Hasil Filter

3253

Total database: 17430
Struktur (SMILES)
2451 (75.3%)
Target
1833 (56.3%)
Genomik
35 (1.1%)
Referensi
3253 (100.0%)

Tipe Molekul

Distribusi Wujud Zat

Status Regulasi

Hasil Pencarian (3253)

Halaman 8 / 66
Arverapamil DB06669
small molecule | CAS: 123932-43-4

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
AS-8112 DB09207
small molecule

AS-8112 is a synthetic compound that acts as a selective antagonist at the dopamine receptor subtypes D2 and D3, and the serotonin receptor 5-HT3. It has been shown to exert potent antiemetic effects in animal studies and has been investigated for potential m…

Kategori:
Dopamine AgentsDopamine AntagonistsDopamine D2 Receptor Antagonists +1
Target Protein:
D(2) dopamine receptorD(3) dopamine receptor5HT3 serotonin receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
AS1409 DB05182
small molecule

AS1409 is a genetically engineered fusion protein made up of two distinct components. One is the cytokine IL12, which has anti-cancer activity. The other is an antibody that targets tumours. It is developed by Antisoma is in a phase I of clinical trial for th…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Asciminib Approved DB12597
small molecule | CAS: 1492952-76-7

Asciminib is a tyrosine kinase inhibitor (TKI) used in the treatment of chronic-phase Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). More specifically, it is an inhibitor of the ABL1 kinase activity of the BCR-ABL1 fusion protein[L38995]…

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsBcr-Abl Tyrosine Kinase Inhibitors +26
Target Protein:
Tyrosine-protein kinase ABL1
Waktu ParuhThe terminal elimin…
Vol. DistribusiAt steady-state, th…
KlirensThe total apparent …
Genetik -
Ascorbic acid Approved DB00126
small molecule | CAS: 50-81-7

A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functio…

Kategori:
Acids, AcyclicAlimentary Tract and MetabolismAntioxidants +20
Target Protein:
Solute carrier family 23 member 2Solute carrier family 23 member 1Hyaluronate lyase +23
Waktu Paruh16 days (3.4 hours …
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 129499-78-1

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicCarbohydratesHydroxy Acids +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ascorbyl phosphate Approved DB11352
small molecule

Ascorbyl phosphate is a synthetic form of Vitamin C and is found in different salt forms such as magnesium ascorbyl phosphate and sodium ascorbyl phosphate. These salts are present in cosmetic products at concentrations ranging from 0.001 % to 3% [A27211]. As…

Kategori:
Acids, AcyclicCarbohydratesHydroxy Acids +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ascrinvacumab DB12261
biotech | CAS: 1463459-96-2

Ascrinvacumab has been used in trials studying the treatment and basic science of Neoplasms, Advanced Solid Tumors, Carcinoma, Hepatocellular, and Malignant Pleural Mesothelioma.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
ASN120290 DB16988
small molecule

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
ASP-3026 DB12729
small molecule | CAS: 1097917-15-1

ASP3026 has been used in trials studying the treatment of Solid Tumor, B-Cell Lymphoma, Advanced Malignancies, Positive for Anaplastic Lymphoma Kinase, and Positive for Proto-Oncogene Tyrosine-Protein Kinase ROS.

Kategori:
Sulfur Compounds
Target Protein:
ALK tyrosine kinase receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Aspartic acid Approved DB00128
small molecule | CAS: 56-84-8

One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.

Kategori:
Amino AcidsAmino Acids, AcidicAmino Acids, Dicarboxylic +5
Target Protein:
Glutamate receptor ionotropic, NMDA 2AGlutamate receptor ionotropic, NMDA 2BGlutamate receptor ionotropic, NMDA 1 +18
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
AstraZeneca COVID-19 Vaccine Approved DB15656
biotech | CAS: 2420395-83-9

The AstraZeneca COVID-19 Vaccine (previously known as ChAdOx1 nCoV-19 or AZD1222) is one of several vaccines developed in 2020 for the prevention of COVID-19 caused by SARS-CoV-2.[L12669,L32649] The ChAdOx1 viral vector was developed at the University of Oxfo…

Kategori:
Biological ProductsComplex MixturesCOVID-19 Vaccines +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Asundexian DB19088
small molecule | CAS: 2064121-65-7

Asundexian is under investigation in clinical trial NCT05686070 (A Study to Test Asundexian for Preventing a Stroke Caused by a Clot in Participants After an Acute Ischemic Stroke or After a High-risk Transient Ischemic Attack, a So-called Mini Stroke).

Kategori:
Acids, CarbocyclicAmidesBenzene Derivatives +2
Target Protein:
Coagulation factor XI
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
AT-001 DB15121
small molecule | CAS: 1355612-71-3

AT-001 is under investigation in clinical trial NCT03062384 (AT-001 for Long-term Preservation of Brain Health in Aging).

Kategori:
Heterocyclic Compounds, Fused-RingPyridinesThiazoles
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
AT1391 DB05120
small molecule

AT1391 is a daily insulin skin patch designed to provide continuous basal levels of insulin for patients with diabetes.

Target Protein:
Insulin receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Atabecestat DB15307
small molecule | CAS: 1200493-78-2

Atabecestat is under investigation in clinical trial NCT02211079 (A Study to Assess Effect of JNJ-54861911 on Pharmacokinetics of Cocktail Representatives for Cytochrome P450 (CYP) 3A4, CYP2B6, CYP2C9, and CYP1A2 Substrates).

Kategori:
Sulfur Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ataciguat DB12805
small molecule | CAS: 254877-67-3

Ataciguat has been investigated for the basic science of Aortic Valve Stenosis.

Kategori:
Acids, CarbocyclicAmidesAminobenzoates +5
Target Protein:
Atrial natriuretic peptide receptor 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Atagabalin DB12032
small molecule | CAS: 223445-75-8

Atagabalin has been used in trials studying the treatment of Insomnia, Primary Insomnia, and Nonrestorative Sleep.

Kategori:
Acids, AcyclicCycloparaffinsFatty Acids +2
Target Protein:
Voltage-dependent calcium channel subunit alpha-2/delta-1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Atamestane DB12194
small molecule | CAS: 96301-34-7

Atamestane has been used in trials studying the treatment of Breast Cancer, Breast Neoplasms, and Neoplasms, Hormone-Dependent.

Kategori:
17-KetosteroidsAdrenal Cortex HormonesAndrostanes +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Atamparib DB19028
small molecule | CAS: 2381037-82-5

Atamparib is under investigation in clinical trial NCT05127590 (RBN-2397 in Combination With Pembrolizumab in Patients With SCCL).

Target Protein:
Protein mono-ADP-ribosyltransferase TIPARP
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
ATB-346 DB15377
small molecule | CAS: 1226895-20-0

ATB-346 is under investigation in clinical trial NCT03220633 (Study To Assess Safety, Tolerability And PK Of ATB-346 In Healthy Subjects).

Kategori:
Naphthaleneacetic AcidsNaphthalenes
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 433937-93-0

Atecegatran metoxil has been used in trials studying the basic science and prevention of Nonvalvular Atrial Fibrillation, Persistent or Permanent Nonvalvular Atrial Fibrillation, and Persistent or Permanent Non-valvular Atrial Fibrillation.

Kategori:
Azetines
Target Protein:
Prothrombin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Atenolol Approved DB00335
small molecule | CAS: 29122-68-7

Atenolol is a cardioselective beta-blocker used in a variety of cardiovascular conditions. Sir James Black, a Scottish pharmacologist, pioneered the use of beta-blockers for the management of angina pectoris in 1958 for which he received the Nobel Prize.[…

Kategori:
Adrenergic AgentsAdrenergic AntagonistsAdrenergic beta-1 Receptor Antagonists +23
Target Protein:
Beta-1 adrenergic receptorBeta-2 adrenergic receptor
Gen Terkait:
ADRB1
Waktu Paruh6-7 hrs.[label]
Vol. DistribusiTotal Vd of 63.8-11…
KlirensTotal clearance is …
Genetik 1 Varian
Atevirdine DB12264
small molecule | CAS: 136816-75-6

Atevirdine has been used in trials studying the treatment of HIV Infections.

Kategori:
Anti-Infective AgentsAnti-Retroviral AgentsAntiviral Agents +3
Target Protein:
Gag-Pol polyprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Aticaprant DB12341
small molecule | CAS: 1174130-61-0

Aticaprant has been used in trials studying the health services research and basic science of Anxiety Disorders and Alcohol Dependence.

Kategori:
Acids, CarbocyclicAmidesBenzene Derivatives +5
Target Protein:
Kappa-type opioid receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Atiprimod DB05513
small molecule | CAS: 123018-47-3

Deskripsi belum tersedia.

Target Protein:
Signal transducer and activator of transcription 3Interleukin-6Tumor necrosis factor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Atisnolerbart DB19418
biotech | CAS: 2456308-79-3

Atisnolerbart is under investigation in clinical trial NCT06602739 (A Study to Demonstrate the Effect of REGN5713-5715 on Reducing Ocular Allergy Signs and Symptoms in Adult Participants With Birch Pollen Allergy).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Atomoxetine Approved DB00289
small molecule | CAS: 83015-26-3

Atomoxetine is a selective norepinephrine (NE) reuptake inhibitor used for the treatment of attention deficit hyperactivity disorder (ADHD). Also known as the marketed product Strattera, atomoxetine is used with other treatment modalities (psychological, educ…

Kategori:
Adrenergic AgentsAgents producing tachycardiaAgents that produce hypertension +17
Target Protein:
Sodium-dependent noradrenaline transporterSodium-dependent serotonin transporterNMDA receptor +2
Gen Terkait:
CYP2D6 CYP2D6 CYP2D6 +3
Waktu ParuhThe reported half-l…
Vol. DistribusiThe reported volume…
KlirensThe clearance rate …
Genetik 6 Varian
Atopaxar DB12046
small molecule | CAS: 751475-53-3

Atopaxar has been investigated for the treatment of Coronary Artery Disease and Acute Coronary Syndrome.

Kategori:
Receptors, Thrombin, antagonists & inhibitors
Target Protein:
Proteinase-activated receptor 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Atractylodes japonica root Approved DB11261
small molecule

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Atractylodes japonica root oil is obtained from the roots of Atractylodes japonica, which is a herb native to eastern Asia. It is present in some cosmetic products such as whitening creams as an active ingredient and lubricant for skin irritation. Atractylode…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Atrazine DB07392
small molecule | CAS: 1912-24-9

Atrazine is a selective triazine herbicide. Inhalation hazard is low and there are no apparent skin manifestations or other toxicity in humans. Acutely poisoned sheep and cattle may show muscular spasms, fasciculations, stiff gait, increased respiratory rates…

Kategori:
AgrochemicalsCompounds used in a research, industrial, or household settingHerbicides +3
Target Protein:
Photosynthetic reaction center cytochrome c subunitReaction center protein H chainReaction center protein L chain +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Atreleuton DB12758
small molecule | CAS: 154355-76-7

Atreleuton has been used in trials studying the treatment of Atherosclerosis and Coronary Artery Disease.

Kategori:
AmidesEnzyme InhibitorsLipoxygenase Inhibitors
Target Protein:
Polyunsaturated fatty acid 5-lipoxygenase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Attapulgite Approved DB01574
small molecule | CAS: 12174-11-7

Attapulgite is a magnesium aluminium phyllosilicate which occurs in a type of clay soil common to the Southeastern United States. When used in medicine, it physically binds to acids and toxic substances in the stomach and digestive tract. For that reason, it …

Kategori:
Alimentary Tract and MetabolismAntidiarrheals, Intestinal Antiinflammatory/antiinfective AgentsAntidotes +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
ATU-027 DB12171
biotech | CAS: 1415935-22-6

Atu027 has been used in trials studying the treatment of Advanced Solid Tumors.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Atuliflapon DB19029
small molecule | CAS: 2041075-86-7

Atuliflapon is under investigation in clinical trial NCT05251259 (Study to Assess the Efficacy and Safety of Atuliflapon in Moderate-to-severe Uncontrolled Asthma).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
ATX-914 DB12673
small molecule

Axt914 is under investigation in clinical trial NCT00417261 (Safety, Tolerability, Pharmacodynamic and Pharmacokinetic Effects of Single and Multiple-Doses of ATF936 and AXT914 Administered Orally in Healthy Subjects.).

Kategori:
Heterocyclic Compounds, Fused-RingQuinazolines
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
ATX-F8-117 DB17712
biotech

ATX-F8-117 is an investigational peptide derived from Factor VIII. Developed by Apitope, it is being investigated for the treatment of hemophilia A.[L46163]

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
AUM-302 DB18114
small molecule | CAS: 1414455-21-2

Deskripsi belum tersedia.

Kategori:
Enzyme InhibitorsProtein Kinase InhibitorsSulfur Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
AUNP-12 DB15771
biotech | CAS: 1353563-85-5

Deskripsi belum tersedia.

Kategori:
Immune Checkpoint Inhibitors
Target Protein:
Programmed cell death 1 ligand 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Auriclosene DB12197
small molecule | CAS: 846056-87-9

Auriclosene has been used in trials studying the treatment of Impetigo, Bacterial Conjunctivitis, Asymptomatic Bacteriuria, and Adenoviral Conjunctivitis.

Kategori:
AlkanesAlkanesulfonic AcidsHydrocarbons, Acyclic +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Aurodox DB04124
small molecule | CAS: 12704-90-4

Aurodox is an antibiotic obtained from a streptomyces variant considered as possibly effective against streptococcus pyogenes infections. It may promote growth in poultry.

Kategori:
AlkenesAnti-Bacterial AgentsAnti-Infective Agents +2
Target Protein:
Elongation factor Tu-B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Aurothioglucose Approved DB09121
small molecule | CAS: 12192-57-3

Aurothioglucose, also known as gold thioglucose, was formerly used to treat rheumatoid arthritis. Contemporary research on the effect of gold salts treatment began in 1935, primarily to reduce inflammation and to slow disease progression in patients with r…

Kategori:
Antiinflammatory and Antirheumatic ProductsAntirheumatic AgentsDrugs that are Mainly Renally Excreted +5
Target Protein:
Adenylate cyclase type 1Adenylate cyclase type 2Adenylate cyclase type 5
Waktu ParuhThe biological half…
Vol. DistribusiReadily accessible …
KlirensWhen a standard wee…
Genetik -
AUY922 DB11881
small molecule | CAS: 747412-64-2

AUY922 has been used in trials studying the treatment of Lymphoma, Breast Cancer, Metastatic Disease, Advanced Solid Tumors, and Hematologic Neoplasms, among others.

Kategori:
Benzene DerivativesHSP90 Heat-Shock Proteins, antagonists & inhibitorsPhenols
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
AV-0113 DB18386
biotech

AV-0113 consists of IL-12 secreting dendritic cells loaded with autologous tumor lysate.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
AV-101 DB12878
small molecule | CAS: 153152-32-0

AV-101 has been used in trials studying the treatment of Neuropathic Pain.

Kategori:
Amino AcidsAmino Acids, Peptides, and ProteinsSweetening Agents
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
AV-412 DB06021
small molecule | CAS: 451493-31-5

Deskripsi belum tersedia.

Kategori:
Antineoplastic AgentsEnzyme InhibitorsHeterocyclic Compounds, Fused-Ring +2
Target Protein:
Epidermal growth factor receptorReceptor tyrosine-protein kinase erbB-2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
AVA-6000 DB17398
small molecule | CAS: 1841402-73-0

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Avadomide DB14857
small molecule | CAS: 1015474-32-4

Avadomide is under investigation in clinical trial NCT02031419 (Novel Combinations of CC-122, CC-223, CC-292, and Rituximab in Diffuse Large B-cell Lymphoma and Follicular Lymphoma).

Kategori:
Heterocyclic Compounds, Fused-RingPiperidinesQuinazolines
Target Protein:
Protein cereblon
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Avanafil Approved DB06237
small molecule | CAS: 330784-47-9

Avanafil is a phosphodiesterase-5 (PDE5) inhibitor used in the treatment of erectile dysfunction. In comparison with other drugs of the same class, it shows greater selectivity for PDE5 over PDE6 than both [sildenafil] and [vardenafil] but less selectivity th…

Kategori:
BCRP/ABCG2 InhibitorsCytochrome P-450 CYP2C9 SubstratesCytochrome P-450 CYP3A Substrates +9
Target Protein:
cGMP-specific 3',5'-cyclic phosphodiesterase
Waktu ParuhStudies have demons…
Vol. DistribusiThe apparent volume…
Klirens-
Genetik -
Menampilkan 351–400 dari 3253
Sebelumnya Halaman 8 / 66 Berikutnya