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13591

Total database: 17430
Struktur (SMILES)
10177 (74.9%)
Target
7625 (56.1%)
Genomik
104 (0.8%)
Referensi
13591 (100.0%)

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Hasil Pencarian (13591)

Halaman 68 / 272
Benapenem DB18883
small molecule | CAS: 1312953-83-5

Benapenem is under investigation in clinical trial NCT04505683 (A Study to Assess Efficacy and Safety Intravenous Benapenem in Patients With Complicated Urinary Tract Infection (Cuti) or Acute Pyelonephritis (AP)).

Kategori:
Amidesbeta-LactamsHeterocyclic Compounds, Fused-Ring +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benazepril Approved DB00542
small molecule | CAS: 86541-75-5

Benazepril, brand name Lotensin, is a medication used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure[A838,A837]. Upon cleavage of its ester group by the liver, benazepril is converted into its active form bena…

Kategori:
ACE Inhibitors and Calcium Channel BlockersACE Inhibitors and DiureticsAgents Acting on the Renin-Angiotensin System +13
Target Protein:
Angiotensin-converting enzyme
Waktu ParuhThe half life of th…
Vol. DistribusiThe final populatio…
KlirensThe final populatio…
Genetik -
Benazeprilat DB14125
small molecule | CAS: 86541-78-8

Deskripsi belum tersedia.

Kategori:
Agents Acting on the Renin-Angiotensin SystemAgents causing angioedemaAgents causing hyperkalemia +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bencyclane DB13488
small molecule | CAS: 2179-37-5

A vasodilator agent found to be effective in a variety of peripheral circulation disorders. It has various other potentially useful pharmacological effects. Its mechanism may involve block of calcium channels.

Kategori:
Agents causing hyperkalemiaAntiarrhythmic agentsBradycardia-Causing Agents +13
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bendazac Approved DB13501
small molecule | CAS: 20187-55-7

Bendazac is an oxyacetic acid [A39863, A39869]. Despite possessing anti-inflammatory, anti-necrotic, choleretic, and anti-lipidemic characteristics, most research has revolved around studying and demonstrating the agent's principal action in inhibiting the de…

Kategori:
Agents causing hyperkalemiaAgents that produce hypertensionAnalgesics +18
Target Protein:
Free radicalsProstaglandin G/H synthase 1Prostaglandin G/H synthase 2
Waktu ParuhThe plasma eliminat…
Vol. DistribusiThe volume of distr…
KlirensThe plasma clearanc…
Genetik -
Bendroflumethiazide Approved DB00436
small molecule | CAS: 73-48-3

A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810)

Kategori:
Antihypertensive AgentsAntihypertensive Agents Indicated for HypertensionBenzothiadiazines +17
Target Protein:
Solute carrier family 12 member 3Solute carrier family 12 member 1Calcium-activated potassium channel subunit alpha-1 +3
Waktu Paruh8.5 hours
Vol. Distribusi-
Klirens-
Genetik -
Benfluorex DB09022
small molecule | CAS: 23602-78-0

Benfluorex is an anorectic and hypolipidemic agent that is structurally related to fenfluramine. It was patented and manufactured by a French pharmaceutical company Servier. The European Medicines Agency (EMA) recommended withdrawing all benfluorex containing…

Kategori:
Alimentary Tract and MetabolismAminesAnti-Obesity Agents +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benidipine DB09231
small molecule | CAS: 105979-17-7

Benidipine has the formula 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylic acid methyl 1-(phenylmethyl)-3-piperidinyl ester hydrochloride. It is a synthetic dihydropyridine derivative that has anti-hypertensive and anti-anginal actions.[A…

Kategori:
Agents causing hyperkalemiaAntiarrhythmic agentsBradycardia-Causing Agents +19
Target Protein:
Voltage-dependent L-type calcium channelVoltage-dependent N-type calcium channel subunit alpha-1BVoltage-dependent T-type calcium channel
Waktu ParuhThe elimination hal…
Vol. DistribusiBenidipine is highl…
Klirens-
Genetik -
Benmoxin DB09246
small molecule | CAS: 7654-03-7

Benmoxin is an irreversible and nonselective monoamine oxidase inhibitor (MAOI) of the hydrazine class. It was first synthesized in 1967 and rapidly used in Europe as an antidepressant. However, this agent is no longer marketed.

Kategori:
Agents that produce hypertensionAgents that reduce seizure thresholdAntidepressive Agents +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benorilate Approved DB13657
small molecule | CAS: 5003-48-5

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicAgents causing hyperkalemiaAgents that produce hypertension +20
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benoxaprofen Approved DB04812
small molecule | CAS: 51234-28-7

The use of benoxaprofen, formerly marketed as Oraflex tablets, was associated with fatal cholestatic jaundice among other serious adverse reactions. The holder of the approved application voluntarily withdrew Oraflex tablets from the market on August 5, 1982.

Kategori:
Acids, AcyclicAgents causing hyperkalemiaAgents that produce hypertension +18
Target Protein:
Acetyl-CoA acetyltransferase, mitochondrial
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benproperine DB13309
small molecule | CAS: 2156-27-6

Deskripsi belum tersedia.

Kategori:
Benzene DerivativesCough and Cold Preparations
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benralizumab Approved DB12023
biotech | CAS: 1044511-01-4

Benralizumab is a humanized recombinant monoclonal antibody of the isotype IgG1k immunoglobulin that specifically binds to the alpha chain of the interleukin 5 receptor (IL-5R) expressed on eosinophils and basophils.[A31294] It inhibits the binding of IL-5 as…

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Asthmatic AgentsAntibodies +13
Target Protein:
Interleukin-5 receptor subunit alphaLow affinity immunoglobulin gamma Fc region receptor III-A
Waktu ParuhThe half-life of Be…
Vol. DistribusiPharmacokinetic rep…
KlirensFor a subject weigh…
Genetik -
Benserazide Approved DB12783
small molecule | CAS: 322-35-0

When levodopa is used by itself as a therapy for treating Parkinson's disease, its ubiquitous metabolism into dopamine is responsible for a resultant increase in the levels of circulating dopamine in the blood and to various extracerebral tissues. This can re…

Kategori:
Anti-Dyskinesia AgentsAnti-Parkinson DrugsAromatic L-amino Acid Decarboxylase Inhibitors +6
Target Protein:
Aromatic-L-amino-acid decarboxylase
Waktu ParuhThe half-life of be…
Vol. DistribusiReadily accessible …
KlirensReadily accessible …
Genetik -
Bentamapimod DB16851
small molecule | CAS: 848344-36-5

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-RingThiazoles
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bentiromide DB00522
small molecule | CAS: 37106-97-1

Bentiromide is a dipeptide that is used in the bentiromide test, which is a screening test for evaluating pancreatic exocrine function and monitoring the adequacy of supplemental pancreatic therapy. It is typically administered orally. Cases of headache and g…

Kategori:
Acids, CarbocyclicAminobenzoatesBenzene Derivatives +7
Target Protein:
Serine protease hepsin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bentonite Approved DB11306
small molecule

Deskripsi belum tersedia.

Kategori:
Aluminium CompoundsAluminum SilicatesAntidotes +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bentoquatam Approved DB00516
small molecule | CAS: 1340-69-8

Bentoquatam is a topical medication intended to act as a shield against exposure to the irritating substance urushiol, found in plants such as poison ivy or poison oak. Bentoquatam contains bentonite, a clay, and is only effective as long as the film is visib…

Kategori:
Aluminium CompoundsAluminum SilicatesDermatologicals +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bentracimab DB16659
biotech | CAS: 2260568-31-6

Bentracimab is under investigation in clinical trial NCT04286438 (Bentracimab (PB2452) in Ticagrelor-treated Patients With Uncontrolled Major or Life-threatening Bleeding or Requiring Urgent Surgery or Invasive Procedure).

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Neutralizing +12
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzamidine DB03127
small molecule | CAS: 618-39-3

Deskripsi belum tersedia.

Kategori:
AmidinesEnzyme InhibitorsProtease Inhibitors +1
Target Protein:
Serine protease 1Urokinase-type plasminogen activatorSuppressor of tumorigenicity 14 protein +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzatropine Approved DB00245
small molecule | CAS: 86-13-5

Benztropine, with the chemical formula 3alpha-diphenylmethoxytropane, is a tropane-based dopamine inhibitor used for the symptomatic treatment of Parkinson's disease. It is a combination molecule between a tropane ring, similar to cocaine, and a diphenyl ethe…

Kategori:
Agents producing tachycardiaAlkaloidsAnti-Dyskinesia Agents +23
Target Protein:
Muscarinic acetylcholine receptor M1Sodium-dependent dopamine transporterHistamine H1 receptor +2
Waktu ParuhThe elimination hal…
Vol. DistribusiBenztropine is expe…
KlirensExtensive pharmacod…
Genetik -
Benzbromarone DB12319
small molecule | CAS: 3562-84-3

Benzbromarone has been used in trials studying the basic science and treatment of Heart Failure, Hyperuricemia, Chronic Kidney Disease, Abnormal Renal Function, and Gout and Asymptomatic Hyperuricemia.

Kategori:
Antigout PreparationsAntirheumatic AgentsBenzofurans +12
Target Protein:
Anoctamin-1Solute carrier family 22 member 12Multidrug resistance-associated protein 1 +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 618-41-7

Deskripsi belum tersedia.

Kategori:
AcidsAcids, NoncarboxylicSulfur Acids +1
Target Protein:
Oxysterols receptor LXR-beta
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzethidine DB01518
small molecule | CAS: 3691-78-9

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzethonium Approved DB11125
small molecule | CAS: 10172-60-8

Benzethonium is a synthetic quaternary ammonium salt with surfactant, antiseptic, and broad spectrum antimicrobial properties. Its salt form, benzethonium chloride, is primarily used as a skin disinfectant at concentrations of 0.1-0.2 %, which are safe and ef…

Kategori:
AminesAnti-Infective AgentsAnti-Infective Agents, Local +7
Waktu ParuhPharmacokinetic stu…
Vol. DistribusiPharmacokinetic stu…
KlirensPharmacokinetic stu…
Genetik -
Benzgalantamine Approved DB19353
small molecule | CAS: 224169-27-1

Benzgalantamine is a prodrug of [galantamine]. Gastrointestinal adverse effects are the most frequently reported side effects in patients undergoing treatment with cholinesterase inhibitors, including galantamine, and are often a reason for treatment disconti…

Kategori:
AlkaloidsAlzheimer Disease, drug therapyAmaryllidaceae Alkaloids +11
Target Protein:
AcetylcholinesteraseCholinesteraseNeuronal acetylcholine receptor subunit alpha-7 +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzhydrocodone Approved DB15465
small molecule | CAS: 1259440-61-3

Benzhydrocodone is a benzylic prodrug of hydrocodone.[L4894] It was developed in an effort to reduce parenteral bioavailability of the active metabolite as a deterrent to abuse.[A182177] Benzhydrocodone is indicated for use in the short-term management of pai…

Kategori:
Opioids
Target Protein:
Mu-type opioid receptor
Waktu ParuhThe hydrocodone met…
Vol. DistribusiThe hydrocodone met…
KlirensThe apparent cleara…
Genetik -
Benzilone DB13369
small molecule | CAS: 16175-92-1

Deskripsi belum tersedia.

Kategori:
Agents producing tachycardiaAlimentary Tract and MetabolismAnticholinergic Agents +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benziodarone Approved DB13277
small molecule | CAS: 68-90-6

Benziodarone is a uricostatic and a uricosuric agent which is sold also under the name Amplivex-Labaz. It is used in the treatment of gout [A175630]. It was withdrawn from France markets and British markets due to its effects causing Jaundice in patients [T48…

Kategori:
Antigout PreparationsAntirheumatic AgentsCardiac Therapy +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benznidazole Approved DB11989
small molecule | CAS: 22994-85-0

Benznidazole was granted accelerated approval for the treatment of Chagas disease in children 2-12 years of age by the FDA on August 29, 2017.[L939] It is the first treatment made available in the United States for Chagas disease.

Kategori:
Agents Against Leishmaniasis and TrypanosomiasisAnti-Infective AgentsAntiparasitic Agents +12
Waktu ParuhThe half life of el…
Vol. DistribusiThe apparent volume…
KlirensThe apparent oral c…
Genetik -
Benzocaine Approved DB01086
small molecule | CAS: 94-09-7

Benzocaine is an ester local anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.[A231219] It is commonly used for local anesthesia in many over the counter products.[L32454,L32459,L32464] Benzocaine was first u…

Kategori:
Acids, CarbocyclicAgents for Treatment of Hemorrhoids and Anal Fissures for Topical UseAminobenzoates +29
Target Protein:
Sodium channel protein type 10 subunit alpha
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzoctamine DB09021
small molecule | CAS: 17243-39-9

Benzoctamine is a drug with two main uses. It can be used as a sedative which does not depress the respiratory system, but rather stimulates it. It can also be used as an anxiolytic with the same efficacy as chlordiazepoxide for treating anxiety neurosis.

Kategori:
Anti-Anxiety AgentsCentral Nervous System DepressantsDibenzo-Bicyclo-Octadiene Derivatives +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzododecinium DB13282
small molecule | CAS: 10328-35-5

Benzododecinium is used as an antiseptic/disinfectant compound. It has been marketed as a tincture for antiseptic product for wounds in the Czech Republic.

Kategori:
AminesAnti-Infective AgentsAnti-Infective Agents, Local +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzoic acid Approved DB03793
small molecule | CAS: 65-85-0

A fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid. As the sodium salt form, sodium benzoate is used as a treatment for urea cycle disorders due to its ability to bind amin…

Kategori:
Acids, CarbocyclicAlimentary Tract and MetabolismAmmonium Ion Binding Activity +18
Target Protein:
Ras-related protein Rab-9ASolute carrier family 15 member 1Cocaine esterase +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzoin Approved DB14020
small molecule | CAS: 119-53-9

Benzoin is a white crystalline compound prepared by condensation of benzaldehyde in potassium cyanide, and is used in organic syntheses. This should not be confused with benzoin gum from STYRAX (see [DB11222]). Benzoin is an FDA-approved colour additive used …

Kategori:
AcetophenonesAnti-Infective Agents, LocalKetones
Target Protein:
Liver carboxylesterase 1
Waktu ParuhNo pharmacokinetic …
Vol. DistribusiNo pharmacokinetic …
KlirensNo pharmacokinetic …
Genetik -
Benzonatate Approved DB00868
small molecule | CAS: 104-31-4

Benzonatate is an oral antitussive drug used in the relief and suppression of cough in patients older than ten years of age.[A5790] Currently, benzonatate is the only non-narcotic antitussive available as a prescription drug.[A189519] It works to reduce the a…

Kategori:
AlkanesAminesAntitussive Agents +8
Target Protein:
Sodium channel protein type 5 subunit alpha
Waktu ParuhThe half life of be…
Vol. DistribusiThere is limited in…
KlirensThere is limited in…
Genetik -
Benzophenone DB01878
small molecule | CAS: 119-61-9

Benzophenone is the organic compound. Substituted benzophenones such as oxybenzone and dioxybenzone are used in sunscreen.

Kategori:
Benzene DerivativesDermatologicalsKetones +2
Target Protein:
Estrogen receptorEstrogen receptor beta
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzoxonium DB13565
small molecule | CAS: 23884-64-2

Deskripsi belum tersedia.

Kategori:
Alimentary Tract and MetabolismAminesAntiinfectives and Antiseptics for Local Oral Treatment +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzoyl peroxide Approved DB09096
small molecule | CAS: 94-36-0

Benzoyl peroxide is a commonly used drug in topical treatments for acne.[L33249,L33264,L33269,L33299,L33314] It has been formulated as products with either a single active ingredient,[L33249,L33299] or with [erythromycin],[L33264] [clindamycin],[L33269] or [a…

Kategori:
Acids, CarbocyclicAnti-Acne PreparationsAnti-Acne Preparations for Topical Use +5
Target Protein:
CatalaseGlutathione peroxidaseAntizyme inhibitor 2 +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzoylecgonine DB01515
small molecule | CAS: 519-09-5

Benzoylecgonine is the major metabolite of cocaine. It is formed by hydrolysis of cocaine in the liver, catalysed by carboxylesterases. It is excreted in the urine of cocaine users after processing in the liver. It is the main pharmaceutical ingredient in the…

Kategori:
AlkaloidsAza CompoundsAzabicyclo Compounds +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 611-73-4

Deskripsi belum tersedia.

Kategori:
Acids, AldehydicAcids, CarbocyclicHydroxy Acids
Target Protein:
2-Hydroxyacid oxidase 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 18481-26-0

Deskripsi belum tersedia.

Kategori:
PyrimidinesSulfur CompoundsThiazoles
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzoylpas DB19382
small molecule | CAS: 13898-58-3

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Beta-lactamaseBeta-lactamase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzphetamine Approved DB00865
small molecule | CAS: 156-08-1

A sympathomimetic agent with properties similar to dextroamphetamine. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222)

Kategori:
Adrenergic AgentsAdrenergic AgonistsAdrenergic alpha-1 Receptor Agonists +28
Target Protein:
Synaptic vesicular amine transporterAlpha-2A adrenergic receptorAlpha-1A adrenergic receptor +1
Waktu Paruh16 to 31 hours
Vol. Distribusi-
Klirens-
Genetik -
Benzquinamide DB00767
small molecule | CAS: 63-12-7

Benzquinamide is a discontinued antiemetic compound with antihistaminic, mild anticholinergic, and sedative properties. The mechanism of action is not known, but presumably benzquinamide works via antagonism of muscarinic acetycholine receptors and histamine …

Kategori:
Agents producing tachycardiaAnticholinergic AgentsHeterocyclic Compounds, Fused-Ring +4
Target Protein:
Histamine H1 receptorMuscarinic acetylcholine receptor M4Muscarinic acetylcholine receptor M1 +3
Waktu Paruh1-1.6 hours (for al…
Vol. Distribusi-
Klirens-
Genetik -
Benzthiazide Approved DB00562
small molecule | CAS: 91-33-8

Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium…

Kategori:
DiureticsGenito Urinary System and Sex HormonesGynecological Antiinfectives and Antiseptics +8
Target Protein:
Solute carrier family 12 member 3Carbonic anhydraseCarbonic anhydrase 2 +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Replicase polyprotein 1ab
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Collagenase 3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Benzyl alcohol Approved DB06770
small molecule | CAS: 100-51-6

Deskripsi belum tersedia.

Kategori:
AlcoholsAnestheticsAnesthetics, Local +18
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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