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16749

Total database: 17430
Struktur (SMILES)
11810 (70.5%)
Target
9015 (53.8%)
Genomik
112 (0.7%)
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16749 (100.0%)

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Halaman 72 / 335
Arformoterol Approved DB01274
small molecule | CAS: 67346-49-0

Arformoterol is a bronchodilator. It works by relaxing muscles in the airways to improve breathing. Arformoterol inhalation is used to prevent bronchoconstriction in people with chronic obstructive pulmonary disease, including chronic bronchitis and emphysema…

Kategori:
Adrenergic AgentsAdrenergic AgonistsAdrenergic beta-2 Receptor Agonists +21
Target Protein:
Beta-2 adrenergic receptor
Waktu ParuhIn COPD patients gi…
Vol. Distribusi-
KlirensIn healthy male sub…
Genetik -
ARG098 DB06338
biotech

ARG098 (anti-Fas IgM monoclonal antibody) was studied in a Phase I clinical trial in 2007 involving patients with rheumatoid arthritis.

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ARG201 DB06621
biotech

ARG201, a bovine-derived Type I collagen, aims to induce immune tolerance in patients with Diffuse Systemic Scleroderma (dcSSc). This drug was investigated in the completed clinical trial NCT0000567 (Multicenter Phase II Trial of Oral Type I Bovine Collagen i…

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Argan oil DB14310
biotech

Argan oil is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Kategori:
Biological ProductsComplex MixturesLipids +3
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Argatroban Approved DB00278
small molecule | CAS: 74863-84-6

Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous corona…

Kategori:
AmidesAmino AcidsAmino Acids, Basic +22
Target Protein:
Prothrombin
Waktu Paruh39 and 51 minutes
Vol. Distribusi* 174 mL/kg * 12.1…
Klirens* 5.1 L/kg/hr [infu…
Genetik -
Arginine DB00125
small molecule | CAS: 74-79-3

An essential amino acid that is physiologically active in the L-form.

Kategori:
Acids, AcyclicAmino AcidsAmino Acids, Basic +14
Target Protein:
Cationic amino acid transporter 3Antizyme inhibitor 2Argininosuccinate lyase +6
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 7675-83-4

Deskripsi belum tersedia.

Kategori:
Amino AcidsAmino Acids, AcidicAmino Acids, Basic +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 4320-30-3

Deskripsi belum tersedia.

Kategori:
Alimentary Tract and MetabolismAmino Acids, Peptides, and ProteinsBile and Liver Therapy +4
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Arginine PCA DB16025
small molecule | CAS: 56265-06-6

Deskripsi belum tersedia.

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Arginineamide DB02299
small molecule

Deskripsi belum tersedia.

Target Protein:
Potassium voltage-gated channel subfamily A member 4
Waktu Paruh-
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small molecule

Deskripsi belum tersedia.

Target Protein:
Argininosuccinate lyaseArgininosuccinate synthase
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ARGX-119 DB18133
biotech

ARGX-119 is a monoclonal antibody that targets and activates muscle-specific kinase (MuSK).

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Arhalofenate DB11811
small molecule | CAS: 24136-23-0

Arhalofenate has been investigated for the treatment of Gout and Hyperuricemia.

Kategori:
AcetatesAcids, AcyclicAcids, Carbocyclic +1
Target Protein:
Peroxisome proliferator-activated receptor gamma
Waktu Paruh-
Vol. Distribusi-
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Arimoclomol Approved DB05025
small molecule | CAS: 289893-25-0

Arimoclomol is a hydroxylamine derivative [A264414] and a heat-shock protein-70 (HSP70) co-inducer.[L51384] Arimoclomol was approved by the FDA on September 20, 2024, making it the first treatment for Niemann-Pick disease, type C (NPC).[L51389] It is also bei…

Kategori:
AminesMATE 1 SubstratesMATE 2 Substrates +3
Waktu ParuhThe elimination hal…
Vol. DistribusiThe mean apparent v…
KlirensThe mean apparent c…
Genetik -
Aripiprazole Approved DB01238
small molecule | CAS: 129722-12-9

Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's.[L45859] It is also indicated as an injection for agitation associated wit…

Kategori:
Adrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-AntagonistsAdrenergic Antagonists +48
Target Protein:
D(2) dopamine receptor5-hydroxytryptamine receptor 2A5-hydroxytryptamine receptor 1A +35
Waktu ParuhThe mean eliminatio…
Vol. DistribusiThe steady-state vo…
KlirensThe clearance of ar…
Genetik -
Aripiprazole lauroxil Approved DB14185
small molecule | CAS: 1259305-29-7

Aripiprazole lauroxil is a long-acting injectable atypical antipsychotic drug used in the treatment of schizophrenia in adult patients. It is a prodrug of [aripiprazole], which acts as a partial agonist at the D2 and 5-HT1A receptors, and as an antagonist at …

Kategori:
Adrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-AntagonistsAdrenergic Antagonists +29
Target Protein:
D(2) dopamine receptor5-hydroxytryptamine receptor 1A5-hydroxytryptamine receptor 2A +22
Waktu ParuhThe mean aripiprazo…
Vol. DistribusiBased on population…
KlirensIn rats, the cleara…
Genetik -
Arketamine DB19150
small molecule | CAS: 33643-49-1

Arketamine is under investigation in clinical trial NCT05414422 (A Randomized, Placebo-controlled, Double-blind Study to Assess Safety and Efficacy of PCN-101 in TRD).

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ARM-210 DB16944
small molecule | CAS: 1467605-57-7

Deskripsi belum tersedia.

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Armodafinil Approved DB06413
small molecule | CAS: 112111-43-0

Armodafinil is the enantiopure of the wakefulness-promoting agent modafinil (Provigil), and is indicated to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea (OSA), narcolepsy, or shift work disorder (SWD)…

Kategori:
Benzene DerivativesBenzhydryl CompoundsCentral Nervous System Agents +21
Target Protein:
Alpha-1D adrenergic receptorSodium-dependent dopamine transporter
Waktu ParuhTerminal half-life …
Vol. DistribusiApparent volume of …
KlirensThe oral clearance …
Genetik -
Arnica montana DB14297
biotech | CAS: 8057-65-6

Arnica montana is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Kategori:
AngiospermsAsteraceaeBiological Products +8
Waktu Paruh-
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Arnica montana flower Approved DB14343
biotech

Arnica montana flower is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Kategori:
AngiospermsAsteraceaeBiological Products +8
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ARO-ANG3 DB17626
biotech

ARO-ANG3 is a subcutaneously administered RNA interference (RNAi)-based investigational medicine targeting angiopoietin-like protein 3 (ANGPTL3). It was granted an orphan drug designation for the treatment of homozygous familial hypercholesterolemia (HoFH).[L…

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ARO-APOC3 DB17625
biotech

ARO-APOC3 is an investigational RNAi therapeutic targeting apolipoprotein C-III (APOC3). It received an Orphan Drug designation by the FDA for the treatment of familial chylomicronemia syndrome.[L45864]

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Aroplatin DB17319
small molecule | CAS: 114488-24-3

Deskripsi belum tersedia.

Kategori:
Antineoplastic AgentsOrganometallic Compounds
Waktu Paruh-
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Arotinoid acid DB02877
small molecule | CAS: 71441-28-6

Arotinoid acid is a retinoic acid analog which acts as a selective RAR agonist.

Kategori:
Acids, CarbocyclicAlkenesBenzene Derivatives +9
Target Protein:
Retinoic acid receptor beta
Waktu Paruh-
Vol. Distribusi-
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Arotinolol DB09204
small molecule | CAS: 68377-92-4

Arotinolol is an alpha- and beta-receptor blocker developed in Japan. It is a thiopropanolamine with a tertiary butyl moiety. It has been studied for its potential to be an antihypertensive therapy.[T87] Artinolol is being developed by Sumitomo Pharmaceutical…

Kategori:
Adrenergic AgentsAdrenergic AntagonistsAdrenergic beta-Antagonists +11
Target Protein:
Beta-1 adrenergic receptorBeta-2 adrenergic receptorAlpha-1 adrenergic receptors
Waktu ParuhThe reported half-l…
Vol. DistribusiThe stereospecifici…
Klirens-
Genetik -
Arrhenatherum elatius pollen Approved DB10879
biotech

Arrhenatherum elatius pollen is the pollen of the Arrhenatherum elatius plant. Arrhenatherum elatius pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityGrass Pollen Allergen ExtractsIncreased Histamine Release +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
ARRY-502 DB16053
small molecule | CAS: 1202891-16-4

ARRY-502 is under investigation in clinical trial NCT01561690 (A Study of ARRY-502 in Patients With Persistent Asthma).

Target Protein:
Prostaglandin D2 receptor 2
Waktu Paruh-
Vol. Distribusi-
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Arsanilic acid DB03006
small molecule | CAS: 98-50-0

An arsenical which has been used as a feed additive for enteric conditions in pigs and poultry. It causes blindness and is ototoxic and nephrotoxic in animals. [PubChem]

Kategori:
Adjuvants, ImmunologicAlkenesAnti-Infective Agents +10
Target Protein:
Lysozyme C
Waktu Paruh-
Vol. Distribusi-
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Arsenic trioxide Approved DB01169
small molecule | CAS: 1327-53-3

Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a natur…

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsArsenicals +16
Target Protein:
Inhibitor of nuclear factor kappa-B kinase subunit betaThioredoxin reductase 1, cytoplasmicTranscription factor Jun +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Arsenite ion DB18509
small molecule | CAS: 15502-74-6

Deskripsi belum tersedia.

Kategori:
AnionsArsenicalsElectrolytes +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Arsenous acid DB04456
small molecule | CAS: 13464-58-9

Deskripsi belum tersedia.

Kategori:
AnionsArsenicalsElectrolytes +1
Target Protein:
Arsenate reductaseArsenical pump-driving ATPase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Arsthinol DB08928
small molecule | CAS: 119-96-0

Arsthinol (INN) is an antiprotozoal agent that was first synthesized by Ernst A.H. Friedheim in 1949 via the complexing of acetarsol with 2,3-dimercaptopropanol. It has since been demonstrated that the agent possesses activity against amoebas and yaws. Consid…

Kategori:
Antiparasitic Products, Insecticides and RepellentsAntiprotozoalsArsenicals
Waktu Paruh-
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Genetik -
ART5803 DB18379
biotech

ART5803 is a humanized one-armed monoclonal antibody with a high affinity for the NMDA receptor.

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Artefenomel DB11809
small molecule | CAS: 1029939-86-3

Artefenomel has been investigated for the treatment of Malaria.

Kategori:
AnionsAnti-Infective AgentsAntimalarials +10
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Artemether Approved DB06697
small molecule | CAS: 71963-77-4

Artemether is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with lumefantrine for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of <i>Plasmodium spp.</i> and…

Kategori:
Anti-Infective AgentsAntimalarialsAntiparasitic Agents +25
Target Protein:
Sodium/potassium-transporting ATPase subunit alpha-1
Waktu ParuhArtemether, 1.6 +/-…
Vol. Distribusi-
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Artemin DB15438
biotech | CAS: 309758-71-2

Artemin is under investigation in clinical trial NCT01842126 (Phase 1 Subcutaneous Single and Multiple Ascending Dose Study of BG00010 (Neublastin)).

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Artemisia absinthium pollen Approved DB10768
biotech

Artemisia absinthium pollen is the pollen of the Artemisia absinthium plant. Artemisia absinthium pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Pollen Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

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Artemisia annua pollen Approved DB10582
biotech

Artemisia annua pollen is the pollen of the Artemisia annua plant. Artemisia annua pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Pollen Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Artemisia californica pollen Approved DB10909
biotech

Artemisia californica pollen is the pollen of the Artemisia californica plant. Artemisia californica pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Pollen Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Artemisia douglasiana pollen Approved DB10761
biotech

Artemisia douglasiana pollen is the pollen of the Artemisia douglasiana plant. Artemisia douglasiana pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Artemisia dracunculus pollen Approved DB10921
biotech

Artemisia dracunculus pollen is the pollen of the Artemisia dracunculus plant. Artemisia dracunculus pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
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Artemisia frigida pollen Approved DB10493
biotech

Artemisia frigida pollen is the pollen of the Artemisia frigida plant. Artemisia frigida pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Pollen Allergenic Extract
Waktu Paruh-
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Genetik -
Artemisia ludoviciana pollen Approved DB10762
biotech

Artemisia ludoviciana pollen is the pollen of the Artemisia ludoviciana plant. Artemisia ludoviciana pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Pollen Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Artemisia tridentata pollen Approved DB10390
biotech

Artemisia tridentata pollen is the pollen of the Artemisia tridentata plant. Artemisia tridentata pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Pollen Allergenic Extract
Waktu Paruh-
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Genetik -
Artemisia vulgaris pollen Approved DB10372
biotech

Artemisia vulgaris pollen is the pollen of the Artemisia vulgaris plant. Artemisia vulgaris pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Pollen Allergenic Extract
Waktu Paruh-
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Genetik -
Artemisia vulgaris root Approved DB14170
biotech

Artemisia vulgaris root allergenic extract is used in allergenic testing.

Kategori:
Non-Standardized Food Allergenic Extract
Waktu Paruh-
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Artemisinin DB13132
small molecule | CAS: 63968-64-9

Artemisinin has been used in trials studying the treatment of Schizophrenia, Malaria, Falciparum, and Plasmodium Falciparum.

Kategori:
Anti-Infective AgentsAntimalarialsAntiparasitic Products, Insecticides and Repellents +13
Target Protein:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Waktu Paruh-
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Artemisone DB16097
small molecule | CAS: 255730-18-8

Artemisone is under investigation in clinical trial NCT00936767 (Artemisone for the Treatment of Uncomplicated Falciparum Malaria in Western Cambodia).

Kategori:
Free RadicalsPeroxidesReactive Oxygen Species +2
Waktu Paruh-
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