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11793

Total database: 17430
Struktur (SMILES)
8607 (73.0%)
Target
6418 (54.4%)
Genomik
102 (0.9%)
Referensi
11793 (100.0%)

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Hasil Pencarian (11793)

Halaman 78 / 236
Cyclosporine Approved DB00091
small molecule | CAS: 59865-13-3

Cyclosporine is a calcineurin inhibitor known for its immunomodulatory properties that prevent organ transplant rejection and treat various inflammatory and autoimmune conditions. It is isolated from the fungus _Beauveria nivea_.[A174049] Initially manufactur…

Kategori:
Agents causing hyperkalemiaAgents Causing Muscle ToxicityAgents that produce hypertension +45
Target Protein:
Guided entry of tail-anchored proteins factor CAMLGProtein phosphatase 3 catalytic subunit alphaCalcineurin subunit B type 2 +2
Waktu ParuhThe half-life of cy…
Vol. DistribusiThe distribution of…
KlirensCyclosporin shows a…
Genetik -
small molecule | CAS: 129033-04-1

Cyclotheonamide A is a cyclic peptide isolated from the marine sponge Theonella.

Kategori:
Amino Acids, Peptides, and ProteinsPeptidesThrombin, antagonists & inhibitors
Target Protein:
Serine protease 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cyclothiazide Approved DB00606
small molecule | CAS: 2259-96-3

As a diuretic, cyclothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like cyclothiazide also inhibit sodium ion transport…

Kategori:
Antihypertensive AgentsCardiovascular AgentsDiuretics +11
Target Protein:
Sodium/potassium-transporting ATPase subunit gammaCarbonic anhydraseCarbonic anhydrase 2 +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cyclouridine DB04627
small molecule | CAS: 3736-77-4

Deskripsi belum tersedia.

Kategori:
Nucleic Acids, Nucleotides, and NucleosidesNucleosidesPyrimidine Nucleosides +2
Target Protein:
Uridine phosphorylase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cyfluthrin DB13828
small molecule | CAS: 68359-37-5

Deskripsi belum tersedia.

Kategori:
AgrochemicalsAntiparasitic Products, Insecticides and RepellentsCompounds used in a research, industrial, or household setting +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CYNK-001 DB15722
biotech

CYNK-001 is a novel allogenic off-the-shelf natural killer (NK) cell therapy originating from human placental CD34+ hematopoietic stem cells and enriched with CD56+/CD3-.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CYNK-101 DB18637
biotech

CYNK-101 is an allogeneic human placental hematopoietic stem cell-derived natural killer (NK) cell therapy product that is genetically modified to express a variant of CD16 (CD16VP).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cyprenorphine DB01480
small molecule | CAS: 4406-22-8

Deskripsi belum tersedia.

Kategori:
AlkaloidsHeterocyclic Compounds, Fused-RingOpiate Alkaloids +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cysteamine Approved DB00847
small molecule | CAS: 60-23-1

Cystinosis is a rare disease caused by mutations in the CTNS gene that encodes for cystinosin, a protein responsible for transporting cystine out of the cell lysosome. A defect in cystinosin function is followed by cystine accumulation throughout the body, es…

Kategori:
Alimentary Tract and MetabolismAminesAmino Acids and Derivatives +11
Target Protein:
SomatostatinCystineNeuropeptide Y receptor type 2
Waktu ParuhThe half-life of cy…
Vol. DistribusiCysteamine has a vo…
KlirensThe plasma clearanc…
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Gag-Pol polyproteinProteinase inhibitor I4, serpin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 17528-66-4

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, NeutralAmino Acids, Peptides, and Proteins +3
Target Protein:
Ribonuclease pancreatic2'-5'-oligoadenylate synthase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Cystic fibrosis transmembrane conductance regulator is under investigation in clinical trial NCT00004806 (Phase I Study of Liposome-Mediated Gene Transfer in Patients With Cystic Fibrosis).

Kategori:
Amino Acids, Peptides, and ProteinsAnion Transport ProteinsATP-Binding Cassette Transporters +12
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cystine Approved DB00138
small molecule | CAS: 56-89-3

A covalently linked dimeric nonessential amino acid formed by the oxidation of cysteine. Two molecules of cysteine are joined together by a disulfide bridge to form cystine.

Kategori:
Amino AcidsAmino Acids, DiaminoAmino Acids, Dicarboxylic +12
Target Protein:
Cystine/glutamate transporterCystinosin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CYT-6091 DB05991
small molecule

CYT-6091 (Aurimune) is an investigational small molecule made up of recombinant human tumor necrosis factor alpha (rhTNF) and thiolyated polyethylene glycol bound to the surface of 27 nm colloidal gold particles. It was under investagtion in clinical trials N…

Kategori:
AlcoholsCompounds used in a research, industrial, or household settingElements +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CYT006-AngQb DB05739
biotech

CYT006-AngQb is a therapeutic vaccine in development for treatment of hypertension. It is designed to instruct the patient’s immune system to produce an antibody response against angiotensin II, a small peptide that causes blood vessels to narrow and results…

Kategori:
Amino Acids, Peptides, and ProteinsPeptides
Target Protein:
Type-1 angiotensin II receptorType-2 angiotensin II receptor
Waktu Paruh4 months
Vol. Distribusi-
Klirens-
Genetik -
Cytidine DB02097
small molecule | CAS: 65-46-3

Deskripsi belum tersedia.

Kategori:
Nucleic Acids, Nucleotides, and NucleosidesNucleosidesPyrimidine Nucleosides +2
Target Protein:
Uridine-cytidine kinase 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 84-52-6

Deskripsi belum tersedia.

Kategori:
Cytosine NucleotidesNucleic Acids, Nucleotides, and NucleosidesNucleotides +3
Target Protein:
Ribonuclease pancreatic
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 63-38-7

Cytidine 5'-(trihydrogen diphosphate). A cytosine nucleotide containing two phosphate groups esterified to the sugar moiety. Synonyms: CRPP; cytidine pyrophosphate. [PubChem]

Target Protein:
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase3-deoxy-manno-octulosonate cytidylyltransferase2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
CDP-glucose 4,6-dehydratase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 63-37-6

A pyrimidine ribonucleoside 5'-monophosphate having cytosine as the nucleobase.

Kategori:
Cytosine NucleotidesNucleic Acids, Nucleotides, and NucleosidesNucleotides +3
Target Protein:
Uridine-cytidine kinase 23-deoxy-manno-octulosonate cytidylyltransferase2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 65-47-4

Cytidine 5'-(tetrahydrogen triphosphate). A cytosine nucleotide containing three phosphate groups esterified to the sugar moiety. [PubChem]

Target Protein:
P2Y purinoceptor 43-deoxy-manno-octulosonate cytidylyltransferaseUridine-cytidine kinase 2 +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cytisine DB09028
small molecule | CAS: 485-35-8

Cytisine is an alkaloid naturally derived from the Fabaceae family of plants including the genera Laburnum and Cytisus. Recent studies have shown it to be a more effective and significantly more affordable smoking cessation treatment than nicotine replacement…

Kategori:
AlkaloidsDrugs Used in Addictive DisordersDrugs Used in Nicotine Dependence +5
Target Protein:
Neuronal acetylcholine receptor subunit alpha-2Neuronal acetylcholine receptor subunit beta-4Neuronal acetylcholine receptor subunit alpha-4 +4
Waktu Paruh4.8 hours.
Vol. DistribusiOral: 6.2 l/kg Oral…
KlirensRenal: 43 mL/min.
Genetik -
Cytochalasin B DB16766
small molecule | CAS: 14930-96-2

Deskripsi belum tersedia.

Kategori:
Biological FactorsCytochalasinsHeterocyclic Compounds, Fused-Ring +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cytochlor DB12383
small molecule | CAS: 32387-56-7

Cytochlor has been used in trials studying the treatment of Head and Neck Cancer and Brain and Central Nervous System Tumors.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cytochrome C DB18543
biotech | CAS: 9007-43-6

Cytochrome C is a hemeprotein that plays a role in the mitochondrial electron-transport chain.

Kategori:
Amino Acids, Peptides, and ProteinsCytochrome c GroupCytochromes +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CZEN 002 DB05479
small molecule

CZEN-002 is a novel, non-azole anti-fungal synthetic octapeptide, derived from alpha-Melanocyte-Stimulating Hormone (a-MSH). CZEN-002 modulates inflammatory and immune responses. It has also been shown to kill Candida albicans (C. albicans), a single-celled f…

Target Protein:
Melanocyte-stimulating hormone receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Chymotrypsinogen B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Chymotrypsinogen B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-157495 DB16938
small molecule | CAS: 1005504-62-0

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
m7GpppX diphosphatase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-3082-L DB17440
biotech | CAS: 2170657-73-3

D-3082-L is one of the components of the human papilloma virus (HPV) type 16 E6/E7 synthetic long peptide (SLP) vaccine ISA101b.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-Alanine DB01786
small molecule | CAS: 338-69-2

The D-enantiomer of alanine.

Target Protein:
ThermolysinD-alanyl-D-alanine carboxypeptidase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-alpha-Tocopherol acetate Approved DB14002
small molecule | CAS: 58-95-7

Alpha-tocopherol is the primary form of vitamin E that is preferentially used by the human body to meet appropriate dietary requirements. In particular, the RRR-alpha-tocopherol (or sometimes called the d-alpha-tocopherol stereoisomer) stereoisomer is conside…

Kategori:
AntioxidantsBenzopyransBiological Factors +12
Target Protein:
SEC14-like protein 3SEC14-like protein 2Nuclear receptor subfamily 1 group I member 2 +3
Waktu Paruh_In addition to any…
Vol. Distribusi_In addition to any…
Klirens_In addition to any…
Genetik -
D-arginine DB04027
small molecule | CAS: 157-06-2

A D-?-amino acid that is the D-isomer of arginine (only the L-form is physiologically active).

Target Protein:
Creatine kinase M-type
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-Aspartic Acid DB02655
small molecule | CAS: 1783-96-6

The D-isomer of aspartic acid. [PubChem]

Kategori:
Amino AcidsAmino Acids, AcidicAmino Acids, Dicarboxylic +1
Target Protein:
Glutamate receptor ionotropic, NMDA 2BGlutamate receptor ionotropic, NMDA 2AGlutamate receptor ionotropic, NMDA 1 +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-Borneol DB17066
small molecule | CAS: 464-43-7

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 643-12-9

D-chiro-Inositol is under investigation in clinical trial NCT03201601 (Evaluation of the Mixture Myoinositol:D-chiro-inositol 3.6:1 in Women With Polycystic Ovary Syndrome).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-Eritadenine DB03769
small molecule | CAS: 23918-98-1

Deskripsi belum tersedia.

Kategori:
Enzyme InhibitorsHeterocyclic Compounds, Fused-RingPurines
Target Protein:
Adenosylhomocysteinase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 870452-26-9

D-fluoromethyltyrosine F-18 is under investigation in clinical trial NCT01089998 (PET/CT Imaging for Radiation Dosimetry, Plasma Pharmacokinetics, Safety and Tolerability in Healthy Volunteers and Safety, Tolerability and Diagnostic Performance of BAY86-9596 …

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 20479-58-7

Deskripsi belum tersedia.

Kategori:
CarbohydratesSugar Phosphates
Target Protein:
Glucose-6-phosphate isomerase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Lactase/phlorizin hydrolase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-glucose Approved DB01914
small molecule | CAS: 50-99-7

Glucose is a simple sugar (monosaccharide) generated during phosynthesis involving water, carbon and sunlight in plants. It is produced in humans via hepatic gluconeogenesis and breakdown of polymeric glucose forms (glycogenolysis). It circulates in human cir…

Kategori:
CarbohydratesCompounds used in a research, industrial, or household settingDiet, Food, and Nutrition +11
Waktu ParuhThe approximate hal…
Vol. DistribusiThe mean volume of …
KlirensThe mean metabolic …
Genetik -
D-Glutamic Acid DB02517
small molecule | CAS: 6893-26-1

Glutamic acid is the most common excitatory neurotransmitter in the central nervous system.

Target Protein:
Thermolysin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 453-17-8

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 591-57-1

An aldotriose which is an important intermediate in glycolysis and in tryptophan biosynthesis.

Target Protein:
Glyceraldehyde-3-phosphate dehydrogenase AGlyceraldehyde-3-phosphate dehydrogenaseNADP-dependent glyceraldehyde-3-phosphate dehydrogenase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-JNKI-1 DB05660
small molecule | CAS: 1198367-70-2

A synthetic, cell permeable peptide that blocks the MAPK-JNK signal pathway; has potential therapeutic value for long-term protection of both the morphological integrity and physiological function of the organ of Corti during times of oxidative stress.

Kategori:
Amino Acids, Peptides, and ProteinsNeuroprotective Agents
Target Protein:
Mitogen-activated protein kinase 8Mitogen-activated protein kinase 9Mitogen-activated protein kinase 10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-Lactic acid DB03066
small molecule | CAS: 10326-41-7

A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)

Kategori:
Hydroxy AcidsLactates
Target Protein:
(S)-2-haloacid dehalogenase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
D-Leucine DB01746
small molecule | CAS: 328-38-1

An essential branched-chain amino acid important for hemoglobin formation. [PubChem]

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Prothrombin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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