Hasil Filter

14063

Total database: 17430
Struktur (SMILES)
10481 (74.5%)
Target
8038 (57.2%)
Genomik
107 (0.8%)
Referensi
14063 (100.0%)

Tipe Molekul

Distribusi Wujud Zat

Status Regulasi

Hasil Pencarian (14063)

Halaman 68 / 282
AZD-8165 DB15132
small molecule | CAS: 1201686-72-7

AZD-8165 is under investigation in clinical trial NCT01150812 (Oral AZD8165 After Single Oral Ascending Doses in Healthy Male Subjects).

Target Protein:
Prothrombin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
AZD-8186 DB15029
small molecule | CAS: 1627494-13-6

AZD-8186 is under investigation in clinical trial NCT03218826 (PI3Kbeta Inhibitor AZD8186 and Docetaxel in Treating Patients Advanced Solid Tumors With PTEN or PIK3CB Mutations That Are Metastatic or Cannot Be Removed by Surgery).

Kategori:
AminesBenzopyransHeterocyclic Compounds, Fused-Ring +1
Target Protein:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
AZD-8418 DB13102
small molecule | CAS: 1198309-73-7

Azd8418 is under investigation in clinical trial NCT01027234 (This Study Will Assess the Safety and Tolerability of AZD8418 After Single Increasing Oral Doses).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
AZD-8848 DB14868
small molecule | CAS: 866269-28-5

AZD-8848 is under investigation in clinical trial NCT01818869 (To Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses AZD8848 in Healthy Subjects).

Kategori:
Acids, CarbocyclicHeterocyclic Compounds, Fused-RingNucleic Acids, Nucleotides, and Nucleosides +4
Target Protein:
Toll-like receptor 7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
AZD-9056 DB12594
small molecule | CAS: 345304-65-6

AZD9056 has been used in trials studying the basic science and treatment of Rheumatoid Arthritis.

Kategori:
Acids, CarbocyclicAmidesBenzene Derivatives +3
Target Protein:
P2X purinoceptor 7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
AZD-9164 DB12115
small molecule | CAS: 1034978-04-5

AZD9164 has been used in trials studying the basic science and treatment of Chronic Obstructive Pulmonary Disease.

Kategori:
Receptor, Muscarinic M3, antagonists & inhibitors
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
AZD-9496 DB15138
small molecule | CAS: 1639042-08-2

AZD-9496 is under investigation in clinical trial NCT02248090 (AZD9496 First Time in Patients Ascending Dose Study).

Kategori:
Acids, CarbocyclicHeterocyclic Compounds, Fused-Ring
Target Protein:
Estrogen receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
AZD-9684 DB05712
small molecule

AZD-9684 is the first member of a new anti-thrombotic class (CPU inhibitors). It is being developed by AstraZeneca.

Kategori:
Acids, AcyclicFatty AcidsFatty Acids, Volatile +1
Target Protein:
Carboxypeptidase B2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
AZD0947 DB04848
small molecule

AZD0947 is a K+ channel opener, which was under investigation by AstraZeneca for the treatment of overactive bladder. As of March 2003, the drug was in phase II trials; however, as of October 2004, it no longer appeared on the company’s development pipeline.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
AZD2066 DB17078
small molecule | CAS: 934282-55-0

Deskripsi belum tersedia.

Kategori:
Gastrointestinal AgentsReceptor, Metabotropic Glutamate 5, antagonists & inhibitors
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
AZD2315 DB06540
biotech | CAS: 457937-78-9

The drug AZD2315, an immunosuppressant developed by AstraZeneca, was in Phase 1 clinical trials for the treatment of rheumatoid arthritis but was discontinued during this phase

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
AZD3409 DB04893
small molecule

AZD3409 is a farnesyl-transferase inhibitor (FAR) indicated for the treatment of solid tumors. Phase I trials were initiated January 2003, and were ongoing as of February 2004. As of February 2007 the development of AZD3409 had been discontinued.

Target Protein:
Protein farnesyltransferase subunit betaProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Waktu Paruh15–20 hours for the…
Vol. Distribusi-
Klirens-
Genetik -
AZD7442 DB15787
biotech

AZD7442 is a combination of SARS-CoV-2 antibodies (AZD8895 + AZD1061) currently undergoing phase I clinical trials for the prevention and treatment of COVID-19.[L15596] It was developed by AstraZeneca with the goal of conferring at least 6 months of protecti…

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Infective AgentsAntibodies +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
AZD8529 DB16073
small molecule | CAS: 1092453-15-0

AZD8529 is under investigation in clinical trial NCT00921804 (Study to Assess the Efficacy, Safety, and Tolerability of AZD8529 in Adult Schizophrenia Patients).

Kategori:
Heterocyclic Compounds, Fused-RingOxazoles
Target Protein:
Metabotropic glutamate receptor 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Azelaic acid Approved DB00548
small molecule | CAS: 123-99-9

Azelaic acid is a saturated dicarboxylic acid found naturally in wheat, rye, and barley. It is also produced by _Malassezia furfur_, also known as _Pityrosporum ovale_, which is a species of fungus that is normally found on human skin. Azelaic acid is effecti…

Kategori:
Acids, AcyclicAnti-Acne PreparationsAnti-Acne Preparations for Topical Use +5
Target Protein:
Thioredoxin reductasePolyprenal reductase3-oxo-5-alpha-steroid 4-dehydrogenase 1 +4
Waktu ParuhThe observed half-l…
Vol. Distribusi-
Klirens-
Genetik -
Azelaprag DB19329
small molecule | CAS: 2049980-18-7

Azelaprag is under investigation in clinical trial NCT06515418 (Efficacy and Safety of Oral Azelaprag Plus Once Weekly Tirzepatide Compared With Tirzepatide Alone in Participants With Obesity Aged 55 Years and Over).

Target Protein:
Apelin receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Azelastine Approved DB00972
small molecule | CAS: 58581-89-8

Azelastine, a phthalazine derivative, is an antihistamine available as an intranasal spray for the treatment of allergic and vasomotor rhinitis and as an ophthalmic solution for the treatment of allergic conjunctivitis.[L8240,L8270] It is a racemic mixture, t…

Kategori:
Anti-Allergic AgentsAntiallergic Agents, Excl. CorticosteroidsAntihistamines for Systemic Use +41
Target Protein:
Histamine H1 receptorHistamine H2 receptorPhospholipase A2 +1
Waktu ParuhBased on intravenou…
Vol. DistribusiAfter intravenous a…
KlirensBased on intravenou…
Genetik -
Azeliragon DB12689
small molecule | CAS: 603148-36-3

Azeliragon has been used in trials studying the treatment of Alzheimer's Disease.

Target Protein:
Advanced glycosylation end product-specific receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Azelnidipine DB09230
small molecule | CAS: 123524-52-7

Azelnidipine is a dihydropyridine calcium channel blocker. It is marketed by Daiichi-Sankyo pharmaceuticals, Inc. in Japan. It has a gradual onset of action and produces a long-lasting decrease in blood pressure, with only a small increase in heart rate, unl…

Kategori:
Acids, AcyclicAgents causing hyperkalemiaAmino Acids +14
Target Protein:
Voltage-dependent L-type calcium channel subunit beta-1
Waktu Paruh16 –28 hours [L1383…
Vol. DistribusiIn a Chinese study …
Klirens-
Genetik -
Azemiglitazone DB16028
small molecule | CAS: 1133819-87-0

Azemiglitazone is under investigation in clinical trial NCT01280695 (A Randomized, Double-blind, Comparator- and Placebo-controlled, Multiple-dose Study to Evaluate the Safety, Tolerability and Efficacy of Three Dose Levels of MSDC-0602 in Type 2 Diabetic Pat…

Kategori:
KetonesSulfur CompoundsThiazoles
Target Protein:
Insulin receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Azenosertib DB18028
small molecule | CAS: 2376146-48-2

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Azficel-T Approved DB11051
biotech

Azficel-T is an autologous cellular product composed of fibroblasts indicated for improvement of the appearance of moderate to severe nasolabial fold wrinkles in adults. Dermal fibroblasts are collected from the post-auricular biopsy tissue and aseptically ex…

Kategori:
Autologous Cultured Cell
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Azidamfenicol DB13294
small molecule | CAS: 13838-08-9

Deskripsi belum tersedia.

Kategori:
AlcoholsAnti-Bacterial AgentsAnti-Infective Agents +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Azidocillin DB08795
small molecule | CAS: 17243-38-8

Azidocillin is a penicillin antibiotic similir to ampicillin.

Kategori:
AmidesAnti-Bacterial AgentsAntibacterials for Systemic Use +8
Target Protein:
Penicillin-binding protein 2aPenicillin-binding protein 1bPenicillin-binding protein 3 +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Azilsartan medoxomil Approved DB08822
small molecule | CAS: 863031-21-4

Azilsartan medoxomil is a prodrug that is broken down to azilsartan, which belongs in the angiotensin-receptor blocking (ARB) drug class. It is a selective AT1 subtype angiotensin II receptor antagonist. Azilsartan medoxomil is a relatively recently-developed…

Kategori:
Agents Acting on the Renin-Angiotensin SystemAgents causing angioedemaAgents causing hyperkalemia +18
Target Protein:
Type-1 angiotensin II receptor
Waktu ParuhThe elimination hal…
Vol. DistribusiThe volume of distr…
KlirensRenal clearance of …
Genetik -
Azimilide DB04957
small molecule | CAS: 149908-53-2

Azimilide is an investigational class III anti-arrhythmic drug that blocks fast and slow components of the delayed rectifier cardiac potassium channels. It is not approved for use in any country, but is currently in clinical trials in the United States.

Kategori:
Antiarrhythmic agentsAntiarrhythmics, Class IIICalcium-Regulating Hormones and Agents +11
Target Protein:
Potassium voltage-gated channel subfamily E member 1Potassium voltage-gated channel subfamily KQT member 1Voltage-gated inwardly rectifying potassium channel KCNH2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Azintamide DB13992
small molecule | CAS: 1830-32-6

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 1826819-58-2

Azintuxizumab vedotin is under investigation in clinical trial NCT02951117 (A Study of Venetoclax and ABBV-838 Combination Therapy With Dexamethasone in Participants With Multiple Myeloma Whose Cancer Has Come Back or Had No Response to Recent Cancer Treatmen…

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Azithromycin Approved DB00207
small molecule | CAS: 83905-01-5

Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration [A174172]. It was initially approved by the FDA in 1991 [A174175]. It is primarily used for the treatment of respiratory, enteric and genito…

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsAntibacterials for Systemic Use +22
Target Protein:
23S ribosomal RNAProtein-arginine deiminase type-4
Waktu ParuhTerminal eliminatio…
Vol. DistribusiAfter oral administ…
KlirensMean apparent plasm…
Genetik -
Azlocillin Approved DB01061
small molecule | CAS: 37091-66-0

Azlocillin is a semisynthetic ampicillin-derived acylureido penicillin.

Kategori:
Agents that reduce seizure thresholdAmidesAnti-Bacterial Agents +11
Target Protein:
Penicillin-binding protein 1A
Waktu ParuhMean elimination ha…
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 123-77-3

Deskripsi belum tersedia.

Kategori:
Anti-HIV AgentsAnti-Infective AgentsAnti-Retroviral Agents +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Azosemide DB08961
small molecule | CAS: 27589-33-9

Azosemide is a loop diuretic used to treat hypertension, edema, and ascites.

Kategori:
AmidesAminesAniline Compounds +7
Waktu ParuhTerminal half life …
Vol. DistribusiPoor affinity for h…
Klirens-
Genetik -
small molecule | CAS: 892497-01-7

Azoximer bromide is under investigation in clinical trial NCT04381377 (Efficacy and Safety of Polyoxidonium® in Hospitalized Patients With Coronavirus Disease COVID-19).

Kategori:
Macromolecular Substances
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Aztreonam Approved DB00355
small molecule | CAS: 78110-38-0

A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-posit…

Kategori:
AmidesAnti-Bacterial AgentsAnti-Infective Agents +9
Target Protein:
Penicillin-binding protein 3Peptidoglycan synthase FtsIBeta-lactamase +1
Waktu ParuhThe serum half-life…
Vol. Distribusi* 12.6 L
Klirens* 91 mL/min [health…
Genetik -
Azurin-p28 DB17241
biotech | CAS: 897026-25-4

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsBacterial ProteinsMetalloproteins +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Azvudine DB16407
small molecule | CAS: 1011529-10-4

Azvudine is under investigation in clinical trial NCT04668235 (Study on Safety and Clinical Efficacy of AZVUDINE in COVID-19 Patients (Sars-cov-2 Infected)).

Kategori:
DeoxyribonucleosidesExperimental Unapproved Treatments for COVID-19Nitrogen Compounds +4
Target Protein:
Broad substrate specificity ATP-binding cassette transporter ABCG2ATP-binding cassette sub-family C member 2ATP-dependent translocase ABCB1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
AZX-100 DB06323
biotech | CAS: 1217194-46-1

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsHeat-Shock ProteinsMolecular Chaperones +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
H subunit of photosynthetic reaction center complexAquaporin ZCytochrome b +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 69984-73-2

Deskripsi belum tersedia.

Target Protein:
Pancreatic triacylglycerol lipaseCytochrome c oxidase subunit 1Cytochrome c oxidase subunit 2 +11
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
B27PD DB16289
biotech | CAS: 160387-12-2

B27PD is under investigation in clinical trial NCT01195948 (Optiquel® as Corticosteroid-sparing Therapy for Chronic Noninfectious Uveitis).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BA-2664 DB01479
small molecule | CAS: 641-82-7

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BA1301 DB19390
biotech

BA1301 is an anti-Claudin18.2 monoclonal antibody conjugated with Duostatin-5.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bacampicillin Approved DB01602
small molecule | CAS: 50972-17-3

Bacampicillin is a prodrug of ampicillin and is microbiologically inactive. It is absorbed following oral administration. During absorption from the gastrointestinal tract, bacampicillin is hydrolyzed by esterases present in the intestinal wall. It is microbi…

Kategori:
AmidesAnti-Bacterial AgentsAnti-Infective Agents +10
Target Protein:
Penicillin-binding protein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Baccharis sarothroides whole Approved DB15502
biotech

Baccharis sarothroides whole allergenic extract is used in allergenic testing.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

BCG SSI has been used in trials studying Tuberculosis.

Kategori:
Live Attenuated Bacillus Calmette-Guerin VaccineLive vaccinesVaccines
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Bacillus Calmette-Guerin (BCG) substrain Russian BCG-I is a live BCG vaccine administered directly into the bladder for the adjuvant treatment of papillary urothelial cell carcinoma of the bladder. Live BCG vaccines administered intravesically have been a gol…

Kategori:
Antineoplastic AgentsLive vaccinesVaccines
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Bacillus calmette-guerin substrain tokyo 172-1 live antigen is under investigation in clinical trial NCT03091660 (S1602: Different Strains of BCG With or Without Vaccine in High Grade Non- Muscle Invasive Bladder Cancer).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bacillus cereus DB19245
biotech | CAS: 68038-62-0

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 68038-65-3

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 68038-66-4

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 3351–3400 dari 14063
Sebelumnya Halaman 68 / 282 Berikutnya