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14063

Total database: 17430
Struktur (SMILES)
10481 (74.5%)
Target
8038 (57.2%)
Genomik
107 (0.8%)
Referensi
14063 (100.0%)

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Hasil Pencarian (14063)

Halaman 72 / 282
Benzbromarone DB12319
small molecule | CAS: 3562-84-3

Benzbromarone has been used in trials studying the basic science and treatment of Heart Failure, Hyperuricemia, Chronic Kidney Disease, Abnormal Renal Function, and Gout and Asymptomatic Hyperuricemia.

Kategori:
Antigout PreparationsAntirheumatic AgentsBenzofurans +12
Target Protein:
Anoctamin-1Solute carrier family 22 member 12Multidrug resistance-associated protein 1 +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 517-60-2

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicBenzene Derivatives
Target Protein:
Phosphoglycerate mutase 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzethonium Approved DB11125
small molecule | CAS: 10172-60-8

Benzethonium is a synthetic quaternary ammonium salt with surfactant, antiseptic, and broad spectrum antimicrobial properties. Its salt form, benzethonium chloride, is primarily used as a skin disinfectant at concentrations of 0.1-0.2 %, which are safe and ef…

Kategori:
AminesAnti-Infective AgentsAnti-Infective Agents, Local +7
Waktu ParuhPharmacokinetic stu…
Vol. DistribusiPharmacokinetic stu…
KlirensPharmacokinetic stu…
Genetik -
Benzgalantamine Approved DB19353
small molecule | CAS: 224169-27-1

Benzgalantamine is a prodrug of [galantamine]. Gastrointestinal adverse effects are the most frequently reported side effects in patients undergoing treatment with cholinesterase inhibitors, including galantamine, and are often a reason for treatment disconti…

Kategori:
AlkaloidsAlzheimer Disease, drug therapyAmaryllidaceae Alkaloids +11
Target Protein:
AcetylcholinesteraseCholinesteraseNeuronal acetylcholine receptor subunit alpha-7 +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzhydrocodone Approved DB15465
small molecule | CAS: 1259440-61-3

Benzhydrocodone is a benzylic prodrug of hydrocodone.[L4894] It was developed in an effort to reduce parenteral bioavailability of the active metabolite as a deterrent to abuse.[A182177] Benzhydrocodone is indicated for use in the short-term management of pai…

Kategori:
Opioids
Target Protein:
Mu-type opioid receptor
Waktu ParuhThe hydrocodone met…
Vol. DistribusiThe hydrocodone met…
KlirensThe apparent cleara…
Genetik -
small molecule | CAS: 495-18-1

Deskripsi belum tersedia.

Kategori:
AminesBenzoatesHydroxy Acids +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzilone DB13369
small molecule | CAS: 16175-92-1

Deskripsi belum tersedia.

Kategori:
Agents producing tachycardiaAlimentary Tract and MetabolismAnticholinergic Agents +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzimidazole DB02962
small molecule | CAS: 51-17-2

Deskripsi belum tersedia.

Kategori:
AnthelminticsAnti-Infective AgentsAntiparasitic Agents +1
Target Protein:
Dual specificity tyrosine-phosphorylation-regulated kinase 1ANicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benziodarone Approved DB13277
small molecule | CAS: 68-90-6

Benziodarone is a uricostatic and a uricosuric agent which is sold also under the name Amplivex-Labaz. It is used in the treatment of gout [A175630]. It was withdrawn from France markets and British markets due to its effects causing Jaundice in patients [T48…

Kategori:
Antigout PreparationsAntirheumatic AgentsCardiac Therapy +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benznidazole Approved DB11989
small molecule | CAS: 22994-85-0

Benznidazole was granted accelerated approval for the treatment of Chagas disease in children 2-12 years of age by the FDA on August 29, 2017.[L939] It is the first treatment made available in the United States for Chagas disease.

Kategori:
Agents Against Leishmaniasis and TrypanosomiasisAnti-Infective AgentsAntiparasitic Agents +12
Waktu ParuhThe half life of el…
Vol. DistribusiThe apparent volume…
KlirensThe apparent oral c…
Genetik -
Benzocaine Approved DB01086
small molecule | CAS: 94-09-7

Benzocaine is an ester local anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.[A231219] It is commonly used for local anesthesia in many over the counter products.[L32454,L32459,L32464] Benzocaine was first u…

Kategori:
Acids, CarbocyclicAgents for Treatment of Hemorrhoids and Anal Fissures for Topical UseAminobenzoates +29
Target Protein:
Sodium channel protein type 10 subunit alpha
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzoctamine DB09021
small molecule | CAS: 17243-39-9

Benzoctamine is a drug with two main uses. It can be used as a sedative which does not depress the respiratory system, but rather stimulates it. It can also be used as an anxiolytic with the same efficacy as chlordiazepoxide for treating anxiety neurosis.

Kategori:
Anti-Anxiety AgentsCentral Nervous System DepressantsDibenzo-Bicyclo-Octadiene Derivatives +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzododecinium DB13282
small molecule | CAS: 10328-35-5

Benzododecinium is used as an antiseptic/disinfectant compound. It has been marketed as a tincture for antiseptic product for wounds in the Czech Republic.

Kategori:
AminesAnti-Infective AgentsAnti-Infective Agents, Local +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzofuran DB04179
small molecule | CAS: 271-89-6

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Endolysin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzoic acid Approved DB03793
small molecule | CAS: 65-85-0

A fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid. As the sodium salt form, sodium benzoate is used as a treatment for urea cycle disorders due to its ability to bind amin…

Kategori:
Acids, CarbocyclicAlimentary Tract and MetabolismAmmonium Ion Binding Activity +18
Target Protein:
Ras-related protein Rab-9ASolute carrier family 15 member 1Cocaine esterase +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzoin Approved DB14020
small molecule | CAS: 119-53-9

Benzoin is a white crystalline compound prepared by condensation of benzaldehyde in potassium cyanide, and is used in organic syntheses. This should not be confused with benzoin gum from STYRAX (see [DB11222]). Benzoin is an FDA-approved colour additive used …

Kategori:
AcetophenonesAnti-Infective Agents, LocalKetones
Target Protein:
Liver carboxylesterase 1
Waktu ParuhNo pharmacokinetic …
Vol. DistribusiNo pharmacokinetic …
KlirensNo pharmacokinetic …
Genetik -
Benzoin resin Approved DB11222
biotech | CAS: 9000-05-9

Benzoin resin is a balsamic resin obtained from the bark of several species of trees in the genus _Styrax_. There are two common kinds of benzoin, benzoin Siam and benzoin Sumatra, that are obtained from different species of the _Styrax_ tree. While benzoin r…

Kategori:
AngiospermsAnti-Infective Agents, LocalBiological Products +11
Waktu ParuhNo pharmacokinetic …
Vol. DistribusiNo pharmacokinetic …
KlirensNo pharmacokinetic …
Genetik -
Benzonatate Approved DB00868
small molecule | CAS: 104-31-4

Benzonatate is an oral antitussive drug used in the relief and suppression of cough in patients older than ten years of age.[A5790] Currently, benzonatate is the only non-narcotic antitussive available as a prescription drug.[A189519] It works to reduce the a…

Kategori:
AlkanesAminesAntitussive Agents +8
Target Protein:
Sodium channel protein type 5 subunit alpha
Waktu ParuhThe half life of be…
Vol. DistribusiThere is limited in…
KlirensThere is limited in…
Genetik -
Benzoxonium DB13565
small molecule | CAS: 23884-64-2

Deskripsi belum tersedia.

Kategori:
Alimentary Tract and MetabolismAminesAntiinfectives and Antiseptics for Local Oral Treatment +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzoyl peroxide Approved DB09096
small molecule | CAS: 94-36-0

Benzoyl peroxide is a commonly used drug in topical treatments for acne.[L33249,L33264,L33269,L33299,L33314] It has been formulated as products with either a single active ingredient,[L33249,L33299] or with [erythromycin],[L33264] [clindamycin],[L33269] or [a…

Kategori:
Acids, CarbocyclicAnti-Acne PreparationsAnti-Acne Preparations for Topical Use +5
Target Protein:
CatalaseGlutathione peroxidaseAntizyme inhibitor 2 +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzoylecgonine DB01515
small molecule | CAS: 519-09-5

Benzoylecgonine is the major metabolite of cocaine. It is formed by hydrolysis of cocaine in the liver, catalysed by carboxylesterases. It is excreted in the urine of cocaine users after processing in the liver. It is the main pharmaceutical ingredient in the…

Kategori:
AlkaloidsAza CompoundsAzabicyclo Compounds +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 611-73-4

Deskripsi belum tersedia.

Kategori:
Acids, AldehydicAcids, CarbocyclicHydroxy Acids
Target Protein:
2-Hydroxyacid oxidase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 18481-26-0

Deskripsi belum tersedia.

Kategori:
PyrimidinesSulfur CompoundsThiazoles
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzoylpas DB19382
small molecule | CAS: 13898-58-3

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Beta-lactamaseBeta-lactamase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Serine protease 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzphetamine Approved DB00865
small molecule | CAS: 156-08-1

A sympathomimetic agent with properties similar to dextroamphetamine. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222)

Kategori:
Adrenergic AgentsAdrenergic AgonistsAdrenergic alpha-1 Receptor Agonists +28
Target Protein:
Synaptic vesicular amine transporterAlpha-2A adrenergic receptorAlpha-1A adrenergic receptor +1
Waktu Paruh16 to 31 hours
Vol. Distribusi-
Klirens-
Genetik -
Benzquinamide DB00767
small molecule | CAS: 63-12-7

Benzquinamide is a discontinued antiemetic compound with antihistaminic, mild anticholinergic, and sedative properties. The mechanism of action is not known, but presumably benzquinamide works via antagonism of muscarinic acetycholine receptors and histamine …

Kategori:
Agents producing tachycardiaAnticholinergic AgentsHeterocyclic Compounds, Fused-Ring +4
Target Protein:
Histamine H1 receptorMuscarinic acetylcholine receptor M4Muscarinic acetylcholine receptor M1 +3
Waktu Paruh1-1.6 hours (for al…
Vol. Distribusi-
Klirens-
Genetik -
Benzthiazide Approved DB00562
small molecule | CAS: 91-33-8

Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium…

Kategori:
DiureticsGenito Urinary System and Sex HormonesGynecological Antiinfectives and Antiseptics +8
Target Protein:
Solute carrier family 12 member 3Carbonic anhydraseCarbonic anhydrase 2 +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzydamine Approved DB09084
small molecule | CAS: 642-72-8

Benzydamine (also known as Tantum Verde or Difflam), available as the hydrochloride salt, is a locally-acting nonsteroidal anti-inflammatory drug (NSAID) with local anaesthetic and analgesic properties. It is used topically for pain relief and anti-inflammato…

Kategori:
Agents causing hyperkalemiaAgents that produce hypertensionAlimentary Tract and Metabolism +18
Target Protein:
Prostaglandin G/H synthase 1Prostaglandin G/H synthase 2
Waktu ParuhApproximately 13 h …
Vol. DistribusiThe volume of distr…
KlirensBenzydamine demonst…
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Replicase polyprotein 1ab
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Collagenase 3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzyl benzoate Approved DB00676
small molecule | CAS: 120-51-4

Benzyl benzoate is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei. It is characterised by severe itching (particularly at night), red spots, and may lead to a secondary infection. Benzyl b…

Kategori:
AcaricidesAcids, CarbocyclicAgrochemicals +8
Target Protein:
Hormone-sensitive lipase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 622-78-6

Deskripsi belum tersedia.

Kategori:
IsocyanatesSulfur Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Cathepsin B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Cathepsin FCruzipain
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzylamine DB02464
small molecule | CAS: 100-46-9

Deskripsi belum tersedia.

Kategori:
AminesBenzene DerivativesBenzyl Compounds
Target Protein:
Serine protease 1Trypsin-2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzylfentanyl DB09182
small molecule | CAS: 1474-02-8

Benzylfentanyl (R-4129) is a fentanyl analog opioid that was on the list of Schedule I drugs in America in 1985 due to its structural similarity to fentanyl. In 2010 it was removed from the list after it was found to have minimal opioid activity. Benzylfentan…

Kategori:
Piperidines
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzylmorphine DB01573
small molecule | CAS: 14297-87-1

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzylpenicillin Approved DB01053
small molecule | CAS: 61-33-6

Benzylpenicillin (Penicillin G) is narrow spectrum antibiotic used to treat infections caused by susceptible bacteria. It is a natural penicillin antibiotic that is administered intravenously or intramuscularly due to poor oral absorption. Penicillin G may al…

Kategori:
AmidesAnti-Bacterial AgentsAnti-Infective Agents +18
Target Protein:
Peptidoglycan synthase FtsIPenicillin-binding protein 1APenicillin-binding protein 1B +5
Waktu ParuhIn adults with norm…
Vol. Distribusi0.53–0.67 L/kg in a…
Klirens560ml/min in health…
Genetik -
small molecule | CAS: 100-87-8

Deskripsi belum tersedia.

Kategori:
AlkanesAlkanesulfonatesAlkanesulfonic Acids +4
Target Protein:
ChymaseSubtilisin BPN'Sigma factor SigB regulation protein RsbQ +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 627861-07-8

Beperminogene perplasmid is under investigation in clinical trial NCT02144610 (Efficacy and Safety of AMG0001 in Subjects With Critical Limb Ischemia).

Kategori:
Vasoprotectives
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bephenium DB13462
small molecule | CAS: 7181-73-9

Deskripsi belum tersedia.

Kategori:
AnthelminticsAntinematodal AgentsAntiparasitic Agents +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bepotastine Approved DB04890
small molecule | CAS: 125602-71-3

Bepotastine is a non-sedating, selective antagonist of the histamine 1 (H1) receptor. Bepotastine was approved in Japan for use in the treatment of allergic rhinitis and uriticaria/puritus in July 2000 and January 2002, respectively, and is marketed by Tanabe…

Kategori:
Anti-Allergic AgentsDrugs that are Mainly Renally ExcretedHistamine Antagonists +2
Target Protein:
Histamine H1 receptor
Waktu ParuhElimination half li…
Vol. Distribusi-
Klirens-
Genetik -
Bepranemab DB17945
biotech | CAS: 2244960-75-4

Bepranemab is a recombinant humanized Igg4P monoclonal antibody directed against human Tau.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bepridil Approved DB01244
small molecule | CAS: 64706-54-3

A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a cal…

Kategori:
Agents causing hyperkalemiaAntiarrhythmic agentsAntihypertensive Agents +20
Target Protein:
Voltage-dependent P/Q-type calcium channel subunit alpha-1AVoltage-dependent T-type calcium channel subunit alpha-1HVoltage-dependent calcium channel subunit alpha-2/delta-2 +7
Waktu Paruh24-50 hours
Vol. Distribusi-
Klirens-
Genetik -
Beractant Approved DB06761
biotech | CAS: 108778-82-1

Beractant is a pulmonary surfactant used for the treatment of Respiratory Distress Syndrome (RDS) in premature infants. Considered a natural source of surfactant as it is made from bovine lung extract, beractant contains a mixture of phospholipids, neutral li…

Kategori:
Alveolar Surface Tension ReductionBradycardia-Causing AgentsComplex Mixtures +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Beraprost DB05229
small molecule | CAS: 88430-50-6

Beraprost is a synthetic analogue of prostacyclin, under clinical trials for the treatment of pulmonary hypertension. It is also being studied for use in avoiding reperfusion injury.

Kategori:
AnticoagulantsAntiplatelet agentsAutacoids +17
Target Protein:
Prostacyclin receptor
Waktu Paruh35–40 minutes
Vol. Distribusi-
Klirens-
Genetik -
Berbamine DB18146
small molecule | CAS: 478-61-5

Deskripsi belum tersedia.

Kategori:
AlkaloidsAnalgesicsAnalgesics, Non-Narcotic +13
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Berberine Approved DB04115
small molecule | CAS: 2086-83-1

An alkaloid from Hydrastis canadensis L., Berberidaceae. It is also found in many other plants. It is relatively toxic parenterally, but has been used orally for various parasitic and fungal infections and as antidiarrheal.

Kategori:
AlkaloidsBenzylisoquinolinesBerberine Alkaloids +1
Target Protein:
Telomerase reverse transcriptaseBaculoviral IAP repeat-containing protein 5HTH-type transcriptional regulator QacR
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 3551–3600 dari 14063
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