumatoid Arthritis.

Target Protein:
C-C chemokine receptor type 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CCX915 DB05159
small molecule

CCX915 is developed by ChemoCentryx which targets the chemokine receptor CCR2 and is in phase 1 of clinical trial for the treatment of Multiple Sclerosis and Neurologic Disorders. The CCR2 receptor is thought to be of central importance to inflammatory diseas…

Target Protein:
C-C chemokine receptor type 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CD564 DB02741
small molecule

Deskripsi belum tersedia.

Target Protein:
Retinoic acid receptor gamma
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CDC-801 DB15640
small molecule | CAS: 192819-27-5

CDC-801 is under investigation in clinical trial NCT00006097 (Chemotherapy in Treating Patients With Chronic Lymphocytic Leukemia).

Target Protein:
3',5'-cyclic-AMP phosphodiesterase 4B3',5'-cyclic-AMP phosphodiesterase 4D3',5'-cyclic-AMP phosphodiesterase 4A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CDD-0102 DB16945
small molecule | CAS: 146422-58-4

Deskripsi belum tersedia.

Kategori:
Muscarinic AgonistsOxazolesReceptor, Muscarinic M1, agonists
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CDP323 DB05092
small molecule

CDP323 is an antagonist of the _vascular cell adhesion molecule 1_ (VCAM-1) binding to alpha4-integrins (other adhesion molecules), a process thought to be implicated in the pathophysiology of Multiple Sclerosis (MS). It is considered a small-molecule prodrug…

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +3
Target Protein:
Integrin alpha-4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CDX-301 DB19293
biotech

CDX-301 is under investigation in clinical trial NCT02129075 (A Vaccine (CDX-1401) With or Without a Biologic Drug (CDX-301) for the Treatment of Patients With Stage IIB-IV Melanoma).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CDX-6210 DB17610
biotech

CDX-6210 is a modified version of a leucine decarboxylase enzyme from _Planctomycetaceae bacterium_.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CDX-6512 DB17841
biotech

CDX-6512 is a modified, gastrointestinal-stable bacterial leucine decarboxylase. Developed by Codexis, it is being investigated for the treatment of homocystinuria And Maple Syrup Urine Disease.[L46651, L46656]

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CE-224535 DB12113
small molecule | CAS: 724424-43-5

CE-224535 has been used in trials studying the treatment of Osteoarthritis.

Kategori:
Acids, CarbocyclicAmidesBenzene Derivatives +4
Target Protein:
P2X purinoceptor 7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CE-326597 DB12694
small molecule | CAS: 870615-40-0

CE-326,597 has been used in trials studying the treatment of Obesity.

Kategori:
BenzazepinesHeterocyclic Compounds, Fused-Ring
Target Protein:
Cholecystokinin receptor type A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cebranopadol DB12830
small molecule | CAS: 863513-91-1

Cebranopadol has been used in trials studying the treatment of Pain, Neoplasms, and Chronic Pain.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Mu-type opioid receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ceclazepide DB17270
small molecule | CAS: 1801749-44-9

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 4251–4300 dari 14063
Sebelumnya Halaman 86 / 282 Berikutnya