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17430

Total database: 17430
Struktur (SMILES)
12313 (70.6%)
Target
9368 (53.7%)
Genomik
112 (0.6%)
Referensi
17430 (100.0%)

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Hasil Pencarian (17430)

Halaman 81 / 349
AZD-1981 DB11946
small molecule | CAS: 802904-66-1

AZD1981 has been used in trials studying the treatment and basic science of Asthma, Postmenopausal, Pharmakokinetic, Asthma Patients, and Drug Interaction, among others.

Target Protein:
Prostaglandin D2 receptor 2
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AZD-2066 DB12644
small molecule | CAS: 934282-55-0

AZD2066 has been used in trials studying the treatment and basic science of Pain, Chronic Pain, Reflux Episodes, Neuropathic Pain, and Diabetic Neuropathy, among others.

Target Protein:
Metabotropic glutamate receptor 5
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AZD-3043 DB12576
small molecule | CAS: 579494-66-9

AZD3043 has been used in trials studying the treatment and basic science of Safety, Sedation, Tolerability, and Pharmacokinetics.

Kategori:
Acids, CarbocyclicCentral Nervous System DepressantsHypnotics and Sedatives
Target Protein:
Gamma-aminobutyric acid receptor subunit gamma-3
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AZD-3759 DB14795
small molecule | CAS: 1626387-80-1

AZD-3759 is under investigation in clinical trial NCT03360929 (Evaluate Safety, Tolerability, Pharmacokinetics and Anti-tumor Activity of AZD3759).

Kategori:
Heterocyclic Compounds, Fused-Ring
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AZD-3839 DB12368
small molecule | CAS: 1227163-84-9

AZD3839 has been used in trials studying the basic science of Safety, Tolerability, Alzheimer's Disease, and Blood Concentration.

Kategori:
Heterocyclic Compounds, Fused-Ring
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AZD-4017 DB14875
small molecule | CAS: 1024033-43-9

AZD-4017 is under investigation in clinical trial NCT01173471 (A Phase IIa Study to Assess the Tolerability, Safety, and Efficacy of AZD4017 for Raised Intra-ocular Pressure).

Kategori:
11-beta-Hydroxysteroid Dehydrogenase Type 1, antagonists & inhibitorsNicotinic AcidsPyridines
Target Protein:
11-beta-hydroxysteroid dehydrogenase 1
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AZD-4547 DB12247
small molecule | CAS: 1035270-39-3

AZD4547 has been used in trials studying the treatment of Cancer, LYMPHOMA, Gastric Cancer, Adenocarcinoma, and Solid Neoplasm, among others.

Target Protein:
Fibroblast growth factor receptor 1
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AZD-4818 DB12002
small molecule | CAS: 1003566-93-5

AZD4818 has been used in trials studying the treatment of Chronic Obstructive Pulmonary Disease (COPD).

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AZD-4877 DB11671
small molecule | CAS: 1176760-49-8

AZD4877 has been used in trials studying the treatment of NHL, Tumors, Cancer, Lymphoma, and Neoplasms, among others.

Kategori:
Acids, CarbocyclicAmidesBenzene Derivatives +2
Target Protein:
Kinesin-like protein KIF11
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AZD-5069 DB16822
small molecule | CAS: 878385-84-3

Deskripsi belum tersedia.

Kategori:
AmidesSulfonesSulfur Compounds
Target Protein:
C-X-C chemokine receptor type 2
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AZD-5153 DB17018
small molecule | CAS: 1869912-39-9

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Bromodomain-containing protein 4
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AZD-5423 DB12280
small molecule | CAS: 1034148-04-3

AZD5423 has been used in trials studying the basic science and treatment of Asthma, Bioavailability and AUC, and Chronic Obstructive Pulmonary Disease (COPD).

Kategori:
AcetatesAcids, AcyclicAmides +4
Target Protein:
Glucocorticoid receptor
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AZD-5672 DB11804
small molecule | CAS: 780750-65-4

Azd5672 has been used in trials studying the basic science and treatment of Pharmacokinetics, Renal Impairment, and Rheumatoid Arthritis.

Kategori:
AcetamidesAmidesAnti-HIV Agents +5
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AZD-5991 DB14792
small molecule | CAS: 2143010-83-5

AZD-5991 is under investigation in clinical trial NCT03218683 (Study of AZD5991 in Relapsed or Refractory Haematologic Malignancies.).

Kategori:
Antineoplastic Agents
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AZD-6280 DB12210
small molecule | CAS: 942436-93-3

AZD6280 has been used in trials studying the basic science of Anxiety.

Kategori:
Heterocyclic Compounds, Fused-RingReceptors, Opioid, delta, agonists
Target Protein:
Gamma-aminobutyric acid receptor subunit alpha-3
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AZD-6482 DB14980
small molecule | CAS: 1173900-33-8

AZD-6482 is under investigation in clinical trial NCT00688714 (Study to Investigate Safety and Tolerability of a Single Dose of AZD6482).

Kategori:
Acids, CarbocyclicAminobenzoatesBenzene Derivatives +3
Target Protein:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
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AZD-7268 DB19203
small molecule | CAS: 1018988-00-5

AZD-7268 is under investigation in clinical trial NCT01020799 (AZD7268 Safety and Tolerability Study).

Kategori:
Heterocyclic Compounds, Fused-RingReceptors, Opioid, delta, agonists
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AZD-7295 DB12724
small molecule | CAS: 929890-64-2

AZD7295 has been investigated for the treatment of Hepatitis C.

Target Protein:
Genome polyprotein
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AZD-7325 DB13994
small molecule | CAS: 942437-37-8

AZD7325 is a high affinity, selective modulator of the GABAA receptor system. [L2936]

Kategori:
GABA ModulatorsHeterocyclic Compounds, Fused-Ring
Target Protein:
Gamma-aminobutyric acid receptor subunit alpha-3Gamma-aminobutyric acid receptor subunit alpha-2
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AZD-7648 DB16834
small molecule | CAS: 2230820-11-6

Deskripsi belum tersedia.

Kategori:
Enzyme InhibitorsHeterocyclic Compounds, Fused-RingProtein Kinase Inhibitors
Target Protein:
DNA-dependent protein kinase catalytic subunit
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AZD-7687 DB14949
small molecule | CAS: 1166827-44-6

AZD-7687 is under investigation in clinical trial NCT01119352 (AZD7687 Multiple Ascending Dose Study).

Kategori:
Acids, AcyclicFatty AcidsFatty Acids, Volatile +1
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AZD-7762 DB12242
small molecule | CAS: 860352-01-8

AZD7762 has been investigated for the treatment of Cancer, Solid Tumors, and Advanced Solid Malignancies.

Kategori:
AmidesSulfur Compounds
Target Protein:
Serine/threonine-protein kinase Chk1
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AZD-8055 DB12774
small molecule | CAS: 1009298-09-2

AZD8055 has been used in trials studying the treatment of Cancer, Lymphomas, Solid Tumors, MALIGNANT GLIOMA, and brainstem glioma, among others.

Kategori:
Oxazines
Target Protein:
Serine/threonine-protein kinase mTOR
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AZD-8165 DB15132
small molecule | CAS: 1201686-72-7

AZD-8165 is under investigation in clinical trial NCT01150812 (Oral AZD8165 After Single Oral Ascending Doses in Healthy Male Subjects).

Target Protein:
Prothrombin
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AZD-8186 DB15029
small molecule | CAS: 1627494-13-6

AZD-8186 is under investigation in clinical trial NCT03218826 (PI3Kbeta Inhibitor AZD8186 and Docetaxel in Treating Patients Advanced Solid Tumors With PTEN or PIK3CB Mutations That Are Metastatic or Cannot Be Removed by Surgery).

Kategori:
AminesBenzopyransHeterocyclic Compounds, Fused-Ring +1
Target Protein:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
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AZD-8330 DB06061
small molecule | CAS: 869357-68-6

AZD-8330 is a potent, selective, orally active MEK inhibitor that blocks signal transduction pathways implicated in cancer cell proliferation and survival. AZD-8330 has shown tumor suppressive activity in multiple preclinical models of human cancer including …

Kategori:
Protein Kinase InhibitorsPyridines
Target Protein:
Mitogen-activated protein kinase kinase kinase 1
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AZD-8418 DB13102
small molecule | CAS: 1198309-73-7

Azd8418 is under investigation in clinical trial NCT01027234 (This Study Will Assess the Safety and Tolerability of AZD8418 After Single Increasing Oral Doses).

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AZD-8848 DB14868
small molecule | CAS: 866269-28-5

AZD-8848 is under investigation in clinical trial NCT01818869 (To Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses AZD8848 in Healthy Subjects).

Kategori:
Acids, CarbocyclicHeterocyclic Compounds, Fused-RingNucleic Acids, Nucleotides, and Nucleosides +4
Target Protein:
Toll-like receptor 7
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AZD-9056 DB12594
small molecule | CAS: 345304-65-6

AZD9056 has been used in trials studying the basic science and treatment of Rheumatoid Arthritis.

Kategori:
Acids, CarbocyclicAmidesBenzene Derivatives +3
Target Protein:
P2X purinoceptor 7
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AZD-9164 DB12115
small molecule | CAS: 1034978-04-5

AZD9164 has been used in trials studying the basic science and treatment of Chronic Obstructive Pulmonary Disease.

Kategori:
Receptor, Muscarinic M3, antagonists & inhibitors
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AZD-9496 DB15138
small molecule | CAS: 1639042-08-2

AZD-9496 is under investigation in clinical trial NCT02248090 (AZD9496 First Time in Patients Ascending Dose Study).

Kategori:
Acids, CarbocyclicHeterocyclic Compounds, Fused-Ring
Target Protein:
Estrogen receptor
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AZD-9684 DB05712
small molecule

AZD-9684 is the first member of a new anti-thrombotic class (CPU inhibitors). It is being developed by AstraZeneca.

Kategori:
Acids, AcyclicFatty AcidsFatty Acids, Volatile +1
Target Protein:
Carboxypeptidase B2
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AZD-9977 DB15418
small molecule | CAS: 1850385-64-6

AZD-9977 is under investigation in clinical trial NCT03843060 (A Phase 1 Study to Assess the Pharmacokinetics of AZD9977 Administered Alone and in Combination With Itraconazole in Healthy Volunteers).

Kategori:
Acids, CarbocyclicBenzene Derivatives
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AZD0947 DB04848
small molecule

AZD0947 is a K+ channel opener, which was under investigation by AstraZeneca for the treatment of overactive bladder. As of March 2003, the drug was in phase II trials; however, as of October 2004, it no longer appeared on the company’s development pipeline.

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AZD2066 DB17078
small molecule | CAS: 934282-55-0

Deskripsi belum tersedia.

Kategori:
Gastrointestinal AgentsReceptor, Metabotropic Glutamate 5, antagonists & inhibitors
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AZD2315 DB06540
biotech | CAS: 457937-78-9

The drug AZD2315, an immunosuppressant developed by AstraZeneca, was in Phase 1 clinical trials for the treatment of rheumatoid arthritis but was discontinued during this phase

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AZD3409 DB04893
small molecule

AZD3409 is a farnesyl-transferase inhibitor (FAR) indicated for the treatment of solid tumors. Phase I trials were initiated January 2003, and were ongoing as of February 2004. As of February 2007 the development of AZD3409 had been discontinued.

Target Protein:
Protein farnesyltransferase subunit betaProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Waktu Paruh15–20 hours for the…
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AZD7442 DB15787
biotech

AZD7442 is a combination of SARS-CoV-2 antibodies (AZD8895 + AZD1061) currently undergoing phase I clinical trials for the prevention and treatment of COVID-19.[L15596] It was developed by AstraZeneca with the goal of conferring at least 6 months of protecti…

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Infective AgentsAntibodies +9
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AZD8529 DB16073
small molecule | CAS: 1092453-15-0

AZD8529 is under investigation in clinical trial NCT00921804 (Study to Assess the Efficacy, Safety, and Tolerability of AZD8529 in Adult Schizophrenia Patients).

Kategori:
Heterocyclic Compounds, Fused-RingOxazoles
Target Protein:
Metabotropic glutamate receptor 1
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AZD8630 DB19397
biotech

AZD8630 is an experimental drug under investigation, as described in the Phase I clinical study titled "Randomised, Blinded, Placebo-controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics (NCT05110976)

Target Protein:
Thymic stromal lymphopoietin
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Azelaic acid Approved DB00548
small molecule | CAS: 123-99-9

Azelaic acid is a saturated dicarboxylic acid found naturally in wheat, rye, and barley. It is also produced by _Malassezia furfur_, also known as _Pityrosporum ovale_, which is a species of fungus that is normally found on human skin. Azelaic acid is effecti…

Kategori:
Acids, AcyclicAnti-Acne PreparationsAnti-Acne Preparations for Topical Use +5
Target Protein:
Thioredoxin reductasePolyprenal reductase3-oxo-5-alpha-steroid 4-dehydrogenase 1 +4
Waktu ParuhThe observed half-l…
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Azelaprag DB19329
small molecule | CAS: 2049980-18-7

Azelaprag is under investigation in clinical trial NCT06515418 (Efficacy and Safety of Oral Azelaprag Plus Once Weekly Tirzepatide Compared With Tirzepatide Alone in Participants With Obesity Aged 55 Years and Over).

Target Protein:
Apelin receptor
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Azelastine Approved DB00972
small molecule | CAS: 58581-89-8

Azelastine, a phthalazine derivative, is an antihistamine available as an intranasal spray for the treatment of allergic and vasomotor rhinitis and as an ophthalmic solution for the treatment of allergic conjunctivitis.[L8240,L8270] It is a racemic mixture, t…

Kategori:
Anti-Allergic AgentsAntiallergic Agents, Excl. CorticosteroidsAntihistamines for Systemic Use +41
Target Protein:
Histamine H1 receptorHistamine H2 receptorPhospholipase A2 +1
Waktu ParuhBased on intravenou…
Vol. DistribusiAfter intravenous a…
KlirensBased on intravenou…
Genetik -
Azeliragon DB12689
small molecule | CAS: 603148-36-3

Azeliragon has been used in trials studying the treatment of Alzheimer's Disease.

Target Protein:
Advanced glycosylation end product-specific receptor
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Azelnidipine DB09230
small molecule | CAS: 123524-52-7

Azelnidipine is a dihydropyridine calcium channel blocker. It is marketed by Daiichi-Sankyo pharmaceuticals, Inc. in Japan. It has a gradual onset of action and produces a long-lasting decrease in blood pressure, with only a small increase in heart rate, unl…

Kategori:
Acids, AcyclicAgents causing hyperkalemiaAmino Acids +14
Target Protein:
Voltage-dependent L-type calcium channel subunit beta-1
Waktu Paruh16 –28 hours [L1383…
Vol. DistribusiIn a Chinese study …
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Azemiglitazone DB16028
small molecule | CAS: 1133819-87-0

Azemiglitazone is under investigation in clinical trial NCT01280695 (A Randomized, Double-blind, Comparator- and Placebo-controlled, Multiple-dose Study to Evaluate the Safety, Tolerability and Efficacy of Three Dose Levels of MSDC-0602 in Type 2 Diabetic Pat…

Kategori:
KetonesSulfur CompoundsThiazoles
Target Protein:
Insulin receptor
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Azenosertib DB18028
small molecule | CAS: 2376146-48-2

Deskripsi belum tersedia.

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biotech

Deskripsi belum tersedia.

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Azficel-T Approved DB11051
biotech

Azficel-T is an autologous cellular product composed of fibroblasts indicated for improvement of the appearance of moderate to severe nasolabial fold wrinkles in adults. Dermal fibroblasts are collected from the post-auricular biopsy tissue and aseptically ex…

Kategori:
Autologous Cultured Cell
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Azidamfenicol DB13294
small molecule | CAS: 13838-08-9

Deskripsi belum tersedia.

Kategori:
AlcoholsAnti-Bacterial AgentsAnti-Infective Agents +7
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Menampilkan 4001–4050 dari 17430
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