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11793

Total database: 17430
Struktur (SMILES)
8607 (73.0%)
Target
6418 (54.4%)
Genomik
102 (0.9%)
Referensi
11793 (100.0%)

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Hasil Pencarian (11793)

Halaman 76 / 236
CRA_9076 DB04215
small molecule

Deskripsi belum tersedia.

Target Protein:
Serine protease 1
Waktu Paruh-
Vol. Distribusi-
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Genetik -
CRA_9678 DB04563
small molecule

Deskripsi belum tersedia.

Target Protein:
Serine protease 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Creatinine DB11846
small molecule | CAS: 60-27-5

Creatinine has been used in trials studying the treatment of Amyotrophic Lateral Sclerosis.

Kategori:
Imidazoles
Waktu Paruh-
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Genetik -
small molecule | CAS: 6903-79-3

COP is under investigation for the treatment of Rheumatoid Arthritis, Mature B-Cell Lymphoma, and Noninflammatory Degenerative Joint Disease. COP has been investigated for the treatment of Diabetic Retinopathy.

Kategori:
Cardiac Therapy
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Crefmirlimab DB17577
biotech | CAS: 2611099-93-3

Crefmirlimab is an anti-human CD8 probe targeting the CD8 antigen, for the diagnosis of various cancers.

Waktu Paruh-
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Crenolanib DB11832
small molecule | CAS: 670220-88-9

Crenolanib is under investigation for the treatment of Diffuse Intrinsic Pontine Glioma and Progressive or Refractory High-Grade Glioma.

Kategori:
Antineoplastic AgentsHeterocyclic Compounds, Fused-RingReceptor, Platelet-Derived Growth Factor alpha, antagonists & inhibitors +2
Target Protein:
Platelet-derived growth factor receptor alphaProto-oncogene tyrosine-protein kinase Src
Waktu Paruh-
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Genetik -
Cridanimod DB13674
small molecule | CAS: 38609-97-1

Deskripsi belum tersedia.

Kategori:
Adjuvants, ImmunologicAntineoplastic and Immunomodulating AgentsHeterocyclic Compounds, Fused-Ring +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Crisaborole Approved DB05219
small molecule | CAS: 906673-24-3

Crisaborole is a novel oxaborole approved by FDA on December 14, 2016 as Eucrisa, a topical treatment of for mild to moderate atopic dermatitis. This non-steroidal agent is efficacious in improving disease severity, reducing the risk of infection and reduci…

Kategori:
Agents for Dermatitis, Excluding CorticosteroidsAnti-Inflammatory AgentsCytochrome P-450 CYP2B6 Inhibitors +9
Target Protein:
3',5'-cyclic-AMP phosphodiesterase 4A3',5'-cyclic-AMP phosphodiesterase 4B3',5'-cyclic-AMP phosphodiesterase 4C +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Crisdesalazine DB18405
small molecule | CAS: 927685-43-6

Deskripsi belum tersedia.

Kategori:
Anti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalBenzene Derivatives +3
Target Protein:
Prostaglandin E synthase
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Crisugabalin DB19300
small molecule | CAS: 2209104-84-5

Crisugabalin is under investigation in clinical trial NCT06490484 (Efficacy and Safety of HSK16149 Capsule in Chinese Patients With Diabetic Peripheral Neuropathic Pain Who Had an Inadequate Response to Pregabalin).

Waktu Paruh-
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Crizanlizumab Approved DB15271
biotech | CAS: 1690318-25-2

Crizanlizumab is a humanized IgG2 monoclonal antibody used to reduce the frequency of vaso-occlusive crises in patients with sickle cell disease.[L10097] Sickle cell disease is a genetically inherited condition prevalent in the Middle East, Africa, and certai…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +10
Target Protein:
P-selectin
Waktu ParuhGiven a 5mg/kg dose…
Vol. DistribusiThe volume of distr…
KlirensGiven a 5mg/kg dose…
Genetik -
Crizotinib Approved DB08865
small molecule | CAS: 877399-52-5

Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibrobl…

Kategori:
AminopyridinesAnaplastic lymphoma kinase (ALK) inhibitorsAntineoplastic Agents +32
Target Protein:
ALK tyrosine kinase receptorHepatocyte growth factor receptorProto-oncogene tyrosine-protein kinase ROS +1
Waktu ParuhFollowing single do…
Vol. DistribusiFollowing a single …
KlirensAt steady-state (25…
Genetik -
Crocin DB11874
small molecule | CAS: 42553-65-1

Crocin has been investigated for the treatment of Hyperglycemia, Metabolic Syndrome, Hypertriglyceridemia, and Hypercholesterolemia.

Kategori:
AlkenesBiological FactorsCondiments +7
Waktu Paruh-
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Crofelemer Approved DB04941
small molecule | CAS: 148465-45-6

Crofelemer, previously known as the investigational drug SP-303, is a novel proanthocyanidin purified from the bark latex of the Amazonian Croton tree <i>Croton lechleri</i>. It is marketed under the brand name Fulyzaq and indicated for the symptomatic treatm…

Kategori:
Alimentary Tract and MetabolismAntidiarrhealsAntidiarrheals, Intestinal Antiinflammatory/antiinfective Agents +11
Target Protein:
Anoctamin-1Cystic fibrosis transmembrane conductance regulator
Waktu ParuhSince crofelemer is…
Vol. DistribusiSince crofelemer is…
KlirensSince crofelemer is…
Genetik -
Cromoglicic acid Approved DB01003
small molecule | CAS: 16110-51-3

A chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack.

Kategori:
Adrenergics, InhalantsAgents for Dermatitis, Excluding CorticosteroidsAlimentary Tract and Metabolism +24
Target Protein:
Heat shock protein HSP 90-alphaProtein S100-P
Waktu Paruh1.3 hours
Vol. Distribusi-
Klirens-
Genetik -
biotech

Each year it is estimated there are 45,000 snakebites in the US and 300,000 to 400,000 bites worldwide. About 8000 of these snakebites involve venomous snake species. The majority of people bitten are males and about 50% occur in the age group of 18 to 28 [F1…

Kategori:
AntiveninsPassively Acquired ImmunityVenom Neutralization
Target Protein:
Group 10 secretory phospholipase A2
Waktu Paruh12 to 23 hours [FDA…
Vol. Distribusi-
KlirensThis product was sh…
Genetik -
biotech

Crotalus scutulatus antivenin is derived and purified immunoglobulin fragments obtained from other domestic animals such as sheep previously immunized with Crotalus scutulatus (also known as the _Mojave rattlesnake_ [L2856]). The final purified antivenin …

Kategori:
AntiveninsPassively Acquired ImmunityVenom Neutralization
Waktu ParuhApproximately 15 ho…
Vol. Distribusi0.3 L/kg [FDA label]
Klirens32 mL/min (approxim…
Genetik -
Crotamiton Approved DB00265
small molecule | CAS: 483-63-6

Crotamiton is a scabicidal and antipruritic agent available as a cream or lotion for topical use only. It is a colorless to slightly yellowish oil, having a faint amine-like odor. It is miscible with alcohol and with methanol.

Kategori:
AgrochemicalsAminesAniline Compounds +6
Target Protein:
Transient receptor potential cation channel subfamily V member 4
Waktu Paruh-
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Crotedumab DB12815
biotech | CAS: 1452387-69-7

Crotedumab has been used in trials studying the treatment of Diabetes Mellitus, Type 2.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
Waktu Paruh-
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Crovalimab Approved DB16128
biotech | CAS: 1917321-26-6

Crovalimab is a humanized monoclonal antibody and complement C5 inhibitor.[L50908] It consists of two heavy chains (451 amino acid residues each) and two light chains (217 amino acid residues each).[L50908] First developed by Chugai Pharmaceutical, in collabo…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodies, MonoclonalAntineoplastic and Immunomodulating Agents +7
Target Protein:
Complement C5
Waktu ParuhThe mean estimated …
Vol. DistribusiThe mean central an…
KlirensIn PNH treatment-na…
Genetik -
CRS-3123 DB12262
small molecule | CAS: 1013915-71-3

CRS3123 has been used in trials studying the treatment of Clostridial Infection and Clostridium Difficile Colitis.

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsHeterocyclic Compounds, Fused-Ring +3
Waktu Paruh-
Vol. Distribusi-
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Genetik -
CRx-119 DB05688
small molecule

CRx-119 is a novel synergistic combination drug candidate discovered using the CombinatoRx combination High Throughput Screening (cHTS(TM)) technology with potential therapeutic use in a broad range of immuno-inflammatory conditions. CRx-119 is a combination …

Target Protein:
Sodium-dependent serotonin transporterSodium-dependent noradrenaline transporter
Waktu Paruh-
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Cryptenamine Approved DB00785
small molecule | CAS: 1356-18-9

Cryptenamine is a mixture of closely related hypotensive alkaloids from Veratrum album (Liliaceae). It has been used in the treatment of hypertension but has largely been replaced by drugs with fewer adverse effects. Cryptenamine has a marked and re-producibl…

Kategori:
AlkaloidsAntihypertensive AgentsCardiovascular Agents +3
Target Protein:
Muscarinic acetylcholine receptor M2Beta adrenergic receptor
Waktu Paruh-
Vol. Distribusi-
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Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
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CSL-689 DB17726
biotech

CSL689 is a recombinant fusion protein linking coagulation factor VIIa with albumin (rVIIa-FP).

Waktu Paruh-
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CSL324 DB16359
biotech

CSL324 is a fully human anti-G-CSFR antibody shown to have the ability to control G-CSF-mediated neutrophilia in cynomolgus macaques.[A225626] It has potential applications in various inflammatory conditions such as cystic fibrosis, inflammatory bowel disease…

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CT-001 DB18284
biotech

Deskripsi belum tersedia.

Waktu Paruh-
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Genetik -
CT-011 DB05916
biotech

CT-011 is a humanized monoclonal antibody directed against a B7 family-associated protein, in patients with advanced haematological malignancies. It is directed against human PD-1 (programmed cell death 1; PDCD1), with immunomodulating and antitumor activitie…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntineoplastic Agents +7
Target Protein:
Programmed cell death protein 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CT-179 DB17114
small molecule | CAS: 1996636-69-1

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
CT-2584 DB13098
small molecule | CAS: 166981-13-1

CT-2584 has been used in trials studying the treatment of Prostate Cancer.

Kategori:
AlkaloidsHeterocyclic Compounds, Fused-RingPhospholipase D, antagonists & inhibitors +2
Target Protein:
Choline-phosphate cytidylyltransferase B
Waktu Paruh-
Vol. Distribusi-
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Genetik -
CTB001 DB18316
biotech

CTB001 is an anti-claudin 18.2 autologous chimeric antigen receptor (CAR) T-cell therapy under investigation for the treatment of gastric cancers.[L48146]

Kategori:
Amino Acids, Peptides, and ProteinsAnticoagulantsAntithrombin Proteins +8
Waktu Paruh-
Vol. Distribusi-
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CTCE-0214 DB05934
small molecule | CAS: 577782-52-6

CTCE-0214 is a stable peptide agonist of stromal cell-derived factor-1 (SDF-1), a key signaling molecule in the proliferation, homing, engraftment and expansion of hematopoietic stem cells and white blood cells.

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Inflammatory AgentsBiological Factors +8
Target Protein:
Stromal cell-derived factor 1
Waktu Paruh-
Vol. Distribusi-
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Genetik -
CTCE-9908 DB05625
small molecule | CAS: 1030384-98-5

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and Proteins
Target Protein:
C-X-C chemokine receptor type 4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ctenocephalides canis Approved DB10690
biotech

Dog flea allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
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Ctenocephalides felis Approved DB10693
biotech

Cat flea allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
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Genetik -
CTI-1601 DB17010
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CTS-21166 DB06073
small molecule

CTS-21166 is a small-molecule beta-secretase inhibitor, which is being developed as a disease-modifying treatment for Alzheimer's disease. CTS-21166 is the only BACE1 inhibitor that has passed Phase I clinical trial thus far. In 2008, CoMentis revealed this s…

Target Protein:
Beta-secretase 1
Waktu Paruh-
Vol. Distribusi-
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CTT-1057 DB14965
small molecule | CAS: 1628717-55-4

CTT-1057 is under investigation in clinical trial NCT03427476 (CTT1057, a Small Molecular Inhibitor of PSMA, as a Novel Imaging Agent of Neovascularization in Renal Cell Carcinoma).

Waktu Paruh-
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CTx-PDE6b DB17858
biotech

CTx-PDE6b is an adeno-associated virus (AAV) based gene therapy designed to deliver a full-length non-mutated copy of the functional human _PDE6b_ gene. Being commercialied by Coave Therapeutics, it is being investigated for the treatment of retinitis pigment…

Waktu Paruh-
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CTX110 DB18626
biotech

CTX110 is an allogeneic CRISPR/Cas9-mediated genetically modified CAR T cell therapy targeting CD19 antigen.

Waktu Paruh-
Vol. Distribusi-
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CTX120 DB18625
biotech

CTX120 is an allogeneic CRISPR/Cas9-mediated genetically modified CAR T cell therapy targeting B-cell maturation antigen.

Waktu Paruh-
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CTX130 DB18627
biotech

CTX130 is an allogeneic CRISPR/Cas9-mediated genetically modified CAR T cell therapy targeting CD70 antigen.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
Cu-64 sartate DB18170
small molecule

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
Cu-67 sartate DB18698
small molecule

Deskripsi belum tersedia.

Waktu Paruh-
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Cudetaxestat DB18203
small molecule | CAS: 1782070-21-6

Deskripsi belum tersedia.

Target Protein:
Autotaxin
Waktu Paruh-
Vol. Distribusi-
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Culex pipiens Approved DB14165
biotech

Culex pipiens allergenic extract is used in allergenic testing.

Kategori:
Non-Standardized Insect Allergenic Extract
Waktu Paruh-
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Cumin Approved DB10864
biotech

Cumin allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract +1
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Cupressus arizonica pollen Approved DB10466
biotech

Cupressus arizonica pollen is the pollen of the Cupressus arizonica plant. Cupressus arizonica pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
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Genetik -
Cupric oxide Approved DB11134
small molecule | CAS: 1317-38-0

Cupric oxide, or copper (II) oxide, is an inorganic compound with the chemical formula CuO. Cupric oxide is used as a precursor in many copper-containing products such as wood preservatives and ceramics. Cupric oxide may be found in over-the-counter vitamin-m…

Kategori:
Diet, Food, and NutritionElementsFood +6
Waktu ParuhNo pharmacokinetic …
Vol. DistribusiFollowing exposure …
KlirensNo pharmacokinetic …
Genetik -
Cupric sulfate Approved DB06778
small molecule | CAS: 7758-98-7

Cupric sulfate is a salt created by treating cupric oxide with sulfuric acid. This forms as large, bright blue crystals containing five molecules of water (CuSO4?5H2O) and is also known as _blue vitriol_. The anhydrous salt is created by heating the hydrate t…

Kategori:
AntidotesAutonomic AgentsCentral Nervous System Agents +10
Waktu ParuhThe biological half…
Vol. DistribusiThe body of a 70 kg…
Klirens-
Genetik -
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