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13591

Total database: 17430
Struktur (SMILES)
10177 (74.9%)
Target
7625 (56.1%)
Genomik
104 (0.8%)
Referensi
13591 (100.0%)

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Hasil Pencarian (13591)

Halaman 65 / 272
Azemiglitazone DB16028
small molecule | CAS: 1133819-87-0

Azemiglitazone is under investigation in clinical trial NCT01280695 (A Randomized, Double-blind, Comparator- and Placebo-controlled, Multiple-dose Study to Evaluate the Safety, Tolerability and Efficacy of Three Dose Levels of MSDC-0602 in Type 2 Diabetic Pat…

Kategori:
KetonesSulfur CompoundsThiazoles
Target Protein:
Insulin receptor
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Azenosertib DB18028
small molecule | CAS: 2376146-48-2

Deskripsi belum tersedia.

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Azficel-T Approved DB11051
biotech

Azficel-T is an autologous cellular product composed of fibroblasts indicated for improvement of the appearance of moderate to severe nasolabial fold wrinkles in adults. Dermal fibroblasts are collected from the post-auricular biopsy tissue and aseptically ex…

Kategori:
Autologous Cultured Cell
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Azidamfenicol DB13294
small molecule | CAS: 13838-08-9

Deskripsi belum tersedia.

Kategori:
AlcoholsAnti-Bacterial AgentsAnti-Infective Agents +7
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Azidocillin DB08795
small molecule | CAS: 17243-38-8

Azidocillin is a penicillin antibiotic similir to ampicillin.

Kategori:
AmidesAnti-Bacterial AgentsAntibacterials for Systemic Use +8
Target Protein:
Penicillin-binding protein 2aPenicillin-binding protein 1bPenicillin-binding protein 3 +2
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Azilsartan medoxomil Approved DB08822
small molecule | CAS: 863031-21-4

Azilsartan medoxomil is a prodrug that is broken down to azilsartan, which belongs in the angiotensin-receptor blocking (ARB) drug class. It is a selective AT1 subtype angiotensin II receptor antagonist. Azilsartan medoxomil is a relatively recently-developed…

Kategori:
Agents Acting on the Renin-Angiotensin SystemAgents causing angioedemaAgents causing hyperkalemia +18
Target Protein:
Type-1 angiotensin II receptor
Waktu ParuhThe elimination hal…
Vol. DistribusiThe volume of distr…
KlirensRenal clearance of …
Genetik -
Azimilide DB04957
small molecule | CAS: 149908-53-2

Azimilide is an investigational class III anti-arrhythmic drug that blocks fast and slow components of the delayed rectifier cardiac potassium channels. It is not approved for use in any country, but is currently in clinical trials in the United States.

Kategori:
Antiarrhythmic agentsAntiarrhythmics, Class IIICalcium-Regulating Hormones and Agents +11
Target Protein:
Potassium voltage-gated channel subfamily E member 1Potassium voltage-gated channel subfamily KQT member 1Voltage-gated inwardly rectifying potassium channel KCNH2
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Azintamide DB13992
small molecule | CAS: 1830-32-6

Deskripsi belum tersedia.

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biotech | CAS: 1826819-58-2

Azintuxizumab vedotin is under investigation in clinical trial NCT02951117 (A Study of Venetoclax and ABBV-838 Combination Therapy With Dexamethasone in Participants With Multiple Myeloma Whose Cancer Has Come Back or Had No Response to Recent Cancer Treatmen…

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Azithromycin Approved DB00207
small molecule | CAS: 83905-01-5

Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration [A174172]. It was initially approved by the FDA in 1991 [A174175]. It is primarily used for the treatment of respiratory, enteric and genito…

Kategori:
Anti-Bacterial AgentsAnti-Infective AgentsAntibacterials for Systemic Use +22
Target Protein:
23S ribosomal RNAProtein-arginine deiminase type-4
Waktu ParuhTerminal eliminatio…
Vol. DistribusiAfter oral administ…
KlirensMean apparent plasm…
Genetik -
Azlocillin Approved DB01061
small molecule | CAS: 37091-66-0

Azlocillin is a semisynthetic ampicillin-derived acylureido penicillin.

Kategori:
Agents that reduce seizure thresholdAmidesAnti-Bacterial Agents +11
Target Protein:
Penicillin-binding protein 1A
Waktu ParuhMean elimination ha…
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small molecule | CAS: 123-77-3

Deskripsi belum tersedia.

Kategori:
Anti-HIV AgentsAnti-Infective AgentsAnti-Retroviral Agents +3
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Azosemide DB08961
small molecule | CAS: 27589-33-9

Azosemide is a loop diuretic used to treat hypertension, edema, and ascites.

Kategori:
AmidesAminesAniline Compounds +7
Waktu ParuhTerminal half life …
Vol. DistribusiPoor affinity for h…
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small molecule | CAS: 892497-01-7

Azoximer bromide is under investigation in clinical trial NCT04381377 (Efficacy and Safety of Polyoxidonium® in Hospitalized Patients With Coronavirus Disease COVID-19).

Kategori:
Macromolecular Substances
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Azoxystrobin DB07401
small molecule | CAS: 131860-33-8

Azoxystrobin is a methoxyacrylate analog and a strobilurin fungicide.

Kategori:
Acids, AcyclicAcrylatesElectron Transport Complex III +2
Target Protein:
Cytochrome c1, heme protein, mitochondrialCytochrome bCytochrome b-c1 complex subunit 1, mitochondrial +7
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Aztreonam Approved DB00355
small molecule | CAS: 78110-38-0

A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-posit…

Kategori:
AmidesAnti-Bacterial AgentsAnti-Infective Agents +9
Target Protein:
Penicillin-binding protein 3Peptidoglycan synthase FtsIBeta-lactamase +1
Waktu ParuhThe serum half-life…
Vol. Distribusi* 12.6 L
Klirens* 91 mL/min [health…
Genetik -
Azvudine DB16407
small molecule | CAS: 1011529-10-4

Azvudine is under investigation in clinical trial NCT04668235 (Study on Safety and Clinical Efficacy of AZVUDINE in COVID-19 Patients (Sars-cov-2 Infected)).

Kategori:
DeoxyribonucleosidesExperimental Unapproved Treatments for COVID-19Nitrogen Compounds +4
Target Protein:
Broad substrate specificity ATP-binding cassette transporter ABCG2ATP-binding cassette sub-family C member 2ATP-dependent translocase ABCB1
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AZX-100 DB06323
biotech | CAS: 1217194-46-1

Deskripsi belum tersedia.

Kategori:
Amino Acids, Peptides, and ProteinsHeat-Shock ProteinsMolecular Chaperones +1
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small molecule

Deskripsi belum tersedia.

Target Protein:
H subunit of photosynthetic reaction center complexAquaporin ZCytochrome b +6
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small molecule | CAS: 69984-73-2

Deskripsi belum tersedia.

Target Protein:
Pancreatic triacylglycerol lipaseCytochrome c oxidase subunit 1Cytochrome c oxidase subunit 2 +11
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B27PD DB16289
biotech | CAS: 160387-12-2

B27PD is under investigation in clinical trial NCT01195948 (Optiquel® as Corticosteroid-sparing Therapy for Chronic Noninfectious Uveitis).

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biotech

Deskripsi belum tersedia.

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BA-2664 DB01479
small molecule | CAS: 641-82-7

Deskripsi belum tersedia.

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BA1301 DB19390
biotech

BA1301 is an anti-Claudin18.2 monoclonal antibody conjugated with Duostatin-5.

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Bacampicillin Approved DB01602
small molecule | CAS: 50972-17-3

Bacampicillin is a prodrug of ampicillin and is microbiologically inactive. It is absorbed following oral administration. During absorption from the gastrointestinal tract, bacampicillin is hydrolyzed by esterases present in the intestinal wall. It is microbi…

Kategori:
AmidesAnti-Bacterial AgentsAnti-Infective Agents +10
Target Protein:
Penicillin-binding protein
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biotech

BCG SSI has been used in trials studying Tuberculosis.

Kategori:
Live Attenuated Bacillus Calmette-Guerin VaccineLive vaccinesVaccines
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biotech

Bacillus Calmette-Guerin (BCG) substrain Russian BCG-I is a live BCG vaccine administered directly into the bladder for the adjuvant treatment of papillary urothelial cell carcinoma of the bladder. Live BCG vaccines administered intravesically have been a gol…

Kategori:
Antineoplastic AgentsLive vaccinesVaccines
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biotech

Bacillus calmette-guerin substrain tice live antigen is a vaccine containing attenuated live culture preparation of the Bacillus of Calmette and Guerin (BCG) strain of *Mycobacterium bovis* for percutaneous use. It is administered to prevent the development o…

Kategori:
Actively Acquired ImmunityIncreased Immunologically Active Molecule ActivityIncreased Macrophage Proliferation +4
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biotech

Bacillus calmette-guerin substrain tokyo 172-1 live antigen is under investigation in clinical trial NCT03091660 (S1602: Different Strains of BCG With or Without Vaccine in High Grade Non- Muscle Invasive Bladder Cancer).

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Bacillus cereus DB19245
biotech | CAS: 68038-62-0

Deskripsi belum tersedia.

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biotech

Deskripsi belum tersedia.

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biotech | CAS: 68038-65-3

Deskripsi belum tersedia.

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biotech | CAS: 68038-66-4

Deskripsi belum tersedia.

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biotech | CAS: 68038-70-0

Deskripsi belum tersedia.

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Baclofen Approved DB00181
small molecule | CAS: 1134-47-0

Baclofen is a gamma-aminobutyric acid (GABA) agonist used as a skeletal muscle relaxant. Although originally designed in 1962 to treat epilepsy, baclofen was not effective in treating this condition but instead was shown to reduce spasticity in selected patie…

Kategori:
Agents Causing Muscle ToxicityAmino AcidsAmino Acids, Peptides, and Proteins +15
Target Protein:
Gamma-aminobutyric acid type B receptor subunit 2C-X-C chemokine receptor type 4Gamma-aminobutyric acid type B receptor subunit 1
Waktu ParuhThe half-life is 2-…
Vol. DistribusiThe volume of distr…
KlirensThe systemic cleara…
Genetik -
BACTEK-R DB16526
biotech

MV130 contains different components of whole heat-inactivated gram-positive and -negative bacteria that are involved in upper and lower respiratory infections. These include streptococcus pneumoniae and staphylococcus aureus. Though studies have shown that it…

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small molecule | CAS: 17499-98-8

A specific bacteriochlorophyll that is similar in structure to CHLOROPHYLL A.

Kategori:
Amino Acids, Peptides, and ProteinsBacteriochlorophyllsHeterocyclic Compounds, Fused-Ring +2
Target Protein:
Bacteriochlorophyll a proteinBacteriochlorophyll a protein
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BacTRL-spike DB15811
biotech

BacTRL-Spike is composed of a bacterial medium with colony-forming-units of live Bifidobacterium longum engineered to deliver synthetic DNA encoding spike protein from SARS-CoV-2 contained by plasmids. The vaccine was developed by Symvivo Corporation. As of J…

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Bafilomycin A1 DB06733
small molecule | CAS: 88899-55-2

The bafilomycins refer to a category of toxic macrolide antibiotics that are derivatives of Streptomyces griseus. These compounds all appear in the same fermentation and have similar biological activity. Bafilomycins are specific inhibitors of vacuolar-type H…

Kategori:
Anti-Infective AgentsAntifungal AgentsEnzyme Inhibitors +3
Target Protein:
V-type proton ATPase catalytic subunit A
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Bafilomycin B1 DB06734
small molecule | CAS: 88899-56-3

Deskripsi belum tersedia.

Kategori:
LactonesPolyketides
Target Protein:
V-type proton ATPase catalytic subunit A
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Baicalein DB16101
small molecule | CAS: 491-67-8

Baicalein is under investigation in clinical trial NCT03830684 (A Randomized, Double-blind, Placebo-controlled, Multicenter and Phase ?A Clinical Trial for the Effectiveness and Safety of Baicalein Tablets in the Treatment of Improve Other Aspects of Healthy …

Kategori:
AntioxidantsBenzopyransBiological Factors +11
Target Protein:
Lactoylglutathione lyaseTumor necrosis factorXanthine dehydrogenase/oxidase +4
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Bakuchiol DB16102
small molecule | CAS: 10309-37-2

Bakuchiol is under investigation in clinical trial NCT03112863 (Comparison of the Cosmetic Effects of Bakuchiol and Retinol).

Kategori:
Benzene Derivatives
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BAL200 DB17793
biotech

Deskripsi belum tersedia.

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Balaglitazone DB12781
small molecule | CAS: 199113-98-9

Balaglitazone has been used in trials studying the treatment of Diabetes Mellitus, Type 2.

Kategori:
Blood Glucose Lowering AgentsCytochrome P-450 CYP2C8 InhibitorsCytochrome P-450 CYP2C8 Inhibitors (strength unknown) +9
Target Protein:
Peroxisome proliferator-activated receptor gamma
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Balapiravir DB12283
small molecule | CAS: 690270-29-2

Balapiravir has been used in trials studying the treatment of Dengue and Hepatitis C, Chronic.

Kategori:
CarbohydratesGlycosidesNucleic Acids, Nucleotides, and Nucleosides
Target Protein:
Genome polyprotein
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Balhimycin DB04111
small molecule | CAS: 140932-79-2

Balhimycin is a novel glycopeptide antibiotic.

Kategori:
Amino Acids, Peptides, and ProteinsCarbohydratesGlycoconjugates +2
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Balicatib DB12239
small molecule | CAS: 354813-19-7

Balicatib has been used in trials studying the treatment of Osteoporosis and Knee Osteoarthritis.

Kategori:
Acids, CarbocyclicAmidesBenzene Derivatives +1
Target Protein:
Cathepsin K
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Baliforsen DB17852
biotech | CAS: 1698048-23-5

Deskripsi belum tersedia.

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Balipodect DB14774
small molecule | CAS: 1238697-26-1

Balipodect is under investigation in clinical trial NCT01892189 (Effects of TAK-063 on Preventing Ketamine-Induced Brain Activity Changes as Well as Psychotic-Like Symptoms in Healthy Male Adults).

Target Protein:
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
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Balixafortide DB15370
biotech | CAS: 1051366-32-5

Balixafortide is under investigation in clinical trial NCT03786094 (Pivotal Study in HER2 Negative, Locally Recurrent or Metastatic Breast Cancer).

Kategori:
Amino Acids, Peptides, and ProteinsPeptides
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