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12560

Total database: 17430
Struktur (SMILES)
9109 (72.5%)
Target
6912 (55.0%)
Genomik
109 (0.9%)
Referensi
12560 (100.0%)

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Hasil Pencarian (12560)

Halaman 72 / 252
small molecule | CAS: 99519-84-3

Carboxyamidotriazole has been used in trials studying the treatment of Lymphoma, Lung Cancer, Breast Cancer, Kidney Cancer, and Ovarian Cancer, among others.

Kategori:
Agents causing hyperkalemiaAntiarrhythmic agentsAntineoplastic Agents +8
Target Protein:
Muscarinic acetylcholine receptor M5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 33286-30-5

Deskripsi belum tersedia.

Kategori:
CarbohydratesDiterpenesGlycosides +1
Target Protein:
ADP/ATP translocase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carboxymethylcellulose Approved DB11059
small molecule | CAS: 9000-11-7

Carboxymethylcellulose is a cellulose derivative that consists of the cellulose backbone made up of glucopyranose monomers and their hydroxyl groups bound to carboxymethyl groups. It is added in food products as a viscosity modifier or thickener and emulsifie…

Kategori:
Anorexigenic Agents & Respiratory and CNS StimulantsArtificial TearsBulk-Forming Laxatives +9
Target Protein:
Solute carrier family 2, facilitated glucose transporter member 1
Waktu ParuhNo pharmacokinetic …
Vol. DistribusiNo pharmacokinetic …
KlirensNo pharmacokinetic …
Genetik -
Carbromal DB13817
small molecule | CAS: 77-65-6

Deskripsi belum tersedia.

Kategori:
AmidesCentral Nervous System DepressantsHypnotics and Sedatives +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carbutamide DB13406
small molecule | CAS: 339-43-5

Deskripsi belum tersedia.

Kategori:
Alimentary Tract and MetabolismAmidesBenzene Derivatives +11
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carbuterol DB13625
small molecule | CAS: 34866-47-2

Deskripsi belum tersedia.

Kategori:
Adrenergics for Systemic UseAdrenergics, InhalantsAlcohols +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cardamom DB16576
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cardarine DB05416
small molecule | CAS: 317318-70-0

Cardarine (GW-501516) is a peroxisome proliferator-activator receptor-delta agonist for the potential treatment of dyslipidemia. Cardarine has been investigated for the treatment of Obesity, Lipid Disorders, and Cardiovascular Disease.

Kategori:
Sulfur Compounds
Target Protein:
Peroxisome proliferator-activated receptor deltaPeroxisome proliferator-activated receptor alpha
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cardiopet DB18913
small molecule | CAS: 855927-17-2

Cardiopet is under investigation in clinical trial NCT01826773 (Cardiopet as PET Imaging Agent to Assess Myocardial Perfusion and Fatty Acid Uptake in Known or Suspected CAD Subjects).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carfecillin DB13506
small molecule | CAS: 27025-49-6

Deskripsi belum tersedia.

Kategori:
AmidesAnti-Bacterial AgentsAnti-Infective Agents +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carfentanil DB01535
small molecule | CAS: 59708-52-0

Carfentanil or carfentanyl (Wildnil) is an analogue of the popular synthetic opioid analgesic fentanyl, and is one of the most potent opioids known (also the most potent opioid used commercially). Carfentanil was first synthesized in 1974 by a team of chemist…

Kategori:
AnalgesicsCarbon RadioisotopesCentral Nervous System Agents +9
Target Protein:
Mu-type opioid receptorDelta-type opioid receptorKappa-type opioid receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 98598-83-5

Carfentanil, C-11 is under investigation in clinical trial NCT01899170 (Towards Individualized Deep Brain Stimulation Treatment of Chronic Neuropathic Pain).

Kategori:
AnalgesicsCarbon RadioisotopesCentral Nervous System Agents +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carfilzomib Approved DB08889
small molecule | CAS: 868540-17-4

Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with re…

Kategori:
Amino Acids, Peptides, and ProteinsAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +8
Target Protein:
Proteasome subunit beta type-5Proteasome subunit beta type-8Proteasome subunit beta type-1 +3
Waktu ParuhFollowing intraveno…
Vol. DistribusiVd, steady state, 2…
KlirensSystemic clearance …
Genetik -
Carglumic acid Approved DB06775
small molecule | CAS: 1188-38-1

Carglumic acid is a drug used for the treatment of hyperammonemia in patients with a deficiency in N-acetyl glutamate synthase. This rare genetic disorder results in elevated blood levels of ammonia, which can eventually cross the blood–brain barrier and caus…

Kategori:
Alimentary Tract and MetabolismAmino AcidsAmino Acids and Derivatives +6
Target Protein:
Carbamoyl-phosphate synthase [ammonia], mitochondrial
Waktu ParuhMedian values for t…
Vol. DistribusiThe apparent volume…
KlirensThe apparent total …
Genetik -
Caricotamide DB18950
small molecule | CAS: 64881-21-6

Caricotamide is under investigation in clinical trial NCT00746590 (Study of Anti-tumour Effects and Safety of Prolarix™ in Hepatocellular Carcinoma).

Target Protein:
Ribosyldihydronicotinamide dehydrogenase [quinone]
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carindacillin Approved DB09319
small molecule | CAS: 35531-88-5

Carindacillin or Carbenicillin isdanyl was an oral penicillin prodrug of [carbenicillin] marketed by Pfizer as Geocillin. It is no longer marketed in the United States.

Kategori:
AmidesAnti-Bacterial AgentsAnti-Infective Agents +10
Target Protein:
Penicillin-binding protein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cariporide DB06468
small molecule | CAS: 159138-80-4

Deskripsi belum tersedia.

Kategori:
AmidinesAntiarrhythmic agentsCardiovascular Agents +3
Target Protein:
Sodium/hydrogen exchanger 1Sodium/hydrogen exchanger 3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cariprazine Approved DB06016
small molecule | CAS: 839712-12-8

Cariprazine is an atypical antipsychotic agent and a piperazine derivative that was first developed in Hungary.[A247100] It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT<sub>1A</sub> receptors and as an antagonist at serot…

Kategori:
Agents that produce hypertensionAntidepressive AgentsAntipsychotic Agents +48
Target Protein:
D(3) dopamine receptorD(2) dopamine receptor5-hydroxytryptamine receptor 1A +5
Waktu ParuhCariprazine and its…
Vol. Distribusi-
Klirens-
Genetik -
Carisbamate DB12338
small molecule | CAS: 194085-75-1

Carisbamate has been investigated in Alcohol Abuse, Substance Abuse, and Alcohol Dependence.

Kategori:
Acids, AcyclicAnticonvulsantsCentral Nervous System Depressants +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carisoprodol Approved DB00395
small molecule | CAS: 78-44-4

Originally approved by the FDA in 1959 [FDA label], carisoprodol is a centrally acting muscle relaxant used in painful musculoskeletal conditions in conjunction with physical therapy and other medications [A176047]. This drug is available by itself in an ora…

Kategori:
CarbamatesCarbamic Acid EstersCentral Nervous System Agents +7
Target Protein:
Gamma-aminobutyric acid receptor subunit alpha-1Gamma-aminobutyric acid receptor subunit beta-2Gamma-aminobutyric acid receptor subunit gamma-2 +2
Waktu ParuhThe terminal half-l…
Vol. Distribusi0.93 to 1.3 L/kg, a…
KlirensFollowing an oral d…
Genetik -
Carlumab DB12718
biotech | CAS: 915404-94-3

Carlumab has been used in trials studying the treatment of Cancer and Prostate Cancer.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carmegliptin DB12268
small molecule | CAS: 813452-18-5

Carmegliptin has been used in trials studying the treatment of Diabetes Mellitus Type 2.

Kategori:
Agents causing angioedemaBlood Glucose Lowering AgentsDipeptidyl Peptidase 4 +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carmofur DB09010
small molecule | CAS: 61422-45-5

Carmofur is a derivative of fluorouracil, and is an antineoplastic agent that has been used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopathy.

Kategori:
AntimetabolitesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carmoterol DB15784
small molecule | CAS: 147568-66-9

Deskripsi belum tersedia.

Kategori:
AminesEthylaminesHeterocyclic Compounds, Fused-Ring +2
Target Protein:
Beta-2 adrenergic receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carmustine Approved DB00262
small molecule | CAS: 154-93-8

A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a c…

Kategori:
Alkylating ActivityAlkylating DrugsAmides +15
Target Protein:
RNAGlutathione reductase, mitochondrialDNA
Waktu Paruh15-30 minutes
Vol. Distribusi-
Klirens-
Genetik -
Carnosine DB11695
small molecule | CAS: 305-84-0

Carnosine has been investigated for the treatment of Gulf War Illness.

Kategori:
Amino Acids, Peptides, and ProteinsDipeptidesNerve Tissue Proteins +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carob Approved DB10852
biotech

Carob allergenic extract is used in allergenic testing.

Kategori:
AntidiarrhealsBiological ProductsBiopolymers +12
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 401905-67-7

Carotegrast methyl is under investigation in clinical trial NCT03531892 (A Study to Evaluate the Safety and Efficacy of AJM300 in Participants With Active Ulcerative Colitis).

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carotuximab DB06322
biotech | CAS: 1268714-50-6

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +5
Target Protein:
Endoglin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Caroverine DB13835
small molecule | CAS: 23465-76-1

Deskripsi belum tersedia.

Kategori:
Agents causing hyperkalemiaAlimentary Tract and MetabolismAntiarrhythmic agents +14
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Caroxazone DB09254
small molecule | CAS: 18464-39-6

Caroxazone is an antidepressant that has been withdrawn from the market. It is a reversible monoamine oxidase inhibitor (MAOI) of both A and B monoamine oxidase subtypes. However, it presents a five-fold preference for the MAO-B subtype.

Kategori:
AcetamidesAgents that produce hypertensionAgents that reduce seizure threshold +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carprofen Approved DB00821
small molecule | CAS: 53716-49-7

Carprofen is a non-steroidal anti-inflammatory drug (NSAID) that is used by veterinarians as a supportive treatment for the relief of arthritic symptoms in geriatric dogs. Carprofen was previously used in human medicine for over 10 years (1985-1995). It was g…

Kategori:
Agents causing hyperkalemiaAgents that produce hypertensionAnalgesics +15
Target Protein:
Prostaglandin G/H synthase 2Prostaglandin G/H synthase 1
Waktu ParuhApproximately 8 hou…
Vol. Distribusi-
Klirens-
Genetik -
Carrot Approved DB10515
biotech

Carrot allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carteolol Approved DB00521
small molecule | CAS: 51781-06-7

A beta-adrenergic antagonist used as an anti-arrhythmia agent, an anti-angina agent, an antihypertensive agent, and an antiglaucoma agent.

Kategori:
Adrenergic AgentsAdrenergic AntagonistsAdrenergic beta-Antagonists +28
Target Protein:
Beta-2 adrenergic receptorBeta-1 adrenergic receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carumonam DB13553
small molecule | CAS: 87638-04-8

Deskripsi belum tersedia.

Kategori:
AmidesAntibacterials for Systemic UseAntiinfectives for Systemic Use +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carvacrol DB16404
small molecule | CAS: 499-75-2

Deskripsi belum tersedia.

Kategori:
Benzene DerivativesMonoterpenesTerpenes
Target Protein:
Transient receptor potential cation channel subfamily V member 3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carvasept DB15886
small molecule | CAS: 5665-94-1

Deskripsi belum tersedia.

Kategori:
Benzene DerivativesMonoterpenesTerpenes
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carvedilol Approved DB01136
small molecule | CAS: 72956-09-3

Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and …

Kategori:
Adrenergic AgentsAdrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-Antagonists +40
Target Protein:
Beta-1 adrenergic receptorAlpha-1A adrenergic receptorAlpha-1 adrenergic receptors +16
Gen Terkait:
ADRB1
Waktu ParuhThe half life of ca…
Vol. DistribusiCarvedilol has a vo…
KlirensThe plasma clearanc…
Genetik 1 Varian
Caryophyllene DB16854
small molecule | CAS: 87-44-5

Deskripsi belum tersedia.

Kategori:
AnalgesicsAnalgesics, Non-NarcoticAnti-Inflammatory Agents +6
Target Protein:
Cannabinoid receptor 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Casdozokitug DB17513
biotech | CAS: 2643331-37-5

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Casein Approved DB10516
biotech | CAS: 9000-71-9

Casein allergenic extract is used in allergenic testing.

Kategori:
Amino Acids, Peptides, and ProteinsAnimal Proteins, DietaryBeverages +17
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cashew Approved DB10653
biotech

Cashew allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cashew fruit Approved DB15602
biotech

Cashew fruit extract is used in allergenic testing.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Casimersen Approved DB14984
biotech | CAS: 1422958-19-7

Duchenne muscular dystrophy (DMD) is an X-linked recessive allelic disorder characterized by a lack of functional dystrophin protein, which leads to progressive impairment of ambulatory, pulmonary, and cardiac function and is invariably fatal. A related, albe…

Kategori:
Antisense OligonucleotidesCytochrome P-450 CYP2C19 InhibitorsCytochrome P-450 CYP2C19 inhibitors (strength unknown) +16
Target Protein:
DMD gene (exon 45 casimersen target site)
Waktu ParuhCasimersen has an e…
Vol. DistribusiCasimersen administ…
KlirensCasimersen administ…
Genetik -
Casimiroin DB08744
small molecule | CAS: 477-89-4

Casimiroin is a quinone reductase 2 inhibitor isolated from _Casimiroa edulis_.

Kategori:
AromataseDioxolesHeterocyclic Compounds, Fused-Ring +2
Target Protein:
Ribosyldihydronicotinamide dehydrogenase [quinone]
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Casirivimab Approved DB15941
biotech | CAS: 2415933-42-3

Casirivimab is a monoclonal antibody combined with [Imdevimab] in Regeneron's antibody cocktail known as REGN-COV2 for the treatment of COVID-19.[L23539] This drug is a combination of antibodies derived from humanized VelocImmune® mice in addition to blood s…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +10
Target Protein:
Spike glycoprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Caspofungin Approved DB00520
small molecule | CAS: 162808-62-0

Caspofungin (brand name Cancidas worldwide) is an antifungal drug and the first member of a new drug class called the echinocandins, as coined by Merck & Co., Inc. It is typically administered intravenously. It shows activity against infections with Aspergill…

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Infective AgentsAntifungal Agents +18
Target Protein:
1,3-beta-glucan synthase component FKS11,3-beta-glucan synthase component GSC2
Waktu Paruh9-11 hours
Vol. Distribusi-
Klirens* 12 mL/min [After …
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Castor oil Approved DB11113
biotech | CAS: 8001-79-4

Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (_Ricinus communis_ L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of [DB02955], which represents up to 90% of the total castor…

Kategori:
Alimentary Tract and MetabolismBiological ProductsComplex Mixtures +10
Target Protein:
Prostaglandin E2 receptor EP3 subtypeProstaglandin E2 receptor EP4 subtype
Waktu ParuhNo pharmacokinetic …
Vol. DistribusiNo pharmacokinetic …
KlirensNo pharmacokinetic …
Genetik -
biotech

Casuarina equisetifolia pollen is the pollen of the Casuarina equisetifolia plant. Casuarina equisetifolia pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 3551–3600 dari 12560
Sebelumnya Halaman 72 / 252 Berikutnya