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12560

Total database: 17430
Struktur (SMILES)
9109 (72.5%)
Target
6912 (55.0%)
Genomik
109 (0.9%)
Referensi
12560 (100.0%)

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Hasil Pencarian (12560)

Halaman 67 / 252
Bromoform DB03054
small molecule | CAS: 75-25-2

Deskripsi belum tersedia.

Kategori:
CarcinogensHydrocarbons, HalogenatedNoxae +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bromopride DB09018
small molecule | CAS: 4093-35-0

Bromopride is a dopamine antagonist used as an antiemetic. Its prokinetic properties are similar to those of metoclopramide. It is unavailable in America or the United Kingdom.

Kategori:
Acids, CarbocyclicAlimentary Tract and MetabolismAmides +22
Target Protein:
D(2) dopamine receptor
Waktu Paruh-
Vol. Distribusi-
KlirensRenal, 10-14% as or…
Genetik -
Bromopyruvate DB17135
small molecule | CAS: 1113-59-3

Deskripsi belum tersedia.

Kategori:
Affinity LabelsCompounds used in a research, industrial, or household settingEnzyme Inhibitors +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bromothalonil Approved DB14199
small molecule | CAS: 35691-65-7

Bromothalonil, also known as Methyldibromo glutaronitrile (MDBGN), is a widely used preservative that can be found in many personal hygiene and industrial products. It is also a known allergen and dermatological irritant that has been banned in many EU countr…

Kategori:
AllergensAntigensBiological Factors +7
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bromotheophylline Approved DB14018
small molecule | CAS: 10381-75-6

Bromotheophylline is the active moiety of pamabrom, a mixture of 2-amino-2-methyl-propanol and bromotheophylline. From this mixture, bromotheophylline acts as a weak diuretic that has been used along with some analgesics to relieve the symptoms of premenstrua…

Kategori:
AlcoholsAlkaloidsAmines +11
Target Protein:
Adenosine receptor
Waktu ParuhThe apparent elimin…
Vol. DistribusiThis pharmacokineti…
KlirensThis pharmacokineti…
Genetik -
Bromperidol Approved DB12401
small molecule | CAS: 10457-90-6

Bromperidol has been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and Psychosomatic Disorders, among others.

Kategori:
Antipsychotic AgentsButyrophenone DerivativesButyrophenones +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Brompheniramine Approved DB00835
small molecule | CAS: 86-22-6

Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria.

Kategori:
Agents producing tachycardiaAnti-Allergic AgentsAnticholinergic Agents +14
Target Protein:
Histamine H1 receptorMuscarinic acetylcholine receptor M1Muscarinic acetylcholine receptor M2 +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bromus inermis pollen Approved DB10355
biotech

Bromus inermis pollen is the pollen of the Bromus inermis plant. Bromus inermis pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bronopol Approved DB13960
small molecule | CAS: 52-51-7

Bronopol, or 2-Bromo-2-nitro-1,3-propanediol, is an organic compound with wide-spectrum antimicrobial properties. First synthesized in 1897, bronopol was primarily used as a preservative for pharmaceuticals and was registered in the United States in 1984 for …

Kategori:
AlcoholsAnti-Infective AgentsAnti-Infective Agents, Local +9
Target Protein:
Thiol groups
Waktu ParuhThe half-life of br…
Vol. DistribusiThe highest concent…
KlirensNo data available.
Genetik -
Brontictuzumab DB12737
biotech | CAS: 1447814-75-6

Brontictuzumab has been used in trials studying the treatment of Adenoid Cystic Carcinoma, Relapsed or Refractory Solid Tumors, and Relapsed or Refractory Lymphoid Malignancies.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodies, MonoclonalAntibodies, Monoclonal, Humanized +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bropirimine DB04168
small molecule | CAS: 56741-95-8

Deskripsi belum tersedia.

Kategori:
Adjuvants, ImmunologicAntineoplastic AgentsImmunologic Factors +3
Target Protein:
Dihydroneopterin aldolase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Brostallicin DB06598
small molecule | CAS: 203258-60-0

Deskripsi belum tersedia.

Kategori:
Amidines
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Brotizolam DB09017
small molecule | CAS: 57801-81-7

Brotizolam is a sedative-hypnotic thienodiazepine drug which is a benzodiazepine analog. It demonstrates anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant effects. Brotizolam has similar effects to short-acting benzodiazepines such a…

Kategori:
Benzodiazepine hypnotics and sedativesBenzodiazepines and benzodiazepine derivativesCentral Nervous System Agents +7
Target Protein:
GABA(A) ReceptorGABA(A) Receptor Benzodiazepine Binding Site
Waktu Paruh4.4 hours.
Vol. Distribusi0.63 l/kg.
KlirensTotal clearance: 10…
Genetik -
Brovanexine DB14720
small molecule | CAS: 54340-61-3

Deskripsi belum tersedia.

Kategori:
Acids, CarbocyclicAmidesBenzene Derivatives +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Brown iron oxide Approved DB14567
small molecule | CAS: 52357-70-7

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Broxuridine DB12028
small molecule | CAS: 59-14-3

Broxuridine has been used in trials studying the treatment of Leukemia, Stage I Prostate Cancer, Stage IIB Prostate Cancer, and Stage IIA Prostate Cancer.

Kategori:
Anti-Infective AgentsAntimetabolitesAntineoplastic Agents +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Broxyquinoline DB13536
small molecule | CAS: 521-74-4

Deskripsi belum tersedia.

Kategori:
Alimentary Tract and MetabolismAntidiarrheals, Intestinal Antiinflammatory/antiinfective AgentsAntiparasitic Products, Insecticides and Repellents +9
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bryostatin 1 DB11752
small molecule | CAS: 83314-01-6

Bryostatin 1 has been investigated for the treatment of HIV Infection and Alzheimer's Disease.

Kategori:
Adjuvants, ImmunologicAnti-Bacterial AgentsAntineoplastic Agents +15
Target Protein:
Protein kinase C epsilon typeProtein kinase C alpha typeCaspase-8 +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BS-001 DB17415
biotech

BS-001 is a recombinant oncolytic herpes simplex virus type II (OH2) therapeutic injection (Vero cell) for human use (rHSV2hGM-CSF).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BSG-005 DB18014
small molecule

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BT200 DB18333
biotech

BT200 (Rondoraptivon pegol) is a PEGylated anti-von Willebrand factor (VWF) aptamer targeted against the VWF A1 domain.[A261491] It is under investigation for the treatment of von Willebrand disease and hemophilia A.[L48156]

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BTA798 DB05181
small molecule

BTA798 is an antiviral for the treatment of HRV, the common cold virus, known to cause significant clinical complications in sufferers of Asthma and Chronic Obstructive Pulmonary Disease.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BTA9881 DB05226
small molecule

BTA9881 is a respiratory syncytial virus (RSV) antiviral drug developed by the Australian company Biota Holdings. It is currently in phase I trials.

Target Protein:
Fusion glycoprotein F0
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BTRX-246040 DB16048
small molecule | CAS: 1307245-86-8

BTRX-246040 is under investigation in clinical trial NCT03193398 (BTRX-246040 Administered Once Daily to Patients With Major Depressive Disorder).

Target Protein:
Nociceptin receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BTRX-335140 DB16068
small molecule | CAS: 2244614-14-8

BTRX-335140 is under investigation in clinical trial NCT04221230 (Study in Major Depressive Disorder With BTRX-335140 vs Placebo).

Kategori:
Heterocyclic Compounds, Fused-RingOxazoles
Target Protein:
Kappa-type opioid receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BTZ-043 DB17737
small molecule | CAS: 1161233-85-7

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bucetin Approved DB13278
small molecule | CAS: 1083-57-4

Bucetin is an analgesic and antipyretic medication which was approved for use in Germany but was withdrawn from the market in 1986 due to renal toxicity caused by the medication.[A175636]

Kategori:
AminesAminophenolsAnalgesics +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bucillamine DB12160
small molecule | CAS: 65002-17-7

Bucillamine has been used in trials studying the treatment and prevention of Gout and Rheumatoid Arthritis.

Kategori:
Amino AcidsAmino Acids, NeutralAmino Acids, Peptides, and Proteins +17
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bucindolol DB12752
small molecule | CAS: 71119-11-4

Bucindolol has been investigated in Heart Failure.

Kategori:
Adrenergic AgentsAdrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-Antagonists +17
Target Protein:
Beta-2 adrenergic receptorBeta-1 adrenergic receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Buckwheat Approved DB10512
biotech

Buckwheat allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bucladesine DB13242
small molecule | CAS: 362-74-3

Deskripsi belum tersedia.

Kategori:
Adenine NucleotidesCardiac Stimulants Excl. Cardiac GlycosidesCardiac Therapy +9
Target Protein:
Plasminogen activator inhibitor 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Buclizine Approved DB00354
small molecule | CAS: 82-95-1

Buclizine is an antihistamine medication with both antiemetic and anticholinergic effects [L6220], belonging to the _piperazine derivative_ family of drugs. It was manufactured by Stuart Pharms and initially approved by the FDA in 1957.[L6217] Following this,…

Kategori:
Agents producing tachycardiaAnticholinergic AgentsAntihistamines for Systemic Use +8
Target Protein:
Histamine H1 receptorMuscarinic acetylcholine receptor M1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Budesonide Approved DB01222
small molecule | CAS: 51333-22-3

Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on …

Kategori:
Adrenal Cortex HormonesAdrenalsAgents to Treat Airway Disease +48
Target Protein:
Glucocorticoid receptorAnnexin A1
Gen Terkait:
TBX21
Waktu ParuhBudesonide has a pl…
Vol. DistribusiThe volume of distr…
KlirensBudesonide has a pl…
Genetik 1 Varian
Budigalimab DB16668
biotech | CAS: 2098225-93-3

Budigalimab is under investigation in clinical trial NCT04807972 (Study to Evaluate Adverse Events and Change in Disease Activity When Intravenous (IV) Infusion of ABBV-927 Is Administered in Combination With IV Modified FOLFIRINOX (Mffx) With or Without IV B…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +6
Target Protein:
Programmed cell death protein 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Budiodarone DB05519
small molecule | CAS: 335148-45-3

Budiodarone (ATI-2042) is an antiarrhythmic related to amiodarone that is currently being studied in clinical trials.

Kategori:
BenzofuransHeterocyclic Compounds, Fused-Ring
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Budipine DB13502
small molecule | CAS: 57982-78-2

Deskripsi belum tersedia.

Kategori:
Anti-Dyskinesia AgentsAnti-Parkinson DrugsCentral Nervous System Agents +2
Target Protein:
Amine oxidase [flavin-containing] B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Buflomedil DB13510
small molecule | CAS: 55837-25-7

Deskripsi belum tersedia.

Kategori:
Adrenergic alpha-AntagonistsAdrenergic AntagonistsAgents that produce hypertension +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bufotenine DB01445
small molecule | CAS: 487-93-4

A hallucinogenic serotonin analog found in frog or toad skins, mushrooms, higher plants, and mammals, especially in the brains, plasma, and urine of schizophrenics. Bufotenin has been used as a tool in CNS studies and misused as a psychedelic.

Kategori:
Amphibian VenomsAntidepressive AgentsBiological Factors +19
Target Protein:
5-hydroxytryptamine receptor 1D5-hydroxytryptamine receptor 2A5-hydroxytryptamine receptor 6 +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bufuralol DB06726
small molecule | CAS: 54340-62-4

Bufuralol is a new, non-selective -adrenoceptor blocking agent.

Kategori:
Adrenergic AgentsAdrenergic AntagonistsAdrenergic beta-Antagonists +8
Target Protein:
Beta adrenergic receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bufylline DB13812
small molecule | CAS: 5634-34-4

Deskripsi belum tersedia.

Kategori:
AlkaloidsAnti-Asthmatic AgentsAutonomic Agents +12
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bulevirtide Approved DB15248
biotech | CAS: 2012558-47-1

Hepatitis D is considered the most severe type of viral hepatitis and leads to the rapid development of cirrhosis, severe decompensation of liver function, and an increased risk of mortality.[A226340,L30235] Until recently, there have been extremely limited t…

Kategori:
Amino Acids, Peptides, and ProteinsAntiinfectives for Systemic UseAntiviral Agents +4
Target Protein:
Hepatic sodium/bile acid cotransporter
Waktu ParuhThe half-life of bu…
Vol. DistribusiThe volume of distr…
KlirensThe clearance after…
Genetik -
Buloxibutid DB18038
small molecule | CAS: 477775-14-7

Deskripsi belum tersedia.

Kategori:
AmidesAnti-Inflammatory AgentsSulfones +1
Target Protein:
Type-2 angiotensin II receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bumadizone Approved DB13286
small molecule | CAS: 3583-64-0

Bumadizone has been approved for use in Germany and Austria, it is a drug with anti-inflammatory, antipyretic, and analgesic properties, and was marketed for the treatment of both rheumatoid arthritis and gout [L5650]. Its use is restricted to these condition…

Kategori:
Acetic Acid Derivatives and Related SubstancesAcids, AcyclicAgents causing hyperkalemia +14
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bumetanide Approved DB00887
small molecule | CAS: 28395-03-1

Bumetanide is a sulfamyl diuretic.

Kategori:
Acids, CarbocyclicAgents Causing Muscle ToxicityAmides +27
Target Protein:
Solute carrier family 12 member 1Solute carrier family 12 member 2Solute carrier family 12 member 4 +2
Waktu Paruh60-90 minutes
Vol. Distribusi-
Klirens* 0.2 - 1.1 mL/min/…
Genetik -
Bunaftine DB13652
small molecule | CAS: 32421-46-8

Deskripsi belum tersedia.

Kategori:
Antiarrhythmic agentsAntiarrhythmics, Class IIICardiac Therapy +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bunamidine DB11501
small molecule | CAS: 3748-77-4

Bunamidine is a veterinary anti-platyhelmintic agent used for taenia infestations.

Kategori:
AnthelminticsAnti-Infective AgentsAntiparasitic Agents
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bunamiodyl DB04814
small molecule | CAS: 1233-53-0

Withdrawn from the Canadian, US, and UK markets in 1963 due to nephropathy.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bunazosin DB12230
small molecule | CAS: 80755-51-7

Bunazosin has been used in trials studying the treatment of High Blood Pressure.

Kategori:
Adrenergic AgentsAdrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-Antagonists +4
Target Protein:
Alpha-1D adrenergic receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Bupranolol DB08808
small molecule | CAS: 14556-46-8

Bupranolol is a non-selective beta blocker with potency similar to [propanolol]. It does not have intrinsic sympathomimetic activity (ISA), but does have strong membrane stabilizing activity.

Kategori:
Adrenergic AgentsAdrenergic AntagonistsAdrenergic beta-Antagonists +17
Target Protein:
Beta-1 adrenergic receptorBeta-2 adrenergic receptorBeta-3 adrenergic receptor
Waktu Paruh2-4 hours
Vol. Distribusi-
Klirens-
Genetik -
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