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16004

Total database: 17430
Struktur (SMILES)
12010 (75.0%)
Target
9041 (56.5%)
Genomik
112 (0.7%)
Referensi
16004 (100.0%)

Tipe Molekul

Distribusi Wujud Zat

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Hasil Pencarian (16004)

Halaman 65 / 321
small molecule | CAS: 174514-58-0

Aluminum zirconium octachlorohydrex gly is complex that consists of aluminum zirconium octachlorohydrate and glycine. It is an active antiperspirant agent [L2705], [L2706]. It diffuses into the sweat pores and prevents perspiration (sweat) from leaving the po…

Target Protein:
Sweat ducts
Waktu Paruh-
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small molecule | CAS: 173762-83-9

Aluminum zirconium pentachlorohydrate is a common active ingredient in personal care products as an antiperspirant agent. Its main mechanism of action is through blocking the pores via formation of polymer complex and preventing sweat from leaving the body.

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small molecule | CAS: 90604-80-1

Aluminum zirconium tetrachlorohydrex gly is a common active ingredient in personal care products as an antiperspirant agent. Its main mechanism of action is through blocking the pores via formation of polymer complex and preventing sweat from leaving the body.

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small molecule | CAS: 134375-99-8

Aluminum zirconium trichlorohydrex gly is a common active ingredient in deodorant and antiperspirant products for the over-the-counter use. It is consisted of a mixture of monomeric and polymeric Zr4+ and Al3+ complexes with hydroxide, chloride and glycine. T…

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biotech | CAS: 2416824-55-8

Alunacedase alfa is a recombinant and soluble glycosylated form of human ACE2. This recombinant version of the enzyme has antihypertensive and potential antineoplastic activities.

Kategori:
Amino Acids, Peptides, and ProteinsCarboxypeptidasesEnzymes +6
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Alvelestat DB11863
small molecule | CAS: 848141-11-7

Alvelestat has been investigated for the basic science of Chronic Obstructive Pulmonary Disease.

Kategori:
Leukocyte Elastase, antagonists & inhibitorsPyridinesSulfur Compounds
Target Protein:
Neutrophil elastase
Waktu Paruh-
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Alverine Approved DB01616
small molecule | CAS: 150-59-4

Alverine is a smooth muscle relaxant used to relieve cramps or spasms of the stomach and intestines. It is therefore useful in treating irritable bowel syndrome (IBS) and similar conditions. It can also be used to help relieve period pain.

Kategori:
Alimentary Tract and MetabolismAminesAntidepressive Agents +9
Target Protein:
5-hydroxytryptamine receptor 1A
Waktu ParuhThe plasma half-lif…
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Alvespimycin DB12442
small molecule | CAS: 467214-20-6

Alvespimycin is a derivative of geldanamycin and heat shock protein (HSP) 90 inhibitor. It has been used in trials studying the treatment of solid tumor in various cancer as an antitumor agent. In comparison to the first HSP90 inhibitor tanespimycin, it exhib…

Kategori:
AmidesHSP90 Heat-Shock ProteinsLactams +1
Target Protein:
Heat shock protein HSP 90-alpha
Waktu ParuhThe half-life acros…
Vol. DistribusiAt the maximum tole…
KlirensThe mean clearance …
Genetik -
Alvimopan Approved DB06274
small molecule | CAS: 156053-89-3

Alvimopan is a peripherally acting ? opioid antagonist. It is used to avoid postoperative ileus following small or large bowel resection and accelerates the gastrointestinal recovery period.

Kategori:
Alimentary Tract and MetabolismDrugs for ConstipationGastrointestinal Agents +3
Target Protein:
Mu-type opioid receptorKappa-type opioid receptorDelta-type opioid receptor
Waktu Paruh10 to 17 hours (gut…
Vol. Distribusi* 30±10 L
Klirens* 402 ± 89 mL/min
Genetik -
biotech | CAS: 137487-62-8

Alvircept Sudotox has been used in trials studying the treatment of HIV Infections.

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Alvocidib DB03496
small molecule | CAS: 146426-40-6

Alvocidib is a synthetic flavonoid based on an extract from an Indian plant for the potential treatment of cancer. It works by inhibiting cyclin-dependent kinases, arresting cell division and causing apoptosis in non-small lung cancer cells.

Kategori:
Antineoplastic AgentsBCRP/ABCG2 SubstratesBenzopyrans +9
Target Protein:
Glycogen phosphorylase, muscle formCyclin-dependent kinase 9Glycogen phosphorylase, brain form +9
Waktu Paruh-
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ALX-009 DB17916
biotech

Deskripsi belum tersedia.

Waktu Paruh-
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AM103 DB05225
small molecule

AM103 is a novel inhibitor of 5-lipoxygenase-activiting protein (FLAP) that has demonstrated potential to treat asthma and cardiovascular disease by preventing the synthesis of LT, which triggers inflammation. It is being developed by Amira.

Kategori:
Acids, AcyclicFatty AcidsFatty Acids, Volatile +2
Target Protein:
Arachidonate 5-lipoxygenase-activating protein
Waktu Paruh-
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AM336 DB06563
biotech | CAS: 247207-64-3

Leconotide (development codes CNSB004 and AM336) is an omega-conotoxin peptide known for its analgesic properties, which work by blocking neuronal voltage-sensitive calcium channels. It was investigated as a potential treatment for various pain conditions.

Kategori:
AnalgesicsAnalgesics, Non-NarcoticAntiarrhythmic agents +17
Waktu Paruh-
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AM365 DB06564
small molecule | CAS: 220984-26-9

Detiviciclovir (AM365) is an antiviral nucleoside analogue.

Kategori:
CarbohydratesGlycosidesNucleic Acids, Nucleotides, and Nucleosides
Waktu Paruh-
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Amantadine Approved DB00915
small molecule | CAS: 768-94-5

An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not…

Kategori:
Adamantane DerivativesAdamantanesAnalgesics +25
Target Protein:
Matrix protein 2Glutamate receptor ionotropic, NMDA 3AD(2) dopamine receptor +3
Waktu ParuhMean half-lives ran…
Vol. Distribusi* 3 to 8 L/kg [heal…
Klirens* 0.2 - 0.3 L/hr/kg…
Genetik -
Amaranthus hybridus pollen Approved DB15503
biotech

Amaranthus hybridus pollen allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
Waktu Paruh-
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Amaranthus retroflexus whole Approved DB10930
biotech

Amaranthus retroflexus whole allergenic extract is used in allergenic testing.

Kategori:
Non-Standardized Pollen Allergenic Extract
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biotech

Amaranthus tuberculatus pollen allergenic extract is used in allergenic testing.

Kategori:
Cell-mediated ImmunityIncreased Histamine ReleaseIncreased IgG Production +1
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Amatuximab DB12845
biotech | CAS: 931402-35-6

Amatuximab has been used in trials studying the treatment and basic science of Mesothelioma, Ovarian Cancer, Ovarian Neoplasms, Pancreatic Cancer, and Mesothelioma, Malignant, among others.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +5
Target Protein:
Mesothelin
Waktu Paruh-
Vol. Distribusi-
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AMB-301 DB18094
biotech

AMB-301 is an AAV gene therapy delivering E-selectin.[L48101] It is under investigation for the treatment of Buerger disease.

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Ambazone DB13697
small molecule | CAS: 539-21-9

Deskripsi belum tersedia.

Kategori:
AmidinesAnti-Infective Agents, LocalGuanidines +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Ambenonium Approved DB01122
small molecule | CAS: 7648-98-8

Ambenonium is a cholinesterase inhibitor. It is used in the management of myasthenia gravis.

Kategori:
AminesAutonomic AgentsBenzylammonium Compounds +9
Target Protein:
Acetylcholinesterase
Waktu Paruh-
Vol. Distribusi-
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Genetik -
Amber DB14326
biotech | CAS: 9000-02-6

Amber is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

Kategori:
Biological ProductsBiopolymersComplex Mixtures +5
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Ambrisentan Approved DB06403
small molecule | CAS: 177036-94-1

Ambrisentan is an orally active selective type A endothelin receptor antagonist indicated for the treatment of pulmonary arterial hypertension. It is approved in Europe, Canada and the United States for use as a single agent to improve exercise ability and de…

Kategori:
Acids, CarbocyclicAntihypertensive AgentsAntihypertensives for Pulmonary Arterial Hypertension +15
Target Protein:
Endothelin-1 receptorEndothelin receptor type B
Waktu ParuhAmbrisentan has a t…
Vol. DistribusiAmbrisentan has a l…
KlirensThe mean oral clear…
Genetik -
Ambroxol Approved DB06742
small molecule | CAS: 18683-91-5

Ambroxol is a secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus. It is the active ingredient of Mucosolvan, Lasolvan or Mucoangin. The substance is a mucoactive drug with several properties including se…

Kategori:
Adrenergics for Systemic UseAminesAnesthetics +13
Waktu Paruh7-12 hours
Vol. Distribusi-
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Genetik -
small molecule | CAS: 96989-76-3

Deskripsi belum tersedia.

Kategori:
AlkaloidsAminesAniline Compounds +4
Waktu Paruh-
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Amcasertib DB14866
small molecule | CAS: 1129403-56-0

Amcasertib is under investigation in clinical trial NCT02483247 (A Study of BBI503 in Combination With Selected Anti-Cancer Therapeutics in Adult Patients With Advanced Cancer).

Target Protein:
Platelet-derived growth factor receptor alpha
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Amcinonide Approved DB00288
small molecule | CAS: 51022-69-6

Amcinonide is a corticosteroid.

Kategori:
Adrenal Cortex HormonesAnti-Inflammatory AgentsCorticosteroid Hormone Receptor Agonists +24
Target Protein:
Steroid hormone receptor ERR1Steroid hormone receptor ERR2Estrogen-related receptor gamma +2
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Amcipatricin DB12333
small molecule | CAS: 143483-67-4

Amcipatricin has been used in trials studying the treatment of Cryptococcosis or Aspergillosis Infections. Amcipatricin (as amcipatricin diascorbate; SPK-843) is a water-soluble partricin derivative patented by SPA Societa Prodotti Antibiotici S.p.A. and deve…

Kategori:
AlkenesHydrocarbons, Acyclic
Waktu Paruh-
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Amdinocillin DB01163
small molecule | CAS: 32887-01-7

Amidinopenicillanic acid derivative with broad spectrum antibacterial action. It is poorly absorbed if given orally and is used in urinary infections and typhus. Amdinocillin is not available in the United States.

Kategori:
AmidesAnti-Bacterial AgentsAnti-Infective Agents +10
Target Protein:
Penicillin-binding protein 2aPenicillin-binding protein 2Penicillin-binding protein 3 +3
Waktu ParuhApproximately 1 hou…
Vol. Distribusi-
Klirens-
Genetik -
Amdoxovir DB06619
small molecule | CAS: 145514-04-1

Deskripsi belum tersedia.

Kategori:
DioxolesHeterocyclic Compounds, Fused-RingNucleic Acids, Nucleotides, and Nucleosides +2
Target Protein:
Gag-Pol polyproteinReverse transcriptase/RNaseH
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
AME-527 DB05879
biotech

AME-527 is a humanized monoclonal antibody that recognizes human TNF-alpha (hTNF-alpha) with high affinity and specificity. AME-527 was generated by protein engineering and identified from a library of antibody variants based on its improved binding propertie…

Target Protein:
Tumor necrosis factor
Waktu Paruh-
Vol. Distribusi-
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Amedalin DB09188
small molecule | CAS: 22136-26-1

Amedalin is a selective norepinephrine reuptake inhibitor developed in the 1970s. It has no significant effect on reuptake of serotonin and dopamine and no antihistamine or anticholinergic properties. This drug was never marketed.

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Amediplase DB06679
biotech | CAS: 151912-11-7

Amediplase is a recombinant chimeric plasminogen activator, consisting of the kringle 2 domain from the A-chain of tissue plasminogen activator (t-PA) and the carboxy terminal region of pro-urokinase. [MeSH]

Kategori:
Agents causing angioedemaAmino Acids, Peptides, and ProteinsAnticoagulants +12
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Vol. Distribusi-
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Amelubant DB06248
small molecule | CAS: 346735-24-8

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicReceptors, Leukotriene B4, antagonists & inhibitors
Target Protein:
Leukotriene B4 receptor 1Leukotriene B4 receptor 2
Waktu Paruh-
Vol. Distribusi-
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Amenamevir DB11701
small molecule | CAS: 841301-32-4

Amenamevir has been used in trials studying the treatment of Herpes Zoster, Herpes Simplex, Herpes Genitalis, and Safety of Amenamevir.

Kategori:
Antiinfectives for Systemic UseAntiviral AgentsAntivirals for Systemic Use +2
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small molecule | CAS: 30578-37-1

Deskripsi belum tersedia.

Kategori:
Adrenergic and Dopaminergic AgentsCardiac Stimulants Excl. Cardiac GlycosidesCardiac Therapy
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Amfecloral DB08924
small molecule | CAS: 5581-35-1

Amfecloral is a stimulant drug of the phenethylamine and amphetamine chemical classes. For a short period of time, it was available under the brand Acutran and indicated as an appetite suppressant, but this product no longer exists. It acts as a prodrug which…

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Amfenac DB15911
small molecule | CAS: 51579-82-9

Deskripsi belum tersedia.

Kategori:
Acids, Carbocyclic
Waktu Paruh-
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AMG 108 DB05545
biotech | CAS: 877879-38-4

AMG 108 was investigated for use as an antirheumatic agent.

Kategori:
Amino Acids, Peptides, and ProteinsAntibodiesBlood Proteins +6
Waktu Paruh-
Vol. Distribusi-
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AMG 424 DB17357
biotech

AMG 424 is a novel, humanized, anti-CD3/CD38 bispecific monoclonal antibody being investigated for multiple myeloma.

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AMG-119 DB17363
biotech

AMG-119 are CAR-T cells targeting delta-like ligand 3 (DLL3).[A254811]

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AMG-131 DB05490
small molecule | CAS: 315224-26-1

AMG-131 (T131), an orally-administered therapy, is expected to lower blood glucose in type II diabetic patients by improving the body’s ability to respond to insulin. T131 is a selective modulator of PPARg (peroxisome proliferator activated receptor gamma), a…

Kategori:
AmidesHeterocyclic Compounds, Fused-RingPPAR gamma, agonists +2
Target Protein:
Peroxisome proliferator-activated receptor gamma
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
AMG-208 DB08079
small molecule | CAS: 1002304-34-8

AMG-208 has been used in trials studying the treatment of Cancer, Tumors, Oncology, Prostate Cancer, and Oncology Patients, among others.

Target Protein:
Hepatocyte growth factor receptor
Waktu Paruh-
Vol. Distribusi-
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Genetik -
AMG-222 DB06011
small molecule | CAS: 913978-37-7

Deskripsi belum tersedia.

Kategori:
Agents causing angioedemaBenzocycloheptenesBlood Glucose Lowering Agents +1
Target Protein:
Dipeptidyl peptidase 4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
AMG-319 DB16879
small molecule | CAS: 1608125-21-8

Deskripsi belum tersedia.

Kategori:
Enzyme InhibitorsHeterocyclic Compounds, Fused-RingNucleic Acids, Nucleotides, and Nucleosides +4
Target Protein:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
AMG-337 DB15639
small molecule | CAS: 1173699-31-4

AMG-337 is under investigation in clinical trial NCT03147976 (QUILT-3.036: AMG 337 in Subjects With Advanced or Metastatic Solid Tumors).

Kategori:
Antineoplastic AgentsPyridines
Target Protein:
Hepatocyte growth factor receptor
Waktu Paruh-
Vol. Distribusi-
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Genetik -
AMG-553 DB18346
biotech

AMG-553 is an adoptive, anti-FLT3 chimeric antigen receptor T-cell therapy generated through transduction of autologous T-cells with a self-inactivating human immunodeficiency virus-1 based lentiviral vector.

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AMG-900 DB17197
small molecule | CAS: 945595-80-2

Deskripsi belum tersedia.

Kategori:
Protein Kinase InhibitorsPyridazines
Target Protein:
Aurora kinase CAurora kinase BAurora kinase A
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Menampilkan 3201–3250 dari 16004
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