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11778

Total database: 17430
Struktur (SMILES)
8554 (72.6%)
Target
6383 (54.2%)
Genomik
96 (0.8%)
Referensi
11778 (100.0%)

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Hasil Pencarian (11778)

Halaman 66 / 236
Cannabinol DB14737
small molecule | CAS: 521-35-7

Cannabinol (CBN) is a physiologically inactive constituent of Cannabis sativa.

Kategori:
BCRP/ABCG2 InhibitorsCannabinoids and similarsCytochrome P-450 CYP1A2 Inhibitors +30
Target Protein:
Cannabinoid receptor 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cannabinor DB05048
small molecule | CAS: 573981-31-4

Cannabinor, a synthetic CB2-selective agonist, is in Phase 2 clinical testing as an analgesic.

Kategori:
Terpenes
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cannabivarin DB14736
small molecule | CAS: 33745-21-0

A natural product found in Cannabis sativa.

Kategori:
Terpenes
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Canoctakin DB18195
biotech | CAS: 1019859-03-0

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Canrenone DB12221
small molecule | CAS: 976-71-6

Canrenone has been used in trials studying the diagnostic of Heart Failure.

Kategori:
Agents causing hyperkalemiaDiureticsFused-Ring Compounds +8
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cantharidin Approved DB12328
small molecule | CAS: 56-25-7

Cantharidin is a naturally occurring odorless, colorless fatty substance of the terpenoid class that is produced as an oral fluid in the alimentary canal of the male blister beetle.[A32891, A32892] For its natural purpose, the male blister beetle secretes and…

Kategori:
BenzofuransCompounds used in a research, industrial, or household settingEnzyme Inhibitors +4
Target Protein:
Serine/threonine-protein phosphatase PP1-alpha catalytic subunitAryl hydrocarbon receptor
Waktu ParuhLittle pharmacodyna…
Vol. DistribusiAfter oral or IP in…
KlirensLittle pharmacodyna…
Genetik -
biotech | CAS: 400010-39-1

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Bacterial AgentsAntibodies +19
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 868747-45-9

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodies, MonoclonalAntibodies, Monoclonal, Humanized +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CAP-1 DB08027
small molecule | CAS: 564475-13-4

Deskripsi belum tersedia.

Target Protein:
Gag-Pol polyprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Capadenoson DB16118
small molecule | CAS: 544417-40-5

Capadenoson is under investigation in clinical trial NCT00518921 (Capadenoson in Angina Pectoris).

Kategori:
Adenosine A receptor agonistsAdenosine A1 Receptor AgonistsAmines +2
Target Protein:
Adenosine receptor A1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Capivasertib Approved DB12218
small molecule | CAS: 1143532-39-1

Hormone receptor (HR) positive, especially estrogen receptor-positive, HER2-negative breast cancer is the most common subtype of metastatic breast cancer, resulting in more than 400,000 deaths annually. Although endocrine-based therapy is the first line of tr…

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsBCRP/ABCG2 Inhibitors +13
Target Protein:
RAC-alpha serine/threonine-protein kinaseRAC-beta serine/threonine-protein kinaseRAC-gamma serine/threonine-protein kinase
Waktu ParuhThe half-life of ca…
Vol. DistribusiThe steady-state or…
KlirensThe steady-state or…
Genetik -
Caplacizumab Approved DB06081
biotech | CAS: 915810-67-2

Caplacizumab, firstly called ALX-0081, is a humanized single-variable-domain immunoglobulin consisting of two identical humanized building blocks genetically linked by a three-alanine linker. Caplacizumab was developed by Ablynx, a Sanofi company and FDA appr…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +17
Target Protein:
von Willebrand factor
Waktu ParuhThe reported half-l…
Vol. DistribusiThe reported volume…
KlirensAs the elimination …
Genetik -
Capmatinib Approved DB11791
small molecule | CAS: 1029712-80-8

Capmatinib is a small molecule kinase inhibitor targeted against c-Met (a.k.a. hepatocyte growth factor receptor [HGFR]), a receptor tyrosine kinase that, in healthy humans, activates signaling cascades involved in organ regeneration and tissue repair.[A19912…

Kategori:
Acids, CarbocyclicAmidesAntineoplastic Agents +20
Target Protein:
Hepatocyte growth factor receptor
Waktu ParuhThe elimination hal…
Vol. DistribusiThe apparent volume…
KlirensThe mean apparent c…
Genetik -
Capra hircus hair Approved DB10876
biotech

Domestic goat hair is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Capravirine DB08502
small molecule | CAS: 178979-85-6

Deskripsi belum tersedia.

Kategori:
Anti-HIV AgentsAnti-Infective AgentsAnti-Retroviral Agents +11
Target Protein:
Gag-Pol polyproteinGag-Pol polyproteinReverse transcriptase/RNaseH
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 2605-79-0

Deskripsi belum tersedia.

Target Protein:
Dihydroorotate dehydrogenase (quinone), mitochondrialPancreatic lipase-related protein 2Ferrichrome-iron receptor +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Capromab pendetide Approved DB00089
biotech | CAS: 145464-28-4

Capromab is a Murine IgG1 monoclonal 7E11-C5.3 antibody that recognizes prostate specific membrane antigen (PSMA – also known as glutamate carboxypeptidase 2) from prostate cancer cells and normal prostate tissue. When linked to pendetide, capromab is used as…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +13
Target Protein:
Glutamate carboxypeptidase 2
Waktu Paruh-
Vol. Distribusi* 4 ± 2.1 L
Klirens* 42 +/- 22 mL/hr
Genetik -
Capromorelin DB15205
small molecule | CAS: 193273-66-4

Capromorelin is under investigation in clinical trial NCT00527046 (Effects Of An Oral Growth Hormone Secretagogue In Older Functionally Limited Adults).

Target Protein:
Growth hormone secretagogue receptor type 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 7377-03-9

Deskripsi belum tersedia.

Kategori:
AminesHydroxy AcidsHydroxylamines
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Caprylic acid DB04519
small molecule | CAS: 124-07-2

Caprylic acid is an eight-carbon chain fatty acid, also known systematically as octanoic acid. It is found naturally in coconuts and breast milk. It is an oily liquid with a slightly unpleasant rancid-like smell that is minimally soluble in water.

Kategori:
Acids, AcyclicFatty AcidsLipids +2
Target Protein:
Peroxisome proliferator-activated receptor alpha3-oxoacyl-[acyl-carrier-protein] synthase 1Acyl-CoA thioesterase I
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 111-87-5

Caprylic alcohol has been used in trials studying the treatment of Essential Tremor.

Kategori:
AlcoholsCompounds used in a research, industrial, or household settingFatty Alcohols +3
Target Protein:
Gap junction alpha-1 protein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Caprylyl glycol DB14589
small molecule | CAS: 1117-86-8

Deskripsi belum tersedia.

Kategori:
AlcoholsFatty AlcoholsLipids
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Capsaicin Approved DB06774
small molecule | CAS: 404-86-4

Capsaicin is most often used as a topical analgesic and exists in many formulations of cream, liquid, and patch preparations of various strengths; however, it may also be found in some dietary supplements. Capsaicin is a naturally-occurring botanical irritant…

Kategori:
AlkaloidsAlkenesAmides +28
Target Protein:
Transient receptor potential cation channel subfamily V member 1Prohibitin-2
Waktu ParuhFollowing oral inge…
Vol. Distribusi-
Klirens-
Genetik -
Capsicum Approved DB10897
biotech

Capsicum (Chili pepper) allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Capsicum oleoresin Approved DB11131
biotech | CAS: 8023-77-6

Capsicum oleoresin is an oily organic resin derived from the fruit of plants in the Capsicum genus, such as chilli peppers. When the plants are finely ground, capsicum oleoresin is formed after the extraction process of capsaicin using oragnic solvents such a…

Kategori:
Biological ProductsComplex MixturesPharmaceutical Preparations +1
Target Protein:
Transient receptor potential cation channel subfamily V member 1
Waktu ParuhFor pharmacokinetic…
Vol. DistribusiFor pharmacokinetic…
KlirensFor pharmacokinetic…
Genetik -
Captodiame DB09014
small molecule | CAS: 486-17-9

Captodiame, also known as captodiamine, is an antihistamine which is used as a sedative and anxiolytic. It is a derivative of diphenhydramine. Captodiame has been suggested for use in preventing benzodiazepine withdrawal syndrome.

Kategori:
Anti-Anxiety AgentsAntidepressive AgentsCentral Nervous System Depressants +7
Target Protein:
5-hydroxytryptamine receptor 2CSigma non-opioid intracellular receptor 1D(3) dopamine receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Captopril Approved DB01197
small molecule | CAS: 62571-86-2

Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldos…

Kategori:
ACE Inhibitors and DiureticsAgents Acting on the Renin-Angiotensin SystemAgents causing angioedema +19
Target Protein:
Angiotensin-converting enzyme72 kDa type IV collagenaseMatrix metalloproteinase-9 +2
Waktu Paruh2 hours
Vol. Distribusi-
Klirens-
Genetik -
CAR BCMA-CS1 DB17313
biotech

CAR BCMA-CS1 is a lentiviral transfected chimeric antigen receptor (CAR) T-cell therapy modified to target B-cell maturation antigen and CS1.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Caramiphen DB11504
small molecule | CAS: 77-22-5

Caramiphen is a cholinergic antagonist used in Parkinson's disease. Additionally, it is used, in combination with [phenylpropanolamine], as a cough suppressant and nasal decongestant for the symptomatic treatment of seasonal respiratory conditions.

Kategori:
Cycloparaffins
Target Protein:
Muscarinic acetylcholine receptor M2Muscarinic acetylcholine receptor M1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Caraway seed Approved DB10671
biotech

Caraway seed allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carbamic Acid DB04261
small molecule | CAS: 463-77-4

Deskripsi belum tersedia.

Kategori:
Acids, Acyclic
Target Protein:
Beta-lactamaseBeta-lactamase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carbamide peroxide Approved DB11129
small molecule | CAS: 124-43-6

Carbamide peroxide, also known as urea-hydrogen peroxide, is a water-soluble, white crystalline solid compound consisting of hydrogen peroxide and urea. As it is a source of hydrogen peroxide, it can be found in disinfecting and dental bleaching products. Som…

Kategori:
AmidesAnionsAnti-Infective Agents +14
Waktu ParuhNo established phar…
Vol. DistribusiNo established phar…
KlirensNo established phar…
Genetik -
Carbamoylcholine Approved DB00411
small molecule | CAS: 462-58-8

Carbamoylcholine, also known as carbachol, is a muscarinic agonist discovered in 1932.[A226315] Carbamoylcholine was initially used as a treatment for migraines,[A226365] induction of diuresis,[A226370] and other parasympathetic effects. Carbamoylcholine w…

Kategori:
AlcoholsAminesAmino Alcohols +28
Target Protein:
Muscarinic acetylcholine receptor M1Muscarinic acetylcholine receptor M2Neuronal acetylcholine receptor subunit alpha-2 +2
Waktu ParuhData regarding the …
Vol. DistribusiData regarding the …
KlirensData regarding the …
Genetik -
Carbapenem DB18912
small molecule | CAS: 78854-41-8

Deskripsi belum tersedia.

Kategori:
AmidesAnti-Bacterial Agentsbeta-Lactams +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 5749-67-7

Deskripsi belum tersedia.

Kategori:
Agents causing hyperkalemiaAgents that produce hypertensionAmides +17
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carbazochrome DB09012
small molecule | CAS: 69-81-8

Carbazochrome is a hemostatic agent that promotes clotting, preventing blood loss from open wounds. It is an oxidation product of adrenaline which enhances the microcirculatory tone [A19747]. In the future this may prevent excessive blood flow during surgical…

Kategori:
Biological FactorsBlood and Blood Forming OrgansCoagulants +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 70063-04-6

Deskripsi belum tersedia.

Kategori:
Biological FactorsCoagulantsHematologic Agents +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carbazole DB07301
small molecule | CAS: 86-74-8

Deskripsi belum tersedia.

Kategori:
CarcinogensHeterocyclic Compounds, Fused-RingIndoles +2
Target Protein:
Ferredoxin CarAcTerminal oxygenase component of carbazole
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carbendazim DB13009
small molecule | CAS: 10605-21-7

Carbendazim has been used in trials studying the treatment of Lymphoma and Unspecified Adult Solid Tumor, Protocol Specific.

Kategori:
Acids, AcyclicAgrochemicalsAnthelmintics +10
Target Protein:
Aryl hydrocarbon receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carbenicillin Approved DB00578
small molecule | CAS: 4697-36-3

Broad-spectrum semisynthetic penicillin derivative used parenterally. It is susceptible to gastric juice and penicillinase and may damage platelet function.

Kategori:
AmidesAnti-Bacterial AgentsAnti-Infective Agents +11
Target Protein:
Penicillin-binding proteinBeta-lactamase Toho-1
Waktu Paruh1 hour
Vol. Distribusi-
Klirens-
Genetik -
Carbenoxolone DB02329
small molecule | CAS: 5697-56-3

An agent derived from licorice root. It is used for the treatment of digestive tract ulcers, especially in the stomach. Antidiuretic side effects are frequent, but otherwise the drug is low in toxicity. [PubChem]

Kategori:
Alimentary Tract and MetabolismAnti-Ulcer AgentsDrugs for Acid Related Disorders +5
Target Protein:
11-beta-hydroxysteroid dehydrogenase 13-alpha-(or 20-beta)-hydroxysteroid dehydrogenase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carbetocin Approved DB01282
small molecule | CAS: 37025-55-1

Carbetocin is a drug used to control postpartum hemorrhage, bleeding after giving birth. It is an analogue of oxytocin, and its action is similar to that of oxytocin -- it causes contraction of the uterus.

Kategori:
Amino Acids, Peptides, and ProteinsDelayed-Action PreparationsDrug Delivery Systems +14
Target Protein:
Oxytocin receptor
Waktu Paruh40 minutes
Vol. Distribusi-
Klirens-
Genetik -
Carbinoxamine Approved DB00748
small molecule | CAS: 486-16-8

Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-recepto…

Kategori:
Aminoalkyl EthersAntihistamines for Systemic UseCentral Nervous System Depressants +8
Target Protein:
Histamine H1 receptor
Waktu Paruh10 to 20 hours
Vol. Distribusi-
Klirens-
Genetik -
Carbocromen Approved DB13279
small molecule | CAS: 804-10-4

Carbocromen was marketed for use in Germany as a vasodilator, however, it has been discontinued due to the risk of arrhythmia development [L5635].

Kategori:
BenzopyransCardiac TherapyCardiovascular Agents +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carbomer DB15649
small molecule | CAS: 9007-20-9

Deskripsi belum tersedia.

Kategori:
Dental MaterialsDrug CarriersEnzyme Inhibitors +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 57916-92-4

Carbomer homopolymer type C is a high molecular polyanionic substance tested for antiulcerogenic activity.

Kategori:
Compounds used in a research, industrial, or household settingDental Cavity PreparationDental Materials +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carbomycin DB11383
small molecule | CAS: 4564-87-8

Carbomycin, also called magnamycin, is crystalline macrolide antibiotic. This antibacterial is obtained from _Streptomyces halstedii_ and it presents a large inhibitory effect against Gram-positive bacteria and some Mycoplasma strains. The structure of carbom…

Kategori:
Anti-Bacterial AgentsCytochrome P-450 CYP3A InhibitorsCytochrome P-450 CYP3A4 Inhibitors +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carbon black DB11980
small molecule | CAS: 1333-86-4

Produced by the incomplete combustion of hydrocarbons, carbon black is an insoluble pigment [A263396] with demonstrated adverse effects on pulmonary function.[A263401] Upon inhalation, carbon black has been reported to trigger an inflammatory response in the …

Kategori:
Complex MixturesParticulate MatterSmoke
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carbon dioxide Approved DB09157
small molecule | CAS: 124-38-9

Carbon dioxide is a colorless, odorless gas vital to life on Earth. This naturally occurring chemical compound is composed of a carbon atom covalently double bonded to two oxygen atoms. Medical Carbon Dioxide is a liquefied medicinal gas, supplied in cylinder…

Kategori:
Carbon Compounds, InorganicGasesMedical Gases +7
Waktu ParuhData not found.
Vol. DistribusiData not found.
KlirensData not found.
Genetik -
Carbon monoxide Approved DB11588
small molecule | CAS: 630-08-0

Carbon monoxide (CO) is a colorless, odorless, and tasteless gas that has a slightly lower density than air. It is toxic to hemoglobin utilizing animals (including humans), when encountered in concentrations above about 35 ppm, although it is also formed in n…

Kategori:
Carbon Compounds, InorganicDiagnostic AgentsGases +6
Target Protein:
Myoglobin
Waktu ParuhThe half-life of ca…
Vol. Distribusi-
Klirens-
Genetik -
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