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15718

Total database: 17430
Struktur (SMILES)
10762 (68.5%)
Target
7957 (50.6%)
Genomik
112 (0.7%)
Referensi
15718 (100.0%)

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Hasil Pencarian (15718)

Halaman 81 / 315
small molecule | CAS: 649735-63-7

Brivanib alaninate has been investigated for the treatment of Colorectal Cancer.

Kategori:
Amino AcidsAmino Acids, Peptides, and Proteins
Target Protein:
Fibroblast growth factor receptor 3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Brivaracetam Approved DB05541
small molecule | CAS: 357336-20-0

Brivaracetam is a racetam derivative of levetiracetam used in the treatment of partial-onset seizures. Brivaracetam binds SV2A with 20 times higher affinity than levetiracetam [A19184]. It is available under the brand name Briviact made by UCB. Briviact recei…

Kategori:
AnticonvulsantsCentral Nervous System AgentsCentral Nervous System Depressants +11
Target Protein:
Synaptic vesicle glycoprotein 2ASodium channel protein
Waktu Paruh7-8h [A19180].
Vol. Distribusi0.5L/kg [FDA Label].
KlirensCL/F of 0.7-1.07 mL…
Genetik -
Brivoligide DB16116
biotech | CAS: 1803075-42-4

Brivoligide is under investigation in clinical trial NCT04104919 (Study to Evaluate a Preop Dose of Brivoligide Injection for Pain After Mastectomy in Patients With High PCS Scores).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Brivudine Approved DB03312
small molecule | CAS: 69304-47-8

Brivudine is used in the treatment of herpes zoster. Although not approved in the U.S. or Canada, it is approved in several European countries.

Kategori:
Anti-Infective AgentsAntiinfectives for Systemic UseAntiviral Agents +9
Target Protein:
Thymidine kinase 2, mitochondrialThymidine kinase, cytosolicDNA polymerase +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BRM-421 DB18364
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Broccoli Approved DB10511
biotech

Broccoli allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Brodalumab Approved DB11776
biotech | CAS: 1174395-19-7

Brodalumab has been used in trials studying the treatment of Asthma, Psoriasis, Crohn's Disease, Psoriatic Arthritis, and Rheumatoid Arthritis. Brodalumab was FDA approved in February, 2017 as Siliq for the treatment of moderate-to-severe plaque psoriasis.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +13
Target Protein:
Interleukin-17 receptor A
Waktu Paruh-
Vol. Distribusi4.62 L.
Klirens0.223 L/day.
Genetik -
Brodimoprim DB13795
small molecule | CAS: 56518-41-3

Deskripsi belum tersedia.

Kategori:
Anti-Infective AgentsAntibacterials for Systemic UseAntiinfectives for Systemic Use +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Brofaromine DB13876
small molecule | CAS: 63638-91-5

Deskripsi belum tersedia.

Kategori:
Antidepressive AgentsCentral Nervous System DepressantsEnzyme Inhibitors +3
Target Protein:
Amine oxidase [flavin-containing] A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Brogidirsen DB18884
biotech | CAS: 2409088-11-3

Brogidirsen is under investigation in clinical trial NCT05996003 (NS-089/NCNP-02-201 in Boys With Duchenne Muscular Dystrophy (DMD)).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Brolucizumab Approved DB14864
biotech | CAS: 1531589-13-5

Brolucizumab, also known as RTH258 or ESBA1008,[A187211] is a monoclonal antibody indicated to treat neovascular age related macular degeneration.[L9089] Brolucizumab was granted FDA approval in October 2019.[L9089]

Kategori:
Amino Acids, Peptides, and ProteinsAngiogenesis InhibitorsAntibodies +14
Target Protein:
Vascular endothelial growth factor A, long form
Waktu ParuhThe systemic half l…
Vol. DistribusiData regarding the …
KlirensData regarding the …
Genetik -
Bromamphenicol DB07492
small molecule | CAS: 16803-75-1

Deskripsi belum tersedia.

Kategori:
AlcoholsBenzene DerivativesGlycols +3
Target Protein:
Dr hemagglutinin structural subunit
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bromazepam Approved DB01558
small molecule | CAS: 1812-30-2

One of the benzodiazepines that is used in the treatment of anxiety disorders. It is a Schedule IV drug in the U.S. and Canada and under the Convention on Psychotropic Substances. It is a intermediate-acting benzodiazepine.

Kategori:
Anti-Anxiety AgentsBenzazepinesBenzodiazepine hypnotics and sedatives +22
Target Protein:
GABA(A) ReceptorGABA(A) Receptor Benzodiazepine Binding Site
Waktu Paruh10-20 hours
Vol. Distribusi1.56 L/kg
Klirens0.82 mL/min/kg.
Genetik -
Bromelains DB13281
biotech | CAS: 9001-00-7

Bromelain is a protease enzyme derived from the stems of pineapples that is composed of a mixture of different thiol endopeptidases and other components like phosphatase, glucosidase, peroxidase, cellulase, escharase, and several protease inhibitors [A27198].…

Kategori:
Cysteine EndopeptidasesCysteine ProteasesDermatologicals +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bromfenac Approved DB00963
small molecule | CAS: 91714-94-2

Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and establ…

Kategori:
Agents causing hyperkalemiaAnalgesicsAnalgesics, Non-Narcotic +16
Target Protein:
Prostaglandin G/H synthase 2Prostaglandin G/H synthase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bromhexine Approved DB09019
small molecule | CAS: 3572-43-8

Bromhexine is mucolytic agent used for a variety of respiratory conditions associated with increased mucus secretion. It is derived from the Adhatoda vasica plant and aids in the clearance of excess mucus, improving breathing and reducing cough. It was introd…

Kategori:
AminesAniline CompoundsCough and Cold Preparations +5
Target Protein:
Transmembrane protease serine 2Angiotensin-converting enzyme 2
Waktu ParuhFollowing single or…
Vol. DistribusiAfter intravenous a…
KlirensThe clearance of br…
Genetik -
Bromisoval DB13370
small molecule | CAS: 496-67-3

Deskripsi belum tersedia.

Kategori:
AmidesCentral Nervous System AgentsCentral Nervous System Depressants +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bromo-WR99210 DB04007
small molecule

Deskripsi belum tersedia.

Target Protein:
Peptide deformylase, mitochondrialDihydrofolate reductase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 3679-64-9

Deskripsi belum tersedia.

Kategori:
Antifungals for Dermatological UseAntifungals for Topical UseDermatologicals
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bromocriptine Approved DB01200
small molecule | CAS: 25614-03-3

Bromocriptine mesylate is a semisynthetic ergot alkaloid derivative with potent dopaminergic activity. It inhibits prolactin secretion and may be used to treat dysfunctions associated with hyperprolactinemia. Bromocriptine is also indicated for the management…

Kategori:
Adrenergic AgonistsAdrenergic alpha-1 Receptor AgonistsAdrenergic alpha-1 Receptor Antagonists +41
Target Protein:
D(2) dopamine receptorD(3) dopamine receptor5-hydroxytryptamine receptor 1D +15
Waktu Paruh2-8 hours
Vol. Distribusi-
Klirens-
Genetik -
Bromodiphenhydramine Approved DB01237
small molecule | CAS: 118-23-0

Bromodiphenhydramine is an ethanolamine antihistamine with antimicrobial property. Bromodiphenhydramine is used in the control of cutaneous allergies. Ethanolamine antihistamines produce marked sedation in most patients.

Kategori:
AminesAminoalkyl EthersAntihistamines for Systemic Use +5
Target Protein:
Histamine H1 receptor
Waktu Paruh1 to 4 hours
Vol. Distribusi-
Klirens-
Genetik -
Bromopride DB09018
small molecule | CAS: 4093-35-0

Bromopride is a dopamine antagonist used as an antiemetic. Its prokinetic properties are similar to those of metoclopramide. It is unavailable in America or the United Kingdom.

Kategori:
Acids, CarbocyclicAlimentary Tract and MetabolismAmides +22
Target Protein:
D(2) dopamine receptor
Waktu Paruh-
Vol. Distribusi-
KlirensRenal, 10-14% as or…
Genetik -
Bromopyruvate DB17135
small molecule | CAS: 1113-59-3

Deskripsi belum tersedia.

Kategori:
Affinity LabelsCompounds used in a research, industrial, or household settingEnzyme Inhibitors +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bromothalonil Approved DB14199
small molecule | CAS: 35691-65-7

Bromothalonil, also known as Methyldibromo glutaronitrile (MDBGN), is a widely used preservative that can be found in many personal hygiene and industrial products. It is also a known allergen and dermatological irritant that has been banned in many EU countr…

Kategori:
AllergensAntigensBiological Factors +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bromotheophylline Approved DB14018
small molecule | CAS: 10381-75-6

Bromotheophylline is the active moiety of pamabrom, a mixture of 2-amino-2-methyl-propanol and bromotheophylline. From this mixture, bromotheophylline acts as a weak diuretic that has been used along with some analgesics to relieve the symptoms of premenstrua…

Kategori:
AlcoholsAlkaloidsAmines +11
Target Protein:
Adenosine receptor
Waktu ParuhThe apparent elimin…
Vol. DistribusiThis pharmacokineti…
KlirensThis pharmacokineti…
Genetik -
Bromperidol Approved DB12401
small molecule | CAS: 10457-90-6

Bromperidol has been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and Psychosomatic Disorders, among others.

Kategori:
Antipsychotic AgentsButyrophenone DerivativesButyrophenones +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Brompheniramine Approved DB00835
small molecule | CAS: 86-22-6

Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria.

Kategori:
Agents producing tachycardiaAnti-Allergic AgentsAnticholinergic Agents +14
Target Protein:
Histamine H1 receptorMuscarinic acetylcholine receptor M1Muscarinic acetylcholine receptor M2 +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bromus inermis pollen Approved DB10355
biotech

Bromus inermis pollen is the pollen of the Bromus inermis plant. Bromus inermis pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bromus secalinus pollen Approved DB10836
biotech

Bromus secalinus pollen is the pollen of the Bromus secalinus plant. Bromus secalinus pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityGrass Pollen Allergen ExtractsIncreased Histamine Release +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bronopol Approved DB13960
small molecule | CAS: 52-51-7

Bronopol, or 2-Bromo-2-nitro-1,3-propanediol, is an organic compound with wide-spectrum antimicrobial properties. First synthesized in 1897, bronopol was primarily used as a preservative for pharmaceuticals and was registered in the United States in 1984 for …

Kategori:
AlcoholsAnti-Infective AgentsAnti-Infective Agents, Local +9
Target Protein:
Thiol groups
Waktu ParuhThe half-life of br…
Vol. DistribusiThe highest concent…
KlirensNo data available.
Genetik -
Brontictuzumab DB12737
biotech | CAS: 1447814-75-6

Brontictuzumab has been used in trials studying the treatment of Adenoid Cystic Carcinoma, Relapsed or Refractory Solid Tumors, and Relapsed or Refractory Lymphoid Malignancies.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodies, MonoclonalAntibodies, Monoclonal, Humanized +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bropirimine DB04168
small molecule | CAS: 56741-95-8

Deskripsi belum tersedia.

Kategori:
Adjuvants, ImmunologicAntineoplastic AgentsImmunologic Factors +3
Target Protein:
Dihydroneopterin aldolase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Brotizolam DB09017
small molecule | CAS: 57801-81-7

Brotizolam is a sedative-hypnotic thienodiazepine drug which is a benzodiazepine analog. It demonstrates anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant effects. Brotizolam has similar effects to short-acting benzodiazepines such a…

Kategori:
Benzodiazepine hypnotics and sedativesBenzodiazepines and benzodiazepine derivativesCentral Nervous System Agents +7
Target Protein:
GABA(A) ReceptorGABA(A) Receptor Benzodiazepine Binding Site
Waktu Paruh4.4 hours.
Vol. Distribusi0.63 l/kg.
KlirensTotal clearance: 10…
Genetik -
biotech

Broussonetia papyrifera pollen is the pollen of the Broussonetia papyrifera plant. Broussonetia papyrifera pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Brovanexine DB14720
small molecule | CAS: 54340-61-3

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicAmidesBenzene Derivatives +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Brown iron oxide Approved DB14567
small molecule | CAS: 52357-70-7

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Broxuridine DB12028
small molecule | CAS: 59-14-3

Broxuridine has been used in trials studying the treatment of Leukemia, Stage I Prostate Cancer, Stage IIB Prostate Cancer, and Stage IIA Prostate Cancer.

Kategori:
Anti-Infective AgentsAntimetabolitesAntineoplastic Agents +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Broxyquinoline DB13536
small molecule | CAS: 521-74-4

Deskripsi belum tersedia.

Kategori:
Alimentary Tract and MetabolismAntidiarrheals, Intestinal Antiinflammatory/antiinfective AgentsAntiparasitic Products, Insecticides and Repellents +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Brussels sprout Approved DB10642
biotech

Brussels sprout allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bryostatin 1 DB11752
small molecule | CAS: 83314-01-6

Bryostatin 1 has been investigated for the treatment of HIV Infection and Alzheimer's Disease.

Kategori:
Adjuvants, ImmunologicAnti-Bacterial AgentsAntineoplastic Agents +15
Target Protein:
Protein kinase C epsilon typeProtein kinase C alpha typeCaspase-8 +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BS-001 DB17415
biotech

BS-001 is a recombinant oncolytic herpes simplex virus type II (OH2) therapeutic injection (Vero cell) for human use (rHSV2hGM-CSF).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BSG-005 DB18014
small molecule

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BSK02 DB17434
biotech

BSK02 is a Sperm Protein-17 oral microparticle vaccine

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BT200 DB18333
biotech

BT200 (Rondoraptivon pegol) is a PEGylated anti-von Willebrand factor (VWF) aptamer targeted against the VWF A1 domain.[A261491] It is under investigation for the treatment of von Willebrand disease and hemophilia A.[L48156]

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BTA798 DB05181
small molecule

BTA798 is an antiviral for the treatment of HRV, the common cold virus, known to cause significant clinical complications in sufferers of Asthma and Chronic Obstructive Pulmonary Disease.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BTA9881 DB05226
small molecule

BTA9881 is a respiratory syncytial virus (RSV) antiviral drug developed by the Australian company Biota Holdings. It is currently in phase I trials.

Target Protein:
Fusion glycoprotein F0
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BTRX-246040 DB16048
small molecule | CAS: 1307245-86-8

BTRX-246040 is under investigation in clinical trial NCT03193398 (BTRX-246040 Administered Once Daily to Patients With Major Depressive Disorder).

Target Protein:
Nociceptin receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BTRX-335140 DB16068
small molecule | CAS: 2244614-14-8

BTRX-335140 is under investigation in clinical trial NCT04221230 (Study in Major Depressive Disorder With BTRX-335140 vs Placebo).

Kategori:
Heterocyclic Compounds, Fused-RingOxazoles
Target Protein:
Kappa-type opioid receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BTZ-043 DB17737
small molecule | CAS: 1161233-85-7

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bucelipase alfa DB16664
biotech | CAS: 9026-00-0

Bucelipase alfa is under investigation in clinical trial NCT00743483 (Efficacy of Bucelipase Alfa (BSSL) in Patients With Cystic Fibrosis and Pancreatic Insufficiency).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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