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14494

Total database: 17430
Struktur (SMILES)
9687 (66.8%)
Target
7525 (51.9%)
Genomik
112 (0.8%)
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14494 (100.0%)

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Hasil Pencarian (14494)

Halaman 85 / 290
Chlortetracycline Approved DB09093
small molecule | CAS: 57-62-5

Chlortetracycline is a _tetracycline_ antibiotic, and historically the first member of this class to be identified. It was discovered in 1945 by the scientist, Benjamin Minge Duggar, working at Lederle Laboratories under the supervision of Yellapragada Subbar…

Kategori:
Agents that produce neuromuscular block (indirect)Alimentary Tract and MetabolismAnti-Bacterial Agents +15
Target Protein:
16S ribosomal RNA30S ribosomal protein S330S ribosomal protein S8 +8
Waktu ParuhThe half-life of Ch…
Vol. DistribusiChlortetracycline h…
Klirens-
Genetik -
Chlorthalidone Approved DB00310
small molecule | CAS: 77-36-1

Chlorthalidone is a thiazide-like diuretic used for the treatment of hypertension and for management of edema caused by conditions such as heart failure or renal impairment. Chlorthalidone improves blood pressure and swelling by preventing water absorption fr…

Kategori:
AmidesAntihypertensive AgentsAntihypertensive Agents Indicated for Hypertension +25
Target Protein:
Carbonic anhydrase 1Solute carrier family 12 member 1
Waktu Paruh40-50 hours[FDA Lab…
Vol. DistribusiChlorthalidone has …
Klirens-
Genetik -
Chlorzoxazone Approved DB00356
small molecule | CAS: 95-25-0

A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p…

Kategori:
Benzoxazoles and derivativesCentral Nervous System AgentsCentral Nervous System Depressants +21
Target Protein:
Calcium-activated potassium channel subunit alpha-1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

This vaccine candidate, developed in China, uses SARS-CoV-2 protein subunits that are entirely engineered, created, and secreted by Chinese Hamster Ovary (CHO) cells[A219758]. The vaccine candidate is sponsored by Anhui Zhifei Longcom Biologic Pharmacy Co., L…

Waktu Paruh-
Vol. Distribusi-
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Genetik -
Cholecalciferol Approved DB00169
small molecule | CAS: 67-97-0

Vitamin D, in general, is a secosteroid generated in the skin when 7-dehydrocholesterol located there interacts with ultraviolet irradiation - like that commonly found in sunlight [L5689]. Both the endogenous form of vitamin D (that results from 7-dehydrochol…

Kategori:
Alimentary Tract and MetabolismBone Density Conservation AgentsCalcium-Regulating Hormones and Agents +28
Target Protein:
Vitamin D3 receptor
Waktu ParuhAt this time, there…
Vol. DistribusiStudies have determ…
KlirensStudies have determ…
Genetik -
Cholecystokinin Approved DB08862
small molecule | CAS: 9011-97-6

Cholecystokinin ( also known as _CCK or CCK-PZ_) is a peptide hormone of the gastrointestinal system which is responsible for stimulating the digestion of fat and protein. Cholecystokinin, previously called _pancreozymin_, is synthesized and secreted by enter…

Kategori:
Amino Acids, Peptides, and ProteinsCholagogues and CholereticsCholecystokinin, agonists +12
Target Protein:
Cholecystokinin receptor type ARAF proto-oncogene serine/threonine-protein kinaseMitogen-activated protein kinase 3 +3
Waktu Paruh2.5 min [L1642]
Vol. Distribusi-
Klirens-
Genetik -
Cholesterol Approved DB04540
small molecule | CAS: 57-88-5

The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.

Kategori:
BCRP/ABCG2 InducersCholestanesCholestenes +6
Target Protein:
Choline-phosphate cytidylyltransferase BNuclear receptor subfamily 1 group I member 3Vitamin D3 receptor +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 1256-86-6

Component of human seminal plasma & spermatozoa.

Kategori:
Anticarcinogenic AgentsCholestanesCholestenes +10
Target Protein:
Nuclear receptor ROR-alpha
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 910-31-6

Cholesteryl chloride, also known as 3-chlorocholest-5-ene, is an organochloride derivative of cholesterol. It is presented as a liquid crystal that forms clockwise liquid crystals.

Kategori:
CholestanesFused-Ring CompoundsSteroids
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 604-33-1

Deskripsi belum tersedia.

Kategori:
CholestanesCholestenesFused-Ring Compounds +4
Target Protein:
Lipase 3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cholestyramine Approved DB01432
small molecule | CAS: 11041-12-6

Cholestyramine or colestyramine is a bile acid sequestrant. Bile acid sequestrants are polymeric compounds which serve as ion exchange resins. Cholestyramine resin is quite hydrophilic, but insoluble in water.

Kategori:
Anion Exchange ResinsAnticholesteremic AgentsBile Acid Sequestrants +14
Target Protein:
Bile acids
Waktu Paruh6 minutes
Vol. Distribusi-
Klirens-
Genetik -
Cholic Acid Approved DB02659
small molecule | CAS: 81-25-4

A major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. [PubChem] Cholic acid, formulated as Cholbam capsules, is approved by the United States Food and Drug Adm…

Kategori:
Alimentary Tract and MetabolismBile Acid PreparationsBile acids and derivatives +17
Target Protein:
Phospholipase A2Ferrochelatase, mitochondrialLiver carboxylesterase 1 +19
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Choline Approved DB00122
small molecule | CAS: 62-49-7

A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.

Kategori:
AlcoholsAminesAmino Alcohols +23
Target Protein:
Neuronal acetylcholine receptor subunit alpha-2Neuronal acetylcholine receptor subunit alpha-7Choline-phosphate cytidylyltransferase B +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 28319-77-9

A component of phosphatidylcholines (lecithins), in which the two hydroxy groups of glycerol are esterified with fatty acids. (From Stedman, 26th ed) It counteracts the effects of urea on enzymes and other macromolecules. [PubChem]

Kategori:
AlcoholsBiological ProductsCarbohydrates +14
Target Protein:
Muscarinic acetylcholine receptor M5Ganglioside GM2 activator
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Choline C 11 Approved DB09277
small molecule | CAS: 87591-54-6

Choline C 11 is a marker for cellular proliferation as its main molecule is a precursor for the biosynthesis of phospholipids which are essential components of all cell membranes.[A32041] It was developed by MCPRF and FDA first approved in September 2012.

Kategori:
Drugs that are Mainly Renally Excreted
Waktu ParuhThe isotope half-li…
Vol. Distribusi-
KlirensAfter intravenous i…
Genetik -
Choline C-11 Approved DB09563
small molecule | CAS: 94793-58-5

Choline C 11 Injection is a radioactive diagnostic agent for positron emission tomography (PET) imaging of pat ients with suspected prostate cancer recurrence and non-informative bone scintigraphy, computerized tomography (CT) or magnetic resonance imaging.

Kategori:
Radioactive Diagnostic AgentRadiopharmaceutical Activity
Waktu Paruh-
Vol. Distribusi11C-choline distrib…
KlirensThe rate of 11C- ch…
Genetik -
small molecule | CAS: 64425-90-7

Choline magnesium trisalicylate is a non-acetylated salicylate used widely as a nonsteroidal anti-inflammatory drug. Trisalicylate significantly reduces methotrexate renal clearance, displacing methotrexate from protein, increasing the fraction unbound by 28%…

Kategori:
Acids, CarbocyclicAgents causing hyperkalemiaAgents that produce hypertension +23
Target Protein:
Prostaglandin G/H synthase 1Prostaglandin G/H synthase 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Choline salicylate Approved DB14006
small molecule | CAS: 2016-36-6

Choline salicylate is an anti-inflammatory pain reliever agent that is related to aspirin. It is used to decrease swelling and to treat mild-moderate pain. It is used to treat arthritis in both children and adults. This medicine can also be used for fever [L2…

Kategori:
Acids, CarbocyclicAlcoholsAmines +20
Target Protein:
Choline-phosphate cytidylyltransferase BAcetylcholinesteraseCholine-phosphate cytidylyltransferase A +4
Waktu ParuhThe plasma half-lif…
Vol. Distribusi0.15 L/kg (salicyla…
Klirens-
Genetik -
Chondroitin sulfate Approved DB09301
small molecule | CAS: 24967-93-9

Chondroitin sulfate is a glycosaminoglycan considered as a symptomatic slow-acting drug for osteoarthritis (SYSADOA).[A7906] The SYSADOA status suggested a pain relief and increased joint mobility after a relative long regular administration, as well as a lon…

Kategori:
Antiinflammatory and Antirheumatic ProductsAntiinflammatory and Antirheumatic Products, Non-SteroidsCarbohydrates +5
Target Protein:
Neurotrophic factor BDNF precursor formGlial cell line-derived neurotrophic factorVascular endothelial growth factor A, long form +1
Waktu ParuhThe approximate hal…
Vol. DistribusiAfter intramuscular…
Klirens-
Genetik -
biotech

Chondrus crispus is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Choriogonadotropin alfa Approved DB00097
biotech | CAS: 177073-44-8

Recombinant human chorionic gonadotropin with 2 subunits, alpha = 92 residues, beta = 145 residues, each with N-and O-linked carbohydrate moieties linked to ASN-52 and ASN-78 (on alpha subunit) and ASN-13, ASN-30, SER-121, SER-127, SER-132 and SER-138 (on bet…

Kategori:
Genito Urinary System and Sex HormonesGonadotropinsGonadotropins and Antigonadotropins +1
Target Protein:
Follicle-stimulating hormone receptorLutropin-choriogonadotropic hormone receptor
Waktu ParuhThe mean terminal h…
Vol. Distribusi* 5.9 ± 1.0 L
Klirens* 0.29 +/- 0.04 L/h…
Genetik -
biotech | CAS: 9002-61-3

Human chorionic gonadotropin (HCG), a polypeptide hormone produced by the human placenta. Endogenously produced HCG interacts with the LHCG receptor of the ovary and promotes the maintenance of the corpus luteum during the beginning of pregnancy. This allows …

Kategori:
Amino Acids, Peptides, and ProteinsBiological ProductsChorionic Gonadotropin +18
Target Protein:
Lutropin-choriogonadotropic hormone receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Chromanol DB13111
small molecule | CAS: 950-99-2

Chromanol has been used in trials studying the treatment of Prostate Cancer.

Kategori:
AntioxidantsBenzopyransBiological Factors +4
Target Protein:
Androgen receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Kategori:
Radioactive Diagnostic AgentRadiopharmaceutical Activity
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Chromic cation DB14525
small molecule | CAS: 16065-83-1

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
Chromic chloride Approved DB09129
small molecule | CAS: 10025-73-7

Chromic chloride, for injection, is a sterile, nonpyrogenic solution intended for use as an additive to solutions for Total Parenteral Nutrition (TPN).

Kategori:
AnionsAntioxidantsBiological Factors +8
Target Protein:
Insulin receptor
Waktu Paruh31- 41 hours
Vol. DistribusiChromium is stored …
Klirens-
Genetik -
Chromic citrate DB14526
small molecule | CAS: 57072-40-9

Deskripsi belum tersedia.

Kategori:
Drugs that are Mainly Renally Excreted
Target Protein:
Cytochrome b5
Waktu ParuhThe elimination hal…
Vol. DistribusiAbsorbed chromium i…
KlirensExcretion of chromi…
Genetik -
Chromic nitrate Approved DB14527
small molecule | CAS: 13548-38-4

Deskripsi belum tersedia.

Kategori:
AnionsDrugs that are Mainly Renally ExcretedElectrolytes +2
Target Protein:
Cytochrome b5
Waktu ParuhThe elimination hal…
Vol. DistribusiAbsorbed chromium i…
KlirensExcretion of chromi…
Genetik -
Chromium Approved DB11136
small molecule | CAS: 7440-47-3

Chromium is a transition element with the chemical symbol Cr and atomic number 24 that belongs to Group 6 of the periodic table. It is used in various chemical, industrial and manufacturing applications such as wood preservation and metallurgy. The uses of ch…

Kategori:
Cell-mediated ImmunityDiet, Food, and NutritionDrugs that are Mainly Renally Excreted +11
Target Protein:
Cytochrome b5
Waktu ParuhThe elimination hal…
Vol. DistribusiAbsorbed chromium i…
KlirensExcretion of chromi…
Genetik -
Chromium Cr-51 Approved DB11140
small molecule | CAS: 14392-02-0

Chromium Cr-51 is an isotope of chromium that has been used as a radioactive label for decades. It is used as a diagnostic radiopharmaceutical agent in nephrology to determine glomerular filtration rate,[A249765,A249770] and in hematology to determine red blo…

Kategori:
Chromium IsotopesElementsIsotopes +4
Waktu ParuhChromium Cr-51 has …
Vol. Distribusi-
Klirens-
Genetik -
Chromium gluconate Approved DB14528
small molecule | CAS: 33661-40-4

Deskripsi belum tersedia.

Kategori:
Drugs that are Mainly Renally Excreted
Target Protein:
Cytochrome b5
Waktu ParuhThe elimination hal…
Vol. DistribusiAbsorbed chromium i…
KlirensExcretion of chromi…
Genetik -
small molecule | CAS: 18984-90-2

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, CyclicAmino Acids, Essential +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Chromium nicotinate Approved DB14529
small molecule | CAS: 64452-96-6

Deskripsi belum tersedia.

Kategori:
Drugs that are Mainly Renally ExcretedNicotinic Acids
Target Protein:
Cytochrome b5
Waktu ParuhThe elimination hal…
Vol. DistribusiAbsorbed chromium i…
KlirensExcretion of chromi…
Genetik -
Chromium picolinate Approved DB11255
small molecule | CAS: 14639-25-9

Chromium picolinate has a chemical formula CrPic3 and reddish-pink color. It is a coordination complex consisting of chromium(III) and picolinic acid. Chromium picolinate is used as a nutritional supplement for optimal insulin function in patients with Type 2…

Kategori:
Compounds used in a research, industrial, or household settingIron Chelating AgentsPyridines +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

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Vol. Distribusi-
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Genetik -
small molecule

Deskripsi belum tersedia.

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Vol. Distribusi-
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Genetik -
small molecule

Deskripsi belum tersedia.

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Genetik -
small molecule

Deskripsi belum tersedia.

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Genetik -
small molecule

Deskripsi belum tersedia.

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Genetik -
small molecule

Deskripsi belum tersedia.

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Chromous sulfate Approved DB14530
small molecule | CAS: 13825-86-0

Deskripsi belum tersedia.

Kategori:
Drugs that are Mainly Renally Excreted
Target Protein:
Cytochrome b5
Waktu ParuhThe elimination hal…
Vol. DistribusiAbsorbed chromium i…
KlirensExcretion of chromi…
Genetik -
Chrysin DB15581
small molecule | CAS: 480-40-0

Deskripsi belum tersedia.

Kategori:
BenzopyransChromonesHeterocyclic Compounds, Fused-Ring +1
Target Protein:
Aldo-keto reductase family 1 member B1Cytochrome P450 1B1Aromatase +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Chrysoeriol DB17283
small molecule | CAS: 491-71-4

Deskripsi belum tersedia.

Kategori:
BenzopyransChromonesFlavonoids +2
Target Protein:
Xanthine dehydrogenase/oxidaseCytochrome P450 1B1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Chrysonilia sitophila Approved DB10935
biotech

Chrysonilia sitophila is a fungus which can provoke allergic reactions. Chrysonilia sitophila extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CHS-828 DB12980
small molecule | CAS: 200484-11-3

CHS-828 has been used in trials studying the treatment of Unspecified Adult Solid Tumor, Protocol Specific.

Kategori:
AmidinesAnionsElectrolytes +2
Target Protein:
Nicotinamide phosphoribosyltransferase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

The ChulaCov19 vaccine is mRNA-based and was developed in Thailand’s Chulalongkorn University in collaboration with the University of Pennsylvania in the US[L30673, L30678]. Pre-clinical studies in mice and monkeys showed evidence that the vaccine facilitates…

Waktu Paruh-
Vol. Distribusi-
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Genetik -
Chymopapain Approved DB06752
biotech | CAS: 9001-09-6

Chymopapain was first isolated in 1941 from the crude latex derived from the fruit of Carica papaya by squeezing the green papaya while on the plant prior to harvest.[L2482]It is an extracellular plant cysteine proteinase similar to papain in specificity.[A32…

Kategori:
Cysteine EndopeptidasesCysteine ProteasesEndopeptidases +5
Target Protein:
Bone marrow proteoglycan
Waktu ParuhFollowing intra-dis…
Vol. Distribusi-
Klirens-
Genetik -
Chymostatin DB01683
small molecule | CAS: 9076-44-2

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsChymotrypsin, antagonists & inhibitorsEnzyme Inhibitors +3
Target Protein:
ChymasePeptide amidase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Chymotrypsin Approved DB09375
small molecule | CAS: 9004-07-3

Chymotrypsin (EC 3.4.21.1) is a digestive enzyme that promotes proteolysis, or the breakdown of proteins and polypeptides. It is a serine protease synthesized in the pancreas and is a vital component in the pancreatic juice. Like most proteolytic enzymes, chy…

Kategori:
Blood and Blood Forming OrgansEndopeptidasesEnzymes +8
Waktu ParuhNo pharmacokinetic …
Vol. DistribusiNo pharmacokinetic …
KlirensNo pharmacokinetic …
Genetik -
CI-1040 DB12429
small molecule | CAS: 212631-79-3

CI-1040 has been used in trials studying the treatment of Lung Cancer, Breast Cancer, Breast Neoplasms, Pancreatic Cancer, and Colorectal Cancer, among others.

Kategori:
Acids, CarbocyclicAmidesBenzene Derivatives +2
Target Protein:
Mitogen-activated protein kinase kinase kinase 1Mitogen-activated protein kinase kinase kinase 2Serine/threonine-protein kinase Sgk1 +12
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 4201–4250 dari 14494
Sebelumnya Halaman 85 / 290 Berikutnya