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6694

Total database: 17430
Struktur (SMILES)
4518 (67.5%)
Target
3751 (56.0%)
Genomik
81 (1.2%)
Referensi
6694 (100.0%)

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Halaman 81 / 134
LX1031 DB05199
small molecule

LX1031 is an orally-dosed drug candidate for irritable bowel syndrome and other gastrointestinal disorders. LX1031 was generated by Lexicon medicinal chemists, and its target was internally identified as a key control point for the regulation of peripheral se…

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +3
Target Protein:
Tryptophan 5-hydroxylase 1
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LX201 DB04943
small molecule

LX201 is a silicone matrix ocular implant that provides sustained release of cyclosporine A (CsA) locally to the eye over the course of one year. LX201 is implanted subconjunctivally (beneath the transparent membrane covering the white of the eye) in a minima…

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LX6171 DB05180
small molecule

LX6171 is an oral drug candidate that was generated by Lexicon medicinal chemists and is being developed to treat disorders characterized by cognitive impairment, such as Alzheimer's disease, schizophrenia or vascular dementia.

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LY-2584702 DB12690
small molecule | CAS: 1082949-67-4

LY2584702 has been used in trials studying the treatment of Cancer, Advanced Cancer, Renal Cell Carcinoma, Metastases, Neoplasm, and Neuroendocrine Tumors, among others.

Kategori:
Ribosomal Protein S6 Kinases, 70-kDa, antagonists & inhibitors
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LY-2623091 DB15367
small molecule | CAS: 1162264-07-4

LY-2623091 is under investigation in clinical trial NCT02194465 (A Study of LY2623091 in Participants With High Blood Pressure).

Target Protein:
Mineralocorticoid receptor
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LY-2811376 DB13065
small molecule | CAS: 1194044-20-6

LY2811376 has been used in trials studying the basic science of Alzheimer's Disease.

Kategori:
Sulfur Compounds
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LY-2886721 DB12547
small molecule | CAS: 1262036-50-9

LY2886721 has been used in trials studying the basic science of Alzheimer's Disease.

Kategori:
Heterocyclic Compounds, Fused-RingPyridines
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LY-294002 DB02656
small molecule | CAS: 154447-36-6

Specific inhibitor of phosphatidylinositol 3-kinase.

Kategori:
BenzopyransEnzyme InhibitorsHeterocyclic Compounds, Fused-Ring +3
Target Protein:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformSerine/threonine-protein kinase pim-1
Waktu Paruh-
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LY-3039478 DB12050
small molecule | CAS: 1421438-81-4

LY3039478 has been used in trials studying the treatment and basic science of LYMPHOMA, Neoplasms, Solid Tumor, COLON CANCER, and BREAST CANCER, among others.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Neurogenic locus notch homolog protein 4Neurogenic locus notch homolog protein 1
Waktu Paruh-
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LY-3200882 DB16064
small molecule | CAS: 1898283-02-7

LY-3200882 is under investigation in clinical trial NCT04158700 (A Study of LY3200882 and Pembrolizumab in Participants With Advanced Cancer).

Target Protein:
TGF-beta receptor type-1
Waktu Paruh-
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LY2140023 DB05096
small molecule

LY2140023 is an investigational drug from Lilly, which is being developed as a new treatment option for schizophrenia. LY2140023 is an oral "prodrug," meaning it is devoid of intrinsic biological activity and, once administered, is metabolized to provide the …

Kategori:
Amino Acids, Peptides, and Proteins
Target Protein:
Metabotropic glutamate receptor 2Metabotropic glutamate receptor 3
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Lycopene Approved DB11231
small molecule | CAS: 502-65-8

Lycopene is a naturally occurring red carotenoid pigment that is responsible for red to pink colors seen in tomatoes, pink grapefruit, and other foods [A27242]. Having a chemical formula of C40H56, lycopene is a tetraterpene assembled from eight isoprene unit…

Kategori:
AlkenesAnti-Inflammatory AgentsAnticarcinogenic Agents +13
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biotech

Vaccine against Lyme disease that contains lipoprotein OspA, an outer surface protein of Borrelia burgdorferi sensu stricto ZS7, as expressed by Escherichia coli. Lipoprotein OspA is a single polypeptide chain of 257 amino acids with lipids covalently bonded …

Target Protein:
Toll-like receptor 2
Waktu Paruh1.2 hours (mammalia…
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Lymecycline Approved DB00256
small molecule | CAS: 992-21-2

Lymecycline is a broad-spectrum second-generation tetracycline antibiotic used for the treatment of acne and other susceptible bacterial infections.[L13880,L13883] It has been proven a cost-effective alternative to treatment with [minocycline] with comparable…

Kategori:
Agents that produce neuromuscular block (indirect)Anti-Bacterial AgentsAnti-Infective Agents +4
Target Protein:
30S ribosomal protein S4
Waktu ParuhThe half-life of ly…
Vol. DistribusiLymecycline is lipo…
KlirensLymecycline is part…
Genetik -
small molecule

Lysergic acid 2,4-dimethylazetidide is under investigation in clinical trial NCT02765802 (A Study to Evaluate Pegylated Interferon Lambda Monotherapy in Patients With Chronic Hepatitis Delta Virus Infection).

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small molecule | CAS: 50-37-3

Debate continues over the nature and causes of chronic flashbacks. Explanations in terms of LSD physically remaining in the body for months or years after consumption have been discounted by experimental evidence. Some say HPPD is a manifestation of post-trau…

Kategori:
Agents that produce hypertensionAlkaloidsAntidepressive Agents +18
Target Protein:
5-hydroxytryptamine receptor 2A5-hydroxytryptamine receptor 1A5-hydroxytryptamine receptor 2B +1
Waktu Paruh3 hours
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Lysine Approved DB00123
small molecule | CAS: 56-87-1

Lysine (abbreviated as Lys or K) is an ?-amino acid with the chemical formula HO2CCH(NH2)(CH2)4NH2. This amino acid is an essential amino acid, which means that humans cannot synthesize it. Its codons are AAA and AAG. Lysine is a base, as are arginine and his…

Kategori:
Amino AcidsAmino Acids, BasicAmino Acids, Diamino +10
Target Protein:
High affinity cationic amino acid transporter 1Cationic amino acid transporter 4Cationic amino acid transporter 3 +2
Waktu Paruh-
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small molecule

Deskripsi belum tersedia.

Target Protein:
Cyclin-dependent kinase 2Beta-lactamase OXA-10UDP-N-acetylmuramoylalanine--D-glutamate ligase +16
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M-2698 DB15431
small molecule | CAS: 1379545-95-5

M-2698 is under investigation in clinical trial NCT01971515 (First-in-Human Dose Escalation Trial in Subjects With Advanced Malignancies).

Target Protein:
RAC-alpha serine/threonine-protein kinaseRAC-gamma serine/threonine-protein kinaseRibosomal protein S6 kinase beta-1
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M-701 DB17504
biotech

M-701 is a recombinant anti-EpCAM/CD3 bispecific antibody.

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small molecule

Deskripsi belum tersedia.

Target Protein:
Beta-lactamaseBeta-lactamase
Waktu Paruh-
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M-Cresol DB01776
small molecule | CAS: 108-39-4

Deskripsi belum tersedia.

Kategori:
Benzene DerivativesPhenols
Target Protein:
Insulin
Waktu Paruh-
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Genetik -
small molecule | CAS: 1637-75-8

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicAmidesBenzamides and benzamide derivatives +3
Target Protein:
Kynureninase
Waktu Paruh-
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Macimorelin Approved DB13074
small molecule | CAS: 381231-18-1

Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH sec…

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +11
Target Protein:
Growth hormone secretagogue receptor type 1
Waktu ParuhThe mean terminal h…
Vol. DistribusiFollowing a single …
KlirensFollowing a single …
Genetik -
Macitentan Approved DB08932
small molecule | CAS: 441798-33-0

Macitentan is a dual endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension (PAH).[L35890] It was first approved by the FDA in 2013. Macitentan differs from its predecessor [bosentan] in part due to its lower risk of hepatotox…

Kategori:
AmidesAntihypertensive AgentsAntihypertensives for Pulmonary Arterial Hypertension +13
Target Protein:
Endothelin-1 receptorEndothelin receptor type B
Waktu ParuhThe half-life of el…
Vol. DistribusiMacitentan has an a…
KlirensClearance data was …
Genetik -
Madecassic acid DB14037
small molecule | CAS: 18449-41-7

Deskripsi belum tersedia.

Kategori:
Terpenes
Waktu Paruh-
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Maduramicin DB11525
small molecule | CAS: 84878-61-5

Maduramicin is an antiprotozoal agent used in veterinary medicine as prophylaxis against coccidiosis. It is a naturally occurring compound which was first isolated from the actinomycete, Actinomadura rubra.

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsIonophores
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Mafenide Approved DB06795
small molecule | CAS: 138-39-6

Mafenide is a sulfonamide-type antimicrobial agent used to treat severe burns. It acts by reducing the bacterial population present in the burn tissue and promotes healing of deep burns.[L36773] In 1998, mafenide acetate was approved under the FDA’s accelerat…

Kategori:
AmidesAnti-Bacterial AgentsAnti-Infective Agents +14
Target Protein:
Carbonic anhydrase 2Carbonic anhydrase 12Carbonic anhydrase 14 +2
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Maftivimab Approved DB15899
biotech | CAS: 2135632-36-7

Ebola virus (EBOV) remains an important human pathogen within the _Ebolavirus_ genus, having been responsible for at least 17 known outbreaks with an average case fatality rate of 43.92%.[A221825] Immune therapy using monoclonal antibodies (mAbs) is becoming …

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Infective AgentsAntibodies +10
Target Protein:
Envelope glycoprotein
Waktu ParuhMaftivimab administ…
Vol. DistribusiMaftivimab administ…
KlirensMaftivimab administ…
Genetik -
Magaldrate Approved DB08938
small molecule | CAS: 74978-16-8

Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market.

Kategori:
Alimentary Tract and MetabolismAlkaliesAluminium Compounds +13
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Magnesium acetate Approved DB13996
small molecule | CAS: 142-72-3

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicAgents that produce neuromuscular block (indirect)Fatty Acids +3
Target Protein:
Sodium/potassium-transporting ATPase subunit alpha-1
Waktu Paruh-
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small molecule | CAS: 16674-78-5

Magnesium acetate tetrahydrate is a hydrated form of anhydrous magnesium acetate salt with the chemical formula of Mg(CH3COO)2 • 4H2O. As a salt form of magnesium, magnesium acetate is one of the bioavailable forms of magnesium and forms a very water soluble …

Kategori:
Agents that produce neuromuscular block (indirect)Laxatives
Target Protein:
Glutamate (NMDA) receptor
Waktu ParuhElimination half-li…
Vol. DistribusiMagnesium ions disp…
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Magnesium Aluminum Silicate Approved DB11230
small molecule | CAS: 1327-43-1

Magnesium aluminum silicate is a naturally occurring mineral obtained from silicate ores of the montmorillonite group [A32782]. It is refined to a powder for use in cosmetic and pharmaceutical applications as an absorbent, anticaking agent, opacifying agent, …

Kategori:
Agents that produce neuromuscular block (indirect)MineralsPharmaceutic Aids +1
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Magnesium ascorbate Approved DB14484
small molecule | CAS: 15431-40-0

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicAntioxidantsBiological Factors +10
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small molecule | CAS: 7018-07-7

Magnesium aspartate is a magnesium salt of aspartic acid that is commonly used as a mineral supplement. It displays high oral bioavailability and water solubiltiy compared to other magnesium salts such as magnesium citrate, magnesium carbonate and magnesium o…

Kategori:
Agents that produce neuromuscular block (indirect)Alimentary Tract and MetabolismAmino Acids +8
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Magnesium carbonate Approved DB09481
small molecule | CAS: 546-93-0

Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label].

Kategori:
Agents that produce neuromuscular block (indirect)Alimentary Tract and MetabolismAluminum and magnesium containing antacids +20
Target Protein:
Glutamate (NMDA) receptor
Waktu ParuhHalf life of 27.7 h…
Vol. DistribusiVd for magnesium is…
KlirensMaximum magnesium c…
Genetik -
Magnesium cation Approved DB01378
small molecule | CAS: 22537-22-0

Magnesium hydroxide is used primarily in "Milk of Magnesia", a white aqueous, mildly alkaline suspension of magnesium hydroxide formulated at about 8%w/v. Milk of magnesia is primarily used to alleviate constipation, but can also be used to relieve indigestio…

Kategori:
Agents that produce neuromuscular block (indirect)Calculi Dissolution AgentIncreased Large Intestinal Motility +9
Target Protein:
Sodium/potassium-transporting ATPase subunit alpha-1
Waktu Paruh-
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Magnesium citrate Approved DB11110
small molecule | CAS: 3344-18-1

Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used.[T215] Magnesium citrate is considered by the FDA as an…

Kategori:
Acids, AcyclicAgents that produce neuromuscular block (indirect)Alimentary Tract and Metabolism +15
Waktu ParuhThe study of the ha…
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Magnesium gluconate Approved DB13749
small molecule | CAS: 59625-89-7

Magnesium gluconate is a magnesium salt of gluconate. It demonstrates the highest oral bioavailability of magnesium salts [L2608] and is used as a mineral supplement. Magnesium is ubiquitous in the human body, and is naturally present in many foods, added to …

Kategori:
Acids, AcyclicAgents that produce neuromuscular block (indirect)Alimentary Tract and Metabolism +7
Waktu Paruh-
Vol. DistribusiAbout 60% of the ma…
KlirensThe kidney plays a …
Genetik -
Magnesium glycinate Approved DB11189
small molecule | CAS: 14783-68-7

Magnesium glycinate is a magnesium salt of glycine that is available as dietary supplements as a source of magnesium. It is used in the treatment of magnesium deficiency.

Kategori:
Agents that produce neuromuscular block (indirect)Laxatives
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Magnesium hydroxide Approved DB09104
small molecule | CAS: 1309-42-8

Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke …

Kategori:
Agents that produce neuromuscular block (indirect)Alimentary Tract and MetabolismAlkalies +22
Waktu ParuhN/A
Vol. DistribusiThe peak action and…
KlirensMagnesium hydroxide…
Genetik -
small molecule | CAS: 34717-03-8

Magnesium orotate is a magnesium salt of orotic acid and is poorly soluble in water. It is a source of magnesium and is used as a mineral supplement to treat Mg deficiency. Orotic acid acts as a transporter that carries magnesium into the cells. It also exhib…

Kategori:
Agents that produce neuromuscular block (indirect)Alimentary Tract and MetabolismMagnesium Compounds +5
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Magnesium oxide Approved DB01377
small molecule | CAS: 1309-48-4

Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses.

Kategori:
Agents that produce neuromuscular block (indirect)Alimentary Tract and MetabolismAluminum and magnesium containing antacids +16
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small molecule | CAS: 7757-87-1

Deskripsi belum tersedia.

Kategori:
AcidsAcids, NoncarboxylicAgents that produce neuromuscular block (indirect) +10
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Magnesium silicate Approved DB13249
small molecule | CAS: 1343-88-0

Magnesium silicate is a compound of magnesium oxide and silicon. It is the magnesium salt of silicic acid containing an unspecified amount of water. The molecular formula can be expressed more clearly as MgSiO3.xH2O.[T186] It is known as talc and it presents …

Kategori:
Agents that produce neuromuscular block (indirect)Alimentary Tract and MetabolismAluminum and magnesium containing antacids +9
Waktu ParuhThe very low absorp…
Vol. DistribusiThe very low absorp…
KlirensThe very low absorp…
Genetik -
small molecule | CAS: 557-04-0

Deskripsi belum tersedia.

Kategori:
Agents that produce neuromuscular block (indirect)Fatty AcidsLipids
Waktu Paruh-
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Magnesium sulfate Approved DB00653
small molecule | CAS: 7487-88-9

A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncou…

Kategori:
Agents causing hyperkalemiaAgents that produce neuromuscular block (indirect)Alimentary Tract and Metabolism +38
Target Protein:
Voltage-dependent L-type calcium channel
Waktu Paruh43.2 hours (for new…
Vol. Distribusi-
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Magnesium trisilicate Approved DB09281
small molecule | CAS: 14987-04-3

Magnesium trisilicate is an inorganic compound that is used as an antacid in the treatment of peptic ulcers.

Kategori:
Agents that produce neuromuscular block (indirect)Aluminum and magnesium containing antacidsAntacids +10
Waktu Paruh16-20 hours
Vol. DistribusiThe hydrated silico…
KlirensMaximum magnesium c…
Genetik -
biotech

Deskripsi belum tersedia.

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Genetik -
biotech

Magnolia kobus flowering top is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

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