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11778

Total database: 17430
Struktur (SMILES)
8554 (72.6%)
Target
6383 (54.2%)
Genomik
96 (0.8%)
Referensi
11778 (100.0%)

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Hasil Pencarian (11778)

Halaman 84 / 236
Delparantag DB12955
small molecule | CAS: 872454-31-4

Delparantag has been used in trials studying the treatment of Angioplasty, Coronary Artery Disease (CAD), and Percutaneous Coronary Intervention.

Target Protein:
Antithrombin-III
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Delpazolid DB13077
small molecule | CAS: 1219707-39-7

Delpazolid (LCB01-0371) is under investigation in clinical trial NCT01554995 (A Clinical Study, Randomized, Double-blind, Placebo-controlled, Single Dose Study).

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsEnzyme Inhibitors +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Iron(3+)-hydroxamate-binding protein FhuDFerrichrome-iron receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Demcizumab DB12734
biotech | CAS: 1243262-17-0

Demcizumab is under investigation for the treatment of Nonsquamous Nonsmall Cell Neoplasm of Lung.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Demeclocycline Approved DB00618
small molecule | CAS: 127-33-3

A tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.

Kategori:
Agents that produce neuromuscular block (indirect)Anti-Bacterial AgentsAnti-Infective Agents +8
Target Protein:
30S ribosomal proteinVasopressin V2 receptor
Waktu Paruh10-17 hours
Vol. Distribusi-
Klirens* Renal cl=35 mL/mi…
Genetik -
Demecolcine DB13318
small molecule | CAS: 477-30-5

Deskripsi belum tersedia.

Kategori:
AlkaloidsAntimitotic AgentsAntineoplastic Agents +5
Target Protein:
Microtubule-associated protein 1BMicrotubule-associated protein 1A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Demegestone DB13857
small molecule | CAS: 10116-22-0

Demegestone is a progesterone receptor agonist that was previously used to treat luteal insufficiency. It was previously marketed in France as Lutionex, but has since been discontinued.

Kategori:
Adrenal Cortex HormonesContraceptive Agents, FemaleContraceptives, Oral +15
Target Protein:
Progesterone receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Demexiptiline DB08998
small molecule | CAS: 24701-51-7

Demexiptiline is marketed under the names Deparon or Tinoran. It is a tricyclic antidepressant which acts primarily as a norepinephrine reuptake inhibitor.

Kategori:
Benzocycloheptenes
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Demoxytocin DB13798
small molecule | CAS: 113-78-0

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsHormonesHormones, Hormone Substitutes, and Hormone Antagonists +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 1009838-50-9

Demplatin pegraglumer is under investigation in clinical trial NCT02043288 (Combination Therapy With NC-6004 and Gemcitabine Versus Gemcitabine Alone in Pancreatic Cancer).

Kategori:
Amino AcidsAmino Acids, AcidicAmino Acids, Dicarboxylic +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Denagliptin DB16134
small molecule | CAS: 483369-58-0

Denagliptin is under investigation in clinical trial NCT00387972 (Study of Denagliptin in Subjects With Type 2 Diabetes Mellitus (T2DM)).

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +1
Target Protein:
Dipeptidyl peptidase 4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Denatonium DB18588
small molecule | CAS: 47324-98-1

Deskripsi belum tersedia.

Kategori:
Abuse-Deterrent FormulationsAminesAmmonium Compounds +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Denecimig DB18426
biotech | CAS: 2488745-86-2

Delpacibart is a humanized, bispecific, bivalent monoclonal antibody against coagulation factor 9.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Denenicokin DB12908
biotech | CAS: 716840-32-3

Denenicokin is under investigation in clinical trial NCT01152788 (Phase II Study of Interleukin-21 (rIL-21) vs Dacarbazine (DTIC) in Patients With Metastatic or Recurrent Melanoma).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Denfivontinib DB17159
small molecule | CAS: 1457983-28-6

Deskripsi belum tersedia.

Target Protein:
Tyrosine-protein kinase MerReceptor-type tyrosine-protein kinase FLT3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

Kategori:
Biological ProductsComplex MixturesVaccines +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Denibulin DB05932
small molecule | CAS: 284019-34-7

Denibulin is a novel small molecule Vascular Disrupting Agent under development by MediciNova for treatment of solid tumor cancers.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Vascular endothelial growth factor A, long formVascular endothelial growth factor receptor 1Vascular endothelial growth factor receptor 3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Denifanstat DB17576
small molecule | CAS: 1399177-37-7

Denifanstat is an orally bioavailable fatty acid synthase (FASN) inhibitor. Due to its antineoplastic activities, it is being investigated for various cancers.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Denileukin diftitox Approved DB00004
biotech | CAS: 173146-27-5

Denileukin diftitox is an IL2-receptor-directed cytotoxin, is a recombinant DNA-derived fusion protein composed of the amino acid sequences for diphtheria toxin fragments A and B (Met<sub>1</sub>-Thr<sub>387</sub>)-His and the sequence for human interleukin-2…

Kategori:
ADP Ribose TransferasesAmino Acids, Peptides, and ProteinsAntineoplastic Agents +15
Target Protein:
Interleukin-2 receptor subunit alphaInterleukin-2 receptor subunit beta
Waktu ParuhThe arithmetic mean…
Vol. DistribusiThe geometric mean …
KlirensThe geometric mean …
Genetik -
Denosumab Approved DB06643
biotech | CAS: 615258-40-7

Denosumab is a novel, fully human IgG2 monoclonal antibody specific to receptor activator of nuclear factor kappa-B ligand (RANKL), suppresses bone resorption via inhibiting RANK-mediated activation of osteoclasts. It is the first and currently the only RANKL…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +16
Target Protein:
Tumor necrosis factor ligand superfamily member 11
Waktu ParuhAfter C<sub>max</su…
Vol. DistribusiThe central volume …
KlirensNo information is a…
Genetik -
biotech

Dental pulp is a soft, connective tissue present in the dental crown of both third molar and first premolar teeth. Dental pulp stem cells (DPSCs) exhibit fibro-blast like plasticity and adherent properties. They are harvested through surgical extraction of wi…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Clavaminate synthase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Deoxycholic acid Approved DB03619
small molecule | CAS: 83-44-3

Deoxycholic acid is a a bile acid which emulsifies and solubilizes dietary fats in the intestine, and when injected subcutaneously, it disrupts cell membranes in adipocytes and destroys fat cells in that tissue. In April 2015, deoxycholic acid was approved by…

Kategori:
Bile Acids and SaltsBSEP/ABCB11 inducersCholagogues and Choleretics +9
Target Protein:
Proliferating cell nuclear antigenSteroid Delta-isomeraseCytochrome C +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 52474-59-6

Deskripsi belum tersedia.

Kategori:
Cytosine NucleotidesDeoxyribonucleotidesHeterocyclic Compounds, Fused-Ring +8
Target Protein:
Ribonuclease pancreatic
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 501-15-5

Sympathomimetic, vasoconstrictor agent.

Kategori:
Agents that produce hypertensionAminesBenzene Derivatives +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deoxyribonuclease I (DNase I) is a human enzyme responsible for the digestion of extracellular DNA7[A227723]. It is normally found in saliva, urine, pancreatic secretions, and blood[A227723]. Because of the hypothesis that increased concentrations of high-mol…

Kategori:
Deoxyribonuclease I, antagonists & inhibitorsDeoxyribonucleasesEndodeoxyribonucleases +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Depatuxizumab DB12826
biotech | CAS: 1471999-69-5

Depatuxizumab has been used in trials studying the treatment and diagnostic of Adenocarcinoma and Advanced Solid Tumors.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 1585973-65-4

Depatuxizumab/Denintuzumab mafodotin has been used in trials studying the treatment of Lymphoma, Gliosarcoma, Glioblastoma, Malignant Glioma, Squamous Cell Tumors, and Glioblastoma Multiforme.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +8
Target Protein:
Tubulin beta chainEpidermal growth factor receptorB-lymphocyte antigen CD19
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Depelestat DB17873
biotech | CAS: 506433-25-6

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsLeukocyte Elastase, antagonists & inhibitors
Target Protein:
Neutrophil elastase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Depemokimab DB18846
biotech | CAS: 2243274-14-6

Depemokimab is under investigation in clinical trial NCT05274750 (Efficacy and Safety of Depemokimab (GSK3511294) in Participants With Chronic Rhinosinusitis With Nasal Polyps).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Phosphopantetheine adenylyltransferase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Depulfavirine DB18890
small molecule | CAS: 867365-76-2

Depulfavirine is under investigation in clinical trial NCT05204394 (Study to Evaluate Efficacy and Safety of Switching to VM-1500A-LAI + 2nrtis From the 1st Line Standard of Care Therapy).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dequalinium Approved DB04209
small molecule | CAS: 6707-58-0

Dequalinium is an antibacterial agent with multi-targeted actions. It also possesses antifungal, antiparasitic, antiviral, anticancer, and neuroprotective properties.[A249255] It is a quaternary ammonium compound,[L42190] as it consists of an amphipathic cati…

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsAnti-Infective Agents, Local +10
Target Protein:
Small conductance calcium-activated potassium channel protein 1Cyclic nucleotide-gated channel alpha-2Small conductance calcium-activated potassium channel protein 2 +10
Waktu ParuhThere is no informa…
Vol. DistribusiThere is no informa…
KlirensThere is no informa…
Genetik -
Deramciclane DB06512
small molecule | CAS: 120444-71-5

Deramciclane (EGIS-3886) is used for the treatment of a number of anxiety disorders. Deramciclane differs from other anti anxiety medications in that it is not a benzodiazepine and so has a different structure and target. It antagonizes 5-HT2A receptors, agon…

Kategori:
Anti-Anxiety AgentsAnticonvulsantsAntidepressive Agents +17
Target Protein:
5-hydroxytryptamine receptor 2A5-hydroxytryptamine receptor 2C
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 24967-94-0

Deskripsi belum tersedia.

Kategori:
AnticoagulantsBlood and Blood Forming OrgansCarbohydrates +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Dersimelagon DB18007
small molecule | CAS: 1835256-48-8

Deskripsi belum tersedia.

Target Protein:
Melanocyte-stimulating hormone receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Desaspidin DB13567
small molecule | CAS: 114-43-2

Deskripsi belum tersedia.

Kategori:
AnthelminticsAnticestodalsAntiparasitic Agents +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Arginase-1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Descartes-30 DB16361
biotech

Descartes-30 is an RNA-engineered off-the-shelf allogeneic mesenchymal stem cell (MSC) product developed by Cartesian Therapeutics.[L27531] The RNA-engineering is performed with Cartesian Therapeutics’ proprietary RNA Armory which is a platform that activates…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Deserpidine Approved DB01089
small molecule | CAS: 131-01-1

Deserpidine is an ester alkaloid drug isolated from Rauwolfia canescens (family Apocynaceae) with antipsychotic and antihypertensive properties that has been used for the control of high blood pressure and for the relief of psychotic behavior.

Kategori:
AlkaloidsAntiadrenergic Agents, Centrally ActingAntihypertensive Agents +8
Target Protein:
Synaptic vesicular amine transporterAngiotensin-converting enzyme
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Desfesoterodine DB15578
small molecule | CAS: 207679-81-0

Desfesoterodine is a metabolite of [tolterodine].

Kategori:
Drugs for Urinary Frequency and IncontinenceGenito Urinary System and Sex HormonesUrologicals
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Desflurane Approved DB01189
small molecule | CAS: 57041-67-5

Desflurane, or I-653, a a volatile anesthetic that is more rapidly cleared and less metabolized than previous inhaled anesthetics such as [methoxyflurane], [sevoflurane], [enflurane], or [isoflurane].[A226390,A39015,A226893]. It was developed in the late 1980…

Kategori:
Agents that produce hypertensionAnestheticsAnesthetics, General +14
Target Protein:
GABA(A) ReceptorGlycine receptor subunit alpha-1Glutamate receptor 1 +4
Waktu ParuhDesflurane has a te…
Vol. DistribusiDesflurane has a me…
KlirensA 26 g dose of desf…
Genetik -
Desidustat DB16135
small molecule | CAS: 1616690-16-4

Desidustat is under investigation in clinical trial NCT04012957 (Desidustat in the Treatment of Anemia in CKD).

Kategori:
Heterocyclic Compounds, Fused-RingQuinolines
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Desipramine Approved DB01151
small molecule | CAS: 50-47-5

Desipramine hydrochloride is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, de…

Kategori:
Adrenergic AgentsAdrenergic Uptake InhibitorsAgents producing tachycardia +52
Target Protein:
Sodium-dependent noradrenaline transporterSodium-dependent serotonin transporter5-hydroxytryptamine receptor 2A +14
Gen Terkait:
CYP2D6 CYP2D6 CYP2D6 +4
Waktu Paruh7-60+ hours; 70% el…
Vol. Distribusi-
Klirens-
Genetik 7 Varian
Desirudin Approved DB11095
biotech | CAS: 120993-53-5

Desirudin is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. Hirudin is a single polype…

Kategori:
Amino Acids, Peptides, and ProteinsAnticoagulantsAntithrombin Proteins +12
Waktu Paruh~2 hours.
Vol. Distribusi0.25 L/kg.
Klirens1.5 to 2.7 mL/min/k…
Genetik -
Deslanoside Approved DB01078
small molecule | CAS: 17598-65-1

Deacetyllanatoside C. A cardiotonic glycoside from the leaves of Digitalis lanata.

Kategori:
Antiarrhythmic agentsCarbohydratesCardanolides +13
Target Protein:
Sodium/potassium-transporting ATPase subunit alpha-1
Waktu Paruh36 hours
Vol. Distribusi-
Klirens-
Genetik -
Desloratadine Approved DB00967
small molecule | CAS: 100643-71-8

Desloratadine is a second generation, tricyclic antihistamine that which has a selective and peripheral H1-antagonist action. It is the active descarboethoxy metabolite of loratidine (a second generation histamine). Desloratidine has a long-lasting effect and…

Kategori:
Anticholinergic AgentsAntihistamines for Systemic UseBenzocycloheptenes +13
Target Protein:
Histamine H1 receptor
Waktu ParuhDesloratadine has a…
Vol. Distribusi-
Klirens-
Genetik -
Deslorelin DB11510
small molecule | CAS: 57773-65-6

Deslorelin acetate is an injectable gonadotropin releasing hormone super-agonist also known as an LHRH agonist. It stops the production of sex hormones.

Kategori:
Adrenal Cortex HormonesAlcohol Dehydrogenase, antagonists & inhibitorsAmino Acids, Peptides, and Proteins +12
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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