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392

Total database: 17430
Struktur (SMILES)
253 (64.5%)
Target
250 (63.8%)
Genomik
6 (1.5%)
Referensi
392 (100.0%)

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Hasil Pencarian (392)

Halaman 7 / 8
rhIGFBP-3 DB05897
biotech

rhIGFBP-3 (recombinant human insulin-like growth factor binding protein-3) is Insmed’s proprietary anti-cancer compound that has demonstrated significant decreases in cancerous growth in several models of human. It is developed by Insmed and is currently unde…

Target Protein:
Insulin-like growth factor 1 receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Rimexolone Approved DB00896
small molecule | CAS: 49697-38-3

Rimexolone is a 1% eye drop solution is a glucocorticoid steroid. It is used to treat inflammation in the eye. It is marketed as Vexol.

Kategori:
Adrenal Cortex HormonesAnti-Inflammatory AgentsCorticosteroid Hormone Receptor Agonists +24
Target Protein:
Glucocorticoid receptorSteroid hormone receptor ERR1
Waktu ParuhThe serum half-life…
Vol. Distribusi-
Klirens-
Genetik -
Rimonabant Approved DB06155
small molecule | CAS: 168273-06-1

Rimonabant is an anorectic anti-obesity drug produced and marketed by Sanofi-Aventis. It is an inverse agonist for the cannabinoid receptor CB1. Its main avenue of effect is reduction in appetite. Rimonabant is the first selective CB1 receptor blocker to be a…

Kategori:
Agents producing tachycardiaAlimentary Tract and MetabolismAnti-Obesity Agents +12
Target Protein:
Cannabinoid receptor 1G-protein coupled receptor 55
Waktu Paruh6 to 9 days with no…
Vol. Distribusi-
Klirens-
Genetik -
Romiplostim Approved DB05332
biotech | CAS: 267639-76-9

Romiplostim is a thrombopoiesis stimulating dimer Fc-peptide fusion protein (peptibody) to increase platelet production through activation of the thrombopoietin receptor. The peptibody molecule has two identical single-chain subunits, each one is made up of 2…

Kategori:
Amino Acids, Peptides, and ProteinsBiological FactorsBlood and Blood Forming Organs +17
Target Protein:
Thrombopoietin receptor
Waktu ParuhImmune thrombocytop…
Vol. DistribusiIn healthy voluntee…
Klirens-
Genetik -
Rosuvastatin Approved DB01098
small molecule | CAS: 287714-41-4

Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous prod…

Kategori:
Agents Causing Muscle ToxicityAlimentary Tract and MetabolismAmides +32
Target Protein:
3-hydroxy-3-methylglutaryl-coenzyme A reductaseIntegrin alpha-L
Gen Terkait:
KIF6 HMGCR ABCG2
Waktu ParuhThe elimination hal…
Vol. DistribusiRosuvastatin underg…
Klirens-
Genetik 3 Varian
Rotigotine Approved DB05271
small molecule | CAS: 99755-59-6

Rotigotine (Neupro) is a non-ergoline dopamine agonist indicated for the treatment of Parkinson's disease (PD) and restless legs syndrome (RLS) in Europe and the United States. It is formulated as a once-daily transdermal patch which provides a slow and const…

Kategori:
Agents that produce hypertensionAnti-Parkinson Agents (Dopamine Agonist)Anti-Parkinson Drugs +23
Target Protein:
D(3) dopamine receptorD(4) dopamine receptorD(2) dopamine receptor +4
Waktu ParuhAfter removal of th…
Vol. DistribusiThe weight normaliz…
Klirens-
Genetik -
Rozanolixizumab Approved DB14919
biotech | CAS: 1584645-37-3

Rozanolixizumab is a humanized high-affinity anti-human neonatal Fc receptor (FcRn) monoclonal antibody (IgG4P) targeting the immunoglobulin G (IgG). Rozonolixizumab itself is an IgG4P, an inactive isotype, to reduce the likelihood of unwanted chain exchange.…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +10
Target Protein:
IgG receptor FcRn large subunit p51
Waktu Paruh-
Vol. DistribusiThe apparent volume…
KlirensThe apparent cleara…
Genetik -
rsPSMA Vaccine Approved DB06361
biotech

Prostate-specific membrane antigen (PSMA) is an ?100 kDa transmembrane glycoprotein that is abundantly and preferentially expressed in prostate cancer, including recurrent and hormone-refractory cases. rsPSMA Vaccine is a subunit vaccine based on a novel rsPS…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Safflower oil Approved DB09446
biotech | CAS: 8001-23-8

Safflower (_Carthamus tinctorius_ L) is a herbaceous plant in the Asteraceae family. Extracted from the seeds of safflowers, safflower oil is a rich source of various saturated fatty acids, monounsaturated fatty acid (oleic acid) or essential n-6 polyunsatura…

Kategori:
Biological ProductsComplex MixturesDiet, Food, and Nutrition +10
Waktu ParuhNo pharmacokinetic …
Vol. DistribusiNo pharmacokinetic …
KlirensNo pharmacokinetic …
Genetik -
Sage oil DB11199
biotech | CAS: 8022-56-8

Sage oil is extracted from sage or *Salvia officinalis*, the herb commonly used for culinary purposes. *Salvia officinalis* is a common sage and a member of the genus *Salvia*, that includes aromatic and perennial plants with flowers. Essential oil has been t…

Kategori:
Agents that reduce seizure thresholdNon-Standardized Food Allergenic ExtractNon-Standardized Plant Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Salicylamide Approved DB08797
small molecule | CAS: 65-45-2

Salicylamide is the common name for the substance o-hydroxybenzamide, or amide of salicyl. Salicylamide is a non-prescription drug with analgesic and antipyretic properties. It has similar medicinal uses to aspirin. Salicylamide is used in combination with bo…

Kategori:
Acids, CarbocyclicAgents causing hyperkalemiaAgents that produce hypertension +16
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Samarium (153Sm) lexidronam Approved DB05273
small molecule | CAS: 122575-21-7

Samarium Sm 153 lexidronam is a radioactive medication used to treat pain caused by cancer that has spread to the bone. It is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents that may be used to diagnose some diseases by studying the functio…

Kategori:
AnalgesicsAnalgesics, Non-NarcoticCentral Nervous System Agents +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

Kategori:
AdoxaceaeAngiospermsBiological Products +10
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sarracenia Purpurea Approved DB13965
biotech

_Sarracenia purpurea_, commonly known as the purple pitcher plant, northern pitcher plant, turtle socks, or side-saddle flower, is a perennial carnivorous plant in the family _Sarraceniaceae_. _Sarracenia purpurea_ attract and trap insects within their pitche…

Kategori:
Miscellaneous Analgesics and Antipyretics
Waktu ParuhNo pharmacokinetic …
Vol. DistribusiNo pharmacokinetic …
KlirensNo pharmacokinetic …
Genetik -
biotech

Bimervax is an adjuvanted non-mRNA COVID-19 vaccine utilizing a SARS-CoV-2 recombinant spike (S) protein receptor binding domain (RBD) fusion heterodimer.[L48902] It is intended to elicit protection against Omicron XBB.1.5, one of the dominant circulating SAR…

Kategori:
COVID-19 VaccinesVaccinesViral Vaccines
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Centruroides (scorpion) Immune F(ab')2 (equine) is a purified preparation of immune globulin F(ab’)2 fragments that are derived from plasma of the horses immunized with venom of *C. noxius*, *C. l. limpidus*, *C. l. tecomanus*, and *C. s. suffusus*. It is int…

Kategori:
AntiveninsPassively Acquired ImmunityVenom Neutralization
Waktu Paruh159 ± 57 h [FDA lab…
Vol. DistribusiSteady state: 13.6 …
Klirens83.5 ± 38.4 ml/Hr […
Genetik -
Segesterone acetate Approved DB14583
small molecule | CAS: 7759-35-5

Segesterone acetate is a steroidal progestin or synthetic progesterone and a 19-norprogesterone derivative with no CH3 group radical in position 6 [A37048]. In animal studies, segesterone acetate was shown to be one of the most potent progestins [A37090]. It …

Kategori:
Adrenal Cortex HormonesContraceptive Agents, FemaleContraceptive Agents, Hormonal +24
Target Protein:
Progesterone receptorAndrogen receptorGlucocorticoid receptor
Waktu ParuhThe mean (SD) half …
Vol. DistribusiThe volume of distr…
KlirensNo pharmacokinetic …
Genetik -
Selegiline Approved DB01037
small molecule | CAS: 14611-51-9

A selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson's disease. It may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may be given with levodop…

Kategori:
Agents that produce hypertensionAgents that reduce seizure thresholdAmines +42
Target Protein:
Amine oxidase [flavin-containing] BSubstance-P receptorAmine oxidase [flavin-containing] A
Waktu Paruh1.2-2 hours
Vol. Distribusi-
Klirens-
Genetik -
Selurampanel DB12367
small molecule | CAS: 912574-69-7

Selurampanel has been investigated in Adrenocortical Adenoma and Sarcoma, Endometrial Stromal.

Kategori:
Heterocyclic Compounds, Fused-RingQuinazolines
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Senna leaf Approved DB15889
biotech

Deskripsi belum tersedia.

Kategori:
AnthracenesAnthraquinonesBiological Products +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
SEP-363856 DB15665
small molecule | CAS: 1310426-33-5

SEP-363856 is a novel psychotropic drug being investigated for the treatment of schizophrenia. Unlike other drugs used for this condition, SEP-363856 does not bind to the dopamine D2 receptors, but exerts actions on the trace amine–associated receptor 1 (TAA…

Target Protein:
5-hydroxytryptamine receptor 1ATrace amine-associated receptor 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sevelamer Approved DB00658
small molecule | CAS: 52757-95-6

Sevelamer is a phosphate binding drug used to prevent hyperphosphataemia in patients with chronic renal failure. It is marketed by Genzyme under the trade name Renagel.

Kategori:
AminesBile Acid SequestrantsChelating Agents +9
Target Protein:
Phosphate
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
SGN-30 DB05471
biotech

SGN-30 is an engineered monoclonal antibody (mAb) that reacts with significant affinity to the CD30 antigen, which is highly expressed on a variety of hematologic malignancies as compared to on normal cells. SGN-30 has been shown to induce direct anti-cancer…

Target Protein:
Nuclear factor NF-kappa-B p105 subunitNuclear factor NF-kappa-B p100 subunit
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Silver Approved DB12965
small molecule | CAS: 7440-22-4

Silver (Ag) is a chemical element that belongs in the family of transition metals in the periodic table. It has a high electrical conductivity, thermal conductivity, and reflectivity. Silver exists as a pure elemental form, alloy with other metals, and minera…

Kategori:
Antiseptics and DisinfectantsDermatologicalsElements +4
Target Protein:
MetallothioneinCeruloplasminAlbumin +1
Waktu ParuhThe biological half…
Vol. DistribusiFollowing exposure …
Klirens-
Genetik -
Sirolimus Approved DB00877
small molecule | CAS: 53123-88-9

Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island).[A242412] It was first isolated and identified as a…

Kategori:
Agents causing angioedemaAnti-Bacterial AgentsAnti-Infective Agents +35
Target Protein:
Serine/threonine-protein kinase mTOR
Waktu ParuhThe mean ± SD termi…
Vol. DistribusiThe mean (± SD) blo…
KlirensIn adult renal tran…
Genetik -
Sodium aurothiomalate Approved DB09276
small molecule | CAS: 12244-57-4

Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold Sodium Thiomalate per mL. It is most effective in act…

Kategori:
Acids, AcyclicAntiinflammatory and Antirheumatic ProductsAntirheumatic Agents +13
Waktu Paruh12.5 days
Vol. DistribusiThe apparent volume…
Klirens7.0 ml/ kg/day
Genetik -
Sodium citrate Approved DB09154
small molecule | CAS: 68-04-2

Sodium citrate is the sodium salt of citric acid. It is white, crystalline powder or white, granular crystals, slightly deliquescent in moist air, freely soluble in water, practically insoluble in alcohol. Like citric acid, it has a sour taste. From the me…

Kategori:
Acids, AcyclicAntacids and AdsorbentsAnticoagulants +21
Target Protein:
Carbonic anhydrase 4
Waktu Paruh18-54 min [A19414]
Vol. Distribusi19-39L [A19414].
KlirensTotal clearance of …
Genetik -
small molecule | CAS: 151-21-3

Sodium Lauryl Sulfate (SLS) is an anionic surfactant naturally derived from coconut and/or palm kernel oil. It usually consists of a mixture of sodium alkyl sulfates, mainly the lauryl. SLS lowers surface tension of aqueous solutions and is used as fat emulsi…

Kategori:
AlcoholsAlkanesulfonatesAlkanesulfonic Acids +9
Target Protein:
Albumin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Solanezumab DB11756
biotech | CAS: 955085-14-0

Solanezumab is under investigation for the treatment of Dementia, Alzheimers Disease, and Alzheimers Disease, Familial.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Spebrutinib DB11764
small molecule | CAS: 1202757-89-8

Spebrutinib has been used in trials studying the treatment of Rheumatoid Arthritis, Lymphoma, Large B-Cell, Diffuse, and Leukemia Lymphocytic Chronic B-Cell.

Kategori:
Acids, AcyclicAcrylatesAmides +2
Target Protein:
Tyrosine-protein kinase BTK
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Squalene Approved DB11460
small molecule | CAS: 111-02-4

Squalene is originally obtained from shark liver oil. It is a natural 30-carbon isoprenoid compound and intermediate metabolite in the synthesis of cholesterol. It is not susceptible to lipid peroxidation and provides skin protection. It is ubiquitously distr…

Kategori:
AlkenesHydrocarbons, AcyclicPolyenes +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sulfacytine Approved DB01298
small molecule | CAS: 17784-12-2

Sulfacytine is a short-acting sulfonamide. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamide…

Kategori:
AmidesAminesAniline Compounds +5
Target Protein:
Dihydropteroate synthase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sulfaphenazole Approved DB06729
small molecule | CAS: 526-08-9

Sulfaphenazole is a sulfonamide antibacterial.

Kategori:
AmidesAminesAniline Compounds +27
Target Protein:
Dihydropteroate synthaseCytochrome P450 2C9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Sulindac Approved DB00605
small molecule | CAS: 38194-50-2

Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) of the arylalkanoic acid class that is marketed by Merck under the brand name Clinoril. Like other NSAIDs, it may be used in the treatment of acute or chronic inflammatory conditions. Sulindac is a pro…

Kategori:
Acetic Acid Derivatives and Related SubstancesAgents causing hyperkalemiaAgents that produce hypertension +20
Target Protein:
Prostaglandin G/H synthase 2Aldo-keto reductase family 1 member B1Prostaglandin G/H synthase 1 +4
Waktu ParuhThe mean half-life …
Vol. Distribusi-
Klirens* Renal cl=68.12 +/…
Genetik -
Sulopenem DB15284
small molecule | CAS: 120788-07-0

Sulopenem is a penem antibacterial. It is marketed as the prodrug [sulopenem etzadroxil] in combination with [probenecid].[L51768]

Kategori:
Amides
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Suvorexant Approved DB09034
small molecule | CAS: 1030377-33-3

Suvorexant is a selective dual antagonist of orexin receptors OX1R and OX2R that promotes sleep by reducing wakefulness and arousal. It has been approved for the treatment of insomnia.

Kategori:
Central Nervous System AgentsCentral Nervous System DepressantsCytochrome P-450 CYP3A Inhibitors +13
Target Protein:
Orexin/Hypocretin receptor type 1Orexin receptor type 2
Waktu ParuhMean half life is a…
Vol. DistribusiMean volume of dist…
Klirens-
Genetik -
small molecule

Synthetic conjugated estrogens A are composed of a blend of the following nine synthetic estrogenic substances: estrone sulfate, sodium equilin sulfate, sodium 17?-dihydroequilin sulfate, sodium 17?-estradiol sulfate, sodium 17?­ dihydroequilin sulfate, sodiu…

Kategori:
Cytochrome P-450 CYP3A SubstratesCytochrome P-450 CYP3A4 SubstratesCytochrome P-450 Substrates +7
Target Protein:
Estrogen receptor
Waktu ParuhThe half life of ba…
Vol. DistribusiThe distribution of…
Klirens-
Genetik -
small molecule | CAS: 746658-13-9

Synthetic conjugated estrogens, B tablets contain a blend of ten synthetic estrogenic substances. The estrogenic substances are: sodium estrone sulfate, sodium equilin sulfate, sodium 17?-dihydroequilin sulfate, sodium 17?-estradiol sulfate, sodium 17?­ dihyd…

Kategori:
Cytochrome P-450 CYP3A SubstratesCytochrome P-450 CYP3A4 SubstratesCytochrome P-450 Substrates +7
Target Protein:
Estrogen receptor
Waktu ParuhThe half life of ba…
Vol. DistribusiThe distribution of…
Klirens-
Genetik -
Tafamidis Approved DB11644
small molecule | CAS: 594839-88-0

Tafamidis and tafamidis meglumine (FX-1006A) are benzoxazole derivatives[A27206] developed by FoldRX.[A189717] Tafamidis is structurally similar to diflusinal.[A189717] Tafamidis was granted an EMA market authorisation on 16 November 2011[L6247] and FDA ap…

Kategori:
Anti-Inflammatory AgentsBCRP/ABCG2 InhibitorsFused-Ring Compounds +8
Target Protein:
Transthyretin
Waktu ParuhThe half life of ta…
Vol. DistribusiThe apparent volume…
KlirensThe oral clearance …
Genetik -
Talquetamab Approved DB16678
biotech | CAS: 2226212-40-2

Talquetamab is a IgG4-PAA bispecific G protein-coupled receptor class C group 5 member D (GPRC5D)-directed CD3 T-cell engager. It consists of two arms - anti-GPRC5D and anti-CD3 arms - linked by two interchain disulfide bonds, each arm comprising a heavy and …

Kategori:
Amino Acids, Peptides, and ProteinsAntibodies, MonoclonalAntineoplastic Agents +7
Target Protein:
T-cell surface glycoprotein CD3G-protein coupled receptor family C group 5 member D
Waktu ParuhThe mean (CV%) term…
Vol. DistribusiThe geometric mean …
KlirensTalquetamab clearan…
Genetik -
Tarlatamab Approved DB17256
biotech | CAS: 2307488-83-9

Tarlatamab is a first-in-class T-cell engager used to treat extensive-stage small cell lung cancer.[L50748] It is a bispecific monoclonal antibody that targets CD3 expressed on the surface of T-cells and delta-like ligand 3 (DLL3), an inhibitory ligand that s…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodies, MonoclonalBispecific Monoclonal Antibodies +5
Target Protein:
Delta-like protein 3T-cell surface glycoprotein CD3
Waktu ParuhThe median terminal…
Vol. DistribusiAt steady-state, th…
KlirensThe systemic cleara…
Genetik -
TDI-01 DB19450
small molecule

TDI-01 is a small molecule is being developed by Beijing Tide Pharmaceutical.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Tea tree oil DB11218
biotech | CAS: 68647-73-4

Tea tree oil is an essential oil derived mainly from the Australian native plant _Melaleuca alternifolia_ via steam distillation of the of the leaves and terminal branches [A32439]. It may be referred to as _Melaleuca alternifolia_ oil. It has been a popular …

Kategori:
Anti-Infective AgentsAnti-Infective Agents, LocalBiological Products +7
Waktu ParuhNo pharmacokinetic …
Vol. DistribusiNo pharmacokinetic …
KlirensNo pharmacokinetic …
Genetik -
biotech

Technetium Tc-99m red blood cells is a radiopharmaceutical diagnostic agent that is intravenously administered to be used in blood pool imaging, including cardiac first pass and gated equilibrium imaging and for detection of sites of gastrointestinal bleeding…

Kategori:
Radioactive Diagnostic AgentRadiopharmaceutical Activity
Waktu ParuhTechnetium Tc 99m d…
Vol. DistribusiFollowing intraveno…
Klirens-
Genetik -
Teclistamab Approved DB16655
biotech | CAS: 2119595-80-9

Teclistamab is an IgG4-PAA bispecific antibody that targets the CD3 receptor expressed on the surface of T cells and B cell maturation antigen (BCMA) expressed on malignant multiple myeloma cells.[A253587] Teclistamab consists of an anti-BCMA arm and an anti-…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodies, MonoclonalAntineoplastic Agents +8
Target Protein:
T-cell surface glycoprotein CD3Tumor necrosis factor receptor superfamily member 17
Waktu ParuhBased on non-compar…
Vol. DistribusiThe mean (CV%) volu…
KlirensTeclistamab exhibit…
Genetik -
Temsirolimus Approved DB06287
small molecule | CAS: 162635-04-3

Temsirolimus is a derivative of sirolimus used in the treatment of renal cell carcinoma (RCC). It was developed by Wyeth Pharmaceuticals under the trade name Torisel. Temsirolimus was approved by the FDA in late May 2007 as well as the European Medicines Agen…

Kategori:
Agents causing angioedemaAnti-Bacterial AgentsAntineoplastic Agents +32
Target Protein:
Serine/threonine-protein kinase mTOR
Waktu ParuhTemsirolimus exhibi…
Vol. Distribusi172 L in whole bloo…
Klirens16.2 L/h (22%)
Genetik -
Tenofovir alafenamide Approved DB09299
small molecule | CAS: 379270-37-8

Tenofovir alafenamide is a novel [tenofovir] prodrug developed in order to improve renal safety when compared to the counterpart [tenofovir disoproxil].[A178060] Both of these prodrugs were first created to cover the polar phosphonic acid group on tenofovir b…

Kategori:
Amino AcidsAmino Acids, Peptides, and ProteinsAntiinfectives for Systemic Use +25
Target Protein:
Reverse transcriptase/RNaseHGag-Pol polyproteinReverse transcriptase +1
Waktu ParuhThe reported half-l…
Vol. DistribusiIn clinical trials,…
KlirensThe reported cleara…
Genetik -
Terbinafine Approved DB00857
small molecule | CAS: 91161-71-6

Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues.[A1279] Like other allylamines, terbinafine inhibits ergosterol synthesis by inh…

Kategori:
Agents Causing Muscle ToxicityAllylamine AntifungalAllylamines +24
Target Protein:
Squalene monooxygenaseSqualene monooxygenase
Waktu ParuhOral terbinafine ha…
Vol. DistribusiA single 250mg oral…
KlirensA single 250mg oral…
Genetik -
Tetracycline Approved DB00759
small molecule | CAS: 60-54-8

Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from b…

Kategori:
Agents that produce neuromuscular block (indirect)Alimentary Tract and MetabolismAnti-Bacterial Agents +32
Target Protein:
30S ribosomal protein S730S ribosomal protein S1430S ribosomal protein S3 +6
Waktu Paruh6-12 hours
Vol. Distribusi-
Klirens-
Genetik -
Tetrofosmin Approved DB11180
small molecule | CAS: 127502-06-1

Tetrofosmin was developed to overcome the non-target uptake of radioligands by the generation of hetero-atomic compounds. It presents a molecular formula of 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane. Tetrofosmin is part of the group of diphosphines. Tetrofos…

Kategori:
Radioactive Diagnostic Agent
Waktu ParuhRefer to [DB09160]
Vol. DistribusiThis pharmacokineti…
KlirensRefer to [DB09160]
Genetik -
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