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16004

Total database: 17430
Struktur (SMILES)
12010 (75.0%)
Target
9041 (56.5%)
Genomik
112 (0.7%)
Referensi
16004 (100.0%)

Tipe Molekul

Distribusi Wujud Zat

Status Regulasi

Hasil Pencarian (16004)

Halaman 84 / 321
Berotralstat Approved DB15982
small molecule | CAS: 1809010-50-1

Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary angioedema (HAE).[L26661] It works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that pro…

Kategori:
BCRP/ABCG2 SubstratesBlood and Blood Forming OrgansCytochrome P-450 CYP2D6 Inhibitors +16
Target Protein:
Plasma kallikrein
Waktu ParuhFollowing a single …
Vol. DistribusiThe blood to plasma…
KlirensThere is no informa…
Genetik -
Bersacapavir DB19035
small molecule | CAS: 1638266-40-6

Bersacapavir is under investigation in clinical trial NCT03365947 (Study of ARO-HBV in Normal Adult Volunteers and Patients With Hepatitis B Virus (HBV)).

Kategori:
Anti-Infective AgentsAntiviral Agents
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bersanlimab DB17377
biotech | CAS: 1987854-08-9

Bersanlimab is an investigational monoclonal antibody directed against intercellular adhesion molecule 1 (ICAM-1).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bersiporocin DB18017
small molecule | CAS: 2241808-52-4

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bertilimumab DB05429
biotech

Bertilimumab is a fully human anti-eotaxin monoclonal antibody with potential in the treatment of allergic disorders, has moved into pre-clinical development. It is developed by MedImmune for the treatment of Allergic Rhinitis.

Target Protein:
Eotaxin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Berubicin DB17149
small molecule | CAS: 677017-23-1

Deskripsi belum tersedia.

Kategori:
Aminoglycoside AntibacterialsAnti-Bacterial AgentsCarbohydrates +2
Target Protein:
DNA topoisomerase 2-alphaDNA topoisomerase 2-beta
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Berzosertib DB11794
small molecule | CAS: 1232416-25-9

Berzosertib (VX-970) has been used in trials studying the treatment of Ovarian Neoplasms, Ovarian Serous Tumor, Adult Solid Neoplasm, Advanced Solid Tumor, and Advanced Solid Neoplasm, among others.

Target Protein:
Serine/threonine-protein kinase ATR
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Besifloxacin Approved DB06771
small molecule | CAS: 141388-76-3

Besifloxacin is a fourth generation fluoroquinolone-type opthalmic antibiotic for the treatment of bacterial conjunctivitis. FDA approved on May 28, 2009.

Kategori:
4-QuinolonesAnti-Bacterial AgentsAnti-Infective Agents +16
Target Protein:
DNA topoisomerase 4 subunit ADNA gyrase subunit BDNA gyrase subunit A +3
Waktu ParuhThe average elimina…
Vol. DistribusiNot absorbed into t…
KlirensN/A
Genetik -
Besifovir DB15671
small molecule | CAS: 441785-25-7

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-RingOrganophosphorus CompoundsPurines +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 441785-26-8

Besifovir dipivoxil is a small-molecule orally available inhibitor of the HBV polymerase. The HBV polymerase is the enzyme that catalyzes the production of new RNA from the existing strand of RNA. Besifovir dipivoxil is believed to inhibit viral proliferation…

Kategori:
Heterocyclic Compounds, Fused-RingOrganophosphorus CompoundsPurines +2
Target Protein:
Protein P
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Besilesomab Approved DB13979
biotech | CAS: 537694-98-7

Besilesomab is a mouse monoclonal antibody labelled with the radioactive isotope technetium-99m for determining the location of inflammation/infection in peripheral bone in adults with suspected osteomyelitis [FDA Label]. Utilised only as a diagnostic agent, …

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Target Protein:
Carcinoembryonic antigen
Waktu ParuhWhole blood concent…
Vol. DistribusiIn the besilesomab …
KlirensOnce administered i…
Genetik -
Beta carotene Approved DB06755
small molecule | CAS: 7235-40-7

Beta-carotene, with the molecular formula C40H56, belongs to the group of carotenoids consisting of isoprene units. The presence of long chains of conjugated double bonds donates beta-carotene with specific colors.[T162] It is the most abundant form of carote…

Kategori:
Alimentary Tract and MetabolismAlkenesBiological Factors +20
Target Protein:
Free radicals
Waktu ParuhThe apparent half-l…
Vol. DistribusiNo pharmacokinetic …
KlirensThe clearance rate …
Genetik -
small molecule | CAS: 9051-97-2

Deskripsi belum tersedia.

Kategori:
Adjuvants, ImmunologicCarbohydratesExperimental Unapproved Treatments for COVID-19 +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Arabinogalactan endo-beta-1,4-galactanase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1ProthrombinTyrosine--tRNA ligase, cytoplasmic
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 22951-96-8

Deskripsi belum tersedia.

Target Protein:
Phenylalanine-4-hydroxylase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Beta-3-Cysteine DB02780
small molecule

Deskripsi belum tersedia.

Target Protein:
Envelope glycoprotein gp160
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Beta-3-Serine DB02904
small molecule

Deskripsi belum tersedia.

Target Protein:
Envelope glycoprotein gp160
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
beta-Alanine DB03107
small molecule | CAS: 107-95-9

beta-Alanine is an amino acid formed in vivo by the degradation of [dihydrouracil] and [carnosine]. Since neuronal uptake and neuronal receptor sensitivity to beta-alanine have been demonstrated, the compound may be a false transmitter replacing GAMMA-AMINOBU…

Kategori:
AlanineAmino AcidsAmino Acids, Peptides, and Proteins
Target Protein:
Sodium- and chloride-dependent GABA transporter 3Pantothenate synthetase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 477-52-1

beta-Apopicropodophyllin is a component of the freshwater plant _Micranthemum umbrosum_.

Kategori:
Biological ProductsComplex MixturesPlant Extracts +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Ribose-5-phosphate isomerase A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Pyruvate kinase PKLRGlycerol kinase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 7660-25-5

Deskripsi belum tersedia.

Target Protein:
Fucose-binding lectin PA-IIL
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
beta-D-fucose DB04062
small molecule | CAS: 28161-52-6

Deskripsi belum tersedia.

Target Protein:
L-arabinose-binding periplasmic proteinArabinose operon regulatory protein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Kategori:
CarbohydratesOligosaccharidesPolysaccharides
Target Protein:
Arabinogalactan endo-beta-1,4-galactanase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 18968-14-4

Deskripsi belum tersedia.

Target Protein:
AlgQ1AlgQ2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 14196-86-2

Deskripsi belum tersedia.

Target Protein:
Galectin-7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
6-phospho-beta-galactosidase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Glycogen phosphorylase, muscle form
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Beta-D-Glucose DB02379
small molecule | CAS: 492-61-5

A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.

Kategori:
CarbohydratesGlucosidesGlycosides +2
Target Protein:
Neutral alpha-glucosidase ABNeutral alpha-glucosidase CHexokinase-4 +91
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 15209-12-8

Deskripsi belum tersedia.

Target Protein:
Glucose-6-phosphate 1-dehydrogenase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 23018-83-9

Deskripsi belum tersedia.

Kategori:
CarbohydratesHexosesMonosaccharides
Target Protein:
Hyaluronate lyaseChondroitinase-ACXylan alpha-1,2-glucuronidase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 7296-60-8

Deskripsi belum tersedia.

Target Protein:
Angiotensin-converting enzymeRibose import binding protein RbsBD-ribose pyranase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 34980-66-0

Deskripsi belum tersedia.

Target Protein:
D-ribose pyranaseADP-ribose pyrophosphatase, mitochondrial
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
beta-Escin DB15774
small molecule | CAS: 26339-90-2

Deskripsi belum tersedia.

Kategori:
CarbohydratesCardiovascular AgentsGlycosides +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 20790-72-1

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, BasicAmino Acids, Diamino +2
Target Protein:
Mannan-binding lectin serine protease 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, AcidicAmino Acids, Dicarboxylic +2
Target Protein:
Beta-lactamase TEM
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 300-85-6

Beta-hydroxybutyrate is being studied in around 230 clinical trials, including NCT06351124 (recruiting for Crohn's disease), NCT05584371 (recruiting for safety and tolerability of exogenous ketosis), NCT04656236 (completed for type 1 diabetes), and NCT0558104…

Kategori:
Acids, AcyclicButyratesExperimental Unapproved Treatments for COVID-19 +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 78995-10-5

Deskripsi belum tersedia.

Kategori:
Piperidines
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 625-08-1

beta-Hydroxyisovaleric acid is under investigation in clinical trial NCT03018496 (Investigating the Effects of Beta-Hydroxy-Beta-Methylbutyrate on Glucose Handling in Older and Younger Men.).

Kategori:
Acids, AcyclicFatty AcidsFatty Acids, Volatile +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, Branched-ChainAmino Acids, Peptides, and Proteins
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 24915-04-6

Deskripsi belum tersedia.

Kategori:
AlkaloidsAntiarrhythmic agentsCardiovascular Agents +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 7296-56-2

Deskripsi belum tersedia.

Target Protein:
L-arabinose-binding periplasmic protein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
beta-L-fucose DB03283
small molecule | CAS: 13224-93-6

Deskripsi belum tersedia.

Target Protein:
AcetylcholinesteraseAlpha-L-fucosidase, putative
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
beta-Mannobiose DB01687
small molecule

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Histo-blood group ABO system transferase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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