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6694

Total database: 17430
Struktur (SMILES)
4518 (67.5%)
Target
3751 (56.0%)
Genomik
81 (1.2%)
Referensi
6694 (100.0%)

Tipe Molekul

Distribusi Wujud Zat

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Hasil Pencarian (6694)

Halaman 84 / 134
small molecule | CAS: 147-73-9

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 208465-21-8

Mesosulfuron-methyl is under investigation in clinical trial NCT01118117 (A Multi-center Clinical Trial of the Misago™ Self-Expanding Stent System for Superficial Femoral Artery).

Kategori:
AmidesSulfonesSulfur Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Mesoxalic acid DB03589
small molecule | CAS: 473-90-5

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicDicarboxylic Acids
Target Protein:
NAD-dependent malic enzyme, mitochondrial
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Metacycline Approved DB00931
small molecule | CAS: 914-00-1

A broad-spectrum semisynthetic antibiotic related to tetracycline but excreted more slowly and maintaining effective blood levels for a more extended period.

Kategori:
Agents that produce neuromuscular block (indirect)Anti-Bacterial AgentsAnti-Infective Agents +4
Target Protein:
16S ribosomal RNA
Waktu Paruh14 hours
Vol. Distribusi-
Klirens-
Genetik -
Metadoxine DB16554
small molecule | CAS: 74536-44-0

Deskripsi belum tersedia.

Kategori:
Alcohol DeterrentsAlimentary Tract and MetabolismAmino Acids +16
Target Protein:
Sodium- and chloride-dependent GABA transporter 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Metamizole Approved DB04817
small molecule | CAS: 50567-35-6

Metamizole (dipyrone) is a pyrazolone derivative that belongs to the group of nonacid nonopioids. It is considered a potent analgesic and antipyretic with favourable gastrointestinal tolerability.[A251885] Metamizole was formerly marketed in the US as Dimetho…

Kategori:
Agents causing hyperkalemiaAgents that produce hypertensionAminopyrine +16
Target Protein:
Prostaglandin G/H synthase 1
Waktu Paruh_In vitro_, the hal…
Vol. DistribusiMetamizole is quick…
KlirensThe clearance of 4-…
Genetik -
Metampicillin DB13836
small molecule | CAS: 6489-97-0

Metampicillin is a penicillin antibiotic prepared by the reaction of ampicillin with formaldehyde. It is hydrolysed in aqueous solution to form ampicillin. Hydrolysis is rapid under acid conditions like the stomach.

Kategori:
AmidesAnti-Bacterial AgentsAnti-Infective Agents +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Metandienone DB13586
small molecule | CAS: 72-63-9

Metandienone is an orally active anabolic androgenic steroid. It was introduced to the market in the 1960s but later discontinued and withdrawn from the market. Although it is prohibited in and outside competition by the World Anti-Doping Agency, metandienone…

Kategori:
Alimentary Tract and MetabolismAnabolic AgentsAnabolic Agents for Systemic Use +11
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Metaxalone Approved DB00660
small molecule | CAS: 1665-48-1

Metaxalone is a moderate to strong muscle relaxant used in the symptomatic treatment of musculoskeletal pain caused by strains, sprains, and other musculoskeletal conditions. It is marketed by King Pharmaceuticals under the brand name Skelaxin®. Its main mech…

Kategori:
Central Nervous System DepressantsCentrally-mediated Muscle RelaxationDrugs that are Mainly Renally Excreted +5
Waktu Paruh9.2 (+/- 4.8) hours
Vol. Distribusi* 800 L
Klirens* 68 +/- 50 L/h [Su…
Genetik -
Methacholine Approved DB06709
small molecule | CAS: 55-92-5

Asthma is a complex condition associated with phenomena such as airway hyperresponsiveness (AHR), in which the smooth muscle in the airways (ASM) excessively contracts in response to stimuli, reducing pulmonary function and causing symptoms such as difficulty…

Kategori:
AminesAmmonium CompoundsAutonomic Agents +17
Target Protein:
Muscarinic acetylcholine receptor M3Muscarinic acetylcholine receptor M2Muscarinic acetylcholine receptor M1 +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Methadone Approved DB00333
small molecule | CAS: 76-99-3

Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins …

Kategori:
AnalgesicsAnticholinergic AgentsAntidepressive Agents +50
Target Protein:
Mu-type opioid receptorNMDA receptorDelta-type opioid receptor +5
Waktu ParuhDue to interindivid…
Vol. DistribusiDue to interindivid…
KlirensDue to interindivid…
Genetik -
Methapyrilene DB04819
small molecule | CAS: 91-80-5

Methapyrilene, formerly marketed in many drug products, was shown to be a potent carcinogen. Manufacturers voluntarily withdrew methapyriline drug products from the market in May and June 1979.

Kategori:
AminesAminopyridinesAnti-Allergic Agents +13
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Methaqualone DB04833
small molecule | CAS: 72-44-6

Methaqualone is a sedative-hypnotic drug that is similar in effect to barbiturates, a general central nervous system depressant. The sedative-hypnotic activity was first noted by Indian researchers in the 1950s and in 1962 methaqualone itself was patented in …

Kategori:
Central Nervous System AgentsCentral Nervous System DepressantsCytochrome P-450 CYP3A Substrates +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Methcathinone DB15339
small molecule | CAS: 5650-44-2

Methcathinone is under investigation in clinical trial NCT02617862 (PCI Imaging System in Pediatric Ophthalmology).

Kategori:
Ketones
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Methenamine Approved DB06799
small molecule | CAS: 100-97-0

Methenamine is a heterocyclic organic compound with a cage-like structure similar to adamantane. In salt form it is used for the treatment of urinary tract infection (Example: methenamine hippurate which is the hippuric acid salt of methenamine).

Kategori:
Acids, CarbocyclicAmidesAmines +14
Waktu ParuhElimination half-li…
Vol. Distribusi-
Klirens70-90% of a single…
Genetik -
Methfuroxam DB16231
small molecule | CAS: 28730-17-8

Methfuroxam is under investigation in clinical trial NCT01213407 (Dendritic Cell Cancer Vaccine for High-grade Glioma).

Kategori:
AmidesAminesAniline Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Beta-lactam-inducible penicillin-binding protein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Methimazole Approved DB00763
small molecule | CAS: 60-56-0

Methimazole is a thionamide antithyroid agent that inhibits the synthesis of thyroid hormones.[A184559,A184733,A184694] It was first introduced as an antithyroid agent in 1949[A184502] and is now commonly used in the management of hyperthyroidism, particularl…

Kategori:
Antithyroid agentsCytochrome P-450 CYP1A2 InhibitorsCytochrome P-450 CYP1A2 Inhibitors (strength unknown) +30
Target Protein:
Thyroid peroxidase
Waktu ParuhFollowing a single …
Vol. DistribusiThe apparent volume…
KlirensFollowing a single …
Genetik -
Methionine Approved DB00134
small molecule | CAS: 63-68-3

A sulfur containing essential amino acid that is important in many body functions. It is a chelating agent for heavy metals.

Kategori:
Amino AcidsAmino Acids, EssentialAmino Acids, Neutral +7
Target Protein:
Methionine synthase reductaseMethionine synthaseMethionine aminopeptidase 2 +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Methionine C-11 DB17147
small molecule | CAS: 60305-58-0

Deskripsi belum tersedia.

Kategori:
Diagnostic RadiopharmaceuticalsTumour Detection
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 15985-39-4

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, Peptides, and ProteinsAmino Acids, Sulfur +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 21752-32-9

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Methocarbamol Approved DB00423
small molecule | CAS: 532-03-6

Methocarbamol was developed in the early 1950s as a treatment for muscle spasticity and the associated pain.[A178441,A178450] It is a guaiacol glyceryl ether.[A178450] Methocarbamol tablets and intramuscular injections are prescription medicines indicated …

Kategori:
Acids, AcyclicBenzene DerivativesCarbamates +14
Target Protein:
Carbonic anhydrase 1
Waktu ParuhThe elimination hal…
Vol. DistribusiVolume of distribut…
Klirens0.2-0.8L/h/kg.[L626…
Genetik -
Methohexital Approved DB00474
small molecule | CAS: 151-83-7

An intravenous anesthetic with a short duration of action that may be used for induction of anesthesia.

Kategori:
AnestheticsAnesthetics, GeneralAnesthetics, Intravenous +10
Target Protein:
Gamma-aminobutyric acid receptor subunit alpha-1
Waktu Paruh5.6 ± 2.7 mi…
Vol. Distribusi-
Klirens-
Genetik -
Methopterin DB16620
small molecule | CAS: 2410-93-7

Methopterin is thought to have effects on osteoclasts and to inhibit inflammatory bone destruction.[A229843]

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Methotrexate Approved DB00563
small molecule | CAS: 59-05-2

Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis.[A180322] This inhibition leads to suppression of inflammation as well as prevention of cell division.[A180322] Because of these effects, methotrexate is of…

Kategori:
Abortifacient AgentsAbortifacient Agents, NonsteroidalAgents Causing Muscle Toxicity +42
Target Protein:
Thymidylate synthaseReduced folate transporterProton-coupled folate transporter +2
Gen Terkait:
ABCC2 MTHFR
Waktu ParuhThe half life of lo…
Vol. DistribusiThe volume of distr…
KlirensMethotrexate cleara…
Genetik 2 Varian
Methoxsalen Approved DB00553
small molecule | CAS: 298-81-7

A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation.

Kategori:
AntipsoriaticsAntipsoriatics for Systemic UseAntipsoriatics for Topical Use +24
Target Protein:
DNACytochrome P450 2A6
Waktu ParuhApproximately 2 hou…
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 180509-15-3

Methoxy arachidonyl fluorophosphonate, commonly referred as MAFP, is an irreversible active site-directed enzyme inhibitor that inhibits nearly all serine hydrolases and serine proteases. It inhibits phospholipase A2 and fatty acid amide hydrolase with specia…

Kategori:
EicosanoidsEnzyme InhibitorsFatty Acids +5
Target Protein:
Fatty-acid amide hydrolase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 677324-53-7

Methoxy polyethylene glycol-epoetin beta is a chemically synthesised Erythropoiesis Stimulating Agent (ESA) with a longer half-life than erythropoietin. ESA is used to increase synthesis of red blood cells to treat chronic kidney disease associated anemia.

Kategori:
AlcoholsAmino Acids, Peptides, and ProteinsAntianemic Preparations +20
Target Protein:
Erythropoietin receptor
Waktu ParuhIn CKD patients on …
Vol. Distribusi~94.74 ml/kg
KlirensIn CKD patients on …
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Pancreatic triacylglycerol lipaseColipase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Methscopolamine bromide Approved DB00462
small molecule | CAS: 155-41-9

A muscarinic antagonist used to study binding characteristics of muscarinic cholinergic receptors.

Kategori:
Agents producing tachycardiaAlkaloidsAnticholinergic Agents +8
Target Protein:
Muscarinic acetylcholine receptor M2Muscarinic acetylcholine receptor M1Muscarinic acetylcholine receptor M3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Methsuximide Approved DB05246
small molecule | CAS: 77-41-8

Mesuximide (or methsuximide) is an anticonvulsant medication. It is sold by Pfizer under the name Petinutin.

Kategori:
Agents causing hyperkalemiaAnti-epileptic AgentAntiarrhythmic agents +18
Target Protein:
Voltage-dependent T-type calcium channel subunit alpha-1G
Waktu Paruh1.4-2.6 hours for m…
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 63177-57-1

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicAntineoplastic AgentsCompounds used in a research, industrial, or household setting +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Methyl aminolevulinate Approved DB00992
small molecule | CAS: 33320-16-0

Methyl aminolevulinate is a prodrug that is metabolised to Protoporphyrin IX (a photosensitizer) used in photodynamic therapy.

Kategori:
Amino AcidsAmino Acids, Peptides, and ProteinsAntineoplastic Agents +11
Target Protein:
Ferrochelatase, mitochondrial
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 2044523-17-1

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Methionine aminopeptidase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Methionine aminopeptidase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Methyl nicotinate Approved DB13882
small molecule | CAS: 93-60-7

Methyl nicotinate is the methyl ester of [DB00627] that is used as an active ingredient as a rubefacient in over-the-counter topical preparations indicated for muscle and joint pain. The action of methyl nicotinate as a rubefacient is thought to involve perip…

Kategori:
Anti-Inflammatory AgentsErythemaInflammation +2
Waktu Paruh_In vitro_, the hal…
Vol. DistribusiAccording to the an…
KlirensNo pharmacokinetic …
Genetik -
small molecule | CAS: 1731-84-6

Deskripsi belum tersedia.

Target Protein:
Immunoglobulin heavy constant gamma 1Neutrophil gelatinase-associated lipocalin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Methyl red DB08209
small molecule | CAS: 493-52-7

Deskripsi belum tersedia.

Kategori:
Coloring AgentsCompounds used in a research, industrial, or household setting
Target Protein:
FMN-dependent NADH-azoreductase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Methyl salicylate Approved DB09543
small molecule | CAS: 119-36-8

Methyl salicylate (oil of wintergreen or wintergreen oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. The compound was first extracted and isolated from plant species Gaultheria procumbens in 1843. It can be ma…

Kategori:
Acids, CarbocyclicAnalgesicsAntirheumatic Agents +16
Target Protein:
Transient receptor potential cation channel subfamily A member 1
Waktu ParuhThe plasma half-lif…
Vol. DistribusiAfter absorption, m…
Klirens-
Genetik -
small molecule | CAS: 85005-92-1

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 1246371-29-8

Methyl undecenoyl leucinate is an active ingredient in whitening creams. It is an ?-MSH antagonist that inhibits melanin synthesis and tyrosinase activity and reduces expression of various melanogenic genes.

Kategori:
Melanin Synthesis Inhibitor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 3943-74-6

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicBenzene DerivativesBenzoates +5
Target Protein:
Endo-1,4-beta-xylanase Y
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Immunoglobulin kappa constantAlkaline phosphatase, placental type
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Squalene--hopene cyclase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Neutrophil collagenaseInterstitial collagenase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 76970-78-0

Methylcantharidimide is under investigation in clinical trial NCT03996681 (TACE Combined With Methylcantharidimide Tablets in the Treatment of Large and Unresectable Hepatocellular Carcinoma).

Kategori:
BenzofuransHeterocyclic Compounds, Fused-Ring
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Methylchloroisothiazolinone Approved DB14197
small molecule | CAS: 26172-55-4

Methylchloroisothiazolinone (MCI) is an isothiazolinone commonly used as a preservative with antibacterial and antifungal properties. It is found within many commercially available cosmetics, lotions, and makeup removers. It is also a known dermatological sen…

Kategori:
Anti-Infective AgentsCell-mediated ImmunityCompounds used in a research, industrial, or household setting +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Methyldiazene DB04361
small molecule | CAS: 26981-93-1

Deskripsi belum tersedia.

Target Protein:
Quinoprotein glucose dehydrogenase B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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