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15718

Total database: 17430
Struktur (SMILES)
10762 (68.5%)
Target
7957 (50.6%)
Genomik
112 (0.7%)
Referensi
15718 (100.0%)

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Hasil Pencarian (15718)

Halaman 83 / 315
Butenafine Approved DB01091
small molecule | CAS: 101828-21-1

Butenafine hydrochloride is a synthetic benzylamine antifungal agent. Butenafine's mechanism of action is believed to involve the synthesis inhibition of sterols. In particular, butenafine acts to inhibit the activity of the squalene epoxidase enzyme that is …

Kategori:
AminesAnti-Infective AgentsAntifungal Agents +7
Target Protein:
Squalene monooxygenaseSqualene monooxygenase
Waktu ParuhFollowing topical a…
Vol. Distribusi-
Klirens-
Genetik -
Butenoic Acid DB02074
small molecule | CAS: 107-93-7

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Buthiazide DB15861
small molecule | CAS: 2043-38-1

Deskripsi belum tersedia.

Kategori:
Antihypertensive AgentsBenzothiadiazinesCardiovascular Agents +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 5072-26-4

Buthionine sulfoximine has been used in trials studying the treatment of Neuroblastoma and Melanoma (Skin).

Kategori:
Amino AcidsAmino Acids, Peptides, and ProteinsAmino Acids, Sulfur +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Butobarbital Approved DB01353
small molecule | CAS: 77-28-1

Butobarbital is a sedative and a hypnotic drug.

Kategori:
Anticholinergic AgentsBarbiturates, PlainCentral Nervous System Agents +7
Target Protein:
Gamma-aminobutyric acid receptor subunit alpha-2Gamma-aminobutyric acid receptor subunit alpha-3Gamma-aminobutyric acid receptor subunit alpha-4 +7
Waktu Paruh37 hours
Vol. Distribusi-
Klirens-
Genetik -
Butoconazole Approved DB00639
small molecule | CAS: 64872-76-0

Butoconazole is an imidazole antifungal used in gynecology.

Kategori:
Anti-Infective AgentsAntifungal AgentsAntifungal Agents (Vaginal) +4
Target Protein:
ErgosterolLanosterol 14-alpha demethylase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Butonate DB11379
small molecule | CAS: 126-22-7

Deskripsi belum tersedia.

Kategori:
Organophosphorus Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Butorphanol Approved DB00611
small molecule | CAS: 42408-82-2

A synthetic morphinan analgesic with narcotic antagonist action. It is used in the management of severe pain.

Kategori:
AlkaloidsAnalgesicsAntitussive Agents +18
Target Protein:
Kappa-type opioid receptorDelta-type opioid receptorMu-type opioid receptor
Waktu ParuhThe elimination hal…
Vol. Distribusi* 305 to 901 L
Klirens* 99 +/- 23 L/h [Yo…
Genetik -
Butriptyline Approved DB09016
small molecule | CAS: 35941-65-2

Butriptyline is a tricyclic antidepressant which has been used in Europe since 1974. It is the isobutyl side chain homologue of amitriptyline.

Kategori:
Agents that produce hypertensionAgents that reduce seizure thresholdAnti-Anxiety Agents +22
Target Protein:
Sodium-dependent serotonin transporterHistamine H1 receptor5-hydroxytryptamine receptor 2A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Butropium DB15968
small molecule | CAS: 107080-63-7

Deskripsi belum tersedia.

Kategori:
AlkaloidsAza CompoundsAzabicyclo Compounds +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Butyl alcohol DB02145
small molecule | CAS: 71-36-3

Deskripsi belum tersedia.

Kategori:
AlcoholsButanolsFatty Alcohols +1
Target Protein:
Haloalkane dehalogenase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Butyl chloride DB11534
small molecule | CAS: 109-69-3

Deskripsi belum tersedia.

Kategori:
AlkanesHydrocarbons, Acyclic
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Butylamine DB03659
small molecule | CAS: 109-73-9

Butylamine is a colourless liquid which acquires a yellow colour upon storage in air. It is one of the four isomeric amines of butane. It is known to have the fishy, ammonia-like odor common to amines.

Kategori:
AlkanesAminesButanes +1
Target Protein:
Candidapepsin-2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 128-37-0

Deskripsi belum tersedia.

Kategori:
AntioxidantsBenzene DerivativesBiological Factors +4
Target Protein:
Carbonic anhydrase 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Butylene glycol Approved DB14110
small molecule | CAS: 107-88-0

Deskripsi belum tersedia.

Kategori:
AlcoholsGlycols
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 551-08-6

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicAnhydridesPhthalic Acids
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Butylparaben Approved DB14084
small molecule | CAS: 94-26-8

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicBenzene DerivativesBenzoates +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Butylphthalide DB12749
small molecule | CAS: 6066-49-5

Butylphthalide has been used in trials studying the prevention of Restenosis.

Kategori:
Antiplatelet agentsCentral Nervous System AgentsCompounds used in a research, industrial, or household setting +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Butylscopolamine Approved DB09300
small molecule | CAS: 7182-53-8

Butylscopolamine is a peripherally acting antimuscarinic, anticholinergic agent. It is used to treat pain and discomfort caused by abdominal cramps, menstrual cramps, or other spasmodic activity in the digestive system. It is also effective at preventing blad…

Kategori:
Agents producing tachycardiaAlimentary Tract and MetabolismAlkaloids +17
Target Protein:
Muscarinic acetylcholine receptor M3Muscarinic acetylcholine receptor M5Muscarinic acetylcholine receptor M2
Waktu ParuhThe half life of el…
Vol. DistribusiThe volume of distr…
KlirensTotal clearace is 1…
Genetik -
Butyramide DB02121
small molecule | CAS: 541-35-5

Deskripsi belum tersedia.

Target Protein:
Aliphatic amidase expression-regulating protein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Butyrfentanyl DB09173
small molecule | CAS: 1169-70-6

Butyrfentanyl or butyrylfentanyl (not to be confused with 3-methylfentanyl) is a potent short-acting synthetic opioid analgesic drug.[A182054] It is an analog of [fentanyl] with roughly 1/30 the potency.[L7811] Butyrfentanyl was first synthesized in 1961 by J…

Kategori:
Cytochrome P-450 CYP2D6 SubstratesCytochrome P-450 CYP3A SubstratesCytochrome P-450 CYP3A4 Substrates +4
Target Protein:
Mu-type opioid receptorKappa-type opioid receptorDelta-type opioid receptor
Waktu ParuhData for the half l…
Vol. DistribusiData for the volume…
KlirensData for the cleara…
Genetik -
Butyric Acid DB03568
small molecule | CAS: 107-92-6

A four carbon acid, CH3CH2CH2COOH, with an unpleasant odor that occurs in butter and animal fat as the glycerol ester.

Kategori:
Acids, AcyclicButyratesCholinesterase Inhibitors +5
Target Protein:
CholinesteraseHistone deacetylase 1(S)-2-haloacid dehalogenase +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 9001-08-5

Deskripsi belum tersedia.

Kategori:
Butyrylcholinesterase, drug effectsCarboxylic Ester HydrolasesCholinesterases +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BVX-001 DB18733
biotech

BVX001 is a a novel, first-in-class CD33/CD7-directed antibody-drug conjugate.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BVX-20 DB18286
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BW-A 58C DB06740
small molecule | CAS: 94015-46-0

BW-A 58C, also known as 2-(4-tert-butylcyclohexyl)-3-hydroxy-1,4-naphthoquinone, is an experimental naphthoquinone antimalarial drug which undergoes extensive alkyl hydroxylation to a single t-butylhydroxy metabolite in man in vivo and also in human liver mic…

Kategori:
NaphthalenesQuinones
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BX-528 DB07136
small molecule | CAS: 607837-17-2

Deskripsi belum tersedia.

Target Protein:
Carboxypeptidase B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BZ371A DB18101
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BZL101 DB05051
small molecule

BZL101 is an oral drug designed for the treatment of advanced breast cancer with a novel mechanism of action. BZL101 targets diseased cells while leaving normal cells healthy and intact.

Kategori:
AngiospermsBiological ProductsComplex Mixtures +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Glycogen phosphorylase, muscle form
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 361440-32-6

Deskripsi belum tersedia.

Target Protein:
Glycogen phosphorylase, muscle form
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Antitumor antibiotic C-1027 apoprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
C-Alpha-stx1 DB17972
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
C-Alpha-stx2 DB17971
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
C-peptide DB16187
small molecule | CAS: 59112-80-0

C-peptide is under investigation in clinical trial NCT00278980 (Effect of C-peptide on Diabetic Peripheral Neuropathy).

Kategori:
Amino Acids, Peptides, and ProteinsBlood Glucose Lowering AgentsHormones +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
C11-12 isoparaffin Approved DB11329
small molecule | CAS: 246538-76-1

C11-12 isoparaffin is a mixture of branched chain hydrocarbons with 11C or 12C's in the alkyl chain. It is found in cosmetic and personal care products as solvents or skin conditioning agent.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
C134 DB18261
biotech

C134 is a genetically engineered oncolytic herpes simplex virus expressing human cytomegalovirus (HCMV) internal repeat short 1 (IRS1).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
C31G DB05398
small molecule

C31G is a potent broad spectrum antimicrobial agent, effective against gram positive and gram negative bacteria, yeast and fungi.C31G, vaginal gel is developed by Biosyn Inc. and has commenced enrollment in a phase III pivotal clinical trial for the reduction…

Kategori:
AminesFatty AcidsLipids +3
Target Protein:
Gag-Pol polyproteinCD9 antigen
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
C326 DB06017
biotech

C326 is an investigational compound under investigation in clinical trial NCT00353756 (Phase 1 Study of Safety and Biological Effects of C326, an Inhibitor of IL-6, in Crohn's Disease) for the treatment of Crohn's Disease. The drug is composed of an IL-6–bind…

Kategori:
Amino Acids, Peptides, and ProteinsMembrane ProteinsPeptides +2
Target Protein:
Interleukin-6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 147859-80-1

CA-074 methyl ester (CA-074Me) is a cell-permeable cathepsin B inhibitor. It is converted by cellular esterases to CA-074.[A258234,A258239]

Kategori:
Amino Acids, Peptides, and ProteinsCathepsin B, antagonists & inhibitorsCathepsin Inhibitors +2
Target Protein:
Cathepsin B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CA-170 DB15772
small molecule

CA-170 is a selective, small molecule inhibitor of PD-L1.

Kategori:
Immune Checkpoint Inhibitors
Target Protein:
Programmed cell death 1 ligand 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cabazitaxel Approved DB06772
small molecule | CAS: 183133-96-2

Cabazitaxel is a taxoid synthesized from 10-deacetylbaccatin III, a compound isolated from the yew tree.[A260621] As a second-generation semisynthetic microtubule inhibitor, cabazitaxel stabilizes microtubules and induces tumour cell death.[A7056] Due to its …

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsBCRP/ABCG2 Inhibitors +25
Target Protein:
Tubulin beta-1 chain
Waktu ParuhFollowing a one-hou…
Vol. DistribusiSteady-state volume…
KlirensBased on the popula…
Genetik -
Cabbage Approved DB10513
biotech

Cabbage allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cabergoline Approved DB00248
small molecule | CAS: 81409-90-7

Cabergoline, an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor. It is used to treat hyperprolactinemic disorders and Parkinsonian Syndrome. Cabergoline possesses potent agonist activity on dopamine D2 receptors.

Kategori:
Agents that produce hypertensionAlkaloidsAnti-Dyskinesia Agents +31
Target Protein:
D(2) dopamine receptor5-hydroxytryptamine receptor 2BD(3) dopamine receptor +18
Waktu ParuhThe elimination hal…
Vol. Distribusi-
Klirens* renal cl=0,008 L/…
Genetik -
Cabiralizumab DB15082
biotech | CAS: 1613144-80-1

Cabiralizumab is under investigation in clinical trial NCT03502330 (APX005M With Nivolumab and Cabiralizumab in Advanced Melanoma, Non-small Cell Lung Cancer or Renal Cell Carcinoma).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cabotegravir Approved DB11751
small molecule | CAS: 1051375-10-0

Cabotegravir, or GSK1265744, is an HIV-1 integrase inhibitor that is prescribed with the non-nucleoside reverse transcriptase inhibitor, [rilpivirine].[A227668,L31188,L31193] Early research into cabotegravir showed it had lower oral bioavailability than [dolu…

Kategori:
Anti-HIV AgentsAnti-Infective AgentsAnti-Retroviral Agents +17
Target Protein:
IntegraseGag-Pol polyprotein
Waktu ParuhThe mean half life …
Vol. DistribusiData regarding the …
KlirensData regarding the …
Genetik -
Cabozantinib Approved DB08875
small molecule | CAS: 849217-68-1

Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer.[L15123] In 2016, a capsule…

Kategori:
AmidesAminesAniline Compounds +16
Target Protein:
Hepatocyte growth factor receptorVascular endothelial growth factor receptor 2Proto-oncogene tyrosine-protein kinase receptor Ret
Waktu ParuhCabozantinib has a …
Vol. DistribusiThe volume of distr…
KlirensAt steady state, th…
Genetik -
CAD106 DB05150
small molecule

CAD106 is an immunotherapeutic product in development for the treatment of Alzheimer's disease. It is designed to induce antibodies against the beta-amyloid-protein that inhibit the formation of plaques in the brain of Alzheimer's disease patients.

Target Protein:
Amyloid-beta precursor protein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cadaverine DB03854
small molecule | CAS: 462-94-2

Cadaverine is a foul-smelling diamine formed by bacterial decarboxylation of lysine.

Kategori:
AminesBiogenic AminesBiogenic Polyamines +8
Target Protein:
Carbonic anhydrase 4Carbonic anhydrase 1Carbonic anhydrase 6 +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cadazolid DB11847
small molecule | CAS: 1025097-10-2

Cadazolid has been used in trials studying the treatment of Clostridium Difficile Infection.

Kategori:
Oxazoles
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 4101–4150 dari 15718
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