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11793

Total database: 17430
Struktur (SMILES)
8607 (73.0%)
Target
6418 (54.4%)
Genomik
102 (0.9%)
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11793 (100.0%)

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Hasil Pencarian (11793)

Halaman 65 / 236
Cariprazine Approved DB06016
small molecule | CAS: 839712-12-8

Cariprazine is an atypical antipsychotic agent and a piperazine derivative that was first developed in Hungary.[A247100] It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT<sub>1A</sub> receptors and as an antagonist at serot…

Kategori:
Agents that produce hypertensionAntidepressive AgentsAntipsychotic Agents +48
Target Protein:
D(3) dopamine receptorD(2) dopamine receptor5-hydroxytryptamine receptor 1A +5
Waktu ParuhCariprazine and its…
Vol. Distribusi-
Klirens-
Genetik -
Carisoprodol Approved DB00395
small molecule | CAS: 78-44-4

Originally approved by the FDA in 1959 [FDA label], carisoprodol is a centrally acting muscle relaxant used in painful musculoskeletal conditions in conjunction with physical therapy and other medications [A176047]. This drug is available by itself in an ora…

Kategori:
CarbamatesCarbamic Acid EstersCentral Nervous System Agents +7
Target Protein:
Gamma-aminobutyric acid receptor subunit alpha-1Gamma-aminobutyric acid receptor subunit beta-2Gamma-aminobutyric acid receptor subunit gamma-2 +2
Waktu ParuhThe terminal half-l…
Vol. Distribusi0.93 to 1.3 L/kg, a…
KlirensFollowing an oral d…
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carmegliptin DB12268
small molecule | CAS: 813452-18-5

Carmegliptin has been used in trials studying the treatment of Diabetes Mellitus Type 2.

Kategori:
Agents causing angioedemaBlood Glucose Lowering AgentsDipeptidyl Peptidase 4 +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carmofur DB09010
small molecule | CAS: 61422-45-5

Carmofur is a derivative of fluorouracil, and is an antineoplastic agent that has been used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopathy.

Kategori:
AntimetabolitesAntineoplastic AgentsAntineoplastic and Immunomodulating Agents +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carmoterol DB15784
small molecule | CAS: 147568-66-9

Deskripsi belum tersedia.

Kategori:
AminesEthylaminesHeterocyclic Compounds, Fused-Ring +2
Target Protein:
Beta-2 adrenergic receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carmustine Approved DB00262
small molecule | CAS: 154-93-8

A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a c…

Kategori:
Alkylating ActivityAlkylating DrugsAmides +15
Target Protein:
RNAGlutathione reductase, mitochondrialDNA
Waktu Paruh15-30 minutes
Vol. Distribusi-
Klirens-
Genetik -
Carnosine DB11695
small molecule | CAS: 305-84-0

Carnosine has been investigated for the treatment of Gulf War Illness.

Kategori:
Amino Acids, Peptides, and ProteinsDipeptidesNerve Tissue Proteins +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 401905-67-7

Carotegrast methyl is under investigation in clinical trial NCT03531892 (A Study to Evaluate the Safety and Efficacy of AJM300 in Participants With Active Ulcerative Colitis).

Kategori:
Amino AcidsAmino Acids, AromaticAmino Acids, Cyclic +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carotuximab DB06322
biotech | CAS: 1268714-50-6

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +5
Target Protein:
Endoglin
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Caroverine DB13835
small molecule | CAS: 23465-76-1

Deskripsi belum tersedia.

Kategori:
Agents causing hyperkalemiaAlimentary Tract and MetabolismAntiarrhythmic agents +14
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Caroxazone DB09254
small molecule | CAS: 18464-39-6

Caroxazone is an antidepressant that has been withdrawn from the market. It is a reversible monoamine oxidase inhibitor (MAOI) of both A and B monoamine oxidase subtypes. However, it presents a five-fold preference for the MAO-B subtype.

Kategori:
AcetamidesAgents that produce hypertensionAgents that reduce seizure threshold +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carphenazine DB01038
small molecule | CAS: 2622-30-2

Carphenazine is an antipsychotic drug, used in hospitalized patients in the management of chronic schizophrenic psychoses.

Kategori:
Dopamine AntagonistsDopamine D2 Receptor Antagonists
Target Protein:
D(2) dopamine receptorD(1A) dopamine receptorD(1B) dopamine receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carprofen Approved DB00821
small molecule | CAS: 53716-49-7

Carprofen is a non-steroidal anti-inflammatory drug (NSAID) that is used by veterinarians as a supportive treatment for the relief of arthritic symptoms in geriatric dogs. Carprofen was previously used in human medicine for over 10 years (1985-1995). It was g…

Kategori:
Agents causing hyperkalemiaAgents that produce hypertensionAnalgesics +15
Target Protein:
Prostaglandin G/H synthase 2Prostaglandin G/H synthase 1
Waktu ParuhApproximately 8 hou…
Vol. Distribusi-
Klirens-
Genetik -
Carpropamide DB02946
small molecule | CAS: 127640-90-8

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carrimycin DB16476
small molecule

Deskripsi belum tersedia.

Kategori:
Anti-Bacterial AgentsExperimental Unapproved Treatments for COVID-19Lactones +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carteolol Approved DB00521
small molecule | CAS: 51781-06-7

A beta-adrenergic antagonist used as an anti-arrhythmia agent, an anti-angina agent, an antihypertensive agent, and an antiglaucoma agent.

Kategori:
Adrenergic AgentsAdrenergic AntagonistsAdrenergic beta-Antagonists +28
Target Protein:
Beta-2 adrenergic receptorBeta-1 adrenergic receptor
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carumonam DB13553
small molecule | CAS: 87638-04-8

Deskripsi belum tersedia.

Kategori:
AmidesAntibacterials for Systemic UseAntiinfectives for Systemic Use +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carvacrol DB16404
small molecule | CAS: 499-75-2

Deskripsi belum tersedia.

Kategori:
Benzene DerivativesMonoterpenesTerpenes
Target Protein:
Transient receptor potential cation channel subfamily V member 3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carvasept DB15886
small molecule | CAS: 5665-94-1

Deskripsi belum tersedia.

Kategori:
Benzene DerivativesMonoterpenesTerpenes
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carvedilol Approved DB01136
small molecule | CAS: 72956-09-3

Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and …

Kategori:
Adrenergic AgentsAdrenergic alpha-1 Receptor AntagonistsAdrenergic alpha-Antagonists +40
Target Protein:
Beta-1 adrenergic receptorAlpha-1A adrenergic receptorAlpha-1 adrenergic receptors +16
Gen Terkait:
ADRB1
Waktu ParuhThe half life of ca…
Vol. DistribusiCarvedilol has a vo…
KlirensThe plasma clearanc…
Genetik 1 Varian
Carya ovata pollen Approved DB10364
biotech

Carya ovata pollen is the pollen of the Carya ovata plant. Carya ovata pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Carya tomentosa pollen Approved DB10926
biotech

Carya tomentosa pollen is the pollen of the Carya tomentosa plant. Carya tomentosa pollen is mainly used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Caryophyllene DB16854
small molecule | CAS: 87-44-5

Deskripsi belum tersedia.

Kategori:
AnalgesicsAnalgesics, Non-NarcoticAnti-Inflammatory Agents +6
Target Protein:
Cannabinoid receptor 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Casdozokitug DB17513
biotech | CAS: 2643331-37-5

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Casein Approved DB10516
biotech | CAS: 9000-71-9

Casein allergenic extract is used in allergenic testing.

Kategori:
Amino Acids, Peptides, and ProteinsAnimal Proteins, DietaryBeverages +17
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cashew Approved DB10653
biotech

Cashew allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cashew fruit Approved DB15602
biotech

Cashew fruit extract is used in allergenic testing.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Casimersen Approved DB14984
biotech | CAS: 1422958-19-7

Duchenne muscular dystrophy (DMD) is an X-linked recessive allelic disorder characterized by a lack of functional dystrophin protein, which leads to progressive impairment of ambulatory, pulmonary, and cardiac function and is invariably fatal. A related, albe…

Kategori:
Antisense OligonucleotidesCytochrome P-450 CYP2C19 InhibitorsCytochrome P-450 CYP2C19 inhibitors (strength unknown) +16
Target Protein:
DMD gene (exon 45 casimersen target site)
Waktu ParuhCasimersen has an e…
Vol. DistribusiCasimersen administ…
KlirensCasimersen administ…
Genetik -
Casimiroin DB08744
small molecule | CAS: 477-89-4

Casimiroin is a quinone reductase 2 inhibitor isolated from _Casimiroa edulis_.

Kategori:
AromataseDioxolesHeterocyclic Compounds, Fused-Ring +2
Target Protein:
Ribosyldihydronicotinamide dehydrogenase [quinone]
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Casopitant DB06634
small molecule | CAS: 414910-27-3

Deskripsi belum tersedia.

Kategori:
Alimentary Tract and MetabolismAmidesAntiemetics +7
Target Protein:
Substance-P receptorCytochrome P450 3A4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Caspofungin Approved DB00520
small molecule | CAS: 162808-62-0

Caspofungin (brand name Cancidas worldwide) is an antifungal drug and the first member of a new drug class called the echinocandins, as coined by Merck & Co., Inc. It is typically administered intravenously. It shows activity against infections with Aspergill…

Kategori:
Amino Acids, Peptides, and ProteinsAnti-Infective AgentsAntifungal Agents +18
Target Protein:
1,3-beta-glucan synthase component FKS11,3-beta-glucan synthase component GSC2
Waktu Paruh9-11 hours
Vol. Distribusi-
Klirens* 12 mL/min [After …
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Castanospermine DB01816
small molecule | CAS: 79831-76-8

Deskripsi belum tersedia.

Kategori:
AnalgesicsAnalgesics, Non-NarcoticAnti-Inflammatory Agents +10
Target Protein:
Glucan 1,3-beta-glucosidase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cathine DB01486
small molecule | CAS: 492-39-7

Cathine, also known as d-norpseudoephedrine and (+)-norpseudoephedrine, is a psychoactive drug with stimulant properties. It belongs to the phenethylamine and amphetamine chemical classes. In the United States, it is classified as a Schedule IV controlled sub…

Kategori:
AlcoholsAlimentary Tract and MetabolismAmines +7
Waktu Paruh5.2 +/- 3.4 hours
Vol. Distribusi-
Klirens-
Genetik -
Cathinone DB01560
small molecule | CAS: 71031-15-7

Cathinone is a monoamine alkaloid found in the shrub Catha edulis (Khat). Closely related to ephedrine, cathine and other amphetamines, it is probably the main contributor to the stimulant effect of Catha edulis. Cathinone differs from many other amphetamines…

Kategori:
Central Nervous System AgentsCentral Nervous System DepressantsCentral Nervous System Stimulants +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Catridecacog Approved DB09310
biotech | CAS: 606138-08-3

Coagulation Factor XIII A-Subunit (Recombinant), also known as catridecacog, is a recombinant form of the Factor XIII-A2 homodimer composed of two factor XIII (FXIII) A-subunits [FDA Label]. For people with congenital deficiency or mutation of Factor XIII, a …

Kategori:
Blood and Blood Forming OrgansBlood Coagulation FactorsHemostatics
Target Protein:
Coagulation factor XIII B chain
Waktu Paruh7.1 days
Vol. Distribusi-
Klirens0.41 mL/h/kg
Genetik -
Catumaxomab Approved DB06607
biotech | CAS: 509077-98-9

Catumaxumab is a trifunctional monoclonal antibody developed for use in cancer treatment. It has affinity for T-cells, accessory immune cells, and cancer cells. Catumaxumab was initially authorized for market by the European Medicines Agency in April 2009 for…

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesAntibodies, Monoclonal +13
Target Protein:
Low affinity immunoglobulin gamma Fc region receptor II-aLow affinity immunoglobulin gamma Fc region receptor III-ALow affinity immunoglobulin gamma Fc region receptor III-B +3
Waktu ParuhCatumaxomab has an …
Vol. Distribusi-
Klirens-
Genetik -
Cauliflower Approved DB10643
biotech

Cauliflower allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseNon-Standardized Food Allergenic Extract +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cavia porcellus skin Approved DB10416
biotech

Cavia porcellus skin or pelt is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cavosonstat DB14775
small molecule | CAS: 1371587-51-7

Cavosonstat is under investigation in clinical trial NCT02589236 (Study of Cavosonstat (N91115) in Patients With CF Homozygous for the F508del-CFTR Mutation).

Kategori:
Benzene Derivatives
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cavrotolimod DB18216
small molecule | CAS: 2378664-12-9

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CB-010 DB17711
biotech

CB-010 is a CRISPR-edited allogeneic CAR-T cell therapy targeting CD19. It is being investigated for the treatment of follicular lymphoma.[L46158]

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CB-103 DB15279
small molecule | CAS: 218457-67-1

CB-103 is under investigation in clinical trial NCT03422679 (Study of CB-103 in Adult Patients With Advanced or Metastatic Solid Tumours and Haematological Malignancies).

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CB-1158 DB15286
small molecule | CAS: 2095732-06-0

CB-1158 is under investigation in clinical trial NCT03910530 (A Study of INCMGA00012, INCB001158, and the Combination in Japanese Participants With Advanced Solid Tumors).

Kategori:
Enzyme Inhibitors
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CB-5083 DB16874
small molecule | CAS: 1542705-92-9

Deskripsi belum tersedia.

Kategori:
Heterocyclic Compounds, Fused-Ring
Target Protein:
Transitional endoplasmic reticulum ATPase
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CBP-501 DB17277
small molecule | CAS: 565434-85-7

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsCell Cycle ProteinsDual-Specificity Phosphatases +11
Target Protein:
MAP/microtubule affinity-regulating kinase 3MAP kinase-activated protein kinase 2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CCR5 mAb DB05906
biotech

CCR5 mAb is a fully human monoclonal antibody that specifically recognizes and binds the chemokine receptor CCR5, which is known to be a key facilitator of infection with human immunodeficiency virus (HIV-1). It was generated by HGS using the Abgenix XenoMous…

Target Protein:
C-C chemokine receptor type 5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CCX-354 DB12963
small molecule | CAS: 1010073-75-2

CCX354-C has been used in trials studying the treatment of Rheumatoid Arthritis.

Target Protein:
C-C chemokine receptor type 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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