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16004

Total database: 17430
Struktur (SMILES)
12010 (75.0%)
Target
9041 (56.5%)
Genomik
112 (0.7%)
Referensi
16004 (100.0%)

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Hasil Pencarian (16004)

Halaman 86 / 321
BG1805 DB18667
biotech

BG1805 is an investigational anti-CLL1 chimeric antigen receptor (CAR) T-cell therapy.

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BGA002 DB17125
biotech

Deskripsi belum tersedia.

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BGB-DXP593 DB16357
biotech

BGB-DXP593 is a SARS-CoV-2 neutralizing antibody.[L27401] It is currently being investigated against COVID-19 in the clinical trial NCT04551898 (Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Neutralizing Antibody BGB-DXP593 in Participants With…

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BGT-DTDS DB18664
biotech

BGT-DTDS is an investigational gene therapy comprising an adeno-associated viral vector type 2 (AAV2) encoding the human _SLC6A3_ gene. It is under investigation for the treatment of dopamine transporter deficiency syndrome (DTDS).

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BHT-3034 DB18045
biotech

BHT-3034 is a DNA plasmid vaccine immunotherapy under investigation for the treatment of myasthenia gravis.[L48086]

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BHV-5000 DB17817
small molecule

BHV-5000 is an orally bioavailable, low-trapping, potent N-methyl-D-aspartate (NMDA) receptor antagonist. The active metabolite of BHV-5000 is [lanicemine].[L46446]

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BI 2536 DB16107
small molecule | CAS: 755038-02-9

BI 2536 is under investigation in clinical trial NCT00376623 (Efficacy and Safety of BI 2536 in Advanced or Metastatic Non Small Cell Lung Cancer).

Kategori:
Antimitotic AgentsHeterocyclic Compounds, Fused-Ring
Target Protein:
Serine/threonine-protein kinase PLK1
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BI 44370 TA DB16037
small molecule | CAS: 866086-05-7

BI 44370 TA is under investigation in clinical trial NCT00751803 (BI 44370 TA in Acute Migraine Attack).

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BI-1206 DB17429
biotech

BI-1206 is a fully human immunoglobulin G1 monoclonal antibody that targets CD32b.

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BI-187004 DB18897
small molecule | CAS: 1303515-32-3

Deskripsi belum tersedia.

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BI-671800 DB12524
small molecule | CAS: 1093108-50-9

Bi 671800 has been used in trials studying the treatment of Asthma and Rhinitis, Allergic, Perennial.

Kategori:
Acids, CarbocyclicAmidesBenzene Derivatives +1
Target Protein:
Prostaglandin D2 receptor 2
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BI-765063 DB17482
biotech

BI-765063 is a humanized IgG4 monoclonal antibody antagonist of signal regulatory protein ? (SIRP?).

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BI-836826 DB17322
biotech

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +8
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BI-836858 DB17267
biotech | CAS: 2206770-25-2

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +10
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BI-836880 DB17484
biotech

BI-836880 is a humanized bispecific nanobody that targets VEGF and Ang2.

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BI-K0376 DB05858
biotech

BI-K0376 is investigated for use/treatment in acne. BI-K0376 is a solid. It is under investigation by Pfizer and has gone through phase I of the clinical trails.

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Biapenem DB13028
small molecule | CAS: 120410-24-4

Biapenem has been used in trials studying the treatment of Bacterial Infections.

Kategori:
AmidesAnti-Bacterial AgentsAnti-Infective Agents +6
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Bibenzonium DB13630
small molecule | CAS: 59866-76-1

Deskripsi belum tersedia.

Kategori:
Cough and Cold Preparations
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Bibrocathol DB13818
small molecule | CAS: 6915-57-7

Deskripsi belum tersedia.

Kategori:
Anti-Infective AgentsBenzene DerivativesOphthalmologicals +2
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Bicalutamide Approved DB01128
small molecule | CAS: 90357-06-5

Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor.

Kategori:
AmidesAminesAndrogen Receptor Antagonists +31
Target Protein:
Androgen receptor
Waktu Paruh5.9 days
Vol. Distribusi-
Klirens* Apparent oral cl=…
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Bicifadine DB04889
small molecule | CAS: 71195-57-8

Bicifadine (DOV-220075) is a nonopioid analgesic. It is an inhibitor of both the norepinephrine and serotonin transporters and an NMDA antagonist with a non-narcotic profile. Bicifadine was shown to have potent analgesic activity in vivo and was chosen for fu…

Kategori:
AnalgesicsCytochrome P-450 CYP1A2 SubstratesCytochrome P-450 CYP2D6 Substrates +2
Target Protein:
Sodium-dependent noradrenaline transporterSodium-dependent serotonin transporterD(2) dopamine receptor
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Bicine DB03709
small molecule | CAS: 150-25-4

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, Peptides, and Proteins
Target Protein:
PlasminogenMembrane-bound lytic murein transglycosylase BUDP-galactopyranose mutase
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Bicisate Approved DB11164
small molecule | CAS: 121251-02-3

Bicisate, also known as ethyl cysteinate dimer (ECD), is a N,N'-1,2-ethylene-di-yl-bis-L-cysteinate diethyl ester. It is used in conjunction with technetium Tc99m as a tracer to measure cerebral blood flow with single-photon emission computed tomography (SPEC…

Kategori:
Diagnostic AgentsDrugs that are Mainly Renally ExcretedRadioactive Diagnostic Agent
Waktu ParuhThe stability of bi…
Vol. DistribusiAfter intravenous a…
KlirensThe clearance of bi…
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Bictegravir Approved DB11799
small molecule | CAS: 1611493-60-7

Bictegravir is a recently approved investigational drug that has been used in trials studying the treatment of HIV-1 and HIV-2 infection. It has been approved for HIV-1 monotherapy combined with 2 other antiretrovirals in a single tablet.[L43677]

Kategori:
Antiinfectives for Systemic UseAntiviral AgentsAntivirals for Systemic Use +11
Target Protein:
Reverse transcriptase/RNaseHIntegrase
Waktu ParuhHalf-life is 17.3 h…
Vol. Distribusi0.2 L/Kg in humans …
KlirensBictegravir is main…
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Bicuculline DB11562
small molecule | CAS: 485-49-4

Bicuculline is a light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungosa, Fumariaceae, and several Corydalis species.

Kategori:
AlkaloidsBenzylisoquinolinesCentral Nervous System Agents +8
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Bicyclol DB16014
small molecule | CAS: 118159-48-1

Bicyclol is under investigation in clinical trial NCT02944552 (The Multi Center, Randomized, Double-blind, Positive Controlled Study of Bicyclol in the Treatment of Acute DILI).

Kategori:
Benzene Derivatives
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Bietaserpine DB13575
small molecule | CAS: 53-18-9

Deskripsi belum tersedia.

Kategori:
AlkaloidsAntiadrenergic Agents, Centrally ActingAntihypertensive Agents +7
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Bifemelane DB13550
small molecule | CAS: 90293-01-9

Deskripsi belum tersedia.

Kategori:
Antidepressive AgentsBenzene DerivativesCentral Nervous System Agents +5
Target Protein:
Amine oxidase [flavin-containing] A
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Bifenthrin DB15056
small molecule | CAS: 82657-04-3

Bifenthrin is under investigation in clinical trial NCT01560247 (Percutaneous Recanalization in Ischemic Stroke Management in Europe Observational Registry).

Kategori:
Cyclopentane MonoterpenesMonoterpenesSarcoma, Experimental, chemically induced +1
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Bifeprunox DB04888
small molecule | CAS: 350992-10-8

Bifeprunox is a novel atypical antipsychotic agent which, along with SLV313, [aripiprazole] and SSR-181507 combines minimal D2 receptor agonism with 5-HT receptor agonism.

Kategori:
Antipsychotic AgentsAntipsychotic Agents (Second Generation [Atypical])Central Nervous System Depressants +2
Target Protein:
5-hydroxytryptamine receptor 1AD(2) dopamine receptor
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biotech

Deskripsi belum tersedia.

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Bifikafusp alfa DB19185
biotech | CAS: 1957239-90-5

Bifikafusp alfa is under investigation in clinical trial NCT05329792 (L19IL2/L19TNF in Skin Cancer Patients).

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Bifonazole Approved DB04794
small molecule | CAS: 60628-96-8

Bifonazole is an azole antifungal drug.

Kategori:
Anti-Infective AgentsAntifungal AgentsAntifungals for Dermatological Use +10
Target Protein:
Lanosterol 14-alpha demethylaseCytochrome P450 2B6
Waktu Paruh1-2 hours
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biotech

Bifunctional epoxide hydrolase 2 is under investigation in clinical trial NCT00654966 (Evaluation of the Effects of Urotensin-II and Soluble Epoxide Hydrolase Inhibitors on Skin Microvessel Tone in Patients With Heart Failure, and in Healthy Volunteers).

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Biguanide Approved DB13100
small molecule | CAS: 56-03-1

Biguanide has been investigated for the treatment of Diabetes Mellitus.

Kategori:
AmidinesBlood Glucose Lowering AgentsGuanidines
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BIIB015 DB06304
biotech

BIIB015 is a humanized, IgG1 [immunoglobulin G 1], DM4-Conjugated, anti-cripto, monoclonal antibody. It has been investigated for the treatment of subjects with relapsed or refractory solid tumours.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +6
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BIIB021 DB12359
small molecule | CAS: 848695-25-0

BIIB021 has been investigated for the treatment of Tumors and Lymphoma.

Kategori:
Heterocyclic Compounds, Fused-RingHSP90 Heat-Shock Proteins, antagonists & inhibitorsPurines
Target Protein:
Heat shock protein HSP 90-alpha
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Bilastine Approved DB11591
small molecule | CAS: 202189-78-4

Bilastine is a novel new-generation antihistamine that is highly selective for the H1 histamine receptor, has a rapid onset and prolonged duration of action.

Kategori:
Antihistamines for Systemic UseDecongestants and AntiallergicsHeterocyclic Compounds, Fused-Ring +8
Target Protein:
Histamine H1 receptor
Waktu ParuhThe mean half life …
Vol. Distribusi-
KlirensBilastine has a tot…
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small molecule | CAS: 114-25-0

Deskripsi belum tersedia.

Target Protein:
Heme oxygenase 1MyoglobinFlavin reductase (NADPH)
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Bimagrumab DB12584
biotech | CAS: 1356922-05-8

Bimagrumab has been used in trials studying the treatment and supportive care of Sarcopenia, Skeletal Muscle, Mechanical Ventilation, Sporadic Inclusion Body Myositis, and Sporadic Inclusion Body Myositis (sIBM), among others.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
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Bimatoprost Approved DB00905
small molecule | CAS: 155206-00-1

Bimatoprost, also known as Latisse or Lumigan, belongs to a group of drugs called prostamides, which are synthetic structural analogs of prostaglandin. Bimatoprost, marketed by Allergan, is administered in both the ophthalmic solution and implant form. It has…

Kategori:
AmidesAntiglaucoma Preparations and MioticsAntihypertensive Agents +19
Target Protein:
Prostaglandin F2-alpha receptorProstaglandin E2 receptor EP1 subtypeProstaglandin E2 receptor EP3 subtype
Waktu ParuhThe elimination hal…
Vol. DistribusiThe volume of distr…
KlirensThe clearance was m…
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Bimekizumab Approved DB12917
biotech | CAS: 1418205-77-2

Bimekizumab is a humanized monoclonal antibody directed towards IL-17, which was approved for use in the EU on August 20, 2021, for the treatment of plaque psoriasis.[L39665,L39680] It is the first IL-17 inhibitor to target both IL-17A and IL-17F.[A244455] It…

Kategori:
Agents reducing cytokine levelsAmino Acids, Peptides, and ProteinsAntibodies +11
Target Protein:
Interleukin-17AInterleukin-17F
Waktu ParuhThe mean terminal e…
Vol. DistribusiIn patients with pl…
KlirensThe median apparent…
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Bimiralisib DB14846
small molecule | CAS: 1225037-39-7

Bimiralisib is under investigation in clinical trial NCT02723877 (PQR309 and Eribulin in Metastatic HER2 Negative and Triple-negative Breast Cancer (PIQHASSO)).

Target Protein:
Serine/threonine-protein kinase mTORPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
Waktu Paruh-
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Bimoclomol DB06258
small molecule | CAS: 130493-03-7

Bimoclomol is an investigational drug that induces stress proteins and has cytoprotective effects.

Target Protein:
Heat shock 70 kDa protein 1BHeat shock 70 kDa protein 1AHeat shock factor protein 1
Waktu Paruh-
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Bimosiamose DB06197
small molecule | CAS: 187269-40-5

Deskripsi belum tersedia.

Kategori:
AlkanesBenzene DerivativesCarbohydrates +3
Target Protein:
E-selectin
Waktu Paruh-
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Bindarit DB12739
small molecule | CAS: 130641-38-2

Bindarit has been used in trials studying the prevention and treatment of Coronary Restenosis and Diabetic Nephropathy.

Kategori:
Acids, AcyclicAnti-Inflammatory AgentsEnzyme Inhibitors +6
Target Protein:
C-C motif chemokine 2
Waktu Paruh-
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Binetrakin DB12182
biotech | CAS: 207137-56-2

Binetrakin has been used in trials studying the treatment of HIV Infections, Sarcoma, Kaposi, Non-Hodgkin's Lymphoma (NHL), Myelodysplastic Syndrome (MDS), and Leukemia, Acute Myelogenous (AML), among others.

Kategori:
Adjuvants, ImmunologicAmino Acids, Peptides, and ProteinsAntineoplastic Agents +9
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Binimetinib Approved DB11967
small molecule | CAS: 606143-89-9

Binimetinib, also known as _Mektovi_, is a potent and selective oral mitogen-activated protein kinase 1/2 (MEK 1/2) inhibitor which is combined with [Encorafenib].[A34275,L3335] On June 27, 2018, the Food and Drug Administration approved the combination of…

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsBCRP/ABCG2 Substrates +16
Target Protein:
Dual specificity mitogen-activated protein kinase kinase 2Dual specificity mitogen-activated protein kinase kinase 1
Waktu ParuhThe mean (CV%) term…
Vol. DistribusiThe geometric mean …
KlirensThe apparent cleara…
Genetik -
Binodenoson DB04853
small molecule | CAS: 144348-08-3

Binodenoson is a pharmacologic stress agent specific to the only adenosine receptor necessary for increased cardiac blood flow, the A<sub>2A</sub> receptor. This specificity allows Binodenoson to deliver - in a single injection - a more effective dose of medi…

Kategori:
Heterocyclic Compounds, Fused-RingNeurotransmitter AgentsNucleic Acids, Nucleotides, and Nucleosides +7
Target Protein:
Adenosine receptor A2a
Waktu Paruh10 &plusmn; 4 minut…
Vol. Distribusi-
Klirens-
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Bintrafusp alfa DB15387
biotech | CAS: 1918149-01-5

Bintrafusp alfa is under investigation in clinical trial NCT03833661 (M7824 Monotherapy in Locally Advanced or Metastatic Second Line (2L) Biliary Tract Cancer (Cholangiocarcinoma and Gallbladder Cancer)).

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