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14494

Total database: 17430
Struktur (SMILES)
9687 (66.8%)
Target
7525 (51.9%)
Genomik
112 (0.8%)
Referensi
14494 (100.0%)

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Hasil Pencarian (14494)

Halaman 83 / 290
Cevimeline Approved DB00185
small molecule | CAS: 107233-08-9

Cevimeline is a parasympathomimetic agent that act as an agonist at the muscarinic acetylcholine receptors M1 and M3. It is indicated by the Food and Drug Administration for the treatment of dry mouth associated with Sjögren's syndrome.

Kategori:
Autonomic AgentsCholinergic AgentsCholinergic Agonists +12
Target Protein:
Muscarinic acetylcholine receptor M3Muscarinic acetylcholine receptor M1
Waktu Paruh5 ± 1 hours
Vol. Distribusi* 6 L/kg
Klirens-
Genetik -
Cevipabulin DB12533
small molecule | CAS: 849550-05-6

Cevipabulin has been used in trials studying the treatment and educational/counseling/training of Tumors and Neoplasms.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cevostamab DB18374
biotech | CAS: 2249888-53-5

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CFG-920 DB19193
small molecule | CAS: 1260006-20-9

CFG-920 is under investigation in clinical trial NCT04060394 (Dose-escalation and Efficacy Study of Lae001/prednisone Plus Afuresertib Patients With M-crpc).

Target Protein:
Steroid 17-alpha-hydroxylase/17,20 lyase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CFT-8634 DB18443
small molecule | CAS: 2704617-96-7

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CG-200745 DB12259
small molecule | CAS: 936221-33-9

Cg200745 has been used in trials studying the treatment of Solid Tumour.

Kategori:
AminesAntineoplastic AgentsHistone Deacetylase Inhibitors +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CG-400549 DB12347
small molecule | CAS: 934628-27-0

CG400549 has been used in trials studying the treatment of Skin Infection.

Kategori:
Sulfur Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CG0070 DB05148
small molecule

CG0070 is investigated in clinical trials for treating bladder cancer. CG0070 is a solid. CG0070 can potentially destroy cancer cells by two different mechanisms: direct cell killing by the virus and immune-mediated cell killing stimulated by GM-CSF. CG0070, …

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CG7870 DB04981
biotech

CG7870 is an oncolytic virus therapy for prostate cancer. It is a replication-selective, prostate-specific antigen-targeted oncolytic adenovirus, for the treatment of hormone-refractory, metastatic prostate cancer.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CGC-11047 DB05722
small molecule | CAS: 206991-64-2

CGC-11047 is a polyamine analog designed to halt cell growth and induce apoptosis.

Kategori:
AminesBiogenic AminesBiogenic Polyamines +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CGI-1842 DB12744
small molecule | CAS: 900573-88-8

JI-101 has been used in trials studying the treatment of Cancer, Colon Cancer, Neuroendocrine, Ovarian Cancer, and Advanced Solid Tumors.

Kategori:
AmidesBenzene DerivativesHeterocyclic Compounds, Fused-Ring +1
Target Protein:
Receptor tyrosine-protein kinase erbB-4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CGP 4832 DB04220
small molecule | CAS: 113303-81-4

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-RingLactams, Macrocyclic
Target Protein:
Ferrichrome-iron receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CGS-27023 DB07556
small molecule | CAS: 161314-70-1

Deskripsi belum tersedia.

Kategori:
AmidesAminesEnzyme Inhibitors +8
Target Protein:
Neutrophil collagenaseA disintegrin and metalloproteinase with thrombospondin motifs 472 kDa type IV collagenase +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CGX-1321 DB17491
small molecule

CGX-1321 is a porcupine inhibitor that affects Wnt production and can block Wnt downstream signaling.[A257038]

Kategori:
Heterocyclic Compounds, Fused-Ring
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 227016-66-2

CH-1504 L-isomer is under investigation in clinical trial NCT01116141 (A Study of CH-4051 in Patients With Rheumatoid Arthritis (RA)).

Waktu Paruh-
Vol. Distribusi-
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Genetik -
CH-5132799 DB13051
small molecule | CAS: 1007207-67-1

CH5132799 has been used in trials studying the treatment of Solid Tumors.

Kategori:
AmidesClass I Phosphatidylinositol 3-Kinases, antagonists & inhibitorsSulfones +1
Target Protein:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Chaetomium globosum Approved DB10430
biotech

Chaetomium globosum is a fungus which can provoke allergic reactions. Chaetomium globosum extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Chamaecyparis obtusa wood oil is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Chamaemelum nobile flower is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Kategori:
AngiospermsAsteraceaeBiological Products +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Chamazulene DB15931
small molecule | CAS: 529-05-5

Deskripsi belum tersedia.

Kategori:
CycloheptanesCycloparaffins
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Chamomile Approved DB14357
biotech

Chamomile is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Kategori:
AngiospermsAsteraceaeBiological Products +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Channel catfish Approved DB15548
biotech

Channel catfish allergenic extract is used in allergenic testing.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Chelerythrine DB17024
small molecule | CAS: 34316-15-9

A benzophenanthridine alkaloid evaluated as a kinase-inhibitor.[A252982]

Kategori:
AlkaloidsAnti-Bacterial AgentsAnti-Infective Agents +4
Target Protein:
P2X purinoceptor 7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Chenodeoxycholic acid Approved DB06777
small molecule | CAS: 474-25-9

Chenodeoxycholic acid (or Chenodiol) is an epimer of ursodeoxycholic acid (DB01586). Chenodeoxycholic acid is a bile acid naturally found in the body. It works by dissolving the cholesterol that makes gallstones and inhibiting production of cholesterol in the…

Kategori:
Alimentary Tract and MetabolismBile Acid PreparationsBile acids and derivatives +12
Target Protein:
Bile acid receptorNuclear receptor subfamily 1 group I member 2G-protein coupled bile acid receptor 1 +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Chenopodium album pollen Approved DB10368
biotech

Chenopodium album pollen is the pollen of the Chenopodium album plant. Chenopodium album pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Chenopodium ambrosioides pollen is the pollen of the Chenopodium ambrosioides plant. Chenopodium ambrosioides pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Chenopodium botrys pollen Approved DB10838
biotech

Chenopodium botrys pollen is the pollen of the Chenopodium botrys plant. Chenopodium botrys pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cherry Approved DB10518
biotech

Cherry allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CHF 4227 DB05882
small molecule

CHF 4227 is a new selective estrogen receptor modulator (SERM). The compound has a high receptor affinity and has shown promising efficacy in the prevention of bone loss in animal models of osteoporosis. Additionally, the compound has shown no uterotrophic ac…

Kategori:
Heterocyclic Compounds, Fused-RingPyrans
Target Protein:
Estrogen receptorEstrogen receptor beta
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CHF-6001 DB12800
small molecule | CAS: 1239278-59-1

CHF6001 has been used in trials studying the treatment of Asthma and Chronic Obstructive Pulmonary Disease.

Kategori:
Acids, CarbocyclicAmidesAminobenzoates +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CHF-6333 DB17815
small molecule | CAS: 1613621-54-7

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
CHF5633 DB18696
biotech

CHF5633 is a fully synthetic pulmonary surfactant preparation comprising DPPC (dipalmitoylphosphatidylcholine), POPG Na (palmitoyl?oleoyl?phosphatidylglycerol sodium), a synthetic SP-C analogue, and a synthetic SP-B analogue.

Kategori:
Amino Acids, Peptides, and ProteinsGlycerophosphatesGlycerophospholipids +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CHGN111 DB06376
small molecule

CHGN111 is an inhibitor of the mitochondrial enzyme CLK-1 which is a demethoxyubiquinone hydroxylase. Numerous parameters of mitochondrial function are altered when the activity of CLK-1 is reduced, which results in a decrease of ROS at critical cellular site…

Target Protein:
Dual specificity protein kinase CLK1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Chiauranib DB16124
small molecule | CAS: 1256349-48-0

Chiauranib is under investigation in clinical trial NCT03974243 (Chiauranib in Combination With Chidamide in Patients With Relapsed/refractory Non-hodgkin's Lymphoma).

Kategori:
Antineoplastic AgentsEnzyme InhibitorsHeterocyclic Compounds, Fused-Ring +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Chicken Approved DB10519
biotech

Chicken allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Chickpea Approved DB10662
biotech

Chickpea allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Chicory leaf DB14376
biotech

Chicory leaf is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Chiglitazar DB19023
small molecule | CAS: 743438-45-1

Chiglitazar is under investigation in clinical trial NCT06125587 (Chiglitazar/metformin in Non-obese Women With PCOS).

Kategori:
Acids, AcyclicFatty AcidsFatty Acids, Volatile +3
Target Protein:
Peroxisome proliferator-activated receptor gammaPeroxisome proliferator-activated receptor alpha
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Chikungunya virus (CHIKV) is a member of the Alphavirus genus that was first identified in Tanzania in 1952.[A262051] It is spread primarily by the bite of infected mosquitos of the _Aedes_ genus. Infection with CHIKV causes chikungunya fever, an illness char…

Kategori:
Live vaccinesVaccinesViral Vaccines
Waktu ParuhThere is limited ph…
Vol. DistribusiThere is limited ph…
KlirensThere is limited ph…
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Chiniofon DB13379
small molecule | CAS: 8002-90-2

Deskripsi belum tersedia.

Kategori:
Antiparasitic Products, Insecticides and RepellentsAntiprotozoalsHeterocyclic Compounds, Fused-Ring +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CHIR-124 DB06852
small molecule | CAS: 405168-58-3

CHIR-124 is a potent inhibitor of Chk1 that potentiates the cytotoxicity of topoisomerase I poisons in vitro and in vivo.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Serine/threonine-protein kinase Chk1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Chitin DB15142
small molecule | CAS: 1398-61-4

Shrimp shell chitin is under investigation in clinical trial NCT00863356 (Trial of a Novel Chitosan Hemostatic Sealant in the Management of Complicated Epistaxis).

Kategori:
BiopolymersCarbohydratesChitin, antagonists & inhibitors +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 9012-76-4

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Chloral betaine DB01494
small molecule | CAS: 2218-68-0

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Chloral hydrate Approved DB01563
small molecule | CAS: 302-17-0

A hypnotic and sedative used in the treatment of insomnia. The safety margin is too narrow for chloral hydrate to be used as a general anesthetic in humans, but it is commonly used for that purpose in animal experiments. It is no longer considered useful as a…

Kategori:
AlcoholsCentral Nervous System AgentsCentral Nervous System Depressants +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Chlorambucil Approved DB00291
small molecule | CAS: 305-03-3

A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Repor…

Kategori:
Agents that reduce seizure thresholdAlkylating ActivityAlkylating Drugs +12
Target Protein:
DNA
Waktu Paruh1.5 hours
Vol. Distribusi-
Klirens-
Genetik -
Chloramphenicol Approved DB00446
small molecule | CAS: 56-75-7

An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein sy…

Kategori:
AlcoholsAmphenicolsAnti-Acne Preparations +34
Target Protein:
50S ribosomal protein L16Dr hemagglutinin structural subunitComplement decay-accelerating factor
Waktu ParuhHalf-life in adults…
Vol. Distribusi-
Klirens-
Genetik -
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