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11778

Total database: 17430
Struktur (SMILES)
8554 (72.6%)
Target
6383 (54.2%)
Genomik
96 (0.8%)
Referensi
11778 (100.0%)

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Hasil Pencarian (11778)

Halaman 64 / 236
Butyrfentanyl DB09173
small molecule | CAS: 1169-70-6

Butyrfentanyl or butyrylfentanyl (not to be confused with 3-methylfentanyl) is a potent short-acting synthetic opioid analgesic drug.[A182054] It is an analog of [fentanyl] with roughly 1/30 the potency.[L7811] Butyrfentanyl was first synthesized in 1961 by J…

Kategori:
Cytochrome P-450 CYP2D6 SubstratesCytochrome P-450 CYP3A SubstratesCytochrome P-450 CYP3A4 Substrates +4
Target Protein:
Mu-type opioid receptorKappa-type opioid receptorDelta-type opioid receptor
Waktu ParuhData for the half l…
Vol. DistribusiData for the volume…
KlirensData for the cleara…
Genetik -
Butyric Acid DB03568
small molecule | CAS: 107-92-6

A four carbon acid, CH3CH2CH2COOH, with an unpleasant odor that occurs in butter and animal fat as the glycerol ester.

Kategori:
Acids, AcyclicButyratesCholinesterase Inhibitors +5
Target Protein:
CholinesteraseHistone deacetylase 1(S)-2-haloacid dehalogenase +1
Waktu Paruh-
Vol. Distribusi-
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Genetik -
BV2 DB02574
biotech

Deskripsi belum tersedia.

Target Protein:
Cholera enterotoxin subunit B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BVX-001 DB18733
biotech

BVX001 is a a novel, first-in-class CD33/CD7-directed antibody-drug conjugate.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
BW-A 58C DB06740
small molecule | CAS: 94015-46-0

BW-A 58C, also known as 2-(4-tert-butylcyclohexyl)-3-hydroxy-1,4-naphthoquinone, is an experimental naphthoquinone antimalarial drug which undergoes extensive alkyl hydroxylation to a single t-butylhydroxy metabolite in man in vivo and also in human liver mic…

Kategori:
NaphthalenesQuinones
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BX-528 DB07136
small molecule | CAS: 607837-17-2

Deskripsi belum tersedia.

Target Protein:
Carboxypeptidase B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
BZ371A DB18101
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 361440-32-6

Deskripsi belum tersedia.

Target Protein:
Glycogen phosphorylase, muscle form
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule

Deskripsi belum tersedia.

Target Protein:
Antitumor antibiotic C-1027 apoprotein
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
C-Alpha-stx1 DB17972
biotech

Deskripsi belum tersedia.

Waktu Paruh-
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Genetik -
C-Alpha-stx2 DB17971
biotech

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
C-peptide DB16187
small molecule | CAS: 59112-80-0

C-peptide is under investigation in clinical trial NCT00278980 (Effect of C-peptide on Diabetic Peripheral Neuropathy).

Kategori:
Amino Acids, Peptides, and ProteinsBlood Glucose Lowering AgentsHormones +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
C11-12 isoparaffin Approved DB11329
small molecule | CAS: 246538-76-1

C11-12 isoparaffin is a mixture of branched chain hydrocarbons with 11C or 12C's in the alkyl chain. It is found in cosmetic and personal care products as solvents or skin conditioning agent.

Waktu Paruh-
Vol. Distribusi-
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C326 DB06017
biotech

C326 is an investigational compound under investigation in clinical trial NCT00353756 (Phase 1 Study of Safety and Biological Effects of C326, an Inhibitor of IL-6, in Crohn's Disease) for the treatment of Crohn's Disease. The drug is composed of an IL-6–bind…

Kategori:
Amino Acids, Peptides, and ProteinsMembrane ProteinsPeptides +2
Target Protein:
Interleukin-6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 147859-80-1

CA-074 methyl ester (CA-074Me) is a cell-permeable cathepsin B inhibitor. It is converted by cellular esterases to CA-074.[A258234,A258239]

Kategori:
Amino Acids, Peptides, and ProteinsCathepsin B, antagonists & inhibitorsCathepsin Inhibitors +2
Target Protein:
Cathepsin B
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
CA-170 DB15772
small molecule

CA-170 is a selective, small molecule inhibitor of PD-L1.

Kategori:
Immune Checkpoint Inhibitors
Target Protein:
Programmed cell death 1 ligand 1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cabazitaxel Approved DB06772
small molecule | CAS: 183133-96-2

Cabazitaxel is a taxoid synthesized from 10-deacetylbaccatin III, a compound isolated from the yew tree.[A260621] As a second-generation semisynthetic microtubule inhibitor, cabazitaxel stabilizes microtubules and induces tumour cell death.[A7056] Due to its …

Kategori:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsBCRP/ABCG2 Inhibitors +25
Target Protein:
Tubulin beta-1 chain
Waktu ParuhFollowing a one-hou…
Vol. DistribusiSteady-state volume…
KlirensBased on the popula…
Genetik -
Cabergoline Approved DB00248
small molecule | CAS: 81409-90-7

Cabergoline, an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor. It is used to treat hyperprolactinemic disorders and Parkinsonian Syndrome. Cabergoline possesses potent agonist activity on dopamine D2 receptors.

Kategori:
Agents that produce hypertensionAlkaloidsAnti-Dyskinesia Agents +31
Target Protein:
D(2) dopamine receptor5-hydroxytryptamine receptor 2BD(3) dopamine receptor +18
Waktu ParuhThe elimination hal…
Vol. Distribusi-
Klirens* renal cl=0,008 L/…
Genetik -
Cabotegravir Approved DB11751
small molecule | CAS: 1051375-10-0

Cabotegravir, or GSK1265744, is an HIV-1 integrase inhibitor that is prescribed with the non-nucleoside reverse transcriptase inhibitor, [rilpivirine].[A227668,L31188,L31193] Early research into cabotegravir showed it had lower oral bioavailability than [dolu…

Kategori:
Anti-HIV AgentsAnti-Infective AgentsAnti-Retroviral Agents +17
Target Protein:
IntegraseGag-Pol polyprotein
Waktu ParuhThe mean half life …
Vol. DistribusiData regarding the …
KlirensData regarding the …
Genetik -
Cabozantinib Approved DB08875
small molecule | CAS: 849217-68-1

Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer.[L15123] In 2016, a capsule…

Kategori:
AmidesAminesAniline Compounds +16
Target Protein:
Hepatocyte growth factor receptorVascular endothelial growth factor receptor 2Proto-oncogene tyrosine-protein kinase receptor Ret
Waktu ParuhCabozantinib has a …
Vol. DistribusiThe volume of distr…
KlirensAt steady state, th…
Genetik -
Cacodylic acid DB02994
small molecule | CAS: 75-60-5

Deskripsi belum tersedia.

Kategori:
AgrochemicalsArsenicalsCompounds used in a research, industrial, or household setting +3
Target Protein:
Nitric oxide synthase 3Aldo-keto reductase family 1 member B1Gag-Pol polyprotein +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cadazolid DB11847
small molecule | CAS: 1025097-10-2

Cadazolid has been used in trials studying the treatment of Clostridium Difficile Infection.

Kategori:
Oxazoles
Waktu Paruh-
Vol. Distribusi-
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Genetik -
small molecule | CAS: 94820-09-4

Deskripsi belum tersedia.

Kategori:
Anti-Infective AgentsAnti-Infective Agents, LocalCicatrizants +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Cadmium DB14085
small molecule | CAS: 7440-43-9

An element with atomic symbol Cd, atomic number 48, and atomic weight 112.41. It is a metal and ingestion will lead to CADMIUM POISONING.

Kategori:
ElementsMetalsMetals, Heavy +1
Waktu Paruh-
Vol. Distribusi-
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Cadonilimab DB16680
biotech | CAS: 2394841-59-7

Cadonilimab is under investigation in clinical trial NCT04220307 (A Study of a PD-1/CTLA-4 Bispecific Antibody AK104 in Patients With Metastatic Nasopharyngeal Carcinoma).

Waktu Paruh-
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Caffeine Approved DB00201
small molecule | CAS: 58-08-2

Caffeine is a drug of the methylxanthine class used for a variety of purposes, including certain respiratory conditions of the premature newborn, pain relief, and to combat drowsiness. Caffeine is similar in chemical structure to [Theophylline] and [Theobromi…

Kategori:
AlkaloidsAnorexigenic Agents & Respiratory and CNS StimulantsBCRP/ABCG2 Inhibitors +34
Target Protein:
Adenosine receptor A15'-nucleotidaseAdenosine receptor A2a +12
Gen Terkait:
CYP1A2
Waktu ParuhIn an average-sized…
Vol. DistribusiCaffeine has the ab…
KlirensThe clearance of ca…
Genetik 1 Varian
Caflanone DB17263
small molecule | CAS: 199167-23-2

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Cagrilintide DB18887
biotech | CAS: 1415456-99-3

Cagrilintide is under investigation in clinical trial NCT06221969 (A Research Study to See How Much Cagrisema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 Inhibitor).

Kategori:
Amino Acids, Peptides, and ProteinsAmyloidAmyloidogenic Proteins +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Calaspargase pegol Approved DB14730
biotech | CAS: 941577-06-6

Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) [A40270]. Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting i…

Kategori:
AlcoholsAmidohydrolasesAsparagine-specific Enzyme +8
Target Protein:
L-asparagine
Waktu Paruh16.1 days [FDA labe…
Vol. DistribusiVss (L): 2.96 [FDA…
Klirens0.147 L/day [FDA la…
Genetik -
Calcifediol Approved DB00146
small molecule | CAS: 19356-17-3

The major circulating metabolite of vitamin D3 (cholecalciferol). It is produced in the liver and is the best indicator of the body's vitamin D stores. It is effective in the treatment of rickets and osteomalacia, both in azotemic and non-azotemic patients. C…

Kategori:
Alimentary Tract and MetabolismAnti-Parathyroid AgentsBone Density Conservation Agents +17
Target Protein:
Vitamin D3 receptor
Waktu Paruh288 hours
Vol. Distribusi-
Klirens-
Genetik -
Calcitonin eel DB12898
biotech | CAS: 57014-02-5

HC-58 has been used in trials studying the prevention of Severe Upper Limb Hemiplegia.

Waktu Paruh-
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Genetik -
biotech | CAS: 83652-28-2

A 37-amino acid peptide derived from the calcitonin gene. It occurs as a result of alternative processing of mRNA from the calcitonin gene. The neuropeptide is widely distributed in the brain, gut, perivascular nerves, and other tissue. The peptide produces m…

Kategori:
Amino Acids, Peptides, and ProteinsCalcitonin Gene-Related Peptide, antagonists & inhibitorsCardiovascular Agents +5
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
biotech | CAS: 12321-44-7

Calcitonin is a polypeptide hormone secreted by the parafollicular cells of the thyroid gland in mammals. It inhibits bone resorption and lowers both serum and urinary calcium concentrations. Human calcitonin is available only in very small quantities but has…

Kategori:
Bone Density Conservation AgentsCalcitonin PreparationsCalcium Homeostasis +1
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Calcitriol Approved DB00136
small molecule | CAS: 32222-06-3

Calcitriol is an active metabolite of vitamin D with 3 hydroxyl (OH) groups and is commonly referred to as 1,25-dihydroxycholecalciferol, or 1alpha,25-dihydroxyvitamin D<sub>3</sub>, 1,25-dihydroxyvitamin D<sub>3</sub>. It is produced in the body after series…

Kategori:
Alimentary Tract and MetabolismAntipsoriaticsAntipsoriatics for Topical Use +27
Target Protein:
Vitamin D3 receptorHomeobox protein Hox-A10
Waktu ParuhAfter administratio…
Vol. DistribusiUpon intravenous ad…
KlirensThe metabolic clear…
Genetik -
Calcium DB01373
small molecule | CAS: 7440-70-2

Calcium plays a vital role in the anatomy, physiology and biochemistry of organisms and of the cell, particularly in signal transduction pathways. The skeleton acts as a major mineral storage site for the element and releases Ca2+ ions into the bloodstream un…

Kategori:
Alimentary Tract and MetabolismAntacids and AdsorbentsBiological Factors +13
Target Protein:
Voltage-dependent L-type calcium channel subunit alpha-1CCalcium-transporting ATPase type 2C member 1Troponin C, skeletal muscle +17
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Calcium alginate Approved DB13372
small molecule | CAS: 9005-35-0

Deskripsi belum tersedia.

Kategori:
Blood and Blood Forming OrgansCarbohydratesCompounds used in a research, industrial, or household setting +3
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Calcium ascorbate Approved DB14483
small molecule | CAS: 5743-27-1

Deskripsi belum tersedia.

Kategori:
Acids, AcyclicAntioxidantsBiological Factors +12
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Calcium carbimide Approved DB09116
small molecule | CAS: 156-62-7

Calcium carbimide, sold as the citrate salt, is an alcohol-sensitizing agent. Its effects are similar to the drug disulfiram (Antabuse) in that it interferes with the normal metabolism of alcohol by preventing the breakdown of the metabolic product acetaldehy…

Kategori:
CarbodiimidesCyanidesDrugs Used in Addictive Disorders +4
Target Protein:
Aldehyde dehydrogenase family 3 member B2Aldehyde dehydrogenase, mitochondrialAldehyde dehydrogenase X, mitochondrial +1
Waktu ParuhCalcium carbimide i…
Vol. DistribusiThe apparent volume…
KlirensAfter intravenous a…
Genetik -
Calcium carbonate Approved DB06724
small molecule | CAS: 471-34-1

Calcium carbonate is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandin…

Kategori:
Alimentary Tract and MetabolismAntacidsAntacids and Adsorbents +12
Waktu Paruh-
Vol. DistribusiCalcium is rapidly …
Klirens-
Genetik -
Calcium cation DB14577
small molecule | CAS: 14127-61-8

Deskripsi belum tersedia.

Kategori:
Blood Coagulation FactorsCalcium SaltsIncreased Coagulation Factor Activity +2
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 7789-75-5

Deskripsi belum tersedia.

Kategori:
Calcium CompoundsFluoridesFluorine Compounds
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Calcium glubionate anhydrous Approved DB13142
small molecule | CAS: 97635-31-9

Calcium glubionate (or glubionate calcium) is a mineral supplement to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets.

Kategori:
Alimentary Tract and MetabolismCalcium SaltsCarbohydrates +3
Waktu Paruh-
Vol. DistribusiPrimarily in bones,…
Klirens-
Genetik -
Calcium glucoheptonate Approved DB00326
small molecule | CAS: 29039-00-7

Calcium supplements such as calcium gluceptate are taken by individuals who are unable to get enough calcium in their regular diet or who have a need for more calcium. They are used to prevent or treat several conditions that may cause hypocalcemia (not enoug…

Kategori:
Acids, AcyclicAlimentary Tract and MetabolismCalcium Salts +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Calcium glycerophosphate Approved DB11264
small molecule | CAS: 27214-00-2

Calcium glycerophosphate is a [DB01373] salt of glycerophosphoric acid that forms a white, fine, slightly hygroscopic powder. The commercial product is a mixture of calcium beta-, and D-, and L -alpha-glycerophosphate. By FDA, calcium glycerophosphate is cons…

Kategori:
AlcoholsCarbohydratesGlycerophosphates +6
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
small molecule | CAS: 7778-54-3

Deskripsi belum tersedia.

Waktu Paruh-
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Calcium lactate Approved DB13231
small molecule | CAS: 814-80-2

Calcium lactate is a salt that consists of two lactate anions for each calcium cation (Ca2+). It is prepared commercially by the neutralization of lactic acid with calcium carbonate or calcium hydroxide. Approved by the FDA as a direct food substance affirmed…

Kategori:
Alimentary Tract and MetabolismCalcium SaltsHydroxy Acids +1
Waktu ParuhNo pharmacokinetic …
Vol. DistribusiThe majority of cal…
KlirensNo pharmacokinetic …
Genetik -
small molecule | CAS: 11116-97-5

Deskripsi belum tersedia.

Kategori:
Alimentary Tract and MetabolismCalcium SaltsMineral Supplements
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
Calcium levulinate Approved DB13800
small molecule | CAS: 591-64-0

The relatively new calcium levulinate is produced from a direct reaction between L- or levulinic acid levulose and calcium hydroxide [L2765]. The resultant calcium levulinate formulation, when used as a calcium supplement, possesses a high calcium content tha…

Kategori:
Alimentary Tract and MetabolismCalcium SaltsEnzyme Inhibitors +2
Target Protein:
Calsequestrin-1CalretininCalmodulin
Waktu ParuhReadily accessible …
Vol. Distribusi99% of the body's c…
KlirensDespite inter-indiv…
Genetik -
small molecule | CAS: 1224727-39-2

Deskripsi belum tersedia.

Waktu Paruh-
Vol. Distribusi-
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Genetik -
Calcium oxide DB15648
small molecule | CAS: 1305-78-8

Deskripsi belum tersedia.

Kategori:
AnionsCompounds used in a research, industrial, or household settingDental Materials +4
Waktu Paruh-
Vol. Distribusi-
Klirens-
Genetik -
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